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De Soto Vacation Rentals

Q: What are some of the best vacation home rentals in De Soto?

* On the Wine Trail * Hot Tub * Wi-Fi * : This vacation home rental outside of De Soto is located on a lake and has a patio, a hot tub, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave.

Dates

November 2026

December 2026

Check prices for these dates

In two weeks

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Our top choices for De Soto vacation rentals

A compact kitchen with wooden walls, a built-in oven, a sink, and a refrigerator.

1. The Cozy Corner

De Soto

yvonne o.

$124 nightly

Nov 8 - Nov 9

Total with taxes and fees

A modern living room with a sectional sofa, a coffee table, a TV mounted on the wall, and a window with blinds.

2. The Lab! Come stay in our brand new space.

Murphysboro

Tim P.

$182 nightly

Nov 10 - Nov 11

Total with taxes and fees

A large outdoor area with a pond, several wooden cabins, and a road.

3. Pet Friendly! Couples Retreat in Southern Illinois

Murphysboro

$212 nightly

Nov 8 - Nov 9

Total with taxes and fees

A spacious living room with a large sofa set, a coffee table, and a television.

4. Step In To the Mediterranean

Carbondale

Marina C.

$828 nightly

Nov 8 - Nov 9

Total with taxes and fees

A modern kitchen with white cabinets, a central island, and a stone fireplace.

5. Minutes from Lake |Fire Pit | Like-New 3BR Retreat

Murphysboro

Scott M.

$401 nightly

Nov 13 - Nov 14

Total with taxes and fees

A compact kitchen with a stone floor, a microwave, a stove, and a refrigerator. There are wooden cabinets and a window with blinds.

6. Fishing Cabin next to Kinkaid Lake

Murphysboro

Dustin M.

$222 nightly

Nov 14 - Nov 15

Total with taxes and fees

A recreational vehicle with a covered living area, a small porch, and a wooden deck.

7. Lois' Hideout Comfy 1 bedroom camper within 7 minutes of Kinkaid Lake.

Oraville

Kevin E.

$119 nightly

Nov 8 - Nov 9

Total with taxes and fees

A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.

8. Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress

Oraville

Joseph S.

$135 nightly

Nov 8 - Nov 9

Total with taxes and fees

A log cabin with a hot tub, a sofa, and a table with a lamp.

9. Screened Hot Tub & Peacocks Nearby

Carbondale

Stacey K.

$280 nightly

Nov 29 - Nov 30

Total with taxes and fees

A living room with two beige sofas, a marble coffee table, and striped curtains.

10. Located in the Luxurious Pine Manor Estates!

Carbondale

adaire p.

$345 nightly

Dec 1 - Dec 2

Total with taxes and fees

A room with a black tufted sofa, two armchairs, a gold coffee table, a patterned rug, a wall-mounted ladder decor, and a framed inspirational quote.

11. The Lux Collective- Private Hot Tub, Dry Bar, 1-Acre Yard & Fire Pit

Murphysboro

"Place overall was decent, it was clean enough. The hot tub and fire pit were a nice touch. The house is very close to the road and there is constant traffic noise even late at night. It is also advertised as more upscale than it was. We noticed several areas of the house that looked like the landlord special took place in getting it ready. Some of the doors didn’t close properly or were only on a single set of hinges instead of multiple. The dining chairs too were not in great shape, they had...

Calista

$205 nightly

Dec 1 - Dec 2

Total with taxes and fees

A spacious living area with a brick wall, hanging chairs, a white sofa, and a coffee table.

12. Third-Floor Suite, SIU Across Street

Carbondale

Kathy A.

$201 nightly

Nov 17 - Nov 18

Total with taxes and fees

A spacious living room with hardwood flooring, a sofa, a chair, and a small table with a lamp.

13. Charming 3-bedroom house in tranquil Oraville minutes from Kinkaid Lake.

Oraville

Greg W.

$160 nightly

Nov 15 - Nov 16

Total with taxes and fees

A small, single-story cabin with a window, situated near a body of water, surrounded by trees.

14. Lakeside 1-bedroom located at Crab Orchard Lake near SIU. Cabin #16

Carbondale

$201 nightly

Nov 14 - Nov 15

Total with taxes and fees

A wooden cabin with a green door, a number '2' sign, a small porch with a wooden railing, and a wall-mounted lantern.

15. 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

Makanda

Alison K.

$162 nightly

Nov 9 - Nov 10

Total with taxes and fees

16. Fantastic 1-bedroom Cabin in peaceful Makanda, Pet-Friendly!

Makanda

Kevin W.

$126 nightly

Nov 15 - Nov 16

Total with taxes and fees

A spacious living area with a blue sofa, a wooden coffee table, and a ceiling fan.

17. Hot Tub Cabin- In the Heart of Shawnee Wine Trail

Carbondale

Jonathan G.

$256 nightly

Nov 15 - Nov 16

Total with taxes and fees

A small house with a covered patio, string lights, and a sliding glass door.

18. Charming 3 bedroom retreat

Herrin

Christina H.

$236 nightly

Nov 9 - Nov 10

Total with taxes and fees

A wooden dining table with chairs, a staircase, a kitchen with dark cabinets, and a window with a view of trees.

