Bolivia may have travel restrictions in place, including self-quarantine, due to COVID-19.

Find out moreOpens in new tab or window

Find Hotels in Santa Cruz

Search over 1 million properties and 550 airlines worldwide

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Free cancellation on most hotels. Because flexibility matters.

Filter by

Popular filters
Star rating
Your budget
Guest rating
Payment type
Property type
Neighborhood
Popular locations
Meal plans available
Amenities
Accessibility
Trip type
Hotel Las Palmas
3 out of 5
Av. El Trompillo, 604, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $57 per night from Jan 20 to Jan 21
1.14 mi from city center
4.2/5Very Good! (52 reviews)

"A bit old. But they were great to accommodate me and my girlfriend at last minute. Basic amenities, ideal for a quick stay over. Thank you"…"

Reviewed on Jun 25, 2019

Hotel Las Palmas
Buganvillas Hotel Suites & Spa
4 out of 5
Av. Roca y Coronado No. 901, Santa Cruz
Free Cancellation
The price is $50 per night from Feb 11 to Feb 12
2.07 mi from city center
3.8/5Good! (68 reviews)

"First a lot of noise,they were construction workers at 7am making a lot noise as you can image. Terrible used bed very old. The rest staff was exelent"…"

Reviewed on Aug 25, 2019

Buganvillas Hotel Suites & Spa
Apart Hotel Buen Retiro
2.5 out of 5
Calle Florida 432, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $40 per night from Jan 19 to Jan 20
0.4 mi from city center
4.5/5Wonderful! (26 reviews)

"Well after travelling in remote Andes, my own bath was a highlight. Having wifi and TV were nice. Place clean, they catered to my disabilities. Staff extremely friendly and helpful. Asked about a box and packing tape as suitcase getting overweight. Since use a cane they had a boy did the running ..."…"

Reviewed on Apr 18, 2019

Apart Hotel Buen Retiro
You could be seeing lower prices

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Swissôtel Santa Cruz De La Sierra
4.5 out of 5
Canal Isuto, Los Pachio, Barrio 2 De Abril, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $100 per night from Feb 2 to Feb 3
2.83 mi from city center
Swissôtel Santa Cruz De La Sierra
Los Tajibos Hotel And Convention Center
4.5 out of 5
Ave. San Martin, #455, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $104 per night from Feb 15 to Feb 16
1.76 mi from city center
4.4/5Excellent! (155 reviews)

"Liked the location. I stayed there on two different occasions and the customer service one time was better than the other, no consistency."…"

Reviewed on Jan 13, 2020

Los Tajibos Hotel And Convention Center
My Green House
2.5 out of 5
80 Ave Juan Jose, Santa Cruz, Departamento de Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $20 per night from Jan 28 to Jan 29
3.85 mi from city center
My Green House
Sun Hotel
3.5 out of 5
Av. Banzer Km 13, Aeropuerto Internacional Viru Viru, Santa Cruz, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $93 per night from Feb 16 to Feb 17
8.97 mi from city center
4/5Very Good! (137 reviews)

"Friendly staff, large Clean rooms, very comfortable bed, good food. Beautiful pool and overall very nice place. Shuttle service to and from airport is excellent."…"

Reviewed on Jan 21, 2020

Sun Hotel
Hotel LP Santa Cruz Centro
3 out of 5
Av.Ejercito Nacional 290, (frente Stadium Tahuichi), Santa Cruz
Free Cancellation
The price is $48 per night from Jan 23 to Jan 24
0.82 mi from city center
3.9/5Good! (237 reviews)

"Staff around around breakfast area was terrible, e.g., not replinishing food, glasses, etc., when she said she would and removing dishes before guest was through."…"

Reviewed on Sep 9, 2019

Hotel LP Santa Cruz Centro
Hotel Cortez
3.5 out of 5
Av. Cristobal de Mendoza 280, Santa Cruz
Free Cancellation
The price is $114 per night from Feb 5 to Feb 6
0.95 mi from city center
4.5/5Wonderful! (34 reviews)

"loved the location great restaurants at close proximity but the hotel restaurant is also great sitting by the pool to eat a Cilpancho very safe and clean transfers from VVI airport can be prearranged with the hotel a little more expensive but worth it It's a 5* plus property"…"

Reviewed on Mar 14, 2019

Hotel Cortez
Camino Real Hotel
4 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $98 per night from Feb 8 to Feb 9
2.27 mi from city center
4.3/5Excellent! (235 reviews)
An oasis in the middle of a hectic business schedu

