A historic downtown street with vintage buildings, a church steeple, and a prominent clock tower.

Great River Road Vacation Rentals

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Check prices for these dates

In two weeks
Oct 2 - Oct 4
In two months
Nov 13 - Nov 15
In three months
Dec 11 - Dec 13
In four months
Jan 8 - Jan 10

Our top choices for Great River Road vacation rentals

A modern kitchen with white cabinets, a stainless steel oven, a microwave, and a refrigerator. There is a dining table with chairs and a ceiling fan.

1. Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
The Hill
9.8 out of 10, Exceptional, (198 reviews)
"Great cottage, pet friendly, wonderful neighborhood to explore and many great food options within walking distance. Would definitely stay again at this cottage."
United States
Scott J.
$141 nightly
The price is $152
Oct 12 - Oct 13
Total with taxes and fees
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
A cabin with a large window, surrounded by trees.

2. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (104 reviews)
"I really enjoyed my time at the stay !"
United States
Ronrecus
$141 nightly
The price is $160
Oct 18 - Oct 19
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A living room with a wooden entertainment center, a white sofa, and a dining area with a white railing.

3. Spacious, cozy home in Saint Louis

Spacious, cozy home in Saint Louis
St. Louis
10.0 out of 10, Exceptional, (44 reviews)
"Very clean. We had a nice stay."
United States
John V.
$269 nightly
The price is $287
Sep 22 - Sep 23
Total with taxes and fees
Spacious, cozy home in Saint Louis
A wooden deck with a view of a park featuring trees and a grassy area.

4. Countryside Private Guest Room

Countryside Private Guest Room
Freeburg
9.8 out of 10, Exceptional, (28 reviews)
"Awesome place to stay really nice host would highly recommend!!!!"
United States
Cayson P.
$92 nightly
The price is $98
Sep 18 - Sep 19
Total with taxes and fees
Countryside Private Guest Room

5. Turn On Inn

Turn On Inn
3.0 star property
Lake Village
9.6 out of 10, Exceptional, (92 reviews)
"Great accomodstion great price!"
United States
martha
$103 nightly
The price is $114
Oct 17 - Oct 18
Total with taxes and fees
Turn On Inn
A hotel room with two beds, green walls, and framed pictures of landscapes.

6. Hudson Inn & Suites

Hudson Inn & Suites
3.0 star property
Hudson
8.2 out of 10, Very good, (919 reviews)
"Friendly staff and safe place to stay."
United States
Terry
$94 nightly
The price is $102
Sep 20 - Sep 21
Total with taxes and fees
Hudson Inn & Suites
A row of single-family homes with a well-maintained lawn and a tree in the foreground.

7. Nauvoo Vacation Villas & Condos

Nauvoo Vacation Villas & Condos
3.0 star property
Nauvoo
9.8 out of 10, Exceptional, (446 reviews)
"A great place to stay!"
United States
Renae
$144 nightly
The price is $153
Sep 21 - Sep 22
Total with taxes and fees
Nauvoo Vacation Villas & Condos
A stone wall with a sign reading "Peter Ray House" in front of a textured wall.

8. Peter Ray House

Peter Ray House
Maeystown
10.0 out of 10, Exceptional, (77 reviews)
"This house was incredible. Loved the history and ambience of the town. Peter was one of the nicest homes I’ve stayed in over the years. I would highly recommend it."
United States
Eric
$212 nightly
The price is $225
Sep 20 - Sep 21
Total with taxes and fees
Peter Ray House
A modern kitchen with stainless steel appliances, a stone accent wall, and a bar area.

9. Aunt Lele's Cozy Cottage

Aunt Lele's Cozy Cottage
Quincy
9.8 out of 10, Exceptional, (46 reviews)
"Perfect place for our family of 5 to enjoy a weekend visiting my wife’s family."
United States
Matt B.
$138 nightly
The price is $157
Sep 20 - Sep 21
Total with taxes and fees
Aunt Lele's Cozy Cottage
A wooden deck with two blue chairs and a flower pot, overlooking a lake with a picnic table and a bench.

10. Mississippi River Cabin

Mississippi River Cabin
Bellevue
9.8 out of 10, Exceptional, (47 reviews)
"Great place"
United States
Greg G.
$252 nightly
The price is $283
Sep 20 - Sep 21
Total with taxes and fees
Mississippi River Cabin
A wooden pergola structure with a metal railing, surrounded by lush green plants.

11. Creative Cozy Urban Retreat

Creative Cozy Urban Retreat
South Minneapolis
9.6 out of 10, Exceptional, (67 reviews)
"Great place to stay. Location was really convenient to downtown, had everything we needed, and check-in and check-out were super easy. Would definitely stay again."
United States
Chad
$116 nightly
The price is $130
Sep 20 - Sep 21
Total with taxes and fees
Creative Cozy Urban Retreat
A kitchen with a central island, wooden cabinets, a stove, and a sink.

