Santo Spirito Vacations
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Your Santo Spirito Vacation
Walking, views and culture are just some of the things waiting for you when you book a Santo Spirito vacation package. Whether you're chasing relaxation, adventure or something else, this residential neighborhood is where you can find it. Your trip to Santo Spirito wouldn't be complete without stopping by leading attractions nearby such as Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel. No matter what your dream Santo Spirito vacation looks like, you can make it a reality with Expedia.
- The Moon Boutique Hotel & Spa
Jul 12 - Jul 19The Moon Boutique Hotel & Spa + Flight
Historic Centre of Florence6 nights9.6/10 - Exceptional (544 reviews)"Great staff, clean rooms and all good on everything."Reviewed May 17, 2026Roundtrip • New York (EWR) - Florence (FLR)EWR - FLR • 1 stop FLR - EWR • 1 stop$2,315$1,581found 1 day agoper traveler - Aurum Uffizi
Jul 31 - Aug 17Aurum Uffizi + Flight
Historic Centre of Florence16 nights7.6/10 - Good (1,002 reviews)"Excellent hotel and staff customer service "Reviewed May 20, 2026Roundtrip • New York (EWR) - Florence (FLR)EWR - FLR • 1 stop FLR - EWR • 1 stop - Aurum Firenze
Jul 31 - Aug 17Aurum Firenze + Flight
Historic Centre of Florence16 nights7.6/10 - Good (1,000 reviews)"The evening adter 10pm manager on duty was very helpful!!! He was able to assist and provide everything we needed. Sorry, I don't remember his name. Thank you! "Reviewed May 19, 2026Roundtrip • New York (EWR) - Florence (FLR)EWR - FLR • 1 stop FLR - EWR • 1 stop - Hotel La Scaletta Al Ponte Vecchio
Jul 31 - Aug 17Hotel La Scaletta Al Ponte Vecchio + Flight
Historic Centre of Florence16 nights8.8/10 - Excellent (998 reviews)"Our experience was consistent with previous reviews. Location is ideal. Easy entrance into main attraction area and with rooms off an interior courtyard property is super quiet at night. Rooftop terrace is ideal. Relaxing, great cocktails and a perfect way to end a day sightseeing in the crowds of Florence. We didn't realize the restaurant is not open for dinner. Breakfast was crowded, food ok. Overall a nice property."Reviewed May 17, 2026Roundtrip • New York (EWR) - Florence (FLR)EWR - FLR • 1 stop FLR - EWR • 1 stop - Il Rivalta - Place of Charme
Jun 27 - Jul 6Il Rivalta - Place of Charme + Flight
Historic Centre of Florence8 nights9.2/10 - Wonderful (526 reviews)"Great location. Nice facilities. "Reviewed May 19, 2026Roundtrip • New York (EWR) - Florence (FLR)EWR - FLR • 1 stop FLR - EWR • 1 stop$3,427$2,437found 1 day agoper traveler
Where to stay in Santo Spirito
Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Santo Spirito Hotel Deals
Hotel Horto Convento
"Amazing stay! Beautiful property! The spa is a wonderful amenity."
Reviewed on May 18, 2026
Palazzo Mannaioni Suites
"Novella was such a breath of fresh air and an amazing resource. She was so kind and gave us the most perfect recommendations. The hotel location was super convenient. Would highly recommend!!!!!"
Reviewed on May 20, 2026
La Torre Del Cestello
Discover the most popular places to visit in Santo Spirito
Porta Romana
Porta Romana is just one of the places to see in Arcetri, so why not enjoy the other things to explore during your travels? Discover the fascinating museums and churches in this vibrant area.
Brancacci Chapel
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
Torrigiani Garden
Explore the great outdoors at Torrigiani Garden, a lovely green space in Florence. Stroll along the riverfront or visit the churches in this vibrant area.
Things to do
City Sightseeing Florence Hop-on Hop-off Bus Tour
Small-Group Wine Tasting Experience in the Tuscan Countryside
