Title: Santo Spirito Vacation Packages 2026 from $1,171 | Expedia.com

[Santo Spirito Travel Guide](https://expedia.com/Florence-Santo-Spirito.dx553248633938935375)[Hotels in Santo Spirito](https://expedia.com/Santo-Spirito-Florence-Hotels.0-n553248633938935375-0.Travel-Guide-Filter-Hotels)[Flights to Florence](https://expedia.com/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.com/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Car Rentals in Santo Spirito](https://expedia.com/Car-Rentals-In-Santo-Spirito.d553248633938935375.Car-Rental-Guide)

![](https://images.trvl-media.com/place/179893/dd801080-5529-49c4-b78b-415c9c4a56e9.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Santo Spirito Vacations from $1,171

## Book a Hotel + Flight or Car together to unlock savings

## Your Santo Spirito Vacation

Walking, views and culture are just some of the things waiting for you when you book a Santo Spirito vacation package. Whether you're chasing relaxation, adventure or something else, this residential neighborhood is where you can find it. Your trip to Santo Spirito wouldn't be complete without stopping by leading attractions nearby such as [Piazza Santo Spirito](https://www.expedia.com/Piazza-Santo-Spirito-Florence.d6265853.Vacation-Attraction), [Santo Spirito Basilica](https://www.expedia.com/Santo-Spirito-Basilica-Florence.d6075452.Vacation-Attraction) and [Brancacci Chapel](https://www.expedia.com/Brancacci-Chapel-Oltrarno.d6143202.Vacation-Attraction). No matter what your dream Santo Spirito vacation looks like, you can make it a reality with Expedia.

## The Latest Santo Spirito Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Aurum Uffizi](https://images.trvl-media.com/lodging/3000000/2550000/2541700/2541615/4fb74083_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Uffizi

Historic Centre of Florence

$1,171

per person

May 20 - May 25

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,000 reviews)

Smaller room then expected and shower did flood the floor so not the best of showers. Bed very comfortable Nice friendly & helpful staff and perfect location to explore the city.

Reviewed on Feb 22, 2026

![Eurostars Florence Boutique](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/88283612_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Eurostars Florence Boutique

Historic Centre of Florence

Save 100% on your flight

$1,269

per person

Apr 22 - Apr 28

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

8.6/10 Excellent! (483 reviews)

The room was clean and the staff very accommodating. The breakfast was quite sufficient and had a good variety. The location is great. It's a short walk from the square, shopping and from restaurants.

Reviewed on Dec 13, 2025

![Aurum Firenze](https://images.trvl-media.com/lodging/29000000/28970000/28962000/28961941/26fd50f1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Firenze

Historic Centre of Florence

$1,190

per person

May 20 - May 25

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,002 reviews)

It was near the train and next to awesome places. The view if you get a balcony is so cute and peaceful

Reviewed on Feb 28, 2026

![Relais Uffizi, Tailor made Hotel](https://images.trvl-media.com/lodging/3000000/2550000/2542800/2542717/3e59e5ae_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Relais Uffizi, Tailor made Hotel

Historic Centre of Florence

Save 100% on your flight

$2,334

per person

May 20 - May 25

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

9.4/10 Exceptional! (120 reviews)

The room was stunning, it was large, the bed was comfy and the design was unique. Staff were very friendly and helpful.

Reviewed on Feb 26, 2026

![Hotel La Scaletta Al Ponte Vecchio](https://images.trvl-media.com/lodging/2000000/1610000/1604300/1604285/d1c916cb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel La Scaletta Al Ponte Vecchio

Historic Centre of Florence

Save 100% on your flight

$1,892

per person

May 20 - May 25

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

8.8/10 Excellent! (965 reviews)

The staff at breakfast prepare plain scrambled eggs for our 7 month old son and were very sweet! This our second time staying here and we absolutely love the hotel. Location, views, comfort. 10/10!

Reviewed on Feb 28, 2026

## Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. [Learn more about Santo Spirito](https://expedia.com/Florence-Santo-Spirito.dx553248633938935375)

![Arcetri showing a bridge and a river or creek](https://images.trvl-media.com/place/6075434/96ba5e7b-ca43-4d9f-9921-bde07164fcbc.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Historic Centre of Florence

10 out of top 10 points of interest in this area

 Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias. 

[Find hotel + flight trips in Historic Centre of Florence](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Historic%20Centre%20of%20Florence&DestID=6141938&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Duomo featuring heritage architecture and street scenes as well as a small group of people](https://images.trvl-media.com/place/6141938/4816fa4b-dceb-4db3-bc3d-7fd0a5eb8789.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Duomo

5/5(2,214 area reviews)

 Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence. 

[Find hotel + flight trips in Duomo](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Duomo&DestID=6084346&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Ponte Vecchio showing a bridge and a river or creek](https://images.trvl-media.com/place/6075434/7c194037-41c2-40fb-a601-3da01105de7b.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### San Giovanni

 If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing. 

