Title: Visit Sanctuary: 2026 Sanctuary, Sanibel Travel Guide | Expedia.com [Hotels in Sanctuary](https://expedia.com/Sanctuary-Sanibel-Hotels.0-n553248635976469368-0.Travel-Guide-Filter-Hotels)[Flights to Sanibel](https://expedia.com/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.com/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Car Rentals in Sanctuary](https://expedia.com/Car-Rentals-In-Sanctuary.d553248635976469368.Car-Rental-Guide)[Sanctuary Vacations](https://expedia.com/Sanctuary.d553248635976469368.Destination-Travel-Guides) # Sanctuary, FL ## Sanibel ## Visit Sanctuary Things to do Hotels Where to stay [Sanibel Travel Guide](https://expedia.com/Sanibel.dx9791) --- ### Popular places to visit ![Seashells on Sanibel Island, Florida](https://images.trvl-media.com/place/553248635976194887/1681d0fb-bad0-43e3-9dad-05ad6264d3a8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Sanibel Island Southern Beach 4.5/5(171 reviews) Why not spend a lazy afternoon at Sanibel Island Southern Beach during your trip to Sanibel? [](https://expedia.com/Sanibel-Island-Southern-Beach-West-End.d553248635976194887.Vacation-Attraction) ![Sanibel Island Lighthouse which includes a beach, general coastal views and a sunset](https://images.trvl-media.com/place/6123905/4ca6a8bf-bcd7-4194-afd1-f40b40c7afaf.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Sanibel Island Lighthouse 4.5/5(1,092 reviews) Although nobody knows how many shipwrecks it’s prevented, this lighthouse has been a welcome beacon for over a century. Visit it on an island that’s noted for shell collecting. [](https://expedia.com/Sanibel-Island-Lighthouse-East-End.d6123905.Vacation-Attraction) ![Bowman\'s Beach which includes general coastal views and a sandy beach](https://images.trvl-media.com/place/6296151/4495298b-a31a-40fc-a275-ded1cba6e62a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Bowman's Beach 4.5/5(481 reviews) Relax and revel in a visit to one of the area’s most beautiful beaches, great for swimming, fishing and finding special seashells. [](https://expedia.com/Bowmans-Beach-West-End.d6296151.Vacation-Attraction) ![Periwinkle Way featuring a garden](https://images.trvl-media.com/place/6298863/ce898fdd-7ebf-4f44-9e80-60e95ba58831.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Periwinkle Way 5/5(2 reviews) The island’s spine is also its commercial hub. Drive or bike the road’s length to find attractions and discover many stores and restaurants. [](https://expedia.com/Periwinkle-Way-Mid-Island.d6298863.Vacation-Attraction) ![J. N. Ding Darling National Wildlife Refuge showing a bridge as well as a small group of people](https://images.trvl-media.com/place/6123903/1af50fa6-38dc-4276-a6dd-5b04d07f72ce.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### J. N. Ding Darling National Wildlife Refuge 4.5/5(39 reviews) See almost anything that flies, swims or crawls in Florida in this protected area. Become acquainted with wildlife while learning about varied species. [](https://expedia.com/J-N-Ding-Darling-National-Wildlife-Refuge-Sanibel.d6123903.Vacation-Attraction) ![Fort Myers featuring a house](https://images.trvl-media.com/place/6296084/23eab012-1f55-4d52-8f9c-07eeb7f56326.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Sanibel Historical Museum and Village You can spend time browsing the exhibits at Sanibel Historical Museum and Village in Sanibel. Wander the beautiful beaches and seaside in this family-friendly area. [](https://expedia.com/Sanibel-Historical-Museum-And-Village-Mid-Island.d6296084.Vacation-Attraction) ### Things to do ![Fort Myers Beach Sunset and Dolphin Watching Cruise](https://mediaim.expedia.com/localexpert/49585125/64783586-41c3-41b7-833b-538357650a0d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fort Myers Beach Sunset and Dolphin Watching Cruise $70 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/fort-myers-beach-sunset-and-dolphin-watching-cruise.a49585125.activity-details) ![Southwest Florida Sunset Sail](https://mediaim.expedia.com/localexpert/3146060/208129dd-2c36-4c94-bbae-6379e223335e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Southwest Florida Sunset Sail $70 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/southwest-florida-sunset-sail.a3146060.activity-details) ![Copacetic Day Sail](https://mediaim.expedia.com/localexpert/3146061/ce46a7d1-6271-4a2e-9229-41a28a522002.