Title: Santa Cruz Vacation Packages 2026 | Expedia.com [Santa Cruz Travel Guide](https://expedia.com/Santa-Cruz.dx6297178)[Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Vacation Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)[Santa Cruz Flights](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santa Cruz Vacations & Trips ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Santa Cruz Vacation With a Santa Cruz vacation package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include [Samaipata](https://www.expedia.com/Samaipata.d6200976.Destination-Travel-Guides), [Roboré](https://www.expedia.com/Robore.d3000408084.Destination-Travel-Guides) and [Camiri](https://www.expedia.com/Camiri.d770.Destination-Travel-Guides). Expedia is a one-stop shop when it comes to planning your Santa Cruz vacation. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other. ## Top destinations in Santa Cruz ![San Lorenzo Cathedral showing a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115563-Santa-Cruz.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Santa Cruz [](https://expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides) ![Samaipata is one of Bolivia's hidden gems. Staying in this quiet town gives you access to the beautiful natural areas that surround it. Quick Tip: Taking a stroll down the streets outside the town offer some pretty jungle views and a glimpse of local life in the countryside. #Bolivia #Travel](https://mediaim.expedia.com/destination/2/06496d3cec9b6cad4a738ddeb6156d1c.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Samaipata [](https://expedia.com/Samaipata.d6200976.Destination-Travel-Guides) ## Best Places to Vacation in Santa Cruz ## 1\. Plan your dream getaway to [Santa Cruz](https://www.expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides) Santa Cruz, located in Bolivia, offers a unique and vibrant atmosphere for city vacationers. With its diverse range of attractions, including shopping centers, charming cafes, colorful flower markets, a zoo, and various excursions, visitors can immerse themselves in the local culture. The city also boasts a beautiful cathedral and is a haven for birdwatching enthusiasts. For those interested in sports, Santa Cruz is known for its passion for soccer. Additionally, the city has a thriving business scene and offers a wide selection of local beers to enjoy. Overall, Santa Cruz provides a delightful and exciting experience for travelers. - The peak season is from July to September - The off-peak season is from October to December - Travelers tend to stay 4 days in Santa Cruz ## 2\. Escape to [Samaipata](https://www.expedia.com/Samaipata.d6200976.Destination-Travel-Guides) with a vacation package Samaipata, located in Santa Cruz, Bolivia, offers a unique outdoor vacation experience. With its diverse geography, this destination is perfect for activities such as hiking, mountain exploration, forest and jungle adventures, camping, and waterfall visits. Wildlife enthusiasts will also enjoy the opportunity for birdwatching and spotting local fauna. Samaipata is also home to an impressive UNESCO World Heritage Site and a zoo. Popular traveler activities include destination activities, tours, and sightseeing. Immerse yourself in the natural beauty and vibrant atmosphere of Samaipata for an unforgettable outdoor vacation. - The peak season is from December to February - The off-peak season is from October to December - Travelers tend to stay 2 days in Samaipata ## 3\. Experience [Warnes](https://www.expedia.com/Warnes.d6352296.Destination-Travel-Guides) with a travel package Warnes, Santa Cruz, Bolivia offers a unique and memorable family vacation experience. The local atmosphere is warm and welcoming, with friendly locals eager to share their culture and traditions. The town is surrounded by beautiful natural landscapes, including lush forests and picturesque mountains, perfect for outdoor activities such as hiking and exploring. Families can also visit local attractions like the Warnes Zoo, which houses a variety of exotic animals, or enjoy traditional Bolivian cuisine at the town's charming restaurants. With its rich history and natural beauty, Warnes is an ideal destination for a family vacation. - The peak season is from September to November - The off-peak season is from March to May ## 4\. Create memories in [San Jose de Chiquitos](https://www.expedia.com/San-Jose-De-Chiquitos.d6344854.Destination-Travel-Guides) with a vacation package San Jose de Chiquitos in Santa Cruz, Bolivia, offers a unique cultural vacation experience. With its sunny weather, lush forests, and stunning natural parks, the town is a haven for nature lovers. Explore the historical urban center and marvel at the beautiful cathedral, a true architectural gem. Immerse