Title: $123 Cheap Flights & Airfare to Santa Cruz - Expedia.com ![The islands of the Galapagos each have there own unique character. Rabida is known for its beautiful and distinctive red sand. #LifeAtExpedia](https://images.trvl-media.com/place/6336653/6ff9b89f-6236-4eaa-85b4-894c9bdaef64.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Delen Wong ![](https://images.trvl-media.com/place/6336653/6ff9b89f-6236-4eaa-85b4-894c9bdaef64.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights to Santa Cruz from $123 [View $123 flight on Wed, Sep 23, 2026](https://expedia.com/Flights-Search?trip=oneway&leg1=from:UIO,to:GPS,departure:9/23/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:122.60&airProductToken=AQo0CjIIwawBEgQxNjg4GJRyIOaTASjKyZgDMMzKmAM4U0AAWAFqBUJBU0lDcghTUk9CMElSSRIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) - [Roundtrip](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travelers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only [Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d738889999009755136.Hotel-Destinations)[Vacation Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d738889999009755136.Vacation-Rental-Destinations)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d738889999009755136.Car-Rental-Destinations)[Santa Cruz Vacations](https://expedia.com/Santa-Cruz.d738889999009755136.Destination-Travel-Guides) ## Popular airlines to Santa Cruz - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AV.svg) Avianca - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_LA.svg) LATAM Airlines Group - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AM.svg) Aeromexico - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) ## How much is the cheapest flight to Santa Cruz? Prices were available within the past 7 days and start at $123 for one-way flights and $257 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Fri, Jun 5 - Mon, Jun 8 GYE Guayaquil SCY San Cristobal $257 Roundtrip found 4 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:SCY,departure:6/5/2026TANYT&leg2=from:SCY,to:GYE,departure:6/8/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:256.56&airProductToken=AQoxCi8IzIIBEgQxNDE5GIYmINLAASju9I4DMNr1jgM4T0AAWAFqAlFQcghPMDBRUEFaSgoxCi8IzIIBEgQxNDE4GNLAASCGJijRl48DMLqYjwM4T0AAWAFqAlFQcghPMDBRUEFaShIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Wed, May 13 - Fri, May 15 GYE Guayaquil SCY San Cristobal $258 Roundtrip found 4 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:SCY,departure:5/13/2026TANYT&leg2=from:SCY,to:GYE,departure:5/15/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:257.71&airProductToken=AQoxCi8IzIIBEgQxNDE5GIYmINLAASiq8IwDMJbxjAM4T0AAWAFqAlFQcghPMDBRUEFaShIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sun, Jan 10 - Thu, Jan 14 UIO Quito SCY San Cristobal $258 Roundtrip found 6 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:UIO,to:SCY,departure:1/10/2027TANYT&leg2=from:SCY,to:UIO,departure:1/14/2027TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:257.91&airProductToken=AQoxCi8IzIIBEgQxNDE5GJRyINLAASiYkqIDMOSTogM4T0AAWAFqAlFQcghPMDBRUEFaSgoxCi8IzIIBEgQxNDE4GNLAASCUciiewqIDMN_DogM4T0AAWAFqAlFQcghPMDBRUEFaShIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Mon, Jun 8 - Mon, Jun 22 GYE Guayaquil SCY San Cristobal $259 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:SCY,departure:6/8/2026TANYT&leg2=from:SCY,to:GYE,departure:6/22/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:258.86&airProductToken=AQo0CjIIwawBEgQxNjgyGIYmINLAASiNlo8DMPuWjwM4U0AAWAFqBUJBU0lDcghTUk9CMElSSQo0CjIIwawBEgQxNjMxGNLAASCGJijZtJADMMe1kAM4U0AAWAFqBUJBU0lDcghTUk9CMElSSRIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sun, Jun 