Santo Spirito Vacations from $756
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Your Santo Spirito Vacation
Walking, views and culture are just some of the things waiting for you when you book a Santo Spirito vacation package. Whether you're chasing relaxation, adventure or something else, this residential neighborhood is where you can find it. Your trip to Santo Spirito wouldn't be complete without stopping by leading attractions nearby such as Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel. No matter what your dream Santo Spirito vacation looks like, you can make it a reality with Expedia.
The Latest Santo Spirito Vacation Packages
The Moon Boutique Hotel & Spa
Reviewed on Nov 17, 2025
Aurum Uffizi
Reviewed on Nov 20, 2025
Hotel Lungarno - Lungarno Collection
Reviewed on Nov 19, 2025
Where to stay in Santo Spirito
Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Santo Spirito Hotel Deals
Hotel Horto Convento
Staff were super lovely, we were greeted by a very enthusiastic and full of character Giovanni who made us feel welcome. The place is very well kept, breakfast had a surprisingly wider variety of food for a continental breakfast, and is in a nice quiet part of Florence that is still accessible to ...
Reviewed on Nov 22, 2025
Palazzo Mannaioni Suites
The hotel room was very spacious and felt very homey. Loved the Kitchenette! And location was walkable to all major attractions.
Reviewed on Dec 2, 2025
La Torre Del Cestello
What a great place. Great communication and staff. The apartment was lovely and large for our family. The location was very good and close to everything.
Reviewed on Nov 26, 2025
Discover the most popular places to visit in Santo Spirito
Porta Romana
Find out about the history of Arcetri when you take a trip to Porta Romana. Amble around this vibrant area's riverfront or experience its fascinating museums.
Brancacci Chapel
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
Torrigiani Garden
Explore the great outdoors at Torrigiani Garden, a lovely green space in Florence. Stroll along the riverfront or visit the notable monuments in this vibrant area.
Things to do
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Florence Half Day Tour with Uffizi, Michelangelo’s David & Accademia