yourself in the local culture by visiting the various churches and experiencing their rich traditions. The scenery in San Jose de Chiquitos is breathtaking, with picturesque landscapes and vibrant colors. Whether you're seeking a peaceful retreat or an adventure-filled getaway, this charming town has it all. - The peak season is from July to September - The off-peak season is from October to December - Travelers tend to stay 2 days in San Jose de Chiquitos ## 6\. Explore [Roboré](https://www.expedia.com/Robore.d3000408084.Destination-Travel-Guides) with a vacation package Concepcion, Santa Cruz, Bolivia, offers a rich cultural experience for travelers. The town is known for its churches, waterfalls, cathedral, and natural beauty. Visitors can explore the picturesque lake, enjoy live music performances, and immerse themselves in local festivals. Concepcion also boasts a vibrant theater scene and opportunities to appreciate art in museums. Whether you're seeking a peaceful retreat in nature or a lively cultural experience, Concepcion has something to offer. With its unique blend of tradition and modernity, this Bolivian town promises an unforgettable vacation for culture enthusiasts. - The peak season is from December to February - The off-peak season is from September to November ## 5\. Discover [Concepcion](https://www.expedia.com/Concepcion.d6353167.Destination-Travel-Guides) with our vacation deals Roboré, located in Santa Cruz, Bolivia, offers a unique cultural vacation experience. Immerse yourself in the vibrant local atmosphere as you explore the town's rich heritage and traditions. Discover the region's indigenous culture through captivating art, music, and dance performances. Indulge in the local cuisine, savoring traditional Bolivian dishes bursting with flavors. Engage with friendly locals and learn about their customs and way of life. Explore the breathtaking natural landscapes surrounding Roboré, from lush rainforests to majestic waterfalls. Whether you're wandering through charming local markets or exploring ancient ruins, Roboré promises an unforgettable cultural adventure. - The peak season is from October to December - The off-peak season is from May to July ### Things to do in Santa Cruz Santa Cruz offers a vibrant mix of culture and family-friendly activities, perfect for a city-themed getaway. Enjoy shopping at local centers and malls, relax at resorts, and explore outdoor adventures. Don't miss out on day trips and wine tastings to experience the region's unique flavors. Whether you’re looking for a beach vacation or engaging activities, Santa Cruz has something for everyone to enjoy. **Shopping** [Ventura Mall](https://www.expedia.com/Ventura-Mall-Santa-Cruz.d553248634697753452.Vacation-Attraction) offers a vibrant shopping experience with entertainment and family-friendly options. For unique crafts, visit [La Recova Artisan Walk](https://www.expedia.com/La-Recova-Artisan-Walk-Santa-Cruz.d553248621532371683.Vacation-Attraction), where local artisans showcase their work. Finally, explore [Patio Design LifeStyle Center](https://www.expedia.com/Patio-Design-LifeStyle-Center-Santa-Cruz.d916427946376515584.Vacation-Attraction) for a mix of shopping and dining in a lively atmosphere. **Recreation** Experience the vibrant energy at the [Ramon Tahuichi Aguilera Stadium](https://www.expedia.com/Ramon-Tahuichi-Aguilera-Stadium-Santa-Cruz.d6098832.Vacation-Attraction), perfect for sports enthusiasts. Enjoy cinematic adventures at [Cine Center](https://www.expedia.com/Cine-Center-Santa-Cruz.d6126769.Vacation-Attraction), ideal for family outings and romantic dates. Immerse yourself in culture at Casa Municipal de Cultura Raúl Otero Reiche, where entertainment and family vibes come alive. **Adventure** Parque Nacional Amboró offers breathtaking hiking trails through diverse ecosystems, where you can spot exotic wildlife. For thrill-seekers, the nearby Lomas de Arena invites you to explore stunning sand dunes, perfect for sandboarding and adrenaline-filled adventures amidst striking landscapes. **Nightlife** In Santa Cruz, dive into vibrant nightlife at Avenida San Martín and Equipetrol, where lively bars and dance clubs come alive. Enjoy live music and local DJs, or relax at rooftop lounges with stunning views. Don’t miss the energetic atmosphere that keeps the city buzzing until dawn. