Title: $235 Cheap Flights & Airfare to Santa Cruz - Expedia.com ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights to Santa Cruz from $235 [View $235 flight on Mon, May 11, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:IAD,to:VVI,departure:5/11/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:234.75&airProductToken=AQpiCi8Iw5oBEgM0MDMYiBgg78QBKJ3WjAMwwdiMAzhBQABYAWoDQkFTcghBTEE0T1oyUwovCMOaARIDMjIxGO_EASC1RSjj34wDMIPijAM4QUAAWAFqA0JBU3IIQUxBNE9aMlMSCggBEAEYASoCQ00YASIECAEQASgCKAMoBDAL) - [Roundtrip](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travelers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only [Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Vacation Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations)[Santa Cruz Vacations](https://expedia.com/Santa-Cruz.d6297178.Destination-Travel-Guides) ## Popular airlines to Santa Cruz - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg) Avianca - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_OB.svg) Boliviana De Aviacion - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_CM.svg) Copa - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UX.svg) Air Europa - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_IB.svg) Iberia - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## How much is the cheapest flight to Santa Cruz? Prices were available within the past 7 days and start at $235 for one-way flights and $501 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Wed, Mar 11 - Thu, Mar 12 MIA Miami VVI Santa Cruz $501 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:3/11/2026TANYT&leg2=from:VVI,to:MIA,departure:3/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:500.63&airProductToken=AQpiCi8Iw5oBEgMxNzMYjAIg78QBKNmphwMwkquHAzhMQABYAWoDQkFTcghMTEFBVFoyUwovCMOaARIDMTI3GO_EASC1RSiUr4cDMMqxhwM4TEAAWAFqA0JBU3IITExBQVRaMlMKYgovCMOaARIDMTI2GLVFIO_EASjasocDMPy0hwM4TEAAWAFqA0JBU3IITExBQVRaMlMKLwjDmgESAzQyNxjvxAEgjAIolLuHAzDQvIcDOExAAFgBagNCQVNyCExMQUFUWjJTEgoIARABGAEqAkNNGAEiBAgBEAEoAigDKAQwCw) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Mon, May 11 - Mon, May 18 IAD Washington VVI Santa Cruz $518 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:IAD,to:VVI,departure:5/11/2026TANYT&leg2=from:VVI,to:IAD,departure:5/18/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:517.63&airProductToken=AQpiCi8Iw5oBEgM0MDMYiBgg78QBKJ3WjAMwwdiMAzhBQABYAWoDQkFTcghBTEE0T1oyUwovCMOaARIDMjIxGO_EASC1RSjj34wDMIPijAM4QUAAWAFqA0JBU3IIQUxBNE9aMlMKYgovCMOaARIDMTI2GLVFIO_EASi4pI0DMNymjQM4QUAAWAFqA0JBU3IIQUxBNE9aMlMKLwjDmgESAzQwNBjvxAEgiBgo8a6NAzCVsY0DOEFAAFgBagNCQVNyCEFMQTRPWjJTEgoIARABGAEqAkNNGAEiBAgBEAEoAigDKAQwCw) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Fri, Mar 20 - Fri, May 8 MIA Miami VVI Santa Cruz $521 Roundtrip found 4 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:3/20/2026TANYT&leg2=from:VVI,to:MIA,departure:5/8/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:520.63&airProductToken=AQpiCi8Iw5oBEgMzMzMYjAIg78QBKJaUiAMw1JWIAzhMQABYAWoDQkFTcghMQUFBVFoyUwovCMOaARIDMjIxGO_EASC1RSjjlogDMIOZiAM4TEAAWAFqA0JBU3IITEFBQVRaMlMKYgovCMOaARIDMTI2GLVFIO_EASj4s4wDMJy2jAM4TEAAWAFqA0JBU3IITExBQVRaMlMKLwjDmgESAzIyNhjvxAEgjAIozbeMAzCSuYwDOExAAFgBagNCQVNyCExMQUFUWjJTEgoIARABGAEqAkNNGAEiBAgBEAEoAigDKAQwCw) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Wed, Apr 