Downtown West Vacations from $167
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Your Downtown West Vacation
Downtown West is beckoning! Whatever type of getaway you're organizing, you can experience and see more of this neighborhood with a Downtown West vacation package. Your trip to Downtown West wouldn't be complete without exploring popular attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. Whatever your travel goals or budget, booking a perfect Downtown West vacation is easy with Expedia.
The Latest Downtown West Vacation Packages
Where to stay in Downtown West
Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
St. Charles Historic District
Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.
Downtown West Hotel Deals
Pear Tree Inn St. Louis Near Union Station
"This was a very nice hotel. The rooms were clean, breakfast amazing. The place was very quiet"
Reviewed on Oct 10, 2026
21C Museum Hotel St Louis
"Unique and beautiful hotel. Staff is efficient and friendly."
Reviewed on Oct 10, 2026
Home2 Suites by Hilton St. Louis Downtown
"Super friendly and helpful staff! Room was clean and comfortable. The breakfast was nothing special, but they could have used a little more help as there seemed to be one overworked staff member in charge of breakfast. This is a unique and historic building, which adds to the charm of this hotel. ..."
Reviewed on Oct 10, 2026
Stay near popular Downtown West attractions
Enterprise Center
City Museum
Washington Avenue Historic District
St. Louis City Hall
St. Louis Aquarium at Union Station
Peabody Opera House
The St. Louis Wheel
Things to do
StL's Signature "Sights and Bites" - Private Tour in St. Louis
St. Louis Ghost Tour: Sinister Sins & Shadows
