Title: Visit Sanctuary: 2026 Sanctuary, Sanibel Travel Guide | Expedia.com [Hotels in Sanctuary](https://expedia.com/Sanctuary-Sanibel-Hotels.0-n553248635976469368-0.Travel-Guide-Filter-Hotels)[Flights to Sanibel](https://expedia.com/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.com/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Car Rentals in Sanctuary](https://expedia.com/Car-Rentals-In-Sanctuary.d553248635976469368.Car-Rental-Guide)[Sanctuary Vacations](https://expedia.com/Sanctuary.d553248635976469368.Destination-Travel-Guides) # Sanctuary, FL ## Sanibel ## Visit Sanctuary Things to do Hotels Where to stay [Sanibel Travel Guide](https://expedia.com/Sanibel.dx9791) --- ### Popular places to visit ![Seashells on Sanibel Island, Florida](https://images.trvl-media.com/place/553248635976194887/1681d0fb-bad0-43e3-9dad-05ad6264d3a8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Sanibel Island Southern Beach 4.5/5(171 reviews) Why not spend a lazy afternoon at Sanibel Island Southern Beach during your trip to Sanibel? [](https://expedia.com/Sanibel-Island-Southern-Beach-West-End.d553248635976194887.Vacation-Attraction) ![Sanibel Island Lighthouse which includes a beach, general coastal views and a sunset](https://images.trvl-media.com/place/6123905/4ca6a8bf-bcd7-4194-afd1-f40b40c7afaf.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Sanibel Island Lighthouse 4.5/5(1,092 reviews) Although nobody knows how many shipwrecks it’s prevented, this lighthouse has been a welcome beacon for over a century. Visit it on an island that’s noted for shell collecting. [](https://expedia.com/Sanibel-Island-Lighthouse-East-End.d6123905.Vacation-Attraction) ![Bowman\'s Beach which includes general coastal views and a sandy beach](https://images.trvl-media.com/place/6296151/4495298b-a31a-40fc-a275-ded1cba6e62a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Bowman's Beach 4.5/5(481 reviews) Relax and revel in a visit to one of the area’s most beautiful beaches, great for swimming, fishing and finding special seashells. [](https://expedia.com/Bowmans-Beach-West-End.d6296151.Vacation-Attraction) ![Periwinkle Way featuring a garden](https://images.trvl-media.com/place/6298863/ce898fdd-7ebf-4f44-9e80-60e95ba58831.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Periwinkle Way 5/5(2 reviews) The island’s spine is also its commercial hub. Drive or bike the road’s length to find attractions and discover many stores and restaurants. [](https://expedia.com/Periwinkle-Way-Mid-Island.d6298863.Vacation-Attraction) ![J. N. Ding Darling National Wildlife Refuge showing a bridge as well as a small group of people](https://images.trvl-media.com/place/6123903/1af50fa6-38dc-4276-a6dd-5b04d07f72ce.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### J. N. Ding Darling National Wildlife Refuge 4.5/5(39 reviews) See almost anything that flies, swims or crawls in Florida in this protected area. Become acquainted with wildlife while learning about varied species. [](https://expedia.com/J-N-Ding-Darling-National-Wildlife-Refuge-Sanibel.d6123903.Vacation-Attraction) ![Sunset on Sanibel Causeway. #beachtips #BVSblue](https://images.trvl-media.com/place/6177558/e2e0a373-ccb0-43b6-a7ae-369395afe76c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Causeway Islands Park B If a restful vacation is part of your travel plans, Causeway Islands Park B might be the perfect place to seek out during your trip to Sanibel. Wander the seaside or discover the beautiful sunrises in this family-friendly area. [](https://expedia.com/Causeway-Islands-Park-B-Sanibel.d6298750.Vacation-Attraction) ### Things to do ![Fort Myers Beach Sunset and Dolphin Watching Cruise](https://mediaim.expedia.com/localexpert/49585125/64783586-41c3-41b7-833b-538357650a0d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fort Myers Beach Sunset and Dolphin Watching Cruise $70 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/fort-myers-beach-sunset-and-dolphin-watching-cruise.a49585125.activity-details) ![Southwest Florida Sunset Sail](https://mediaim.expedia.com/localexpert/3146060/208129dd-2c36-4c94-bbae-6379e223335e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Southwest Florida Sunset Sail $70 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/southwest-florida-sunset-sail.a3146060.activity-details) ![Copacetic Day Sail](https://mediaim.expedia.com/localexpert/3146061/ce46a7d1-6271-4a2e-9229-41a28a522002.