[Find hotel + flight trips in San Giovanni](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=San%20Giovanni&DestID=553248635976383065&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes](https://images.trvl-media.com/place/6084343/def994ac-70f7-40cd-89a8-ec519f783ac9.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Maria Novella

4.5/5(1,057 area reviews)

 Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty. 

[Find hotel + flight trips in Santa Maria Novella](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Maria%20Novella&DestID=6084343&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Piazza Santa Croce showing a city and street scenes](https://images.trvl-media.com/place/6248194/236c34a1-6c95-481e-b9b8-957b594360cd.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Croce

4.5/5(211 area reviews)

 One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants. 

[Find hotel + flight trips in Santa Croce](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Croce&DestID=6084344&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Santo Spirito Hotel Deals

![Hotel Horto Convento](https://images.trvl-media.com/lodging/18000000/17940000/17933900/17933824/9c90a529_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Horto Convento

Viale Ariosto, 13 Florence FI

Fully refundableReserve now, pay when you stay

$98 nightly

$125 total

Mar 8 - Mar 9

Total with taxes and fees

9.8/10 Exceptional! (624 reviews)

It was a nice, clean and quiet hotel.

Reviewed on Mar 1, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=17933824&PinnedHotelID=17933824&HadPinnedHotel=true&regionId=553248633938935375)

![Palazzo Mannaioni Suites](https://images.trvl-media.com/lodging/3000000/2530000/2524400/2524373/5017fcc9_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Palazzo Mannaioni Suites

Via Maffia 9 - 17r Florence FI

$104 nightly

$131 total

Mar 4 - Mar 5

Total with taxes and fees

9.2/10 Wonderful! (1,088 reviews)

Beautiful room, very thorough check in with a very nice man who gave us great dining recommendations. We loved having a big fridge. The shower was a bit small but overall we really enjoyed the room.

Reviewed on Feb 26, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F4%2F2026&endDate=3%2F5%2F2026&selected=2524373&PinnedHotelID=2524373&HadPinnedHotel=true&regionId=553248633938935375)

![UNA Hotels Vittoria Firenze](https://images.trvl-media.com/lodging/1000000/910000/905700/905634/534e501f_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

UNA Hotels Vittoria Firenze

Via Pisana 59 Florence FI

$112 nightly

$140 total

Mar 29 - Mar 30

Total with taxes and fees

8.4/10 Very Good! (1,000 reviews)

Perfect stay! Not only was the check-in smooth, but everything else was also satisfying. The breakfast was delicious, the staff were friendly, and the location was ideal. There wasn't a single thing I didn't like. I’ll definitely be back!

Reviewed on Jan 1, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=905634&PinnedHotelID=905634&HadPinnedHotel=true&regionId=553248633938935375)

[See all 495 properties in Santo Spirito](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026&regionId=553248633938935375)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

[](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

[](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

[](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

[](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

[](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click)

### Discover the most popular places to visit in Santo Spirito

![Ancient Roman gate into the old city of Florence, Italy. Porta Romana or Porta San Pier Gattolino](https://images.trvl-media.com/place/501037/2773ddf7-7ad2-4b95-a43a-15f2a40703cd.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Porta Romana

4/5(14 reviews)

Porta Romana is just one of the places to see in Arcetri, so why not enjoy the other things to explore during your travels? Discover the acclaimed art scene and stunning cathedral in this vibrant area. 

[](https://expedia.com/Porta-Romana-Oltrarno.d501037.Vacation-Attraction)

![Brancacci Chapel which includes heritage architecture and a church or cathedral](https://images.trvl-media.com/place/6143202/ad4f7c9f-cf49-4c66-b85b-1564733b578e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Brancacci Chapel

A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.

[](https://expedia.com/Brancacci-Chapel-Historic-Centre-of-Florence.d6143202.Vacation-Attraction)

#### Piazza del Carmine

5/5(1 review)

You can learn about the history of Florence with a stop at Piazza del Carmine. Amble around this vibrant area's riverfront or experience its acclaimed art scene. 

[](https://expedia.com/Piazza-Del-Carmine-Historic-Centre-of-Florence.d6265851.Vacation-Attraction)

### Things to do

![Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour](https://mediaim.expedia.com/localexpert/507532/cbdef260-9919-420e-a482-1d2f9b3d6ccc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$26

per adult

**80%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florence-duomo-priority-access-express-guided-tour.a507532.activity-details)

![Micheal Angelo's David](https://mediaim.expedia.com/localexpert/2479829/2bebb71d-abeb-452a-9a00-2b6fddf3b233.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

$37

per adult

**86%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florences-accademia-gallery-priority-entrance-ticket.a2479829.activity-details)

![Tuscany Experience In Pisa, Siena, San Gimignano & Chianti](https://mediaim.expedia.com/localexpert/880286/269c0081-b51e-4e1d-ac21-b19cf125da10.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

$101

per adult

**92%** of travellers recommend

[](https://expedia.com/things-to-do/tuscany-experience-in-pisa.a880286.activity-details)

[See all activities in Florence](https://expedia.com/things-to-do/search?rid=553248633938935375)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.