Downtown West Vacations from $269

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Your Downtown West Vacation

Downtown West is beckoning! Whatever type of getaway you're organizing, you can experience and see more of this neighborhood with a Downtown West vacation package. Your trip to Downtown West wouldn't be complete without exploring popular attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. Whatever your travel goals or budget, booking a perfect Downtown West vacation is easy with Expedia.

The Latest Downtown West Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

Save 100% on your flight
$269
per person
Dec 2 - Dec 5
found 1 day ago
Roundtrip flight included
Cleveland (CLE) to St. Louis (STL)
9.2/10 Wonderful! (1,672 reviews)
Would of been great if the fire alarm didn’t malfunction at 4:30am and the ran out of breakfast items

Reviewed on Sep 25, 2026

The Principal Hotel

The Principal Hotel

$409
per person
Nov 5 - Nov 9
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to St. Louis (STL)
9.6/10 Exceptional! (396 reviews)
Moonrise Hotel

Moonrise Hotel

Delmar Loop
$664
per person
Nov 12 - Nov 15
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9/10 Wonderful! (2,016 reviews)
Good stay.

Reviewed on Sep 26, 2026

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

Downtown St. Louis
Save 100% on your flight
$562
per person
Dec 2 - Dec 5
found 1 day ago
Roundtrip flight included
Cleveland (CLE) to St. Louis (STL)
8.6/10 Excellent! (4,227 reviews)
Upon check-in, unable to obtain our room key due to a hotel technology problem. An employee walked us to our room and later keys were finally delivered to us. We used the valet parking option which worked very well. The breakfast buffet had many good items, but some of the hot foods were cold. Overall staff was good.

Reviewed on Sep 26, 2026

The Cheshire

The Cheshire

$524
per person
Oct 27 - Oct 30
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.8/10 Excellent! (1,004 reviews)
Just stayed one night with my husband but we want to come back. Good location, loved the British theme going, breakfast was excellent, fun exploring all the floors in the hotel as it has 4 floors. Did not visit the restaurants but I bet they were good and they gave us a coupon to user but we did not as we checked in late. Our room was quiet on the first floor. Good parking available. Staff were friendly and helpful during our whole stay. Loved the room author thing going on and labels on doors as it was fun to read, lots of good artwork, loved the author of your room having a book in the room like ours was Ann Sewell who wrote Black Beauty and we had a paper back copy of it in our room. If I was to ask for anything , it would be a small refrigerator as my husband travels with meds and a grab bar to step out of the tub. Would highly recommend.

Reviewed on Sep 25, 2026

Where to stay in Downtown West

Find the best Downtown West areas and neighborhoods for the activities you enjoy most. Learn more about Downtown West
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

4 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis
The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Find hotels in Clayton
A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Find hotels in Central West End
A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Find hotels in St. Charles Historic District
A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Find hotels in Creve Coeur

Downtown West Hotel Deals

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

201 S 20th St St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
$161 total
Oct 1 - Oct 2
Total with taxes and fees
9.4/10 Exceptional! (1,548 reviews)
"Great breakfast and happy hour. I would highly recommend."

Reviewed on Sep 25, 2026

Drury Plaza Hotel St. Louis Union Station
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$117 nightly
$137 total
Oct 1 - Oct 2
Total with taxes and fees
Pear Tree Inn St. Louis Near Union Station
21C Museum Hotel St Louis

21C Museum Hotel St Louis

1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
$173 total
Oct 18 - Oct 19
Total with taxes and fees
9/10 Wonderful! (2,120 reviews)
"A bit off the beating path, but well worth the walk or ride there. Unfortunately I was only there for a day, so missed out on many of the amenities. But will definitely book here again and take advantage of all they have to offer. P.S. The room are well kept, roomy, and comfortable."

Reviewed on Sep 24, 2026

21C Museum Hotel St Louis
See all 1,959 properties in Downtown West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Downtown West attractions

A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
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A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
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The National Blues Museum in Saint Louis, Missouri.

Washington Avenue Historic District

Food, fashion and the blues reign supreme in this creative district of downtown St. Louis. Wander elegant tree-lined streets and delve into city history at museums.
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A historic building with a red-tiled roof and ornate architectural details.

St. Louis City Hall

Learn about the local history of St. Louis with a stop at St. Louis City Hall. Experience the area's acclaimed art scene or attend a baseball game.
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St. Louis Aquarium at Union Station

9.0/10 (17 reviews)
Meet the animals who live at St. Louis Aquarium at Union Station during your trip to St. Louis.
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Energizer Park

Catch an event at Energizer Park during your trip to St. Louis.
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The St. Louis Wheel

9.2/10 (13 reviews)
Enjoy an outing to The St. Louis Wheel during your stay in St. Louis.
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Stifel Theatre

You can make plans for a show at Stifel Theatre on your trip to St. Louis.
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Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
Self Guided Walking & Driving Audio Tour St. Louis

Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP

$15
per traveler
Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$25
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.