Downtown West Vacations from $407

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Your Downtown West Vacation

Downtown West is beckoning! Whatever type of getaway you're organizing, you can experience and see more of this neighborhood with a Downtown West vacation package. Your trip to Downtown West wouldn't be complete without exploring popular attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. Whatever your travel goals or budget, booking a perfect Downtown West vacation is easy with Expedia.

The Latest Downtown West Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Residence Inn St Louis Westport

Residence Inn St Louis Westport

Westport
Save 100% on your flight
$407
per person
Nov 13 - Nov 16
found 18 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (429 reviews)
It’s nice place to stay the staff was amazing, the only thing that wasn’t ok to our house keeping enter our room with out permission and we were out and about……

Reviewed on Sep 22, 2026

The Wildwood Hotel

The Wildwood Hotel

Save 100% on your flight
$410
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,679 reviews)
Room was clean, yet picures and description are a bit deceiving. Overall, stay was good and would come back again.

Reviewed on Oct 4, 2026

Moonrise Hotel

Moonrise Hotel

Delmar Loop
Save 100% on your flight
$470
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (2,026 reviews)
The sheets were stained and dirty, the bed was not well made. The staff at reception, especially Nina, are amazing and extremely helpful!! I wish the hotel were tidier and lobby furniture freshened up some, the location is ideal!

Reviewed on Oct 5, 2026

The Cheshire

The Cheshire

Save 100% on your flight
$604
per person
Nov 5 - Nov 9
found 4 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,006 reviews)
The Knight Center at Washington University

The Knight Center at Washington University

Save 100% on your flight
$504
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (685 reviews)
Beautiful location, nice room, quiet hotel, and in walking distance to eateries. If it is colder you may not want to walk to restaurants but there are food options on campus.

Reviewed on Oct 4, 2026

Where to stay in Downtown West

Find the best Downtown West areas and neighborhoods for the activities you enjoy most. Learn more about Downtown West
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

4 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis
The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Find hotels in Clayton
A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Find hotels in Central West End
A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Find hotels in St. Charles Historic District
A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Find hotels in Creve Coeur

Downtown West Hotel Deals

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

201 S 20th St St. Louis MO
Fully refundableReserve now, pay when you stay
$118 nightly
$140 total
Nov 1 - Nov 2
Total with taxes and fees
9.4/10 Exceptional! (1,569 reviews)
"The room was very clean and well-maintained. Staff was friendly and the amenities were very generous. Beautiful historical hotel. Close to the Aquarium and various restaurants."

Reviewed on Oct 5, 2026

Drury Plaza Hotel St. Louis Union Station
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$104 nightly
$122 total
Oct 11 - Oct 12
Total with taxes and fees
Pear Tree Inn St. Louis Near Union Station
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

1221 Locus Street St. Louis MO
Fully refundableReserve now, pay when you stay
$98 nightly
$114 total
Oct 13 - Oct 14
Total with taxes and fees
7.8/10 Good! (974 reviews)
"Great location Downtown. Staff were great. Parking on street is fine."

Reviewed on Oct 5, 2026

Home2 Suites by Hilton St. Louis Downtown
See all 1,961 properties in Downtown West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations
Golf Vacations
Golf Vacations
Luxury Vacations
Luxury Vacations
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Romantic Vacations
Ski Vacations
Ski Vacations
Gay Friendly Vacations
LGBTQ Friendly Vacations
LGBTQ Friendly Vacations
Adventure Vacations
Adventure Vacations
Vacations in Month
Where to go when
Where to go when
Honeymoon Vacations
Honeymoon Vacations
Mountain Vacations
Mountain Vacations
Fishing Vacations
Fishing Vacations
Adults Only Vacations
Adults Only Vacations
Waterpark Vacations
Waterpark Vacations
Scuba Diving Vacations
Scuba Diving Vacations
Yoga Vacations
Yoga Vacations
Cheap Vacations
Cheap Vacations
Solo Vacations
Solo Vacations

Stay near popular Downtown West attractions

A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
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The National Blues Museum in Saint Louis, Missouri.

Washington Avenue Historic District

Food, fashion and the blues reign supreme in this creative district of downtown St. Louis. Wander elegant tree-lined streets and delve into city history at museums.
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A historic building with a red-tiled roof and ornate architectural details.

St. Louis City Hall

Learn about the local history of St. Louis with a stop at St. Louis City Hall. Experience the area's acclaimed art scene or attend a baseball game.
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St. Louis Aquarium at Union Station

9.0/10 (17 reviews)
Meet the animals who live at St. Louis Aquarium at Union Station during your trip to St. Louis.
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Energizer Park

Catch an event at Energizer Park during your trip to St. Louis.
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The St. Louis Wheel

9.2/10 (13 reviews)
Enjoy an outing to The St. Louis Wheel during your stay in St. Louis.
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Stifel Theatre

You can make plans for a show at Stifel Theatre on your trip to St. Louis.
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Things to do

Self Guided Walking & Driving Audio Tour St. Louis

Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP

$15
per traveler
Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
Landmarks Downtown-West Walking Tour

Landmarks Downtown-West Walking Tour

$20
per adult
Landmarks Downtown-West Walking Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.