Depew Vacations from $406

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Your Depew Vacation

A great way to experience this interesting city is with a customized Depew vacation package. Base yourself in the neighborhood of Downtown Buffalo, which is great for nightlife, shopping and bars and pubs or choose someplace else — our packages are all about you. Make your trip to Depew even more fulfilling by going sightseeing. Walden Galleria Mall, Holiday Twin Rinks and Eastern Hills Mall are some of the popular attractions you'll want to explore. Whoever you're taking time off with and whatever your bank balance, your ultimate Depew vacation is just clicks away with Expedia.

The Latest Depew vacation packages

Price found within the past 48 hours. Click for updated prices.
La Quinta Inn by Wyndham Buffalo Airport

La Quinta Inn by Wyndham Buffalo Airport

3 out of 5
Price was $538, price is now $406 per person
$406
per person
Mar 19 - Mar 22
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (1,312 reviews)
This was a wonderful place to stay, and we’re very glad we booked it. The room was spotless, extremely clean, and very comfortable. Everything felt well maintained and welcoming. The receptionist was friendly and helpful, and the breakfast was delicious with a good variety of options. The overall atmosphere of the hotel was pleasant and relaxing. I would highly recommend this hotel to anyone visiting Buffalo, and I will definitely stay here again on my next visit.

Reviewed on Jan 14, 2026

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
Price was $684, price is now $465 per person
$465
per person
Mar 19 - Mar 22
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (2,709 reviews)
The closeness to the airport. Wingnuts had amazing food!

Reviewed on Jan 13, 2026

The Richardson Hotel

The Richardson Hotel

3.5 out of 5
Elmwood Bidwell
Save 100% on your flight
Price was $906, price is now $658 per person
$658
per person
Mar 19 - Mar 22
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
9/10 Wonderful! (1,002 reviews)
Room was great though the door handle in the bathroom was broken and we were afraid to close the door and get locked in. Breakfast buffet needs work. One of the 3 days there was an empty milk carafe so no milk for the coffee or cereal. Nobody in site at the breakfast zone or the front desk.

Reviewed on Jan 13, 2026

Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Downtown Buffalo
Price was $628, price is now $482 per person
$482
per person
Apr 1 - Apr 5
found 12 hours ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (1,617 reviews)
Room was clean, older little worn furniture, but still halfway decent staff was great

Reviewed on Jan 12, 2026

Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
Price was $617, price is now $475 per person
$475
per person
Mar 19 - Mar 22
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (1,834 reviews)
The room was nice. But breakfast could have been a little better, and i was disappointed that the hot tub was out of order. That should come off the amenities list.

Reviewed on Jan 12, 2026

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Discover the most popular places to visit in Depew

NFL Salute to Service Buffalo Bills Ralph Wilson Stadium

Highmark Stadium

Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's entertainment choices and great live music.

Highmark Stadium
A beautiful sunset today at ub! At least there is one perk to being stuck on campus for 12 hours! 🌅🌅🌅 #ub #universityatbuffalo #buffalo #sunset #baridpoint #oozefestpits #springsemester #academicspine #campuslife

University At Buffalo - North Campus

Enjoy the collegiate vibe when you visit University At Buffalo - North Campus, during your trip to Amherst. Experience the area's acclaimed theater scene and great live music.

University At Buffalo - North Campus
More food than I can eat.

Walden Galleria Mall

You can enjoy retail therapy at Walden Galleria Mall during your trip to Cheektowaga. Experience the area's entertainment choices and great live music.

Walden Galleria Mall

What to do in Depew

Buffalo Sabres Ice Hockey Game at Keybank Center

Buffalo Sabres Ice Hockey Game at Keybank Center

$63
per adult
Buffalo Sabres Ice Hockey Game at Keybank Center
Niagara Falls Self-Guided Driving Audio Tour from Toronto

Niagara Falls Self-Guided Driving Audio Tour from Toronto

$17
per traveler
Niagara Falls Self-Guided Driving Audio Tour from Toronto
Niagara Falls, USA: Guided Tour & Optional Maid of the Mist

Niagara Falls, USA: Guided Tour & Optional Maid of the Mist

$60
per adult
Niagara Falls, USA: Guided Tour & Optional Maid of the Mist
See all activities in Depew

Depew Hotel Deals

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $96 total per night from Jan 15 to Jan 16
$96 total
Jan 15 - Jan 16
Total with taxes and fees
7.8/10 Good! (2,826 reviews)
Excellent stay. Thank you.

