Downtown West Vacations from $257

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Your Downtown West Vacation

Downtown West is beckoning! Whatever type of getaway you're organizing, you can experience and see more of this neighborhood with a Downtown West vacation package. Your trip to Downtown West wouldn't be complete without exploring popular attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. Whatever your travel goals or budget, booking a perfect Downtown West vacation is easy with Expedia.

The Latest Downtown West Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

$257
per person
Oct 23 - Oct 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,657 reviews)
Staff was very welcoming when I arrived. Received an upgrade to a King room, which was spacious, clean and comfortable. Nice property.

Reviewed on Sep 11, 2026

Remodeled and Inviting Free EV

Remodeled and Inviting Free EV

Save 100% on your flight
$325
per person
Oct 23 - Oct 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (2 reviews)
It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it

Reviewed on Aug 7, 2026

Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

Midtown
Save 100% on your flight
$368
per person
Dec 3 - Dec 7
found 23 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.8/10 Good! (1,002 reviews)
The Cheshire

The Cheshire

Save 100% on your flight
$380
per person
Oct 23 - Oct 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,004 reviews)
Fantastic hotel and great breakfast. Very quaint with a cool speakeasy type bar downstairs and a great Italian restaurant next door. Loved everything about this hotel especially the rooms named after British authors. Our room was the author of Goldie Locks and the 3 Bears, but someone had taken the book! Can't wait to come back!

Reviewed on Sep 11, 2026

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Save 100% on your flight
$402
per person
Oct 23 - Oct 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,033 reviews)

Where to stay in Downtown West

Find the best Downtown West areas and neighborhoods for the activities you enjoy most. Learn more about Downtown West
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

3 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis
The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Find hotels in Clayton
A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Find hotels in Central West End
A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Find hotels in Creve Coeur
A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Find hotels in St. Charles Historic District

Downtown West Hotel Deals

21C Museum Hotel St Louis

21C Museum Hotel St Louis

1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
$173 total
Oct 11 - Oct 12
Total with taxes and fees
21C Museum Hotel St Louis
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

1221 Locus Street St. Louis MO
Fully refundableReserve now, pay when you stay
$98 nightly
$114 total
Sep 20 - Sep 21
Total with taxes and fees
Home2 Suites by Hilton St. Louis Downtown
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO
Fully refundableReserve now, pay when you stay
$98 nightly
$114 total
Sep 27 - Sep 28
Total with taxes and fees
7.8/10 Good! (964 reviews)
"The hotel stay was wonderful. The staff was very courteous. The issue was the parking in the area but would come back if I can."

Reviewed on Sep 11, 2026

Tru By Hilton St. Louis Downtown
See all 1,973 properties in Downtown West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Downtown West attractions

A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
See properties
A city street with a red car, a blue fire hydrant, and a building with a spire.

Washington Avenue Historic District

Food, fashion and the blues reign supreme in this creative district of downtown St. Louis. Wander elegant tree-lined streets and delve into city history at museums.
See properties
A historic building with a red-tiled roof and ornate architectural details.

St. Louis City Hall

Learn about the local history of St. Louis with a stop at St. Louis City Hall. Experience the area's acclaimed art scene or attend a baseball game.
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St. Louis Aquarium at Union Station

9.0/10 (17 reviews)
Meet the animals who live at St. Louis Aquarium at Union Station during your trip to St. Louis.
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Energizer Park

Catch an event at Energizer Park during your trip to St. Louis.
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The St. Louis Wheel

9.2/10 (13 reviews)
Enjoy an outing to The St. Louis Wheel during your stay in St. Louis.
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Stifel Theatre

You can make plans for a show at Stifel Theatre on your trip to St. Louis.
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Things to do

The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

$175
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$25
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.