Santo Spirito

Florence

Brancacci Chapel which includes heritage architecture, a church or cathedral and a sunset
Brancacci Chapel which includes heritage architecture and a church or cathedral
Brancacci Chapel featuring heritage elements
Brancacci Chapel which includes a church or cathedral and heritage architecture
Arcetri which includes a city and landscape views

Popular places to visit

Piazza Santo Spirito

Piazza Santo Spirito

Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and notable monuments in this vibrant area.

Piazza Santo Spirito
Porta Romana

Porta Romana

Find out about the history of Arcetri when you take a trip to Porta Romana. Amble around this vibrant area's riverfront or experience its fascinating museums.

Porta Romana
Brancacci Chapel which includes heritage architecture and a church or cathedral

Brancacci Chapel

A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.

Brancacci Chapel

Santo Spirito Basilica

Learn about the local history of Florence when you spend time at Santo Spirito Basilica. Stroll along the riverfront or visit the notable monuments in this vibrant area.

Santo Spirito Basilica

Santa Maria della Carmine

You can learn about the history of Florence with a visit to Santa Maria della Carmine. Visit the stunning cathedral and notable monuments in this vibrant area.

Santa Maria della Carmine

Piazza del Carmine

You can learn about the history of Florence with a stop at Piazza del Carmine. Amble around this vibrant area's riverfront or experience its acclaimed art scene.

Piazza del Carmine

Things to do

Having fun while tasting Chianti

Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence

$222
per adult
100% of travellers recommend
Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence
Florence: Santa Monaca Church Italian Opera Concert Ticket

Florence: Santa Monaca Church Italian Opera Concert Ticket

$35
per adult
100% of travellers recommend
Florence: Santa Monaca Church Italian Opera Concert Ticket
Join your expert guide on this Florence Food Venture - Your Local Guide knows all the spots for delicious eats.

Florence Evening Food Tour with Florentine Steak & Tuscan Wine

$120
per adult
100% of travellers recommend
Florence Evening Food Tour with Florentine Steak & Tuscan Wine
Pizza Dinner and Italian Opera Arias Concert in Florence

Pizza Dinner and Italian Opera Arias Concert in Florence

$81
per adult
84% of travellers recommend
Pizza Dinner and Italian Opera Arias Concert in Florence
Picture 6 for Activity Florence: Lasagna and Spaghetti-Making Class

Florence: Lasagna and Spaghetti-Making Class

$82
per adult
100% of travellers recommend
Florence: Lasagna and Spaghetti-Making Class
Italian Opera in Santa Monaca Church with Dinner

Italian Opera in Santa Monaca Church with Dinner

$93
per adult
Italian Opera in Santa Monaca Church with Dinner
See all activities in Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13, Florence, FI
$245 nightly
The price is $286 total per night from Sep 29 to Sep 30
$286 total
Sep 29 - Sep 30
Total with taxes and fees
Stay at this 4-star hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.6/10 Exceptional! (558 reviews)
"We stayed at Hotel Horto Convento for three nights, and I must say the building with its Florentine charm took our breath away as soon as we walked in! Beyond the beautiful and character-filled architecture, the rooms were very well refurbished and spotless. The location is also excellent , within ..."

Reviewed on Sep 10, 2025

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r, Florence, FI
$212 nightly
The price is $249 total per night from Sep 15 to Sep 16
$249 total
Sep 15 - Sep 16
Total with taxes and fees
Stay at this 4-star residence in Florence. Enjoy free WiFi, concierge services, and satellite TV channels. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,018 reviews)
"Excellent service, warm and very helpful in all ways. Wonderful location. Would recommend without reservation."

Reviewed on Sep 9, 2025

Palazzo Mannaioni Suites
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59, Florence, FI
$180 nightly
The price is $214 total per night from Oct 13 to Oct 14
$214 total
Oct 13 - Oct 14
Total with taxes and fees
Stay at this 4-star boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (989 reviews)
"Amazing place, love the decor!"

Reviewed on Jul 28, 2025

UNA Hotels Vittoria Firenze
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8, Florence, FI
$181 nightly
The price is $213 total per night from Oct 15 to Oct 16
$213 total
Oct 15 - Oct 16
Total with taxes and fees
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Uffizi Gallery ...
9/10 Wonderful! (205 reviews)
"Not having a person at the front is very Inconvenient. Is very hard to get a taxi in early hours"

Reviewed on Sep 2, 2025

La Torre Del Cestello
Casa Santo Nome di Gesù

Casa Santo Nome di Gesù

Piazza del Carmine, 21, Florence, FI
$180 nightly
The price is $212 total per night from Sep 28 to Sep 29
$212 total
Sep 28 - Sep 29
Total with taxes and fees
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (320 reviews)
"Beautiful building and garden. Room is stunning! The only issue is that air condition in the building is weak but regardless, it’s so beautiful that it doesn’t matter. There is still some heat regulation that makes is ok."

Reviewed on Aug 21, 2025

Casa Santo Nome di Gesù
Hotel Firenze 2000

Hotel Firenze 2000

2 out of 5
Viale Raffaello Sanzio, 16, Florence, FI
$80 nightly
The price is $99 total per night from Sep 21 to Sep 22
$99 total
Sep 21 - Sep 22
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Popular attractions Ponte Vecchio and Uffizi Gallery are located ...
7/10 Good! (170 reviews)
"The staff was very nice!"

Reviewed on Jul 19, 2025

Hotel Firenze 2000
See all 469 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Santo Spirito

Brancacci Chapel which includes a church or cathedral and heritage architecture

San Frediano

San Frediano is popular for its stunning river views, and if you're looking for more to see and do, you might think about a trip to Piazza Santo Spirito or Santo Spirito Basilica.

San Frediano
Arcetri which includes a river or creek, a sunset and a bridge

Oltrarno

4.5/5(529 area reviews)

South of the River Arno, this quarter boasts part of Florence's historic center, featuring notable sites like Santo Spirito di Firenze, Palazzo Pitti, Belvedere, and Piazzale Michelangelo.

Oltrarno
Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes

Santa Maria Novella

4.5/5(1,057 area reviews)

Enjoy the popular shops in Santa Maria Novella. Palazzo dei Congressi is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Maria Novella
Uffizi Gallery which includes street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing.

San Giovanni
Duomo featuring heritage architecture and street scenes as well as a small group of people

Duomo

5/5(2,214 area reviews)

Cathedral of Santa Maria del Fiore and Uffizi Gallery are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

Duomo
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Uffizi Gallery are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

Historic Centre of Florence
See our Where To Stay guide

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Santo Spirito

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