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Find the best attractions in Santa Cruz Santa Cruz, Bolivia, offers a delightful blend of culture and adventure, making it perfect for family vacations and city explorations. Key attractions include national parks, impressive cathedrals, and historic landmarks. Visitors can enjoy outdoor activities and cultural experiences, with nearby points of interest like Santa Barbara and the scenic Santa Cruz Beach enhancing your trip. Whether seeking adventure or cultural immersion, Santa Cruz has something for everyone. - **[Plaza 24 de Septiembre: ](https://www.expedia.com/Plaza-24-De-Septiembre-Santa-Cruz.d6098828.Vacation-Attraction)** This vibrant square serves as the heart of Santa Cruz, surrounded by historical architecture and lively cafes. It's a perfect spot to immerse yourself in local culture, enjoy street performances, and savor Bolivian cuisine while soaking up the bustling city vibes. - **[Amboró National Park: ](https://www.expedia.com/Amboro-National-Park-Santa-Cruz.d6098839.Vacation-Attraction)** A paradise for adventure seekers, this national park boasts diverse ecosystems and stunning landscapes. Hike through lush forests, encounter unique wildlife, and revel in the breathtaking views, making it an ideal destination for outdoor enthusiasts and nature lovers. - **[San Lorenzo Cathedral: ](https://www.expedia.com/San-Lorenzo-Cathedral-Santa-Cruz.d6098830.Vacation-Attraction)** A stunning example of colonial architecture, this cathedral reflects the rich cultural heritage of Santa Cruz. Its intricate design and serene atmosphere make it a perfect place for reflection and appreciation of local artistry. ### Best time to go to Santa Cruz The best time to visit Santa Cruz can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Santa Cruz falls in October, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature in Santa Cruz falls in June, visitor numbers are average and weather is mostly sunny with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 78.3°F (25.700000000000003°C) | Light Rain | Mostly Sunny | Slightly Low | Average | | February | 77.0°F (25.0°C) | Light Rain | Mostly Cloudy | Slightly High | Average | | March | 76.5°F (24.700000000000003°C) | Light Rain | Mostly Sunny | Average | Slightly High | | April | 74.5°F (23.6°C) | Light Rain | Mostly Sunny | Average | Slightly High | | May | 70.2°F (21.200000000000003°C) | Light Rain | Mostly Sunny | Slightly Low | Average | | June | 67.8°F (19.9°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | July | 68.5°F (20.3°C) | No Rain | Mostly Sunny | Average | Average | | August | 72.9°F (22.700000000000003°C) | No Rain | Sunny | Slightly High | Slightly Low | | September | 77.9°F (25.5°C) | Light Rain | Sunny | Slightly High | Slightly High | | October | 79.5°F (26.4°C) | Light Rain | Mostly Sunny | Average | Average | | November | 79.3°F (26.3°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | December | 78.4°F (25.8°C) | Light Rain | Mostly Sunny | Slightly Low | Average | ### Tips to save on your trip to Santa Cruz - Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to Santa Cruz. - Consider traveling to Santa Cruz during the low season (June, August and November) for more affordable options. - Use the *Price per traveler* filter on Expedia to find a package deal that suits your budget. - Check the *VIP Access properties* filter to discover outstanding hotels with added member perks at select properties. ## Find the Best Santa Cruz Vacation Packages ## Santa Cruz Essential Information | Language | Spanish | | --------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | Bolivian bolivianos | | Local Welcome | ¡Hola! | | Local Goodbye | Adiós | | Closest Airport | Viru Viru Intl. Airport (VVI) | | Top Sights | [Santa Cruz Zoo](https://www.expedia.com/Santa-Cruz-Zoo-Santa-Cruz.d6098836.Vacation-Attraction), [Amboró National Park](https://www.expedia.com/Amboro-National-Park-Santa-Cruz.d6098839.Vacation-Attraction) and [Municipal Botanical Garden of Santa Cruz](https://www.expedia.com/Municipal-Botanical-Garden-Of-Santa-Cruz-Santa-Cruz.d553248635951339810.Vacation-Attraction) | ## Santa Cruz Hotel Deals ![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/53c67151_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ibis Santa Cruz DE LA Sierra AVENIDA CRISTOBAL DE MENDOZA Santa Cruz $49 nightly $49 total Feb 12 - Feb 13 9.4/10 Exceptional! (85 reviews) Awesome Reviewed on Feb 6, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F12%2F2026&endDate=2%2F13%2F2026&selected=87138613&PinnedHotelID=87138613&HadPinnedHotel=true®ionId=6297178) ![Marriott Santa Cruz de la Sierra Hotel](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/a95726cf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Marriott Santa Cruz de la Sierra Hotel 4to Anillo Entre Radial 23 Santa Cruz Santa Cruz $127 nightly $127 total Feb 27 - Feb 28 9/10 Wonderful! (213 reviews) Muy bien exelente Reviewed on Dec 9, 2025 [](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=21490226&PinnedHotelID=21490226&HadPinnedHotel=true®ionId=6297178) ![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel Ave. San Martin, #455 Santa Cruz $144 nightly $144 