A stone pathway leading to a coastal area with a clear view of the ocean.

Santa Cruz Vacations & Trips from $704

Book a Hotel + Flight or Car together to unlock savings

Your Santa Cruz Vacation

With a Santa Cruz vacation package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include Samaipata, Roboré and Camiri. Expedia is a one-stop shop when it comes to planning your Santa Cruz vacation. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other.

Top destinations in Santa Cruz

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Dec 14 - Dec 18

    Ibis Santa Cruz DE LA Sierra + Flight

    Equipetrol
    4 nights
    3.0 star property
    9.4/10 - Exceptional (159 reviews)
    Roundtrip • San Juan (SJU) - Santa Cruz (VVI)
    SJU - VVI • 1 stop VVI - SJU • 1 stop
    $789
    $704
    per traveler
    found 20 hours ago
    Ibis Santa Cruz DE LA Sierra
  • Dec 14 - Dec 18

    Swissôtel Santa Cruz De La Sierra + Flight

    Santa Cruz
    4 nights
    4.5 star property
    9.2/10 - Wonderful (91 reviews)
    "Great location, great view. Employees were very helpful. One thing, water was coming out from the shower to the bed area through the glass door. It was messy. Other than that. Everything was good."
    Reviewed November 6, 2026
    Roundtrip • San Juan (SJU) - Santa Cruz (VVI)
    SJU - VVI • 1 stop VVI - SJU • 1 stop
    $1,054
    $813
    per traveler
    found 20 hours ago
    Swissôtel Santa Cruz De La Sierra
  • Jan 19 - Jan 25

    Camino Real Hotel + Flight

    Santa Cruz
    6 nights
    4.5 star property
    9.0/10 - Wonderful (457 reviews)
    "Muy bueno"
    Reviewed October 31, 2026
    Roundtrip • Chicago (ORD) - Santa Cruz (VVI)
    ORD - VVI • 1 stop VVI - ORD • 1 stop
    $1,690
    $1,357
    per traveler
    found 1 day ago
    Camino Real Hotel
  • Dec 14 - Dec 18

    Hotel Cortez + Flight

    Equipetrol
    4 nights
    3.5 star property
    9.4/10 - Exceptional (162 reviews)
    "El hotel es fantastico, el desayuno excelente, los servicios que brinda el hotel son un plus para el huésped. En general, el personal es atento y amable. Sin embargo, tuvimos problemas en el check in, la señorita que nos recibió indicó que no teníamos reservación. Se le indicó que la reservación se había hecho por Expedia y ella insistió en que no teníamos alguna. Cuando llamé a Expedia, nos dijo que, aunque el hotel estaba lleno, nos darían una habitación. Esta señorita parece no ser tan..."
    Reviewed October 16, 2026
    Roundtrip • San Juan (SJU) - Santa Cruz (VVI)
    SJU - VVI • 1 stop VVI - SJU • 1 stop
    $923
    $790
    per traveler
    found 20 hours ago
    Hotel Cortez
  • Jan 19 - Jan 25

    Novotel Santa Cruz De La Sierra + Flight

    Santa Cruz
    6 nights
    5.0 star property
    9.0/10 - Wonderful (133 reviews)
    "Love staying there…. Very clean and staff always willing to assist."
    Reviewed October 21, 2026
    Roundtrip • Chicago (ORD) - Santa Cruz (VVI)
    ORD - VVI • 1 stop VVI - ORD • 1 stop
    $1,446
    $1,244
    per traveler
    found 1 day ago
    Novotel Santa Cruz De La Sierra

Discover the most popular places to visit in Santa Cruz

What to do in Santa Cruz

Santa Cruz Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Santa Cruz

Things to do in Santa Cruz

Santa Cruz offers a vibrant mix of culture and family-friendly activities, perfect for a city-themed getaway. Enjoy shopping at local centers and malls, relax at resorts, and explore outdoor adventures. Don't miss out on day trips and wine tastings to experience the region's unique flavors. Whether you’re looking for a beach vacation or engaging activities, Santa Cruz has something for everyone to enjoy.

Shopping

Ventura Mall offers a vibrant shopping experience with entertainment and family-friendly options. For unique crafts, visit La Recova Artisan Walk, where local artisans showcase their work. Finally, explore Patio Design LifeStyle Center for a mix of shopping and dining in a lively atmosphere.