1 - Thu, Apr 2 MIA Miami VVI Santa Cruz $526 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:4/1/2026TANYT&leg2=from:VVI,to:MIA,departure:4/2/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:525.63&airProductToken=AQpiCi8Iw5oBEgMyNDYYjAIg78QBKJCWiQMwypeJAzhMQABYAWoDQkFTcghMTEFBVFoyUwovCMOaARIDMTI3GO_EASC1RSi0m4kDMOKdiQM4TEAAWAFqA0JBU3IITExBQVRaMlMKYgovCMOaARIDMjIwGLVFIO_EASj0o4kDMJemiQM4RUAAWAFqA0JBU3IIRUxBQVRaMlMKLwjDmgESAzQzMhjvxAEgjAIo-aiJAzC1qokDOEVAAFgBagNCQVNyCEVMQUFUWjJTEgoIARABGAEqAkNNGAEiBAgBEAEoAigDKAQwCw) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Sun, Mar 15 - Sat, Apr 11 MIA Miami VVI Santa Cruz $530 Roundtrip found 6 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:3/15/2026TANYT&leg2=from:VVI,to:MIA,departure:4/11/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:529.63&airProductToken=AQpECiAIw5oBEgMyMjcYjAIg78QBKMPchwMwgd6HAzhUQABYAQogCMOaARIDMjIxGO_EASC1RSjD3ocDMOPghwM4VEABWAEKRAogCMOaARIDMjIwGLVFIO_EASiUiYoDMLeLigM4VEAAWAEKIAjDmgESAzQyNxjvxAEgjAIo04yKAzCPjooDOFRAAVgBEgoIARABGAEqAkNNGAEiBAgBEAEoBDAB) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Sun, Mar 15 - Thu, Apr 16 MIA Miami VVI Santa Cruz $540 Roundtrip found 6 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:3/15/2026TANYT&leg2=from:VVI,to:MIA,departure:4/16/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:539.63&airProductToken=AQpECiAIw5oBEgMyMjcYjAIg78QBKMPchwMwgd6HAzhUQABYAQogCMOaARIDMjIxGO_EASC1RSjD3ocDMOPghwM4VEABWAEKRAogCMOaARIDMjIwGLVFIO_EASi0wYoDMNfDigM4TEAAWAEKIAjDmgESAzQyNxjvxAEgjAIo88SKAzCvxooDOExAAVgBEgoIARABGAEqAkNNGAEiBAgBEAEoBDAB) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Sun, Mar 8 - Sat, Mar 14 MIA Miami VVI Santa Cruz $548 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:3/8/2026TANYT&leg2=from:VVI,to:MIA,departure:3/14/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:547.13&airProductToken=AQpiCi4IwawBEgE3GIwCIMEzKK-NhwMwi4-HAzhVQABYAWoFTElHSFRyCFVaT0IxSVI5CjAIwawBEgMxNjcYwTMgtUUo1o-HAzDLkYcDOFVAAVgBagVMSUdIVHIIVVpPQjFJUjkKYgowCMGsARIDMTY2GLVFIMEzKKzKhwMwl8yHAzhVQABYAWoFTElHSFRyCFVaT0IxSVI5Ci4IwawBEgE2GMEzIIwCKOLRhwMw0tOHAzhVQAFYAWoFTElHSFRyCFVaT0IxSVI5EgoIARABGAEqAkFWGAEiBAgBEAEoAigDKAQwAQ) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Fri, May 29 - Mon, Jun 8 MIA Miami VVI Santa Cruz $566 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:5/29/2026TANYT&leg2=from:VVI,to:MIA,departure:6/8/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:565.13&airProductToken=AQpgCi4IzIIBEgQyNjkzGIwCIItiKLmgjgMwkqOOAzhOQABYAWoCU0xyCE5MRVNMRDhUCi4IzIIBEgQyNDA2GItiILVFKOirjgMwg62OAzhOQAFYAWoCU0xyCE5MRVNMRDhUCmAKLgjMggESBDI0MDcYtUUgi2Io1ZKPAzD6k48DOE5AAFgBagJTTHIITkxFU0xEOFQKLgjMggESBDI2OTgYi2IgjAIou5SPAzCol48DOE5AAVgBagJTTHIITkxFU0xEOFQSDAgBEAEYASoCTEEyABgBIgQIARABKAIoBCgGMAE) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Sun, Oct 4 - Fri, Oct 23 BWI Baltimore VVI Santa Cruz $620 