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Copacetic Day Sail $70 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/copacetic-day-sail.a3146061.activity-details) ![Dolphin Wildlife Cruise Fort Myers Beach](https://mediaim.expedia.com/localexpert/49515597/7ddf5e09-b4b4-4b06-b75b-dc221f49d5cd.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Dolphin Wildlife Cruise Fort Myers Beach $64 per adult [](https://expedia.com/things-to-do/dolphin-wildlife-cruise-fort-myers-beach.a49515597.activity-details) ![Dolphin and Sightseeing Tiki Cruise](https://mediaim.expedia.com/localexpert/46963437/b9695ee5-1948-4f45-9a2c-697f0e0f2655.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fort Myers Beach Dolphin & Sightseeing Tour Refreshments Included $65 per adult [](https://expedia.com/things-to-do/fort-myers-beach-dolphin-sightseeing-tour-refreshments-included.a46963437.activity-details) ![Kayaking Rock Creek in the Bunche Beach Preserve](https://mediaim.expedia.com/localexpert/2599835/df2b31b4-45e3-4e6d-bcdf-fac67a52c2a6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Guided Kayak Eco Tour - Bunche Beach $70 per adult **98%** of travellers recommend [](https://expedia.com/things-to-do/guided-kayak-eco-tour-bunche-beach.a2599835.activity-details) [See all activities in Sanibel](https://expedia.com/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities) --- ## Sanctuary Hotel Deals ![Margaritaville Beach Resort Fort Myers ](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/09777b0c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Margaritaville Beach Resort Fort Myers 251 Crescent Street Fort Myers Beach FL $398 nightly $444 total Apr 14 - Apr 15 Total with taxes and fees Book a stay at this beach hotel in Fort Myers Beach. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the pool and the helpful staff ... 9/10 Wonderful! (1,947 reviews) Room was perfect and the food was excellent! Reviewed on Mar 17, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F14%2F2026&endDate=4%2F15%2F2026&selected=95126992&PinnedHotelID=95126992&HadPinnedHotel=true®ionId=553248635976469368) ![Sanibel Island Beach Resort](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f97bdde8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sanibel Island Beach Resort 1231 Middle Gulf Dr Sanibel FL $342 nightly $379 total Apr 12 - Apr 13 Total with taxes and fees Book a stay at this beach hotel in Sanibel. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the pool and the restaurant in our reviews. ... 9.2/10 Wonderful! (1,685 reviews) Lounge chairs and towels were always avaliable, even when some saved them. Maintenance, Pool, Housekeeping, Restaurant staff all great. Some at the front desk weren't very personable. Heated pool was amazing. Our room was always cleaned in a timely manner Reviewed on Mar 17, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=17298818&PinnedHotelID=17298818&HadPinnedHotel=true®ionId=553248635976469368) ![Lani Kai Beachfront Resort](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/9bc89705_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Lani Kai Beachfront Resort 1400 Estero Blvd Fort Myers Beach FL $273 nightly $305 total Mar 22 - Mar 23 Total with taxes and fees Book a stay at this beach hotel in Fort Myers Beach. Enjoy free WiFi, 3 restaurants, and a beach locale. Popular attractions Key West Express and Crescent Beach ... 9/10 Wonderful! (1,318 reviews) The room was clean and nicely appointed. The view was spectacular. The food at the two restaurants we tried was excellent. Reviewed on Mar 17, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F22%2F2026&endDate=3%2F23%2F2026&selected=438796&PinnedHotelID=438796&HadPinnedHotel=true®ionId=553248635976469368) ![Hilton Garden Inn Ft Myers](https://images.trvl-media.com/lodging/1000000/850000/848800/848740/8dde6ece_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hilton Garden Inn Ft Myers 12600 University Dr Fort Myers FL $116 nightly $130 total Mar 29 - Mar 30 Total with taxes and fees Book a stay at this business-friendly hotel in Fort Myers. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ... 