Santa Cruz Vacations & Trips from $501

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Top destinations in Santa Cruz

A woman sitting on a beach facing the ocean with a sea turtle nearby.

Puerto Ayora

Puerto Ayora
A tortoise in a lush green forest.

Santa Rosa

Santa Rosa

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Cally Galapagos

Hotel Cally Galapagos

$501
per person
Dec 1 - Dec 5
found 10 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
8.6/10 Excellent! (29 reviews)
Good location and great staff.

Reviewed on Apr 10, 2026

Casa de Nelly

Casa de Nelly

$612
per person
Dec 28 - Jan 2
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to San Cristobal (SCY)
8.6/10 Excellent! (9 reviews)
Great spot, close to everything, staff was very helpful, beautiful view from up top

Reviewed on Apr 16, 2026

Hotel Albemarle Galapagos Beachfront

Hotel Albemarle Galapagos Beachfront

$865
per person
Dec 16 - Dec 21
found 1 day ago
Roundtrip flight included
Quito (UIO) to Isla Baltra (GPS)
9/10 Wonderful! (112 reviews)
La Casa de Marita

La Casa de Marita

$985
per person
Dec 15 - Dec 21
found 1 day ago
Roundtrip non-stop flight included
Quito (UIO) to Isla Baltra (GPS)
9/10 Wonderful! (110 reviews)
Hotel is conveniently located close to the harbor where many tours disembark, but still close enough to town to be easily walkable. The beach behind the property is gorgeous and somewhat secluded. The staff were very helpful and friendly, and were able to accommodate our super early check-in. The room was clean and comfortable, and the bathroom was especially spacious! Water temperature in the shower was nice and warm, but the pressure was a bit low, which can be expected. The balcony with hammock made for a wonderful setting and view each evening. We ate dinner multiple times at the hotel due to convenience, and the food was very good! We had Tapas during Sunset one night, which was a fun experience as well. The breakfast is delicious and filling enough for a day of adventure. Would love to stay here again, highly recommend!

Reviewed on Aug 31, 2026

Hotel Galapagos Tortuga Bay

Hotel Galapagos Tortuga Bay

$558
per person
Dec 1 - Dec 5
found 10 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
7.6/10 Good! (5 reviews)

Find the Best Santa Cruz Vacation Packages

Santa Cruz Essential Information

Language
Spanish
Currency
U.S dollars
Local Welcome
¡Hola!
Local Goodbye
Adiós

Santa Cruz Hotel Deals

Hotel Fiesta

Hotel Fiesta

Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
$149 nightly
$149 total
Nov 13 - Nov 14
Hotel Fiesta
Hotel el descanso del Guia

Hotel el descanso del Guia

Calle Delfin, Barrio el Mirador Puerto Ayora Galapagos
$68 nightly
$68 total
Nov 13 - Nov 14
8.8/10 Excellent! (234 reviews)
"Espectacular la atención de los recepcionistas, del personal de limpieza y de la persona que atiende en el restaurante. Muchísimas gracias por todo"

Reviewed on Oct 10, 2026

Hotel el descanso del Guia
Maidith Galapagos Inn

Maidith Galapagos Inn

Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
$117 nightly
$117 total
Oct 19 - Oct 20
10/10 Exceptional! (168 reviews)
"me gusto el hotel, es comodo, esta bien ubicado, el dueño esta siempre ahi, te ayudan en todo lo que puedan, ya tiene sus añitos el hotel pero esta bien cuidado, es comodo, no es para nada elegante, mas bien es acogedor, comodo, mas intimo, con personal local amables, cuidado, seguro, limpio."

Reviewed on Oct 12, 2026

Maidith Galapagos Inn
See all 222 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Cruz attractions

A beach with a small island in the distance.
Photo by Elizabeth Oates

Tortuga Bay Beach

9.6/10 (488 reviews)
If a restful vacation is part of your travel plans, Tortuga Bay Beach might be the perfect place to seek out during your trip to Bella Vista. While you're in the area, wander around the parks.
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A rocky shoreline with mangrove trees and calm ocean waters.
Photo by Luis Felipe

El Garrapatero Beach

9.2/10 (154 reviews)
Why not spend a carefree afternoon at El Garrapatero Beach during your travels in El Cascajo? While you're in the area, wander around the parks.
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Playa de los Alemanes

8.8/10 (262 reviews)
If a restful vacation is part of your travel plans, Playa de los Alemanes might be the perfect place to seek out during your trip to Puerto Ayora. While you're here, you can savor the top-notch restaurants.
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Malecon

9.2/10 (350 reviews)
You can find out about the history of Puerto Ayora with a visit to Malecon. Wander the waterfront and beaches in the area.
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Los Gemelos Sinkholes

9.2/10 (143 reviews)
Commune with nature and explore the great outdoors at Los Gemelos Sinkholes during your travels in Santa Rosa. Wander the waterfront and beaches in the area.
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What to do in Santa Cruz

El Chato 2 Reserve Admission Ticket in Santa Cruz Island

El Chato 2 Reserve Admission Ticket in Santa Cruz Island

$8
per traveler
El Chato 2 Reserve Admission Ticket in Santa Cruz Island
Private Tour Sighting Giant Tortoises and Lava Tunnels

Giant Turtle Watching and Lava Tunnels Tour

$40
per adult
Giant Turtle Watching and Lava Tunnels Tour
Half Day Bay Tour in Santa Cruz Island

Half Day Bay Tour in Santa Cruz Island

$80
per adult
Half Day Bay Tour in Santa Cruz Island
See all activities in Santa Cruz
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.