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:BWI,to:VVI,departure:10/4/2026TANYT&leg2=from:VVI,to:BWI,departure:10/23/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:619.73&airProductToken=AQqXAQoxCNWCARIEMTg5OBjBRSCIOCi9wpkDMIDEmQM4S0AAWAFqBTJfZWNvcghLTkEwQTBFTgowCNWCARIDMjA1GIg4IMEzKOjGmQMwlMmZAzhLQABYAWoFMl9lY29yCEtOQTBBMEVOCjAIwawBEgMxNjcYwTMgtUUolsqZAzCGzJkDOFNAAFgBagUyX2Vjb3IIS05BMEEwRU4KlwEKMAjBrAESAzE2Nhi1RSDBMyiHl5sDMPKYmwM4VEAAWAFqBTJfZWNvcghHTkEwQTBFTgowCNWCARIDNTA4GMEzIIg4KOqZmwMwoJybAzhHQABYAWoFMl9lY29yCEdOQTBBMEVOCjEI1YIBEgQyNjgyGIg4IMFFKMiemwMw-p-bAzhHQABYAWoFMl9lY29yCEdOQTBBMEVOEgoIARABGAEqAlVBGAEiBAgBEAEoAigDKAQwCw) ![Boliviana De Aviacion](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/OB.gif) Sun, Mar 15 - Fri, Mar 20 MIA Miami VVI Santa Cruz $652 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:3/15/2026TANYT&leg2=from:VVI,to:MIA,departure:3/20/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:651.13&airProductToken=AQopCicIz4QBEgM3NjcYjAIgtUUomN6HAzCy4YcDOFNAAFgBcgZTSVVTRUIKKQonCM-EARIDNzYyGLVFIIwCKJOQiAMwrZOIAzhTQABYAXIGU0lVU0VCEgoIARABGAEqAk9CGAEiBAgBEAEoAigEKAYwAQ) ## Airports in Santa Cruz Prices were available within the past 7 days. Prices and availability are subject to change. [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:VVI,departure:2/23/2026TANYT&leg2=from:VVI,to:CMH,departure:3/10/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) VVI Viru Viru Intl. Cheapest [Flights from $771 ](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:VVI,departure:2/23/2026TANYT&leg2=from:VVI,to:CMH,departure:3/10/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) **Enjoy extra legroom, flight flexibility, and a seamless travel experience.** \*Flight schedules are subject to change. \*Flight schedules are subject to change. - Top Flights Destinations - Top Santa Cruz Hotels - Airlines Operating - Expedia's Latest Trends ### Top Flight Destinations In Santa Cruz - [Flights to Santa Cruz ](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights) - [Flights to Samaipata ](https://expedia.com/Cheap-Flights-To-Samaipata.d6200976.Travel-Guide-Flights) - [Flights to Warnes ](https://expedia.com/Cheap-Flights-To-Warnes.d6352296.Travel-Guide-Flights) - [Flights to Roboré ](https://expedia.com/Cheap-Flights-To-Robore.d3000408084.Travel-Guide-Flights) - [Flights to San Jose de Chiquitos ](https://expedia.com/Cheap-Flights-To-San-Jose-De-Chiquitos.d6344854.Travel-Guide-Flights) - [Flights to Bolivian Yungas ](https://expedia.com/Cheap-Flights-To-Bolivian-Yungas.d6212715.Travel-Guide-Flights) - [Flights to La Higuera ](https://expedia.com/Cheap-Flights-To-La-Higuera.d830373381713960960.Travel-Guide-Flights) - [Flights to Vallegrande ](https://expedia.com/Cheap-Flights-To-Vallegrande.d6350207.Travel-Guide-Flights) - [Flights to Puerto Quijarro ](https://expedia.com/Cheap-Flights-To-Puerto-Quijarro.d3000389058.Travel-Guide-Flights) - [Flights to San Ignacio de Velasco ](https://expedia.com/Cheap-Flights-To-San-Ignacio-De-Velasco.d6161202.Travel-Guide-Flights) - [Flights to Cuevas ](https://expedia.com/Cheap-Flights-To-Cuevas.d6350209.Travel-Guide-Flights) - [Flights to Colinas del Urubo ](https://expedia.com/Cheap-Flights-To-Colinas-Del-Urubo.d6349680.Travel-Guide-Flights) - [Flights to Camiri ](https://expedia.com/Cheap-Flights-To-Camiri.d770.Travel-Guide-Flights) - [Flights to La Guardia ](https://expedia.com/Cheap-Flights-To-La-Guardia.d6347124.Travel-Guide-Flights) - [Flights to San Javier ](https://expedia.com/Cheap-Flights-To-San-Javier.d6350629.Travel-Guide-Flights) - [Flights to