Downtown West Vacations from $441

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Your Downtown West Vacation

Downtown West is beckoning! Whatever type of getaway you're organizing, you can experience and see more of this neighborhood with a Downtown West vacation package. Your trip to Downtown West wouldn't be complete without exploring popular attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. Whatever your travel goals or budget, booking a perfect Downtown West vacation is easy with Expedia.

The Latest Downtown West Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Camden on the Lake Resort & Spa

Camden on the Lake Resort & Spa

$441
per person
Oct 29 - Nov 2
found 21 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (1,003 reviews)
Residence Inn by Marriott St. Louis West County

Residence Inn by Marriott St. Louis West County

$676
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (266 reviews)
Ive stayed here before. Rooms are nice because they have a desk kitchen snd couch. Bed was not good. We stayed here because our ac went out. I called and confirmed pet friendly booked and paid for the room only to arrive and be told its $100 pet fee. Thats not fair or ok.

Reviewed on Sep 4, 2026

Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

Save 100% on your flight
$619
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8/10 Very Good! (1,002 reviews)
Everything was amazing but the tv you can only watch one channel . So I believe upgrade on the tv every will be great.

Reviewed on Sep 12, 2026

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

St. Charles Historic District
Save 100% on your flight
$675
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (1,072 reviews)
Friendly Staff Great location Accessible parking Clean rooms

Reviewed on Sep 17, 2026

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

Save 100% on your flight
$592
per person
Nov 3 - Nov 10
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8/10 Very Good! (1,005 reviews)

Where to stay in Downtown West

Find the best Downtown West areas and neighborhoods for the activities you enjoy most. Learn more about Downtown West
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

4 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis
The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Find hotels in Clayton
A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Find hotels in Central West End
A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Find hotels in Creve Coeur
A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Find hotels in St. Charles Historic District

Downtown West Hotel Deals

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

201 S 20th St St. Louis MO
Fully refundableReserve now, pay when you stay
$135 nightly
$161 total
Sep 27 - Sep 28
Total with taxes and fees
Drury Plaza Hotel St. Louis Union Station
21C Museum Hotel St Louis

21C Museum Hotel St Louis

1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
$173 total
Oct 11 - Oct 12
Total with taxes and fees
9/10 Wonderful! (2,112 reviews)
"Interesting concept, but poorly executed. Unfortunately, this did not feel like a true 4-star hotel experience. The location can be convenient if you are visiting the Gateway Arch or attending an event downtown, and for us it worked well because we could walk to the AC/DC concert. Otherwise, there ..."

Reviewed on Sep 16, 2026

21C Museum Hotel St Louis
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$117 nightly
$137 total
Sep 22 - Sep 23
Total with taxes and fees
8.8/10 Excellent! (2,196 reviews)
"close to downtown, love the free happy hour and free breakfast. when in Stlouis I always stay at the Pear Tree inn"

Reviewed on Sep 17, 2026

Pear Tree Inn St. Louis Near Union Station
See all 1,973 properties in Downtown West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
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Kid Friendly Vacations
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Golf Vacations
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Luxury Vacations
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Romantic Vacations
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Ski Vacations
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LGBTQ Friendly Vacations
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Adventure Vacations
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Where to go when
Where to go when
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Honeymoon Vacations
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Mountain Vacations
Fishing Vacations
Fishing Vacations
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Adults Only Vacations
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Waterpark Vacations
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Scuba Diving Vacations
Yoga Vacations
Yoga Vacations
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Cheap Vacations
Solo Vacations
Solo Vacations

Stay near popular Downtown West attractions

A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
See properties
The National Blues Museum in Saint Louis, Missouri.

Washington Avenue Historic District

Food, fashion and the blues reign supreme in this creative district of downtown St. Louis. Wander elegant tree-lined streets and delve into city history at museums.
See properties
A historic building with a red-tiled roof and ornate architectural details.

St. Louis City Hall

Learn about the local history of St. Louis with a stop at St. Louis City Hall. Experience the area's acclaimed art scene or attend a baseball game.
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St. Louis Aquarium at Union Station

9.0/10 (17 reviews)
Meet the animals who live at St. Louis Aquarium at Union Station during your trip to St. Louis.
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Energizer Park

Catch an event at Energizer Park during your trip to St. Louis.
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The St. Louis Wheel

9.2/10 (13 reviews)
Enjoy an outing to The St. Louis Wheel during your stay in St. Louis.
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Stifel Theatre

You can make plans for a show at Stifel Theatre on your trip to St. Louis.
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Things to do

The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

$175
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
Self Guided Walking & Driving Audio Tour St. Louis

Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP

$15
per traveler
Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.