Recreation

Experience the vibrant energy at the Ramon Tahuichi Aguilera Stadium, perfect for sports enthusiasts. Enjoy cinematic adventures at Cine Center, ideal for family outings and romantic dates. Immerse yourself in culture at Casa Municipal de Cultura Raúl Otero Reiche, where entertainment and family vibes come alive.

Adventure

Parque Nacional Amboró offers breathtaking hiking trails through diverse ecosystems, where you can spot exotic wildlife. For thrill-seekers, the nearby Lomas de Arena invites you to explore stunning sand dunes, perfect for sandboarding and adrenaline-filled adventures amidst striking landscapes.

Nightlife

In Santa Cruz, dive into vibrant nightlife at Avenida San Martín and Equipetrol, where lively bars and dance clubs come alive. Enjoy live music and local DJs, or relax at rooftop lounges with stunning views. Don’t miss the energetic atmosphere that keeps the city buzzing until dawn.

Find the best attractions in Santa Cruz

Santa Cruz, Bolivia, offers a delightful blend of culture and adventure, making it perfect for family vacations and city explorations. Key attractions include national parks, impressive cathedrals, and historic landmarks. Visitors can enjoy outdoor activities and cultural experiences, with nearby points of interest like Santa Barbara and the scenic Santa Cruz Beach enhancing your trip. Whether seeking adventure or cultural immersion, Santa Cruz has something for everyone.

  • Plaza 24 de Septiembre: This vibrant square serves as the heart of Santa Cruz, surrounded by historical architecture and lively cafes. It's a perfect spot to immerse yourself in local culture, enjoy street performances, and savor Bolivian cuisine while soaking up the bustling city vibes.
  • Amboró National Park: A paradise for adventure seekers, this national park boasts diverse ecosystems and stunning landscapes. Hike through lush forests, encounter unique wildlife, and revel in the breathtaking views, making it an ideal destination for outdoor enthusiasts and nature lovers.
  • San Lorenzo Cathedral: A stunning example of colonial architecture, this cathedral reflects the rich cultural heritage of Santa Cruz. Its intricate design and serene atmosphere make it a perfect place for reflection and appreciation of local artistry.

Best time to go to Santa Cruz

The best time to visit Santa Cruz can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Santa Cruz falls in October, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature in Santa Cruz falls in June, visitor numbers are average and weather is mostly sunny with light rain.

Tips to save on your trip to Santa Cruz

  • Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to Santa Cruz.
  • Consider traveling to Santa Cruz during the low season (June, August and November) for more affordable options.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Frequently Asked Questions

How much does a Santa Cruz vacation package cost?

Vacation packages in Santa Cruz, Bolivia are centered on Santa Cruz city. A week-long trip there typically costs around $1,350 per adult, with prices ranging from around $550 to $2,050 per adult.


*Package prices shown are the average total cost per adult across Expedia bookings over the past year and may change depending on availability, dates, and demand.

How can I save money on a Santa Cruz vacation package?

When you bundle, you can save up to 30%*. To save money on a Santa Cruz package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.

What's included in a Santa Cruz vacation package?

A Santa Cruz vacation package in Santa Cruz lets you combine flights, hotel stays, and rental cars. Many hotels offer airport shuttle service to Santa Cruz (VVI-Viru Viru Intl.), and most hotels provide free breakfast.


Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.

How do I find cheap Santa Cruz vacation package deals?

Santa Cruz vacation packages are available in Santa Cruz, where prices start around $190 per adult for weekend trips.


Bundling your flight and hotel can offer additional savings compared with booking separately. Week-long Santa Cruz packages typically save around $40 per adult, and weekend trips can save around $15 per adult.


Browse cheap vacation packages in Santa Cruz on Expedia to compare current deals.


*Package prices shown are the average total cost per adult across Expedia bookings over the past year and may change depending on availability, dates, and demand.

What is the best time to visit Santa Cruz?

The best time for a Santa Cruz vacation package in Santa Cruz city is typically March, May, and July, which are the peak booking months. In March, average temperatures are around 76°F with highs of 85°F, while May sees average temperatures of 70°F with highs of 78°F. Timing reflects Santa Cruz city specifically, so conditions may differ elsewhere in the region.