19. 30-Acre Woods, Trail & Salt Hot Tub

Carbondale

Jody O.

$301 nightly

Nov 8 - Nov 9

Total with taxes and fees

A rustic cabin with a stone chimney, wooden deck, and a porch.

20. Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Makanda

Janine B.

$196 nightly

Nov 16 - Nov 17

Total with taxes and fees

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Find vacation rentals that suit your style

Top De Soto Hotel Reviews

A hotel lobby with a marble floor, a reception desk, a sign for 'Restrooms', and a large chandelier.

Walker's Bluff Casino Resort

Carterville

10/10 Excellent

Gail

An indoor swimming pool with four lounge chairs and a metal ladder.

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

10/10 Excellent

Brianna

A modern dining area with round tables and chairs, large windows, and a chandelier.

Holiday Inn Express & Suites Carbondale - University Area by IHG

Carbondale

10/10 Excellent

Teresa

A hotel entrance with a 'Welcome' sign and a 'Hampton Inn' sign.

Hampton Inn Carbondale

Carbondale

10/10 Excellent

John

A Comfort Inn & Suites hotel with a covered entrance, multiple floors, and a landscaped front yard.

Comfort Inn & Suites Marion I-57

Marion

10/10 Excellent

Gary

A modern living room with a fireplace, a bookshelf, a large wall clock, and a cozy seating area.

Country Inn & Suites by Radisson, Marion, IL

Marion

10/10 Excellent

This has become our go-to overnight stop between Atlanta and Kansas City with the family. The hotel is newly renovated and safe, and the staff is always super-friendly. The kids love the indoor pool and the hubby loves the workout room. The beds/pillows are comfy, the room is clean, and the bathrooms include all the basics. The included breakfast has everything you could want…a selection of hot items and a make-your-own waffle station…plus oatmeal, fruit, yogurts, cereals, etc. A selection of...

Beth

A Holiday Inn Express hotel with a brick facade, large windows, and a central entrance with columns.

Holiday Inn Express Hotel & Suites Marion Northeast by IHG

Marion

10/10 Excellent

Justin

A hotel room with a king-sized bed, a nightstand, a wall-mounted lamp, and a separate bathroom with a bathtub and a tiled shower area.

Comfort Inn & Suites Carbondale University Area

Carbondale

10/10 Excellent

Judith

A Best Western hotel with a parking lot and a covered entrance.

Best Western Marion Hotel

Marion

10/10 Excellent

Alice

A hotel room with a large framed picture of a tree on the wall, a neatly made bed with white bedding, and two bedside lamps.

Super 8 by Wyndham Carbondale

Carbondale

10/10 Excellent

Anonymous traveler

A modern living room with a stone fireplace, a large painting, and a dining area with wooden chairs.

Fairfield Inn and Suites by Marriott Marion

Marion

10/10 Excellent

Our stay at Fairfield Inn was a quick but pleasant stay. During our visit to Marion we were under the weather with a cold. Our housekeeper must have noticed our vitamin C and medicine to help because she (Desiree) even left us an extra box of Kleenex. As small a gesture as it was, it was a very sweet one! I would recommend anyone staying in the area to stay here. They also have a nice coffee/tea bar and it was stocked with decaffeinated products. That was another pleasant thing to cap off a...

Anonymous traveler

A reception area with a stone counter, a clock, and a reception desk.

Super 8 by Wyndham Marion

Marion

10/10 Excellent

Chris

A room with a bed, a bench, a sink, a door, and a bathtub.

Americas Best Value Inn West Frankfort

West Frankfort

10/10 Excellent

Everything was good until my car didn’t get fixed on time so I asked to stay an hour after check out time at 11 and the person(Man) I talk to said YES THAT WAS FINE. So when I’m leaving a lady said to me “NEXT TIME NO STAYING LONGER THEN CHECK OUT TIME” I told her I had an agreement with someone else already who works there also & then said with an ATTITUDE “THAT DOES NOT MATTER” She was extremely rude and definitely doesn’t know the situation between me and the other worker

Greg

Find out more about De Soto

Everything you need to know about De Soto vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the De Soto vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect De Soto vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

De Soto vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in De Soto. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit De Soto in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $126 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on De Soto rentals

At Expedia, we put the best De Soto vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top De Soto rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream De Soto vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around De Soto. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Can I find a vacation rental in De Soto?

Yes, you can find vacation rentals near well known local attractions in De Soto, or you can choose a secluded option if you're looking for a relaxing stay.

What are some of the best vacation home rentals in De Soto?

* On the Wine Trail * Hot Tub * Wi-Fi *: This vacation home rental outside of De Soto is located on a lake and has a patio, a hot tub, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave.

What can I see and do in De Soto?

While you're exploring the area, De Soto City Park and Little Grand Canyon Trail Trailhead are a couple of picturesque spots to get outside and enjoy nature. Southern Illinois University and Crab Orchard Golf Club are a couple of places you'll find in the larger area.

What are vacation rentals like in De Soto?

Vacation rentals are private accommodations you can stay in for several days or longer in De Soto. Vacation rentals feature amenities such as kitchens and laundry facilities so you'll have everything you need. If you're concerned about cleanliness, vacation rentals can offer a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also have more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family trip.