Concepcion ](https://expedia.com/Cheap-Flights-To-Concepcion.d6353167.Travel-Guide-Flights) - [Flights to Estancia Aguas Calientes ](https://expedia.com/Cheap-Flights-To-Estancia-Aguas-Calientes.d631238765802795008.Travel-Guide-Flights) - [Flights to Chochis ](https://expedia.com/Cheap-Flights-To-Chochis.d553248635935195575.Travel-Guide-Flights) - [Flights to Santa Rosa De La Mina ](https://expedia.com/Cheap-Flights-To-Santa-Rosa-De-La-Mina.d3000007078.Travel-Guide-Flights) - [Flights to Puerto Suarez ](https://expedia.com/Cheap-Flights-To-Puerto-Suarez.d3000470804.Travel-Guide-Flights) ### Top Flight Destinations In the World - [Flights to United Kingdom ](https://expedia.com/Destinations-In-United-Kingdom.d190.Flight-Destinations) - [Flights to China ](https://expedia.com/Destinations-In-China.d37.Flight-Destinations) - [Flights to Russia ](https://expedia.com/Destinations-In-Russia.d153.Flight-Destinations) - [Flights to United States of America ](https://expedia.com/Destinations-In-United-States-Of-America.d201.Flight-Destinations) - [Flights to Colombia ](https://expedia.com/Destinations-In-Colombia.d38.Flight-Destinations) - [Flights to Canada ](https://expedia.com/Destinations-In-Canada.d31.Flight-Destinations) - [Flights to Türkiye ](https://expedia.com/Destinations-In-Turkiye.d183.Flight-Destinations) - [Flights to Brazil ](https://expedia.com/Destinations-In-Brazil.d23.Flight-Destinations) - [Flights to Switzerland ](https://expedia.com/Destinations-In-Switzerland.d174.Flight-Destinations) - [Flights to Greece ](https://expedia.com/Destinations-In-Greece.d67.Flight-Destinations) - [Flights to India ](https://expedia.com/Destinations-In-India.d80.Flight-Destinations) - [Flights to France ](https://expedia.com/Destinations-In-France.d59.Flight-Destinations) - [Flights to Argentina ](https://expedia.com/Destinations-In-Argentina.d8.Flight-Destinations) - [Flights to Italy ](https://expedia.com/Destinations-In-Italy.d86.Flight-Destinations) - [Flights to Indonesia ](https://expedia.com/Destinations-In-Indonesia.d81.Flight-Destinations) - [Flights to South Korea ](https://expedia.com/Destinations-In-South-Korea.d94.Flight-Destinations) - [Flights to Sweden ](https://expedia.com/Destinations-In-Sweden.d173.Flight-Destinations) - [Flights to Spain ](https://expedia.com/Destinations-In-Spain.d166.Flight-Destinations) - [Flights to Mexico ](https://expedia.com/Destinations-In-Mexico.d117.Flight-Destinations) - [Flights to Thailand ](https://expedia.com/Destinations-In-Thailand.d178.Flight-Destinations) ### Top Santa Cruz Hotels - [Ibis Santa Cruz DE LA Sierra ](https://expedia.com/Santa-Cruz-Hotels-Ibis-Santa-Cruz-DE-LA-Sierra.h87138613.Hotel-Information) - [Marriott Santa Cruz de la Sierra Hotel ](https://expedia.com/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) - [Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel ](https://expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) - [Sun Hotel ](https://expedia.com/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) - [TRYP by Wyndham Santa Cruz ](https://expedia.com/Santa-Cruz-Hotels-TRYP-By-Wyndham-Santa-Cruz.h45617372.Hotel-Information) - [HOTEL OSHO ](https://expedia.com/Santa-Cruz-Hotels-HOTEL-OSHO.h75254801.Hotel-Information) - [Hotel Las Américas ](https://expedia.com/Santa-Cruz-Hotels-Hotel-Las-Americas.h112993678.Hotel-Information) - [Camino Real Hotel ](https://expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) - [Delfines Collection Hotel By Mercure ](https://expedia.com/Santa-Cruz-Hotels-Delfines-Collection-Hotel-By-Mercure.h90301892.Hotel-Information) - [Novotel Santa Cruz De La Sierra ](https://expedia.com/Santa-Cruz-Hotels-Novotel-Santa-Cruz-De-La-Sierra.h69566260.Hotel-Information) - [Hampton by Hilton Santa Cruz/Equipetrol, Bolivia ](https://expedia.com/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information) - [Apart Hotel Premium Suites Santa Cruz ](https://expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information) - [Premium Suites Deluxe Aparthotel Equipetrol ](https://expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information) - [Hotel Cortez ](https://expedia.com/Santa-Cruz-Hotels-Hotel-Cortez.h13455822.Hotel-Information) - [Lido Hotel ](https://expedia.com/Santa-Cruz-Hotels-Hotel-Lido.h98237549.Hotel-Information) - [Swissôtel Santa Cruz De La Sierra ](https://expedia.com/Santa-Cruz-Hotels-Swissotel-Santa-Cruz-De-La-Sierra.h60335614.Hotel-Information) - [Hotel LP Equipetrol ](https://expedia.com/Santa-Cruz-Hotels-Hotel-LP-Equipetrol.h10209582.Hotel-Information) - [Chairú Eco Hotel ](https://expedia.com/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information) - [Equipetrol Suites Apart Hotel ](https://expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information) - [Prince Hotel ](https://expedia.com/Santa-Cruz-Hotels-Prince-Hotel.h117976126.Hotel-Information) ### Airlines Operating - [Amber Air ](https://expedia.com/Amber-Air-Flights.c0A.Travel-Guide-Airlines) - [BlueAir ](https://expedia.com/BlueAir-Flights.c0B.Travel-Guide-Airlines) - [Catovair ](https://expedia.com/Cobra-Aviation-Flights.c0C.Travel-Guide-Airlines) - [Darwin Airline SA Lugano ](https://expedia.com/Darwin-Airline-SA-Lugano-Flights.c0D.Travel-Guide-Airlines) - [Evergreen International ](https://expedia.com/Evergreen-International-Flights.c0E.Travel-Guide-Airlines) - [Ghadames Air Transport ](https://expedia.com/Ghadames-Air-Transport-Flights.c0G.Travel-Guide-Airlines) - [Aircompany Kokshetau ](https://expedia.com/AirCompany-Kokshetau-Flights.c0K.Travel-Guide-Airlines) - [Palau Asia ](https://expedia.com/Palau-Asia-Flights.c0P.Travel-Guide-Airlines) - [Royal Airways Limited ](https://expedia.com/Royal-Airways-Limited-Flights.c0S.Travel-Guide-Airlines) - [Vietnam Air Service Co. ](https://expedia.com/Vietnam-Air-Service-Co-Flights.c0V.Travel-Guide-Airlines) ### Expedia's Latest Trends Hotels - [Resorts & Hotels with Spas in La Paz](https://expedia.com/Destinations-In-La-Paz-Spa-Hotel.0-0-d6297090-tSpaHotel.Hotel-Filter-Destinations) - [Hotels in La Guardia](https://expedia.com/La-Guardia-Hotels.d6347124.Travel-Guide-Hotels) - [Extended Stay Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels-Extended-Stay-Hotels.0-0-d6053940-tExtendedStayHotels.Travel-Guide-Filter-Hotels) - [Golf Hotels in La Paz](https://expedia.com/Destinations-In-La-Paz-Golf-Hotel.0-0-d6297090-tGolfHotel.Hotel-Filter-Destinations) - [Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels) - [Hotels with Hot Tubs in