total Feb 22 - Feb 23 8.8/10 Excellent! (357 reviews) Welcoming clean rooms, friendly staff, continental breakfast with natural drinks Reviewed on Jan 29, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=18758&PinnedHotelID=18758&HadPinnedHotel=true®ionId=6297178) [See all 317 properties in Santa Cruz](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F10%2F2026&endDate=2%2F11%2F2026®ionId=6297178) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ Friendly Vacations [](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adventure Vacations [](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click) ![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Honeymoon Vacations [](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ## Frequently asked questions ### How much does a Santa Cruz vacation package cost? ### How do I get a cheap travel package to Santa Cruz? ### How far in advance should I book my Santa Cruz vacation? ### What does an Expedia Santa Cruz travel package include? ### What should I know before booking a Santa Cruz travel package? ### Can I choose my airline with a Santa Cruz Expedia vacation package? ### Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages? ### If I'm not able to travel, can I cancel my Santa Cruz vacation package? ### Discover the most popular places to visit in Santa Cruz ![Plaza 24 de Septiembre which includes heritage architecture and heritage elements as well as a large group of people](https://images.trvl-media.com/place/6098828/2cbd296e-1bf4-483c-835b-4827ab9257d1.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Plaza 24 de Septiembre 4.5/5(26 reviews) The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere. [](https://expedia.com/Plaza-24-De-Septiembre-Santa-Cruz.d6098828.Vacation-Attraction) ![San Lorenzo Cathedral which includes heritage elements, heritage architecture and a church or cathedral](https://images.trvl-media.com/place/6098830/07633da9-6b86-46e4-8a7c-5cc7962f1701.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Lorenzo Cathedral 4.5/5(15 reviews) One of the most iconic landmarks in Santa Cruz is the city’s mighty cathedral, which houses a museum displaying important artwork. [](https://expedia.com/San-Lorenzo-Cathedral-Santa-Cruz.d6098830.Vacation-Attraction) #### Ventura Mall 4.5/5(28 reviews) During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area. [](https://expedia.com/Ventura-Mall-Santa-Cruz.d553248634697753452.Vacation-Attraction) ### What to do in Santa Cruz ![Tickets Admission Ernesto Che Guevara Historical Museum in Vallegrande](https://mediaim.expedia.com/localexpert/4191385/9530c6db-4a68-46b4-b263-bae4498beefe.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guided visit to the Che Guevara Memorial in Vallegrande $19 per adult [](https://expedia.com/things-to-do/guided-visit-to-the-che-guevara-memorial-in-vallegrande.a4191385.activity-details) ![Vallegrande City](https://mediaim.expedia.com/localexpert/4231179/1a3f0126-8501-4ae1-ad3f-63dd629727fe.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Vallegrande City Tour $29 per adult [](https://expedia.com/things-to-do/vallegrande-city-tour.a4231179.activity-details) ![Common grave, where the body of Che Guevara was found in 1997.](https://mediaim.expedia.com/localexpert/4190544/8d37523f-4917-493e-ab9d-482c2c1915da.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guided tour of the Che Guevara Museum in Vallegrande $19 per adult [](https://expedia.com/things-to-do/guided-tour-of-the-che-guevara-museum-in-vallegrande.a4190544.activity-details) [See all activities in Santa Cruz](https://expedia.com/things-to-do/search?rid=6297178) Explore a world of travel with Expedia ## Other vacations you might like - Top cities in Santa Cruz - Vacations and getaways similar to Santa Cruz - Best vacation destinations by month - Expedia's Latest Trends - [Santa Cruz Vacations ](https://expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides) - [Samaipata Vacations ](https://expedia.com/Samaipata.d6200976.Destination-Travel-Guides) - [Warnes Vacations ](https://expedia.com/Warnes.d6352296.Destination-Travel-Guides) - [Roboré Vacations ](https://expedia.com/Robore.d3000408084.Destination-Travel-Guides) - [San Jose de Chiquitos Vacations ](https://expedia.com/San-Jose-De-Chiquitos.d6344854.Destination-Travel-Guides) - [Puerto Quijarro Vacations ](https://expedia.com/Puerto-Quijarro.d3000389058.Destination-Travel-Guides) - [Vallegrande Vacations ](https://expedia.com/Vallegrande.d6350207.Destination-Travel-Guides) - [Concepcion Vacations ](https://expedia.com/Concepcion.d6353167.Destination-Travel-Guides) - [San Ignacio de Velasco Vacations ](https://expedia.com/San-Ignacio-De-Velasco.d6161202.Destination-Travel-Guides) - 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