Depew Vacations from $185

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Your Depew Vacation

A great way to experience this interesting city is with a customized Depew vacation package. Base yourself in the neighborhood of Downtown Buffalo, which is great for nightlife, shopping and bars and pubs or choose someplace else — our packages are all about you. Make your trip to Depew even more fulfilling by going sightseeing. Walden Galleria Mall, Holiday Twin Rinks and Eastern Hills Mall are some of the popular attractions you'll want to explore. Whoever you're taking time off with and whatever your bank balance, your ultimate Depew vacation is just clicks away with Expedia.

The Latest Depew vacation packages

Price found within the past 48 hours. Click for updated prices.
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
Price was $287, price is now $185 per person
$185
per person
Jan 23 - Jan 25
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (2,709 reviews)
Great spot, super easy and convenient to downtown Buffalo and the airport.

Reviewed on Nov 26, 2025

Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Downtown Buffalo
Price was $673, price is now $454 per person
$454
per person
Feb 13 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (1,617 reviews)
I love staying here whenever I’m in Buffalo!

Reviewed on Nov 24, 2025

Springhill Suites Buffalo Airport

Springhill Suites Buffalo Airport

2.5 out of 5
Price was $512, price is now $350 per person
$350
per person
Feb 13 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Buffalo (BUF)
9/10 Wonderful! (812 reviews)
Trouble with room keys ever time I used

Reviewed on Nov 5, 2025

Buffalo Marriott Niagara

Buffalo Marriott Niagara

3.5 out of 5
Price was $570, price is now $398 per person
$398
per person
Feb 13 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Buffalo (BUF)
8.4/10 Very Good! (1,004 reviews)
Very clean rooms. Updated and comfortable. Love that there is no carpet in the rooms as it usually creates a lot of dust. The front desk assigned me a room but it was not ready yet. She immediately reassigned and provided me with a complimentary breakfast (although I didn't use it as I had to leave). Fabulous stay!

Reviewed on Nov 13, 2025

M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
Price was $516, price is now $361 per person
$361
per person
Feb 13 - Feb 16
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Buffalo (BUF)
7.4/10 Good! (2,426 reviews)
Good for a 1 to 4 day stay

Reviewed on Nov 27, 2025

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Discover the most popular places to visit in Depew

NFL Salute to Service Buffalo Bills Ralph Wilson Stadium

Highmark Stadium

4/5(406 reviews)

Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's entertainment choices and great live music.

Highmark Stadium
A nice day for a walk in the fall by the pillars. #universityatbuffalo#buffalo #ub #college #hiking #lake #berries #fall

University At Buffalo - North Campus

4.5/5(108 reviews)

Enjoy the collegiate vibe when you visit University At Buffalo - North Campus, during your trip to Amherst. Experience the area's great live music and entertainment choices.

University At Buffalo - North Campus
Buffalo Zoo

Buffalo Zoo

4/5(428 reviews)

See more than 1,200 animals at this small zoo in Buffalo’s Delaware Park. Explore the rainforest building or see the big cats of the African plains.

Buffalo Zoo

What to do in Depew

TR is waiting to greet you!

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

$13
per adult
100% of travellers recommend
Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour
Buffalo Sabres Ice Hockey Game at Keybank Center

Buffalo Sabres Ice Hockey Game at Keybank Center

$32
per adult
Buffalo Sabres Ice Hockey Game at Keybank Center
American Falls Adventure with Maid of the Mist & Cave of the Winds from USA

Niagara Falls USA: Maid of the Mist & Cave Adventure

$129
per adult
94% of travellers recommend
Niagara Falls USA: Maid of the Mist & Cave Adventure
See all activities in Depew

Depew Hotel Deals

Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Two Fountain Plaza Buffalo NY
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $122 total per night from Nov 28 to Nov 29
$122 total
Nov 28 - Nov 29
Total with taxes and fees
8/10 Very Good! (1,639 reviews)
Clean room and great staff...especially Mr. Daryl and Ms. C (with the micro twists at the front desk). Thanks for everything!!!

Reviewed on Nov 25, 2025

Hyatt Regency Buffalo / Hotel and Conference Center
Garden Place Hotel

Garden Place Hotel

3.5 out of 5
6615 Transit Road Buffalo NY
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $87 total per night from Dec 1 to Dec 2
$87 total
Dec 1 - Dec 2
Total with taxes and fees
7.6/10 Good! (2,099 reviews)
The staff was professional and very courteous The room was cery clean. I had an amazing stay

Reviewed on Nov 26, 2025

Garden Place Hotel
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $79 total per night from Dec 1 to Dec 2
$79 total
Dec 1 - Dec 2
Total with taxes and fees
7.8/10 Good! (2,733 reviews)
Room was clean, check in was smooth, coffee was good-- which is all that I ask of a place to rest

Reviewed on Nov 21, 2025

Buffalo Airport Hotel
See all 866 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Depew Vacation Packages

Depew Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Buffalo Niagara Intl. Airport (BUF)
Population
15,100
Max Temp Winter
30ºF
Max Temp Summer
75ºF
Top Sights
Buffalo Zoo, Buffalo Museum of Science and Albright - Knox Art Gallery

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Frequently asked questions

How much does a Depew vacation package cost?
You can pick up a vacation package to this destination from $185 on Expedia. But how much your vacation to Depew costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Depew?
If you'd like to snag a cheap Depew vacation package, consider traveling in December, January and February. You'll typically find lower rates on flights and accommodations during these quieter months — ideal for a budget-friendly break.
How many days is enough for Depew?
With a well-organized schedule, you can easily tick off the top Depew attractions in a few days. But if you want to explore off the beaten track or go on day tours, consider booking your Depew vacation for longer.
How to find the best Depew package deals?
Finding a cheap Depew package deal is a breeze with Expedia. After you've entered your destination and travel dates under our "Packages" tab, set your budget range, add a couple of filters and browse what's available. You can fine-tune your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most affordable Depew package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Depew vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a customized Depew vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Depew?
If you're considering a spur-of-the-moment Depew adventure, browse our last-minute deals that can be booked up to one week before you take off. Don't want to leave things to the last minute? You can score amazing deals on your hotels and flights by booking ahead.
How to plan a trip to Depew?

  1. Choose when to get away: Check your schedule and get your bags packed. Your preferred time of year and the type of activities available will also help you decide when to escape to Depew.
  2. Plan your budget wisely: On top of the cost of your accommodations, you should factor in other expenses too. These include flights, food and transportation. Also, set aside some extra funds for unexpected costs that may crop up during your trip to Depew.
  3. Organize your Depew escape with our trip planning tool: Look for and book accommodations and experiences all in one place. You can also collaborate with your group to plan an unforgettable trip to Depew together.
  4. Decide how many days away: Start by compiling a list of the attractions you'd like to get to in Depew. Then, estimate how long you'll need at each, as well as any travel time.
  5. Combine your flights and hotel: Awesome destination, check. Length of stay, check. All that's left is to choose a Depew vacation package that brings all your bookings together.
  6. Book any day trips or activities: Here's the fun part — organizing everything you want to see and do. Check out some of the top things to do in Depew in Depew and reserve your tickets early to save time (and maybe some money too!).

Does Expedia offer Book Now, Pay Later Depew vacation packages?
Your Depew break should be an escape from your busy life, not a source of money-related stress. So to give you that extra flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and spread the total cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.