12. Cozy upstairs bungalow

Cozy upstairs bungalow
Carthage
10.0 out of 10, Exceptional, (20 reviews)
"Thanks for a terrific place to stay! Everything was as expected. Fridge, washer/dryer, and A/C all worked great. The beds were super comfy, the temperature was perfect, and it was dark and quiet at night. Will stay again next time we’re passing through."
United States
Sara
$137 nightly
The price is $145
Oct 16 - Oct 17
Total with taxes and fees
Cozy upstairs bungalow
A white two-story house with a covered porch, a chimney, and a small garden area with chairs and a table.

13. Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!
Ste. Genevieve
10.0 out of 10, Exceptional, (289 reviews)
"The place was easy to find. Cute, clean, and relaxing. It was the perfect stay for our trip. Highly recommend. "
United States
Shayna P.
$181 nightly
The price is $202
Sep 23 - Sep 24
Total with taxes and fees
Beautiful Modern Loft In Wine Country!
A room with a table and two chairs, a window with a view of a lake and greenery.

14. Riverfront Cabin With Small Beach Short Drive From Nauvoo

Riverfront Cabin With Small Beach Short Drive From Nauvoo
Niota
8.2 out of 10, Very good, (55 reviews)
"This was such a great getaway spot! We needed peace and we got it."
United States
Anonymous traveler
$93 nightly
The price is $98
Sep 23 - Sep 24
Total with taxes and fees
Riverfront Cabin With Small Beach Short Drive From Nauvoo
A wooden cabin with a green door, a number '2' sign, a small porch with a wooden railing, and a wall-mounted lantern.

15. 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (74 reviews)
"Very clean and comfortable stay"
United States
Alison K.
$164 nightly
The price is $181
Sep 28 - Sep 29
Total with taxes and fees
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
A large indoor swimming pool with a high ceiling and wooden beams, surrounded by large windows and a view of the outdoors.

16. Charming, Farmhouse Chic, Cozy|Fireplace|12 Min to Town|Beautiful View

Charming, Farmhouse Chic, Cozy|Fireplace|12 Min to Town|Beautiful View
The Galena Territory
10.0 out of 10, Exceptional, (55 reviews)
"Very nice place to stay. We enjoyed being there. "
United States
Ruth D.
$239 nightly
The price is $253
Sep 22 - Sep 23
Total with taxes and fees
Charming, Farmhouse Chic, Cozy|Fireplace|12 Min to Town|Beautiful View
A hallway with a wooden wall, a door leading to a bedroom, and a staircase.

17. St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, Exceptional, (163 reviews)
"Very nice very clean property. Very much enjoyed our stay"
United States
Joe R.
$249 nightly
The price is $267
Sep 20 - Sep 21
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!
A natural outdoor setting with a stone fire pit surrounded by wooden benches and a wooden bridge.

18. Your home away from home in the Country

Your home away from home in the Country
Coatsburg
9.8 out of 10, Exceptional, (44 reviews)
"We will make your place a regular stay when in town to visit my son and wife!"
United States
Kimberly G.
$151 nightly
The price is $160
Sep 21 - Sep 22
Total with taxes and fees
Your home away from home in the Country
A cozy cabin interior with a stone fireplace, wooden walls, and various framed pictures.

19. Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus

Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus
Carbondale
9.2 out of 10, Wonderful, (153 reviews)
"Great place to get away while still being close enough to town"
United States
Travis S.
$143 nightly
The price is $151
Sep 20 - Sep 21
Total with taxes and fees
Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus
A room with a bench, a wall-mounted sign, and a potted plant.

20. Ranch styled home, in a quiet neighborhood, totally remodeled in 2020.

Ranch styled home, in a quiet neighborhood, totally remodeled in 2020.
Bellevue
9.8 out of 10, Exceptional, (127 reviews)
"Super convenient and comfy place to stay in the Bellevue area."
United States
Bruce B.
$180 nightly
The price is $201
Sep 21 - Sep 22
Total with taxes and fees
Ranch styled home, in a quiet neighborhood, totally remodeled in 2020.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Great River Road Hotel Reviews

AmericInn by Wyndham Prairie du Chien

AmericInn by Wyndham Prairie du Chien

10/10 Excellent
"We only stayed one night. But definitely enjoyed our stay it was quiet, and clean"
Nathan 1-night trip
Posted 2 days ago
AmericInn by Wyndham Prairie du Chien

Find out more about Great River Road

Everything you need to know about Great River Road vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Great River Road vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Great River Road vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Great River Road vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Great River Road. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Great River Road in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Great River Road rentals

At Expedia, we put the best Great River Road vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Great River Road rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Great River Road vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Great River Road. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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