Reviewed on Jan 10, 2026

Buffalo Airport Hotel
M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave Buffalo NY
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $147 total per night from Jan 15 to Jan 16
$147 total
Jan 15 - Jan 16
Total with taxes and fees
7.2/10 Good! (2,601 reviews)
Was good for the kids to use the pool.and being close to the mall was a plus. We stayed in the Atrium room first floor and it was clean but outdated like from the 70's and the tub was chipped and the doors wouldn't close properly . There was a ton of hockey teams there that partied in the atrium ...

Reviewed on Jan 9, 2026

M Hotel Buffalo
Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Two Fountain Plaza Buffalo NY
$143 nightly
The price is $167 total per night from Jan 28 to Jan 29
$167 total
Jan 28 - Jan 29
Total with taxes and fees
8/10 Very Good! (1,707 reviews)
Location

Reviewed on Jan 9, 2026

Hyatt Regency Buffalo / Hotel and Conference Center
See all 882 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Depew Vacation Packages

Depew Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Buffalo Niagara Intl. Airport (BUF)
Population
15,100
Max Temp Winter
30ºF
Max Temp Summer
75ºF
Top Sights
Buffalo Zoo, Buffalo Museum of Science and Albright - Knox Art Gallery

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Frequently asked questions

How much does a Depew vacation package cost?
You can pick up a vacation package to this destination from $406 on Expedia. But how much your vacation to Depew costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Depew?
If you'd like to snag a cheap Depew vacation package, consider traveling in December, January and February. You'll typically find lower rates on flights and accommodations during these quieter months — ideal for a budget-friendly break.
How many days is enough for Depew?
With a well-organized schedule, you can easily tick off the top Depew attractions in a few days. But if you want to explore off the beaten track or go on day tours, consider booking your Depew vacation for longer.
How to find the best Depew package deals?
Finding a cheap Depew package deal is a breeze with Expedia. After you've entered your destination and travel dates under our "Packages" tab, set your budget range, add a couple of filters and browse what's available. You can fine-tune your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most affordable Depew package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Depew vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a customized Depew vacation by choosing your preferred airline, accommodation type and car class.
When to book a vacation package to Depew?
If you're considering a spur-of-the-moment Depew adventure, browse our last-minute deals that can be booked up to one week before you take off. Don't want to leave things to the last minute? You can score amazing deals on your hotels and flights by booking ahead.
How to plan a trip to Depew?

  1. Choose when to get away: Check your schedule and get your bags packed. Your preferred time of year and the type of activities available will also help you decide when to escape to Depew.
  2. Plan your budget wisely: On top of the cost of your accommodations, you should factor in other expenses too. These include flights, food and transportation. Also, set aside some extra funds for unexpected costs that may crop up during your trip to Depew.
  3. Organize your Depew escape with our trip planning tool: Look for and book accommodations and experiences all in one place. You can also collaborate with your group to plan an unforgettable trip to Depew together.
  4. Decide how many days away: Start by compiling a list of the attractions you'd like to get to in Depew. Then, estimate how long you'll need at each, as well as any travel time.
  5. Combine your flights and hotel: Awesome destination, check. Length of stay, check. All that's left is to choose a Depew vacation package that brings all your bookings together.
  6. Book any day trips or activities: Here's the fun part — organizing everything you want to see and do. Check out some of the top things to do in Depew in Depew and reserve your tickets early to save time (and maybe some money too!).

Does Expedia offer Book Now, Pay Later Depew vacation packages?
Your Depew break should be an escape from your busy life, not a source of money-related stress. So to give you that extra flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and spread the total cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.