"Absolutely one of the best price/offering options. The location, the amenities, the spa and the caring staff make a huge difference. This was a very stressful trip and my last stop was in Hotel Camino Real in Sta. Cruz. A real blessing given how stressed I was towards the end of my business tour. ..."…"

Reviewed on Feb 11, 2020

Camino Real Hotel
Suites Apart Hotel Ortiz
3 out of 5
Bolivar 657 Zona Central, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $47 per night from Jan 19 to Jan 20
0.47 mi from city center
3.4/5 (5 reviews)

"Staff was really helpful. The apartment format of the room was really comfortable."…"

Reviewed on Nov 8, 2016

Suites Apart Hotel Ortiz
Suites Toborochi
3.5 out of 5
Jaime Freyre 7, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $51 per night from Jan 19 to Jan 20
1.08 mi from city center
4.2/5Excellent! (47 reviews)

"Very comfortable and quiet place and very good location."…"

Reviewed on Dec 1, 2019

Suites Toborochi
Biocentro Guembe Hotel
3.5 out of 5
Km. 5 camino a Porongo, Santa Cruz
Get Rates
4.6 mi from city center
4.3/5Excellent! (3 reviews)
Un lugar para disfrutar en pareja, con la familia

"Es un lugar para disfrutar el pareja, aunque exageran en el tema de no ingresar alimentos, por cuanto podrían habilitar un hervidos y unas bolsitas de te y sobres de café para la noche. El lugar en si muy muy bueno, con múltiples atractivos demoras en forma razonable dos a tres días en recorrer ..."…"

Reviewed on Aug 2, 2017

Biocentro Guembe Hotel
Senses Centro
3.5 out of 5
calle Rene Moreno casi esquina Pari 247, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $55 per night from Jan 19 to Jan 20
0.17 mi from city center
3.8/5Good! (49 reviews)

"There was noise in the hotel from other guests and they did nothing."…"

Reviewed on Dec 1, 2020

Senses Centro
Senses Boutique Hotel
3.5 out of 5
Calle 24 de Septiembre, Esq. Sucre No 5, Plaza Principal, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $70 per night from Jan 19 to Jan 20
0.08 mi from city center
4/5Very Good! (249 reviews)

"No hot water. I complained multiple times to no avail."…"

Reviewed on Mar 5, 2020

Senses Boutique Hotel
Radisson Hotel Santa Cruz
5 out of 5
Avenida Segunda 4, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $88 per night from Jan 22 to Jan 23
3.28 mi from city center
4.5/5Wonderful! (168 reviews)

"The pool was dirty, we found a roach in our bathroom. The lobby bathrooms did not have soap, toilet paper..."…"

Reviewed on Oct 9, 2020

Radisson Hotel Santa Cruz
Casa por Temporadas
3.5 out of 5
Avenida Cristo Redentor, frente al cementerio Las Misiones, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $115 per night from Jan 19 to Jan 20
7.18 mi from city center
5/5Exceptional! (1 review)
Great place to stay, great attention

"The owners were happy to answer all our questions by email before our arrival. The pool was very nice but know that it has no shallow end. The pool table and air hockey table were nice additions, especially if it happens to rain while you are there. The owners know a great taxi driver if you don't ..."…"

Reviewed on Sep 21, 2016

Casa por Temporadas
Hotel LP Equipetrol
3.5 out of 5
Dr Victor Pinto, Equipetrol, esquina Marcelo Terceros Banzer, Santa Cruz
Free Cancellation
The price is $55 per night from Jan 19 to Jan 20
1.81 mi from city center
3.9/5Very Good! (113 reviews)

"I honesty think that they need to change the beds, my doughter and I had bad beds, and as we are in pandemic so we did can not had dinner in the hotel, so we need to buy from out of it in a delivery service"…"

Reviewed on Oct 12, 2020

Hotel LP Equipetrol
Terranova Suites
3.5 out of 5
7º Anillo 400 mts al Oeste de, Av. Cristo Redentor, Santa Cruz, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $58 per night from Jan 20 to Jan 21
4.4 mi from city center
3.9/5Good! (71 reviews)

"Good option for business travelers because it is closes of ViruViru airport and from down town Santa Cruz"…"

Reviewed on Dec 26, 2020

Terranova Suites
Apart Hotel Premium Suites Equipetrol
3.5 out of 5
Calle Las Begonias No. 30, 1 block from San Martin Avenue, Santa Cruz, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is $49 per night from Feb 1 to Feb 2
1.89 mi from city center
4.3/5Excellent! (22 reviews)

"Elevator is a must!(to be 100% great) otherwise beds ok and place nice. Great stuff for your money"…"

Reviewed on May 5, 2019

Apart Hotel Premium Suites Equipetrol
Don't see what you're looking for?
See all available properties in Santa Cruz
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Visiting Santa Cruz

Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafés, zoo, and cathedral.

