Cheap Flights to La Serena from $386

Plan your trip for April if you want to get a good price on your fare. It's the cheapest month to fly to La Serena. If possible, avoid traveling during busy periods such as school vacation time or public holidays.

You can fly to La Serena without any stops from 12 US destinations. To find a nonstop route, check "Direct flights only" when looking for flights to La Serena on Expedia. Then, explore the options and pick the best departure out of any of these cities:

• New York
• Miami
• Dallas
• Washington
• Boston

To find cheap flights to La Serena, book as early as possible and travel during the low season. Want an insider tip? Depart on a Thursday and you'll typically save 16% on average compared to those who travel on a Sunday.* Sign up for price tracking on the Expedia app and we'll let you know the moment your fares drop.

*Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.

While booking in advance is typically the best way to save cash, don't panic if your La Serena getaway is last minute. It's still possible to find cheap flights to La Serena, especially if your plans have a little wiggle room. Try switching up your trip dates, exploring different ticket types or departing from another hub.

Get the travel dates you want and a fare that fits your budget by booking your domestic flight to La Serena up to 28 days in advance. Lock in tickets two to four months ahead if you're visiting La Serena from an international destination.*

*Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.

Sundays are generally the best day to book a cheap flight to La Serena, with savings of about 8% on average compared to Fridays. If you purchase tickets on a Friday, be ready to pay a higher price as this is typically the most expensive day.*

*Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.

Bundle your flight and hotel and you could save hundreds of dollars. Plus, you can add extras like car rentals and tours to your La Serena flight and hotel package deal. With Expedia, it's simple to book all your La Serena travel plans in one place.

If you bought your flight to La Serena within the last 24 hours, you can often change or cancel it for free. After that, additional charges may apply depending on the airline's rules and restrictions. For more information, visit our Customer Service Portal. Bear in mind that some flights are non-refundable, so you may be issued a credit toward a future trip instead of a direct refund. When browsing on Expedia, use the "Changes included" or "No cancel fee" filters to find tickets with flexible change policies.