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Copacetic Day Sail $70 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/copacetic-day-sail.a3146061.activity-details) ![Dolphin Wildlife Cruise Fort Myers Beach](https://mediaim.expedia.com/localexpert/49515597/7ddf5e09-b4b4-4b06-b75b-dc221f49d5cd.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Dolphin Wildlife Cruise Fort Myers Beach $64 per adult [](https://expedia.com/things-to-do/dolphin-wildlife-cruise-fort-myers-beach.a49515597.activity-details) ![Kayaking Rock Creek in the Bunche Beach Preserve](https://mediaim.expedia.com/localexpert/2599835/df2b31b4-45e3-4e6d-bcdf-fac67a52c2a6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guided Kayak Eco Tour - Bunche Beach $70 per adult **98%** of travellers recommend [](https://expedia.com/things-to-do/guided-kayak-eco-tour-bunche-beach.a2599835.activity-details) ![Dolphin and Sightseeing Tiki Cruise](https://mediaim.expedia.com/localexpert/46963437/b9695ee5-1948-4f45-9a2c-697f0e0f2655.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fort Myers Beach Dolphin & Sightseeing Tour Refreshments Included $65 per adult [](https://expedia.com/things-to-do/fort-myers-beach-dolphin-sightseeing-tour-refreshments-included.a46963437.activity-details) [See all activities in Sanibel](https://expedia.com/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities) --- ## Sanctuary Hotel Deals ![Holiday Inn Express Cape Coral-Fort Myers Area by IHG](https://images.trvl-media.com/lodging/1000000/30000/26900/26860/ab39b98c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express Cape Coral-Fort Myers Area by IHG 1538 Cape Coral Pkwy E Cape Coral FL $101 nightly $113 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this business-friendly hotel in Cape Coral. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9.2/10 Wonderful! (1,284 reviews) Clean room, good breakfast, easy parking. Reviewed on Mar 6, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=26860&PinnedHotelID=26860&HadPinnedHotel=true®ionId=553248635976469368) ![Margaritaville Beach Resort Fort Myers ](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Margaritaville Beach Resort Fort Myers 251 Crescent Street Fort Myers Beach FL $474 nightly $529 total Mar 8 - Mar 9 Total with taxes and fees Book a stay at this beach hotel in Fort Myers Beach. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the pool and the helpful staff ... 9/10 Wonderful! (1,924 reviews) Simply amazing! Reviewed on Mar 6, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=95126992&PinnedHotelID=95126992&HadPinnedHotel=true®ionId=553248635976469368) ![Sanibel Island Beach Resort](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f97bdde8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sanibel Island Beach Resort 1231 Middle Gulf Dr Sanibel FL $447 nightly $496 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this beach hotel in Sanibel. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the pool and the restaurant in our reviews. ... 9.2/10 Wonderful! (1,662 reviews) This property was just ok, we were 1st given a room that was dirty for example (stains on the chair, holes in the curtains, bathtub was cracked) and old. The rooms did not look like the pictures posted. They did accommodate us for a room change to a more updated one. Some of the staff could have ... Reviewed on Mar 7, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=17298818&PinnedHotelID=17298818&HadPinnedHotel=true®ionId=553248635976469368) ![Lani Kai Beachfront Resort](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Lani Kai Beachfront Resort 1400 Estero Blvd Fort Myers Beach FL $266 nightly $297 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this beach hotel in Fort Myers Beach. Enjoy free WiFi, an outdoor pool, and a beach locale. Popular attractions Key West Express and Crescent ... 9/10 Wonderful! (1,288 reviews) The view is amazing from every room. Beautiful beach and rooms are clean Reviewed on Mar 7, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=438796&PinnedHotelID=438796&HadPinnedHotel=true®ionId=553248635976469368) ![Hilton Garden Inn Ft Myers](https://images.trvl-media.com/lodging/1000000/850000/848800/848740/8dde6ece_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hilton Garden Inn Ft Myers 12600 University Dr Fort Myers FL $135 nightly $151 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this business-friendly hotel in Fort Myers. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ... 8.8/10 Excellent! (1,011 reviews) The property is very well kept and the staff was so helpful and polite. The pool and hot tub were excellent. The rooms were your basic hotel rooms. Only thing I could say is that the pillows weren’t the best. I had read that in other reviews. I was happy to see that the rooms were cleaned everyday, ... Reviewed on Mar 6, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=848740&PinnedHotelID=848740&HadPinnedHotel=true®ionId=553248635976469368) ![Marriott Sanibel Harbour Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/0ef86cd3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Marriott Sanibel Harbour Resort & Spa 17260 Harbour Pointe Dr Fort Myers FL $380 nightly $424 total Apr 6 - Apr 7 Total with taxes and fees Book a stay at this spa resort in Fort Myers. Enjoy 3 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the property ... 8.4/10 Very Good! (1,009 reviews) Would not recommend. For the positive, we did have good customer service when I had to challenge the bill because the previous guest's bar bill was put on our room. Also, the view was nice, looking at the harbor. Noise from the bridge is loud when on the balcony but you cannot hear it when the door ... Reviewed on Mar 5, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=3079&PinnedHotelID=3079&HadPinnedHotel=true®ionId=553248635976469368) [See all 13,070 properties in Sanctuary](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F8%2F2026&endDate=3%2F9%2F2026®ionId=553248635976469368) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX-NH_SPRING_PROMO_553248635976469368) ## Check Sanctuary hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=2026-03-07&endDate=2026-03-08)[Mar 7 - Mar 8](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=2026-03-07&endDate=2026-03-08) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=2026-03-08&endDate=2026-03-09)[Mar 8 - Mar 9](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=2026-03-08&endDate=2026-03-09) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026)[Mar 13 - Mar 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=3%2F13%2F2026&endDate=3%2F15%2F2026) --- ### Other neighborhoods around Sanctuary ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Del Sega If you're spending some time in Del Sega, Blind Pass Beach and J. N. Ding Darling National Wildlife Refuge are top sights worth seeing. [](https://expedia.com/Fort-Myers-Del-Sega.dx553248635976469672) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Heron's Landing Though Heron's Landing might not have many top sights, you can venture to the surrounding area to see attractions like Bowman's Beach and Blind Pass Beach. [](https://expedia.com/Sanibel-Herons-Landing.dx553248635976479011) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Tradewinds 4.5/5(5 area reviews) While Tradewinds might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge. [](https://expedia.com/Fort-Myers-Tradewinds.dx553248635976472762) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Chateaux Sur Mer Though Chateaux Sur Mer might not have many top sights, you can venture to the surrounding area to see attractions like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge. [](https://expedia.com/Sanibel-Chateaux-Sur-Mer.dx553248635976472800) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### West End While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach. [](https://expedia.com/Sanibel-West-End.dx977664051587067904) ![View of the Beach on the Gulf of Mexico at Sanibel Island Florida](https://images.trvl-media.com/place/553248635976479667/c29c42a5-d3e6-4e4c-a465-1be77fd7c74e.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Gulf Shores While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge. [](https://expedia.com/Sanibel-Gulf-Shores.dx553248635976479667) [See our Where To Stay guide](https://expedia.com/Sanibel.dx9791.Where-To-Stay?rfrr=TG.LP.Dest.Neigh.Neighborhoods) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Sanctuary, FL ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app