Downtown West Vacations from $252

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Your Downtown West Vacation

Downtown West is beckoning! Whatever type of getaway you're organizing, you can experience and see more of this neighborhood with a Downtown West vacation package. Your trip to Downtown West wouldn't be complete without exploring popular attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. Whatever your travel goals or budget, booking a perfect Downtown West vacation is easy with Expedia.

The Latest Downtown West Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

2.5 out of 5
Price was $312, price is now $252 per person
$252
per person
Jun 24 - Jun 26
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8/10 Very Good! (1,001 reviews)
Room was very clean, but I didn't like the carpeting. There was a large spot on the chair. Looked like blood. I didn't like not having a vent in the bathroom. I did like the large bottles of shampoo, body wash, conditioner & lotion. The bed was a little too firm & lumpy. Not comfy hotel quality. Very happy with the free breakfast.

Reviewed on May 3, 2026

Alhonna Resort LLC

Alhonna Resort LLC

3 out of 5
Save 100% on your flight
Price was $1,052, price is now $747 per person
$747
per person
Jul 21 - Jul 27
found 1 day ago
Roundtrip flight included
New York (NYC) to St. Louis (STL)
8.8/10 Excellent! (264 reviews)
The sraff was amazing needed help fixing my trolling motor the maintenance man was so helpful and the room was amazing

Reviewed on Apr 30, 2026

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
Central West End
Price was $636, price is now $470 per person
$470
per person
Jul 8 - Jul 11
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (1,003 reviews)
This was a weekend staycation for my wife and I and as usual we were not disappointed. Very helpful staff and excellent accommodations.

Reviewed on May 4, 2026

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Price was $1,075, price is now $813 per person
$813
per person
Jun 12 - Jun 18
found 1 hour ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
8.4/10 Very Good! (818 reviews)
Room decent but customer service was excellent. Breakfast should be free

Reviewed on May 4, 2026

Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch

4 out of 5
Downtown St. Louis
Price was $915, price is now $718 per person
$718
per person
Jun 25 - Jun 29
found 1 day ago
Roundtrip flight included
Dallas (DAL) to St. Louis (STL)
8.8/10 Excellent! (1,034 reviews)
Amazing location and area . Easy to get around and property was clean and organized

Reviewed on May 4, 2026

Where to stay in Downtown West

Find the best Downtown West areas and neighborhoods for the activities you enjoy most. Learn more about Downtown West
Downtown St. Louis

Downtown St. Louis

3 out of top 10 points of interest in this area
4/5(4,044 area reviews)

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis

Downtown West Hotel Deals

21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $165 total per night from May 24 to May 25
$165 total
May 24 - May 25
Total with taxes and fees
9/10 Wonderful! (1,818 reviews)
All the restaurants and bar were excellent.

Reviewed on May 4, 2026

21C Museum Hotel St Louis
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from May 12 to May 13
$140 total
May 12 - May 13
Total with taxes and fees
8.8/10 Excellent! (1,953 reviews)
Place was clean, staff was friendly even with it being packed it was still nice.

Reviewed on May 3, 2026

Pear Tree Inn St. Louis Near Union Station
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

3 out of 5
1221 Locus Street St. Louis MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $114 total per night from May 21 to May 22
$114 total
May 21 - May 22
Total with taxes and fees
8/10 Very Good! (749 reviews)
Clean room, breakfast is very good, staff are very friendly

Reviewed on May 4, 2026

Home2 Suites by Hilton St. Louis Downtown
See all 1,879 properties in Downtown West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Downtown West

Union Station, St. Louis, MO

St. Louis Union Station

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.

St. Louis Union Station
Aerial view of vibrant downtown St. Louis with Enterprise Center and St. Louis Wheel, St. Louis, Missouri, United States.

Enterprise Center

Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.

Enterprise Center
City Museum

City Museum

This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.

City Museum

Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
St. Louis Premium Driving Tour with Boat Ride & Arch

St. Louis Premium Driving Tour with Boat Ride & Arch

$174
per adult
100% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$30
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.