Santo Spirito Vacations from $1,116

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Your Santo Spirito Vacation

Walking, views and culture are just some of the things waiting for you when you book a Santo Spirito vacation package. Whether you're chasing relaxation, adventure or something else, this residential neighborhood is where you can find it. Your trip to Santo Spirito wouldn't be complete without stopping by leading attractions nearby such as Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel. No matter what your dream Santo Spirito vacation looks like, you can make it a reality with Expedia.

The Latest Santo Spirito Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Grand Universe Lucca, Autograph Collection

Grand Universe Lucca, Autograph Collection

Lucca Historical Center
$1,116
per person
Nov 1 - Nov 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9.4/10 Exceptional! (57 reviews)
Great location, nice & helpful staff .

Reviewed on Aug 24, 2026

Dimora Palanca Boutique & SPA

Dimora Palanca Boutique & SPA

Historic Centre of Florence
$1,259
per person
Nov 1 - Nov 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9.2/10 Wonderful! (68 reviews)
This hotel is definitely not 5*, no amenities provided, very poor breakfast, like at 3* hotel, room was full of dark black hair, and most important pay attention to the location , as it’s in central station area, and we felt unsafe to walk there in the evening

Reviewed on Aug 27, 2026

Aurum Firenze

Aurum Firenze

Historic Centre of Florence
$1,119
per person
Oct 21 - Oct 27
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
7.6/10 Good! (1,004 reviews)
Room is very small

Reviewed on Aug 21, 2026

The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa

Historic Centre of Florence
$1,117
per person
Oct 30 - Nov 5
found 22 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (584 reviews)
The Rif - Boutique Hotel

The Rif - Boutique Hotel

Pisa City Centre
$2,077
per person
Oct 7 - Oct 12
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
8.8/10 Excellent! (70 reviews)

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence
A historic building with ornate carvings and statues, featuring large wooden doors and steps leading up to it.

Duomo

Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence.

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A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty.

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A stone bridge with green shutters over a river.

San Giovanni

If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing.

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A bustling European square with historic buildings, shops, and a prominent clock tower.

Santa Croce

One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants.

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Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
$178 nightly
$212 total
Aug 29 - Aug 30
Total with taxes and fees
9.8/10 Exceptional! (715 reviews)
"Great place, and the front desk gentleman was very helpful and kind all the time."

Reviewed on Aug 27, 2026

Hotel Horto Convento
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
$99 nightly
$125 total
Aug 31 - Sep 1
Total with taxes and fees
9.2/10 Wonderful! (300 reviews)
"We had a wonderful 3 night stay here. The room was spacious with beautiful views overlooking the Arno river. The air conditioning worked very well in the room and was much appreciated during a heat wave in August. The location could not be beat. It is away from the major crowds, but still surrounded ..."

Reviewed on Aug 25, 2026

La Torre Del Cestello
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

Via Pisana 59 Florence FI
Fully refundableReserve now, pay when you stay
$83 nightly
$108 total
Aug 29 - Aug 30
Total with taxes and fees
8.4/10 Very Good! (1,006 reviews)
"Very clean, nice rooms, staff and great breakfast / evening food in the restaurant. Location 20min walk to main Santa Maria Station."

Reviewed on Aug 16, 2026

UNA Hotels Vittoria Firenze
See all 500 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santo Spirito attractions

A town square with historic buildings, a church, and a bell tower.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and notable monuments in this vibrant area.
See properties
An arched stone gateway with a crest, flanked by buildings and a street with parked cars and bicycles.

Porta Romana

8.6/10 (29 reviews)
Porta Romana is just one of the places to see in Arcetri, so why not enjoy the other things to explore during your travels? Discover the fascinating museums and churches in this vibrant area.
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A historic stone church with a large wooden door and steps leading up to it.

Brancacci Chapel

10.0/10 (1 review)
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
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Santo Spirito Basilica

8.0/10 (3 reviews)
Learn about the local history of Florence when you spend time at Santo Spirito Basilica. Stroll along the riverfront or visit the notable monuments in this vibrant area.
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Piazza del Carmine

10.0/10 (3 reviews)
You can learn about the history of Florence with a stop at Piazza del Carmine. Amble around this vibrant area's riverfront or experience its acclaimed art scene.
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Santa Maria della Carmine

10.0/10 (1 review)
You can learn about the history of Florence with a visit to Santa Maria della Carmine. Visit the stunning cathedral and notable monuments in this vibrant area.
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Il Nabucco di Matteo Gabellini

You can study the exhibits at Il Nabucco di Matteo Gabellini, a museum with a story of its own, during your travels to Florence. Discover the fascinating museums and stunning cathedral in this vibrant area.
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Church of St Felix

Church of St Felix is just one of the places to see in Florence, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's riverfront or experience its fascinating museums.
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Things to do

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

$28
per adult
76% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$18
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
People riding scooters in Tuscany

Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine

$133
per adult
100% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.