The Best Hotels Closest to Colleton Medical Center in Walterboro for 2026

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Our top choices for Colleton Medical Center hotels

A hotel room with a bed, bedside lamps, a nightstand, a mirror, and a framed photo collage on the wall.

A pool area with lounge chairs, a pool, and a building with a 'Sleep Inn' sign.

A living room with a sofa, armchair, and a small round table with a lamp and decorative items.

A modern living room with a sofa, armchair, and coffee table, a desk with a computer, and a staircase leading to an upper level.

1. Sleep Inn Walterboro I-95

1.2 mi from Colleton Medical Center

France

$84 nightly

$94 total

Oct 20 - Oct 21

Total with taxes and fees

A hotel room with a bed, bedside tables, a desk, a TV, a window, and a door.

A hallway with a Christmas tree on a pedestal table, a door, a wall clock, and a calendar.

A two-story building with a brick facade, multiple windows, and a staircase leading to the upper level.

A bathroom with a granite countertop, a sink, a vanity with a mirror, and a microwave.

2. Southern Inn By OYO Walterboro I-95

1.1 mi from Colleton Medical Center

jesus

$44 nightly

$49 total

Oct 1 - Oct 2

Total with taxes and fees

A reception area with a marble counter, a glass door entrance, and a wooden floor.

A kitchen with a microwave, coffee maker, and fruit juice dispenser.

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a framed picture on the wall.

A reception area with a wooden wall, a sofa, a chair, and a potted plant.

3. Travelodge by Wyndham Walterboro

1.1 mi from Colleton Medical Center

Gabriella

$57 nightly

$64 total

Oct 1 - Oct 2

Total with taxes and fees

A hotel with a covered front porch, a two-story building, and a parking lot with motorcycles.

A reception desk with a framed welcome sign, a computer, and a potted plant.

A hotel bathroom with a granite countertop, a sink, a mirror, and a towel rack.

A poolside area with a lifeguard chair, a pool ladder, and two white chairs.

4. Super 8 by Wyndham Walterboro

1.5 mi from Colleton Medical Center

David

$45 nightly

$50 total

Oct 6 - Oct 7

Total with taxes and fees

A spacious hotel lobby with a central bar area, multiple seating arrangements, and large windows providing natural light.

A rack of dumbbells with weights labeled 5 and 10.

A modern hotel with a flat roof, a prominent entrance, and a parking lot.

A snack display with various packaged snacks and beverages.

5. Hampton Inn & Suites Walterboro

4.3 mi from Colleton Medical Center

Lauren

$162 nightly

$182 total

Oct 12 - Oct 13

Total with taxes and fees

A room with a window view of a forest path, a white air conditioning unit, a grey upholstered bench, and a wall-mounted lamp.

A hotel room with a wooden dining table, blue sofa, and a small wooden coffee table. A hallway leads to the bathroom.

A conference room with a large table, blue chairs, a television on a cabinet, and a patterned carpet.

A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.

6. Holiday Inn Exp Walterboro by IHG

4.2 mi from Colleton Medical Center

Jennifer

$148 nightly

$166 total

Oct 4 - Oct 5

Total with taxes and fees

A hotel room with two beds, a desk, a chair, and a large window with curtains.

A gym with cardio equipment, weight machines, and a treadmill.

A reception area with a wooden counter, a potted plant, and a tiled floor.

A hotel hallway with a blue carpet, white walls, and doors on both sides.

7. Comfort Inn & Suites Walterboro I-95

4.1 mi from Colleton Medical Center

andrew

$95 nightly

$107 total

Oct 25 - Oct 26

Total with taxes and fees

A Microtel Inn Suites by Wyndham with a parking lot and a red car parked in front.

A modern hotel lobby with wooden counters, a digital screen, a coffee machine, and a tiled floor.

Two cold drink vending machines and a snack shelf stocked with various brands.

A swimming pool with a white fence, a lifeguard chair, and a sign indicating no diving.

8. Microtel Inn & Suites by Wyndham Walterboro

4.3 mi from Colleton Medical Center

Sarah

$94 nightly

$106 total

Oct 4 - Oct 5

Total with taxes and fees

A hotel room with two beds, a chair, a desk, and a mirror.

A reception area with a wooden desk, framed awards, and a red carpet with the hotel name.

A kitchen area with a coffee machine, a microwave, a toaster, and a refrigerator.

9. Econo Lodge Walterboro I-95

3.7 mi from Colleton Medical Center

anita

$47 nightly

$52 total

Oct 20 - Oct 21

Total with taxes and fees

A modern living room with a sofa, a round table, a TV mounted on a wooden wall, and a kitchen area in the background.

A modern living room with large windows, a ceiling fan, and a mix of seating including a sofa, armchairs, and ottomans.

A self-service breakfast area with coffee machines, a microwave, and a beverage dispenser.

A hotel room with a bed, a mounted TV, a mirror, and a wooden panel wall.

10. Best Western Of Walterboro

3.9 mi from Colleton Medical Center

JUAN

$88 nightly

$99 total

Oct 4 - Oct 5

Total with taxes and fees

A Quality Inn hotel with a prominent sign, a covered entrance, and a parking lot.

A waffle maker with a digital display and a push button.

A reception desk with a 'Quality by Choice Hotels' sign, a Dell computer, and a stone-patterned wall.

A hotel room with a bed, a flat-screen TV, a microwave, a refrigerator, a desk, and a painting on the wall.

11. Quality Inn Walterboro I-95

4.3 mi from Colleton Medical Center

Marvin

$62 nightly

$70 total

Oct 28 - Oct 29

Total with taxes and fees

A hotel lobby with seating arrangements, a television, a kitchen area, and a large window with curtains.

A hotel room with a bed, a desk with a TV, a chair, a desk lamp, and a bedside table with a lamp.

A reception desk at Days Inn with a 'Hello Sunshine' sign, a clock, and a framed certificate on the wall.

A swimming pool with lounge chairs and umbrellas, a building with balconies, and a sign indicating shallow water.

12. Days Inn by Wyndham Walterboro

4.2 mi from Colleton Medical Center

christopher

$67 nightly

$75 total

Oct 4 - Oct 5

Total with taxes and fees

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A small office space with a desk, chair, and a microwave.

A room with a floral sofa, a small table, a lamp, a framed picture on the wall, and a window with curtains.

A motel with a covered parking area, multiple rooms, and a central building with a blue roof.

13. Rodeway Inn Walterboro I-95

4 mi from Colleton Medical Center

Patricia

$50 nightly

$55 total

Oct 29 - Oct 30

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

A bathroom with a sink, mirror, and shower.

A Red Roof hotel with a modern design, featuring a flat roof and a prominent Red Roof sign.

A wooden gazebo with a green roof, surrounded by a grassy area and a wooden fence.

14. Red Roof Inn Walterboro

3.8 mi from Colleton Medical Center

wendy

$55 nightly

$62 total

Oct 1 - Oct 2

Total with taxes and fees

A reception desk with a Baymont Inn & Suites sign, a chandelier, and a fire extinguisher.

A Baymont Inn & Suites building with a prominent sign, a fountain, and statues in front.

A kitchen with a refrigerator, microwave, coffee maker, and various appliances.

A hotel room with two beds, a desk, a chair, a mirror, and a window.

15. Baymont by Wyndham Walterboro

3.9 mi from Colleton Medical Center

Marguerite

$44 nightly

$49 total

Oct 1 - Oct 2

Total with taxes and fees

A hotel room with two beds, a bedside table with a phone, and a wall-mounted light.

A building with a registration sign, a flat facade, and a clear blue sky.

A compact room with a flat-screen TV mounted on the wall, a small black refrigerator, a wooden dining table with a single chair, and a metal folding chair.

A room with a tiled floor, a white door, and a window with blinds. There are two round tables with chairs.

16. Moonnight inn.

4.1 mi from Colleton Medical Center

John

$50 nightly

$56 total

Oct 7 - Oct 8

Total with taxes and fees

View all properties

Compare popular hotels close to Colleton Medical Center

Property	Star rating	Guest rating
Sleep Inn Walterboro I-95	7.6 Good 650 reviews	View
Southern Inn By OYO Walterboro I-95	6.6 108 reviews	View
Travelodge by Wyndham Walterboro	6.4 599 reviews	View
Super 8 by Wyndham Walterboro	6.2 220 reviews	View
Hampton Inn & Suites Walterboro	9.2 Wonderful 1,002 reviews	View

Top Colleton Medical Center Hotel Reviews

Baymont by Wyndham Walterboro

10/10 Excellent

"Pool closed. Ice machine broken. Everything else fine. Great bargain price on Hotel’s.COM"

Red Roof Inn Walterboro

10/10 Excellent

"Clean room"

Quality Inn Walterboro I-95

10/10 Excellent

"No problems. Efficient. Comfortable beds. Nice continental. Friendly hosts"

Moonnight inn.

