Downtown West Vacations from $209
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Your Downtown West Vacation
Downtown West is beckoning! Whatever type of getaway you're organizing, you can experience and see more of this neighborhood with a Downtown West vacation package. Your trip to Downtown West wouldn't be complete without exploring popular attractions nearby such as Busch Stadium, Gateway Arch and Dome at America’s Center. Whatever your travel goals or budget, booking a perfect Downtown West vacation is easy with Expedia.
The Latest Downtown West Vacation Packages
The Knight Center at Washington University
Reviewed on Oct 8, 2026
Where to stay in Downtown West
Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
St. Charles Historic District
Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.
Downtown West Hotel Deals
Pear Tree Inn St. Louis Near Union Station
"The food and drink options were perfect. This place is amazing for kids! Pet friendly! Walking distance to some great stuff. Our air stopped working at some point. That and the stuff splattered all over the curtains were the only negative. Will 100% use them in the future!"
Reviewed on Oct 8, 2026
21C Museum Hotel St Louis
"Wonderful vibrant bar and restaurant scene. Location is walkable, but we had to use the valet parking which was an additional cost of $55 per day since the hotel did not have parking."
Reviewed on Oct 8, 2026
Home2 Suites by Hilton St. Louis Downtown
"Good location within walking distance to some restaurants and bars. Nice, spacious rooms. We were put in a room with a roll-in shower which we didn’t need and the shower water flowed through half the bathroom and one morning it also flowed into the non-carpeted hallway. Strange design but not a dealbreaker. ..."
Reviewed on Oct 8, 2026
Stay near popular Downtown West attractions
Enterprise Center
City Museum
Washington Avenue Historic District
St. Louis City Hall
St. Louis Aquarium at Union Station
The St. Louis Wheel
Stifel Theatre
Things to do
Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP
