Santo Spirito Vacations from $950
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Your Santo Spirito Vacation
Walking, views and culture are just some of the things waiting for you when you book a Santo Spirito vacation package. Whether you're chasing relaxation, adventure or something else, this residential neighborhood is where you can find it. Your trip to Santo Spirito wouldn't be complete without stopping by leading attractions nearby such as Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel. No matter what your dream Santo Spirito vacation looks like, you can make it a reality with Expedia.
The Latest Santo Spirito Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Aurum Firenze
Historic Centre of Florence
Save 100% on your flight
Price was $1,650, price is now $950 per person
$950
per person
Sep 28 - Oct 3
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
7.4/10 Good! (1,008 reviews)
Good service and the room was clean
Reviewed on Jul 10, 2026
The Moon Boutique Hotel & Spa
Historic Centre of Florence
Price was $2,059, price is now $1,336 per person
$1,336
per person
Sep 12 - Sep 16
found 2 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (570 reviews)
Wonderful stay, attentive staff, very clean room.
The spa facilities are very high quality and had a lovely massage.
Good choices for breakfast.
I would certainly recommend staying here, the spa was a particular highlight that is free for guests to use.
Reviewed on Jul 2, 2026
Hotel La Scaletta Al Ponte Vecchio
Historic Centre of Florence
Save 100% on your flight
Price was $2,500, price is now $1,668 per person
$1,668
per person
Oct 3 - Oct 9
found 3 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
8.8/10 Excellent! (1,002 reviews)
Excellent location! Rooftop lounge perfect for sunset!!
Reviewed on Jul 11, 2026
Where to stay in Santo Spirito
Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Historic Centre of Florence
10 out of top 10 points of interest in this area
Lose yourself in the Renaissance charm of Florenceās old town, where masterpieces by Brunelleschi and Giotto line up alongside cafĆ©s, gelato shops and trattorias.
Santo Spirito Hotel Deals
Hotel Horto Convento
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $179 total per night from Aug 10 to Aug 11
$179 total
Aug 10 - Aug 11
Total with taxes and fees
9.8/10 Exceptional! (686 reviews)
"Beautiful, clean, amazing breakfast, really nice staff. 10/10 recommendation"
Reviewed on Jul 7, 2026
La Torre Del Cestello
Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $151 total per night from Aug 11 to Aug 12
$151 total
Aug 11 - Aug 12
Total with taxes and fees
9/10 Wonderful! (276 reviews)
"Clean room with good location and air conditioner Shops and restaurants nearby"
Reviewed on Jul 10, 2026
UNA Hotels Vittoria Firenze
Via Pisana 59 Florence FI
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $110 total per night from Jul 26 to Jul 27
$110 total
Jul 26 - Jul 27
Total with taxes and fees
8.4/10 Very Good! (1,001 reviews)
"Great staff and well located especially for the West Bank of the city. Slightly too far out for the city etc"
Reviewed on May 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Santo Spirito attractions
Things to do
City Sightseeing Florence Hop-on Hop-off Bus Tour
$33
per adult
76% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
$126
per adult
100% of travellers recommend
The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery
$78
per adult
98% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.