Cochabamba](https://expedia.com/Destinations-In-Cochabamba-Hotels-With-Hot-Tubs.0-0-d6297089-tHotelsWithHotTubs.Hotel-Filter-Destinations) - [Casinos in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels-Casino-Hotel.0-0-d6053940-tCasinoHotel.Travel-Guide-Filter-Hotels) - [La Paz hotels](https://expedia.com/Destinations-In-La-Paz.d6297090.Hotel-Destinations) - [Hotels near Amboró National Park](https://expedia.com/Amboro-National-Park-Hotels.0-l6098839-0.Travel-Guide-Filter-Hotels) - [Family Hotels in Florida Province](https://expedia.com/Destinations-In-Florida-Province-Family-Hotel.0-0-d553248635975751209-tFamilyHotel.Hotel-Filter-Destinations) - [Hotels in Colinas del Urubo](https://expedia.com/Colinas-Del-Urubo-Hotels.d6349680.Travel-Guide-Hotels) - [Hotels in Estancia Bella Vista](https://expedia.com/Estancia-Bella-Vista-Hotels.d6350895.Travel-Guide-Hotels) - [Resorts & Hotels with Spas in Potosi](https://expedia.com/Destinations-In-Potosi-Spa-Hotel.0-0-d6297171-tSpaHotel.Hotel-Filter-Destinations) Flights - [Flights to Oruro](https://expedia.com/Destinations-In-Oruro.d553248628939824197.Flight-Destinations) - [Flights to Chuquisaca](https://expedia.com/Destinations-In-Chuquisaca.d6053936.Flight-Destinations) - [Cheap Flights to Santa Cruz](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights) - [Flights to La Paz](https://expedia.com/Destinations-In-La-Paz.d6297090.Flight-Destinations) Cars - [Car rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide) Activities - [Things to do in La Paz](https://expedia.com/Things-To-Do-In-La-Paz.d6297090.Travel-Guide-Activities) Packages - [Santa Cruz Zoo](https://expedia.com/Santa-Cruz-Zoo-Santa-Cruz.d6098836.Vacation-Attraction) - [Santa Cruz la Vieja Historical Park](https://expedia.com/Santa-Cruz-La-Vieja-Historical-Park-San-Jose-de-Chiquitos.d553248621532375546.Vacation-Attraction) - [Noel Kempff Mercado National Park](https://expedia.com/Noel-Kempff-Mercado-National-Park-Santa-Cruz.d6098841.Vacation-Attraction) - [Santa Cruz Vacation](https://expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides) - [Cochabamba Vacation](https://expedia.com/Cochabamba.d6297089.Destination-Travel-Guides) Vacation Rentals - [Beni Vacation Rentals](https://expedia.com/Destinations-In-Beni.d6297087.Vacation-Rental-Destinations) General - [Visit Cochabamba](https://expedia.com/Cochabamba.dx6297089) - [Visit La Paz](https://expedia.com/La-Paz.dx6297090) - [Visit Santa Cruz](https://expedia.com/Santa-Cruz.dx6053940) - [Visit Tarija](https://expedia.com/Tarija.dx6297175) - [Visit San Jose de Chiquitos](https://expedia.com/San-Jose-De-Chiquitos.dx6344854) ## Trending flights to Santa Cruz These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Wed, Mar 11 - Thu, Mar 12 MIA Miami VVI Santa Cruz $501 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:VVI,departure:3/11/2026TANYT&leg2=from:VVI,to:MIA,departure:3/12/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:500.63&airProductToken=AQpiCi8Iw5oBEgMxNzMYjAIg78QBKNmphwMwkquHAzhMQABYAWoDQkFTcghMTEFBVFoyUwovCMOaARIDMTI3GO_EASC1RSiUr4cDMMqxhwM4TEAAWAFqA0JBU3IITExBQVRaMlMKYgovCMOaARIDMTI2GLVFIO_EASjasocDMPy0hwM4TEAAWAFqA0JBU3IITExBQVRaMlMKLwjDmgESAzQyNxjvxAEgjAIolLuHAzDQvIcDOExAAFgBagNCQVNyCExMQUFUWjJTEgoIARABGAEqAkNNGAEiBAgBEAEoAigDKAQwCw) \*Available to One Key members.