If you'd prefer a quieter trip with fewer visitors, consider traveling in January or October. January offers average temperatures of 78°F with highs of 87°F, and October is slightly warmer with average temperatures of 80°F and highs of 89°F.

What types of vacation packages are available in Santa Cruz?

Vacation packages in Santa Cruz, concentrated in the city of Santa Cruz, come in several styles:

  • For breakfast-inclusive stays: Surbackpackers, rated 9.5 out of 10 by travelers, offers complimentary breakfast and free WiFi.
  • For budget-friendly options: The 4.5-star Gran Hotel Santa Cruz provides family rooms, an outdoor pool, and free breakfast, making it a good value choice.
  • For couples: Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel, a 3.5-star property rated 8.9 out of 10 by travelers, features a hot tub and outdoor pool. Guests often highlight its excellent location and friendly staff.
  • For families: The 4.5-star Camino Real Hotel, rated 8.8 out of 10 by travelers, includes family rooms and an indoor pool. Travelers frequently praise the super helpful staff and nice pool.

Which destinations should I consider for a Santa Cruz vacation?

For a Santa Cruz vacation, the region offers several distinct areas to consider as your base, each catering to different travel styles:

  • Santa Cruz: This city is the main base for travelers seeking city and urban attractions, cultural experiences and is well-suited for business travel or family-friendly trips.
  • Samaipata: For those interested in cultural attractions combined with outdoor activities and scenic views, Samaipata offers an adventure-focused stay.
  • Cuevas: Couples looking for a romantic getaway with opportunities for outdoor activities and scenic views will find Cuevas to be a fitting choice.
  • Warnes: Ideal for families, Warnes provides a mix of family-friendly attractions, outdoor activities, and urban conveniences.

Is Santa Cruz better suited for a beach vacation or a cultural trip?

Santa Cruz, Bolivia is primarily a cultural and urban destination, known for its rich heritage and city attractions. Travelers seeking a Santa Cruz vacation will find plenty to explore, from historic landmarks to vibrant city life.


The city of Santa Cruz offers a wealth of cultural experiences, including the central Plaza 24 de Septiembre and the impressive San Lorenzo Cathedral.

Which airport should I use for a Santa Cruz vacation?

For a Santa Cruz vacation, the primary gateway is Santa Cruz (VVI-Viru Viru Intl.) Airport, which serves the region. Another option within the city is Santa Cruz (SRZ-El Trompillo) Airport. Both airports provide access to the city of Santa Cruz and the wider region, with onward travel available to your chosen base.

What are the top things to do in Santa Cruz?

A Santa Cruz vacation in Bolivia is best explored from the city of Santa Cruz, which serves as a vibrant base for cultural and urban attractions. From here, you can discover a range of sights both within the city and in the surrounding region:


Browse and book things to do in Santa Cruz on Expedia.

What is the best time to book a Santa Cruz vacation package?

Book your Santa Cruz vacation package around 2 weeks in advance, with packages located in Santa Cruz. It gives you time to secure your preferred flights and hotel while rates are still competitive. Most travelers book between 1 and 6 weeks out.


March, May, and July are the most popular months for Santa Cruz packages in Santa Cruz, so booking earlier is advisable if you're traveling during those months.

How many days do you need for a Santa Cruz vacation?

Most Santa Cruz vacation packages last around 5 days, with stays in Santa Cruz, a central urban destination known for its cultural attractions. Week-long trips are popular, and weekend getaways are also common, giving you ample time to explore sights like Plaza 24 de Septiembre.

Can I change or cancel my Santa Cruz vacation package if my plans change?

Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.

Do One Key members get extra savings when booking Santa Cruz vacation packages?

Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.

Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?

Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Santa Cruz vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.

How do I find last-minute vacation packages to Santa Cruz?

To find last-minute vacation packages to Santa Cruz, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.

How does free cancellation work on Santa Cruz vacation packages?

Free cancellation on a Santa Cruz vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.

Is it cheaper to book a Santa Cruz vacation as a package or separately?

Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Santa Cruz getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.

Why should I book my Santa Cruz vacation package with Expedia?

Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.