Santa Cruz Vacations & Trips

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Top destinations in Santa Cruz

A coastal landscape with clear turquoise waters, a sandy beach, and volcanic rocks.
FlightsFlightsHotelsHotels

Puerto Ayora

Puerto Ayora
A tortoise in a lush green forest.
FlightsFlightsHotelsHotels

Santa Rosa

Santa Rosa

Find the Best Santa Cruz Vacation Packages

Santa Cruz Essential Information

Language
Spanish
Currency
U.S dollars
Local Welcome
¡Hola!
Local Goodbye
Adiós

Santa Cruz Hotel Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
$137 nightly
The price is $137 total per night from Jul 15 to Jul 16
$137 total
Jul 15 - Jul 16
9/10 Wonderful! (421 reviews)
"My stay was amazing. From first entering the lobby where guest and staff were gathered to watch Ecuador advance in the World Cup. To the wonderful breakfast served by fantastic people. Front desk staff who help coordinate day trips, call taxi and provide great restaurant recommendations"

Reviewed on Jul 8, 2026

Hotel Fiesta
Hotel el descanso del Guia

Hotel el descanso del Guia

3.5 out of 5
Calle Delfin, Barrio el Mirador Puerto Ayora Galapagos
$74 nightly
The price is $74 total per night from Jul 27 to Jul 28
$74 total
Jul 27 - Jul 28
8.8/10 Excellent! (217 reviews)
"Un lindo lugar, muy cerca del terminal."

Reviewed on Jul 9, 2026

Hotel el descanso del Guia
Finch Bay Galapagos Hotel

Finch Bay Galapagos Hotel

4.5 out of 5
Barrio Punta Estrada Puerto Ayora Galapagos
$547 nightly
The price is $602 total per night from Jul 14 to Jul 15
$602 total
Jul 14 - Jul 15
9.4/10 Exceptional! (102 reviews)
"The staff and service are exceptional! The venue cannot be beaten. It’s the only place with a private beach. They have complementary water taxis that take you everywhere. When we got off our boat, they were waiting for us without us, even having to notify them. Definitely would recommend this hotel ..."

Reviewed on Jul 4, 2026

Finch Bay Galapagos Hotel
See all 225 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Stay near popular Santa Cruz attractions

A beach with a small island in the distance.
Photo by Elizabeth Oates
Open Photo by Elizabeth Oates

Tortuga Bay Beach

9.6/10 (488 reviews)
If a restful vacation is part of your travel plans, Tortuga Bay Beach might be the perfect place to seek out during your trip to Bella Vista. While you're in the area, wander around the parks.
See properties

What to do in Santa Cruz

Private Tour Sighting Giant Tortoises and Lava Tunnels

Giant Turtle Watching and Lava Tunnels Tour

$40
per adult
Giant Turtle Watching and Lava Tunnels Tour
El Chato 2 Reserve Admission Ticket in Santa Cruz Island

El Chato 2 Reserve Admission Ticket in Santa Cruz Island

$8
per traveler
El Chato 2 Reserve Admission Ticket in Santa Cruz Island
Half Day Bay Tour in Santa Cruz Island

Half Day Bay Tour in Santa Cruz Island

$80
per adult
Half Day Bay Tour in Santa Cruz Island
See all activities in Santa Cruz
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.