21 - Wed, Jun 24 GYE Guayaquil SCY San Cristobal $262 Roundtrip found 1 hour ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:SCY,departure:6/21/2026TANYT&leg2=from:SCY,to:GYE,departure:6/24/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:261.16&airProductToken=AQoxCi8IzIIBEgQxNDIzGIYmINLAASidqZADMImqkAM4T0AAWAFqAlFQcghPMDBRUEFaShIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Tue, Apr 28 - Wed, May 6 UIO Quito SCY San Cristobal $262 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:UIO,to:SCY,departure:4/28/2026TANYT&leg2=from:SCY,to:UIO,departure:5/6/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:261.79&airProductToken=AQojCiEIzIIBEgQxNDE5GJRyINLAASjsx4sDMLbJiwM4UUAAWAEKIwohCMyCARIEMTQxOBjSwAEglHIo3qKMAzCgpIwDOE9AAFgBEgoIARABGAEqAkxBGAEiBAgBEAEoBDAB) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sun, Jun 21 - Wed, Jun 24 GYE Guayaquil SCY San Cristobal $264 Roundtrip found 1 hour ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GYE,to:SCY,departure:6/21/2026TANYT&leg2=from:SCY,to:GYE,departure:6/24/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:263.46&airProductToken=AQoxCi8IzIIBEgQxNDIzGIYmINLAASidqZADMImqkAM4T0AAWAFqAlFQcghPMDBRUEFaSgoxCi8IzIIBEgQxNDE4GNLAASCGJij-yZADMOfKkAM4T0AAWAFqAlFQcghPMDBRUEFaShIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![LATAM Airlines Group](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LA.gif) Sat, Jun 13 - Thu, Jun 18 UIO Quito SCY San Cristobal $266 Roundtrip just found [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:UIO,to:SCY,departure:6/13/2026TANYT&leg2=from:SCY,to:UIO,departure:6/18/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:265.24&airProductToken=AQoxCi8IzIIBEgQxNDE5GJRyINLAASjOzY8DMJrPjwM4T0AAWAFqAlFQcghPMDBRUEFaSgoxCi8IzIIBEgQxNDE4GNLAASCUcijeh5ADMKCJkAM4T0AAWAFqAlFQcghPMDBRUEFaShIKCAEQARgBKgJMQRgBIgQIARABKAIoBCgGMAE) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Tue, Sep 22 - Fri, Sep 25 UIO Quito SCY San Cristobal $267 Roundtrip found 5 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:UIO,to:SCY,departure:9/22/2026TANYT&leg2=from:SCY,to:UIO,departure:9/25/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:266.20&airProductToken=AQo0CjIIwawBEgQxNjMwGJRyINLAASi8vZgDMKe_mAM4U0AAWAFqBUJBU0lDcghTUk9CMElSSQo0CjIIwawBEgQxNjMxGNLAASCUcijV4JgDMKfimAM4U0AAWAFqBUJBU0lDcghTUk9CMElSSRIKCAEQARgBKgJBVhgBIgQIARABKAIoAygEMAE) ![World Ticket Ltd](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/w1.gif) Sun, May 17 - Fri, May 29 GPS Santa Cruz Island IBB Isabela Island $481 Roundtrip found 1 day ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:GPS,to:IBB,departure:5/17/2026TANYT&leg2=from:IBB,to:GPS,departure:5/29/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:480.14&airProductToken=AQorCikI12ISAzQzNhjmkwEgqAgo1J-NAzDyn40DOFlAAFgBcghZRU1UV0VSVAorCikI12ISAzQzMxioCCDmkwEo5KSOAzCCpY4DOFlAAFgBcghZRU1UV0VSVBIKCAEQARgBKgJXMhgBIgQIARABKAIoAygEMAE) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=FTG_SPRING_PROMO_) ## Airports in Santa Cruz Prices were available within the past 7 days. Prices and availability are subject to change. [](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:GPS,departure:3/17/2026TANYT&leg2=from:GPS,to:CMH,departure:4/1/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) GPS Seymour Cheapest [Flights from $1,483 ](https://www.expedia.com/Flights-Search?leg1=from:CMH,to:GPS,departure:3/17/2026TANYT&leg2=from:GPS,to:CMH,departure:4/1/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) ## Trending flights to Santa Cruz These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, Apr 8 - Mon, Apr 20 MIA Miami SCY San Cristobal $381 Roundtrip found 2 days ago [](https://expedia.com/Flights-Search?trip=roundtrip&leg1=from:MIA,to:SCY,departure:4/8/2026TANYT&leg2=from:SCY,to:MIA,departure:4/20/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:380.43&airProductToken=AQpFCiAIwawBEgQ3Mzc5GIwCIIYmKOjiiQMw--SJAzhVQABYAQohCMGsARIEMTYzMBiGJiDSwAEo2eeJAzDH6IkDOFVAAVgBCkUKIQjBrAESBDE2ODMY0sABIIYmKI3wigMw-_CKAzhVQABYAQogCMGsARIENzM3OBiGJiCMAiiR8ooDMJ_0igM4VUABWAESCggBEAEYASoCQVYYASIECAEQASgEMAE) ## Book with confidence **Enjoy extra legroom, flight flexibility, and a seamless travel experience.