10/10 Excellent

"We stay here twice a year on the way to Florida and back."

Holiday Inn Exp Walterboro by IHG

10/10 Excellent

"Hotel was very nice. All staff we came in contact with was friendly, polite, and cracked jokes with this crazy group of ladies. Will definitely stay here again when in the area."

Southern Inn By OYO Walterboro I-95

10/10 Excellent

"Bee was great!! Good price = good hotel"

Charming Retreat on 20 Acres w/ Private Lake!

10/10 Excellent

"We stayed for 2 weeks and the peacefulness of the location was what we needed in the evenings. Will save this location for future use."

Willow Retreat

10/10 Excellent

"Very nice place to stay. Clean and everything in good working order. Host was very accommodating."

Frequently asked questions

What's the area like around Colleton Medical Center?

Colleton Medical Center is located in Walterboro. This welcoming area is known for its array of dining options. You'll find 45 hotels and other accommodations within a few miles for a convenient home base.

What's the best place to stay near Colleton Medical Center?

Baymont by Wyndham Walterboro is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 3.9 mi (6.2 km) from Colleton Medical Center. Other good choices within a few miles include Microtel Inn & Suites by Wyndham Walterboro and Travelodge by Wyndham Walterboro.

How many hotels will I be able to find close to Colleton Medical Center?

Expedia has 45 hotels and other accommodations a few miles from Colleton Medical Center.

If I need to cancel the hotel reservation for my stay near Colleton Medical Center, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to view the best deals available near Colleton Medical Center.

Where can I learn more about changing or cancelling my trip in the area near Colleton Medical Center?

To access more information about rescheduling or cancelling your stay near Colleton Medical Center, click here.

Room 1

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Be picky

Check prices for these dates

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Star rating

Guest rating

Our top choices for Colleton Medical Center hotels

1. Sleep Inn Walterboro I-95

2. Southern Inn By OYO Walterboro I-95

3. Travelodge by Wyndham Walterboro

4. Super 8 by Wyndham Walterboro

5. Hampton Inn & Suites Walterboro

6. Holiday Inn Exp Walterboro by IHG

7. Comfort Inn & Suites Walterboro I-95

8. Microtel Inn & Suites by Wyndham Walterboro

9. Econo Lodge Walterboro I-95

10. Best Western Of Walterboro

11. Quality Inn Walterboro I-95

12. Days Inn by Wyndham Walterboro

13. Rodeway Inn Walterboro I-95

14. Red Roof Inn Walterboro

15. Baymont by Wyndham Walterboro

16. Moonnight inn.

Compare popular hotels close to Colleton Medical Center

Top Colleton Medical Center Hotel Reviews

Baymont by Wyndham Walterboro

Red Roof Inn Walterboro

Quality Inn Walterboro I-95

Moonnight inn.

Holiday Inn Exp Walterboro by IHG

Southern Inn By OYO Walterboro I-95

Charming Retreat on 20 Acres w/ Private Lake!

Willow Retreat

Frequently asked questions

Find hotels near Colleton Medical Center, Walterboro from $49

Upfront pricing

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Colleton Medical Center hotels

1. Sleep Inn Walterboro I-95

2. Southern Inn By OYO Walterboro I-95

3. Travelodge by Wyndham Walterboro

4. Super 8 by Wyndham Walterboro

5. Hampton Inn & Suites Walterboro

6. Holiday Inn Exp Walterboro by IHG

7. Comfort Inn & Suites Walterboro I-95

8. Microtel Inn & Suites by Wyndham Walterboro

9. Econo Lodge Walterboro I-95

10. Best Western Of Walterboro

11. Quality Inn Walterboro I-95

12. Days Inn by Wyndham Walterboro

13. Rodeway Inn Walterboro I-95

14. Red Roof Inn Walterboro

15. Baymont by Wyndham Walterboro

16. Moonnight inn.

Compare popular hotels close to Colleton Medical Center

Top Colleton Medical Center Hotel Reviews

Baymont by Wyndham Walterboro

Red Roof Inn Walterboro

Quality Inn Walterboro I-95

Moonnight inn.

Holiday Inn Exp Walterboro by IHG

Southern Inn By OYO Walterboro I-95

Charming Retreat on 20 Acres w/ Private Lake!

Willow Retreat

Frequently asked questions