  • There are 88 hotels and other accommodations in Santa Cruz
  • The closest major airport is in Santa Cruz (VVI-Viru Viru Intl.), 9.8 mi (15.8 km) from the city center

Sightseeing and Staying in Santa Cruz

Cultural venues in the city include Sacred Art Museum, Franco Aleman Cultural Center, and Guarani Nandereko Nomai Art and Culture Center. The picturesque setting of Arenal Park and Lomas de Arena Regional Park exemplify the city's natural beauty. Shopping is one of the favorite things to do, so consider an excursion to La Recova Artisan Walk, Artecampo, and Ventura Mall.

In Santa Cruz, there are 88 hotels and other lodging options so you'll have plenty of choices for a perfect holiday retreat. These are highly ranked ones based on Expedia user reviews:

  • Marriott Santa Cruz de la Sierra Hotel - This 4.5-star hotel features a full-service spa, a restaurant, and an outdoor pool.
  • La Quinta Apart Hotel - Our customers like the breakfast and pool at this aparthotel. With a stay at this 3.5-star aparthotel, guests can enjoy access to 3 outdoor pools and a restaurant, along with an in-room kitchen.
  • Radisson Hotel Santa Cruz - This 4-star hotel features free breakfast, a restaurant, and an outdoor pool. Expedia customers like its breakfast and pool.

Dressing for Santa Cruz

  • Between January and March, you can expect the daytime average to be around 87°F and the nighttime average to be 69°F
  • From April to June, temperatures average about 85°F during the day and 59°F at night
  • July through September averages 85°F during the day and 57°F at night
  • In October-December, the average temperature is 89°F during the day and 67°F at night
  • Average annual rainfall for Santa Cruz is 1.89 inches
  • Hottest months are usually November and October with an average temperature of 88°F, while the coldest months are July and June with an average of 60°F

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a favorite with Expedia customers. This 5-star hotel offers a full-service spa and a restaurant. Reviews from our site also recommend Cosmopolitano Hotel Boutique and Radisson Hotel Santa Cruz as top options for your trip.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation’s cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click “Search”, then use the filter option “free cancellation” to view top deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best budget-friendly accommodation in Santa Cruz?
Based on reviews, Hotel LP Equipetrol is a popular 3.5-star hotel for our travelers looking for an economical choice, and features free WiFi and a restaurant. Other good choices to stay on the cheap include Yotau All Suites Hotel and Hotel LP Santa Cruz Centro.
What's the best accommodation for a family trip to Santa Cruz?
Suites Toborochi is a top 3.5-star aparthotel on Expedia for families, and features an outdoor pool and a restaurant. Other choices for your stay with the kids include Inboccalupo The Hotel Boutique and Terranova Suites. Kids of all ages will also enjoy a visit to Santa Cruz Zoo.
What's the best place to stay for a romantic vacation to Santa Cruz?
Buganvillas Hotel Suites & Spa is a favorite 4-star hotel for couples, and features in-room massages and rainfall showerheads.
What's the best pet-friendly hotel in Santa Cruz?
Hotel LP Equipetrol is a top hotel for people traveling with their pets, and offers a restaurant and concierge services for its human guests. Other good options for you and your pet’s trip include Casa por Temporadas and Hotel La Siesta.
Where is the best place to stay close to Plaza 24 de Septiembre?
Adjacent to Plaza 24 de Septiembre, Senses Boutique Hotel is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers 3 restaurants and free breakfast. Other good options within a short distance include Hotel Canciller and Nomad Hostel.
What about the best place to stay near Ventura Mall?
One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and free breakfast. Marriott Santa Cruz de la Sierra Hotel and Hotel LP Equipetrol are two other good choices in the immediate area.
What's the best luxury accommodation in Santa Cruz?
Los Tajibos Hotel And Convention Center is a 4.5-star hotel with 3 restaurants and 2 bars, and it’s a popular choice for Expedia travelers looking for a pampering stay.
What's the best boutique accommodation in Santa Cruz?
Senses Boutique Hotel is a favorite 3.5-star hotel with our travelers looking for a stylish accommodation, featuring 52 guestrooms, 3 restaurants, and a bar.
What are some accommodations with pools in Santa Cruz?
Casa Blanca Hotel is a popular 3.5-star hotel featuring an outdoor pool, a children’s pool, and free breakfast. A couple of other options that offer an onsite pool include Biocentro Guembe Hotel and Torre Hotel Ejecutivo.

Recent reviews of Santa Cruz hotels

More trip options