** ## Travel information \*Flight schedules are subject to change. \*Flight schedules are subject to change. ## Explore a world of travel with Expedia - Top Flights Destinations - Top Santa Cruz Hotels - Airlines Operating ### Top Flight Destinations In Santa Cruz - [Flights to Puerto Ayora ](https://expedia.com/Cheap-Flights-To-Puerto-Ayora.d602686.Travel-Guide-Flights) - [Flights to Santa Cruz Island ](https://expedia.com/Cheap-Flights-To-Santa-Cruz-Island.d6053670.Travel-Guide-Flights) - [Flights to Isabela Island ](https://expedia.com/Cheap-Flights-To-Isabela-Island.d6085329.Travel-Guide-Flights) - [Flights to Baltra ](https://expedia.com/Cheap-Flights-To-Baltra.d6223000.Travel-Guide-Flights) - [Flights to Santa Rosa ](https://expedia.com/Cheap-Flights-To-Santa-Rosa.d6053725.Travel-Guide-Flights) - [Flights to Bellavista ](https://expedia.com/Cheap-Flights-To-Bellavista.d6342722.Travel-Guide-Flights) - [Flights to Daphne Islands ](https://expedia.com/Cheap-Flights-To-Daphne-Islands.d6336492.Travel-Guide-Flights) - [Flights to Santiago Island ](https://expedia.com/Cheap-Flights-To-Santiago-Island.d6336381.Travel-Guide-Flights) - [Flights to Bartolome Island ](https://expedia.com/Cheap-Flights-To-Bartolome-Island.d6336382.Travel-Guide-Flights) - [Flights to Rabida Island ](https://expedia.com/Cheap-Flights-To-Rabida-Island.d6336653.Travel-Guide-Flights) - [Flights to North Seymour Island ](https://expedia.com/Cheap-Flights-To-North-Seymour-Island.d6336659.Travel-Guide-Flights) - [Flights to El Cascajo ](https://expedia.com/Cheap-Flights-To-El-Cascajo.d6222749.Travel-Guide-Flights) ### Top Flight Destinations In the World - [Flights to South Korea ](https://expedia.com/Destinations-In-South-Korea.d94.Flight-Destinations) - [Flights to Indonesia ](https://expedia.com/Destinations-In-Indonesia.d81.Flight-Destinations) - [Flights to Mexico ](https://expedia.com/Destinations-In-Mexico.d117.Flight-Destinations) - [Flights to Spain ](https://expedia.com/Destinations-In-Spain.d166.Flight-Destinations) - [Flights to Argentina ](https://expedia.com/Destinations-In-Argentina.d8.Flight-Destinations) - [Flights to Italy ](https://expedia.com/Destinations-In-Italy.d86.Flight-Destinations) - [Flights to Greece ](https://expedia.com/Destinations-In-Greece.d67.Flight-Destinations) - [Flights to India ](https://expedia.com/Destinations-In-India.d80.Flight-Destinations) - [Flights to Sweden ](https://expedia.com/Destinations-In-Sweden.d173.Flight-Destinations) - [Flights to Norway ](https://expedia.com/Destinations-In-Norway.d138.Flight-Destinations) - [Flights to Japan ](https://expedia.com/Destinations-In-Japan.d89.Flight-Destinations) - [Flights to United States of America ](https://expedia.com/Destinations-In-United-States-Of-America.d201.Flight-Destinations) - [Flights to France ](https://expedia.com/Destinations-In-France.d59.Flight-Destinations) - [Flights to Germany ](https://expedia.com/Destinations-In-Germany.d64.Flight-Destinations) - [Flights to Brazil ](https://expedia.com/Destinations-In-Brazil.d23.Flight-Destinations) - [Flights to Türkiye ](https://expedia.com/Destinations-In-Turkiye.d183.Flight-Destinations) - [Flights to China ](https://expedia.com/Destinations-In-China.d37.Flight-Destinations) - [Flights to United Kingdom ](https://expedia.com/Destinations-In-United-Kingdom.d190.Flight-Destinations) - [Flights to Russia ](https://expedia.com/Destinations-In-Russia.d153.Flight-Destinations) - [Flights to Colombia ](https://expedia.com/Destinations-In-Colombia.d38.Flight-Destinations) ### Top Santa Cruz Hotels - [Hotel Fiesta ](https://expedia.com/Puerto-Ayora-Hotels-Hotel-Fiesta.h9690626.Hotel-Information) - [Maidith Galapagos Inn ](https://expedia.com/Puerto-Ayora-Hotels-Maidith-Galapagos-Inn.h88474681.Hotel-Information) - [Finch Bay Galapagos Hotel ](https://expedia.com/Puerto-Ayora-Hotels-Finch-Bay-Galapagos-Hotel.h1862515.Hotel-Information) - [El Barranco Galapagos ](https://expedia.com/Puerto-Ayora-Hotels-Hotel-Barranco-Galapagos.h111508035.Hotel-Information) - [Ikala Galapagos Hotel ](https://expedia.com/Puerto-Ayora-Hotels-Ikala-Galapagos-Hotel.h23688395.Hotel-Information) - [Hotel el descanso del Guia ](https://expedia.com/Puerto-Ayora-Hotels-Hotel-El-Descanso-Del-Guia.h17525206.Hotel-Information) - [Capitan Max B&B ](https://expedia.com/Puerto-Ayora-Hotels-Capitan-Max-BB.h14716616.Hotel-Information) - [Fernandina Hotel & Spa Galápagos ](https://expedia.com/Puerto-Ayora-Hotels-HOTEL-FERNANDINA.h90029511.Hotel-Information) - [Royal Palm Galapagos, Curio Collection Hotel by Hilton ](https://expedia.com/Santa-Rosa-Hotels-The-Royal-Palm-Hotel.h12535025.Hotel-Information) - [Hotel Ninfa ](https://expedia.com/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) - [Hotel Cucuve ](https://expedia.com/Puerto-Ayora-Hotels-Hotel-Cucuve.h13147131.Hotel-Information) - [Posada del Mar ](https://expedia.com/Puerto-Ayora-Hotels-Posada-Del-Mar.h41941787.Hotel-Information) - [Galapagos Dreams ](https://expedia.com/Puerto-Ayora-Hotels-GALAPAGOS-DREAMS.h11698055.Hotel-Information) - [Galapagos Verde Azul ](https://expedia.com/Puerto-Ayora-Hotels-Galapagos-Verde-Azul.h9577577.Hotel-Information) - [Blu Galapagos Sustainable Waterfront Lodge ](https://expedia.com/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) - [Angermeyer Waterfront Inn ](https://expedia.com/Puerto-Ayora-Hotels-Angermeyer-Waterfront-Inn.h4884897.Hotel-Information) - [Hotel Palace Galapagos ](https://expedia.com/Puerto-Ayora-Hotels-Hotel-Palace-Galapagos.h11050675.Hotel-Information) - [Hotel Flamingo ](https://expedia.com/Puerto-Ayora-Hotels-Hotel-Flamingo.h16231438.Hotel-Information) - [Suymar Ecolodge Galapagos ](https://expedia.com/Puerto-Ayora-Hotels-Suymar-Ecolodge-Galapagos.h14734307.Hotel-Information) - [Hostal North Seymour ](https://expedia.com/Puerto-Ayora-Hotels-Hostal-North-Seymour.h20369256.Hotel-Information) ### Airlines Operating - [Olympus Airways ](https://expedia.com/Olympus-Airways-Flights.c11.Travel-Guide-Airlines) - [Amber Air ](https://expedia.com/Amber-Air-Flights.c0A.Travel-Guide-Airlines) - [BlueAir ](https://expedia.com/BlueAir-Flights.c0B.Travel-Guide-Airlines) - [Catovair ](https://expedia.com/Cobra-Aviation-Flights.c0C.Travel-Guide-Airlines) - [Darwin Airline SA Lugano ](https://expedia.com/Darwin-Airline-SA-Lugano-Flights.c0D.Travel-Guide-Airlines) - [Evergreen International ](https://expedia.com/Evergreen-International-Flights.c0E.Travel-Guide-Airlines) - [Ghadames Air Transport ](https://expedia.com/Ghadames-Air-Transport-Flights.c0G.Travel-Guide-Airlines) - [Aircompany Kokshetau ](https://expedia.com/AirCompany-Kokshetau-Flights.c0K.Travel-Guide-Airlines) - [Palau Asia ](https://expedia.com/Palau-Asia-Flights.c0P.Travel-Guide-Airlines) - [Royal Airways Limited ](https://expedia.com/Royal-Airways-Limited-Flights.c0S.Travel-Guide-Airlines) \*Available to One Key members.