8.8/10 Excellent! (1,002 reviews) Great spot Reviewed on Mar 15, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=848740&PinnedHotelID=848740&HadPinnedHotel=true®ionId=553248635976469368) ![Marriott Sanibel Harbour Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/0ef86cd3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Marriott Sanibel Harbour Resort & Spa 17260 Harbour Pointe Dr Fort Myers FL $380 nightly $424 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this spa resort in Fort Myers. Enjoy 3 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the property ... 8.4/10 Very Good! (1,000 reviews) No boat rides. Mini-fridge shelf rail on door missing; fridge cabinet cracked; lamp plug receptacles too weak to power BiPap. Maid skipped room one day and almost next. Staff great. Esp valets. Reviewed on Mar 18, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=3079&PinnedHotelID=3079&HadPinnedHotel=true®ionId=553248635976469368) ![Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/a69cd385_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG 11171 Summerlin Square Drive Fort Myers Beach FL $116 nightly $129 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this business-friendly hotel in Fort Myers Beach. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9.4/10 Exceptional! (1,011 reviews) It was ok. Nothing great, nothing terrible. The tv remote didn’t work properly. The breakfast was really good with a great selection of choices. It was close to the Sanibel causeway, that was the most positive thing about it in my opinion. Reviewed on Mar 18, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=49152700&PinnedHotelID=49152700&HadPinnedHotel=true®ionId=553248635976469368) [See all 13,149 properties in Sanctuary](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F19%2F2026&endDate=3%2F20%2F2026®ionId=553248635976469368) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Sanctuary hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=2026-03-18&endDate=2026-03-19)[Mar 18 - Mar 19](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=2026-03-18&endDate=2026-03-19) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=2026-03-19&endDate=2026-03-20)[Mar 19 - Mar 20](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=2026-03-19&endDate=2026-03-20) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)[Mar 20 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026)[Mar 27 - Mar 29](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976469368&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026) --- ### Other neighborhoods around Sanctuary ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Del Sega If you're spending some time in Del Sega, Blind Pass Beach and J. N. Ding Darling National Wildlife Refuge are top sights worth seeing. [](https://expedia.com/Fort-Myers-Del-Sega.dx553248635976469672) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Heron's Landing Though Heron's Landing might not have many top sights, you can venture to the surrounding area to see attractions like Bowman's Beach and Blind Pass Beach. [](https://expedia.com/Sanibel-Herons-Landing.dx553248635976479011) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Tradewinds 4.5/5(5 area reviews) While Tradewinds might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge. [](https://expedia.com/Fort-Myers-Tradewinds.dx553248635976472762) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Chateaux Sur Mer Though Chateaux Sur Mer might not have many top sights, you can venture to the surrounding area to see attractions like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge. [](https://expedia.com/Sanibel-Chateaux-Sur-Mer.dx553248635976472800) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### West End While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach. [](https://expedia.com/Sanibel-West-End.dx977664051587067904) ![View of the Beach on the Gulf of Mexico at Sanibel Island Florida](https://images.trvl-media.com/place/553248635976479667/c29c42a5-d3e6-4e4c-a465-1be77fd7c74e.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Gulf Shores While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge. [](https://expedia.com/Sanibel-Gulf-Shores.dx553248635976479667) [See our Where To Stay guide](https://expedia.com/Sanibel.dx9791.Where-To-Stay?rfrr=TG.LP.Dest.Neigh.Neighborhoods) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Sanctuary, FL ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app