A historic downtown street with vintage buildings, a church steeple, and a prominent clock tower.

Great River Road Vacation Rentals

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Check prices for these dates

In two weeks
Sep 18 - Sep 20
In two months
Oct 30 - Nov 1
In three months
Nov 27 - Nov 29
In four months
Dec 25 - Dec 27

Our top choices for Great River Road vacation rentals

A modern kitchen with white cabinets, a stainless steel oven, a microwave, and a refrigerator. There is a dining table with chairs and a ceiling fan.

1. Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
The Hill
9.8 out of 10, Exceptional, (196 reviews)
"Looks exactly like the pictures. Clean, beautiful shower. Friendly staff, had no problems answering questions, had all the things you needed to relax for a few days with a couple of friends. The neighborhood is lovely & peaceful at night. Beautiful yard. So pleased I came across this cottage. Thanks guy, our stay was awesome"
United States
Crystal
$141 nightly
The price is $152
Sep 7 - Sep 8
Total with taxes and fees
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
A cabin with a large window, surrounded by trees.

2. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
9.8 out of 10, Exceptional, (100 reviews)
"I really enjoyed my time at the stay !"
United States
Ronrecus
$141 nightly
The price is $160
Oct 4 - Oct 5
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A wooden deck with a view of a park featuring trees and a grassy area.

3. Countryside Private Guest Room

Countryside Private Guest Room
Freeburg
9.8 out of 10, Exceptional, (28 reviews)
"Awesome place to stay really nice host would highly recommend!!!!"
United States
Cayson P.
$88 nightly
The price is $93
Sep 6 - Sep 7
Total with taxes and fees
Countryside Private Guest Room
A living room with a wooden entertainment center, a white sofa, and a dining area with a white railing.

4. Spacious, cozy home in Saint Louis

Spacious, cozy home in Saint Louis
St. Louis
10.0 out of 10, Exceptional, (44 reviews)
"Was very clean and very quit neighborhood"
United States
Judith H.
$270 nightly
The price is $288
Sep 7 - Sep 8
Total with taxes and fees
Spacious, cozy home in Saint Louis

5. Turn On Inn

Turn On Inn
3.0 star property
Lake Village
9.6 out of 10, Exceptional, (92 reviews)
"Great accomodstion great price!"
United States
martha
$105 nightly
The price is $116
Oct 5 - Oct 6
Total with taxes and fees
Turn On Inn
A hotel room with two beds, green walls, and framed pictures of landscapes.

6. Hudson Inn & Suites

Hudson Inn & Suites
3.0 star property
Hudson
8.2 out of 10, Very Good, (909 reviews)
"Friendly staff and safe place to stay."
United States
Terry
$81 nightly
The price is $88
Oct 6 - Oct 7
Total with taxes and fees
Hudson Inn & Suites
A log cabin with a metal roof, two windows, a door, and a porch with two rocking chairs and a small table.

7. Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (424 reviews)
"Cabin was cute and cozy!! "
United States
Anonymous traveler
$189 nightly
The price is $200
Sep 7 - Sep 8
Total with taxes and fees
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
A row of single-family homes with a well-maintained lawn and a tree in the foreground.

8. Nauvoo Vacation Villas & Condos

Nauvoo Vacation Villas & Condos
3.0 star property
Nauvoo
9.8 out of 10, Exceptional, (442 reviews)
"A great place to stay!"
United States
Renae
$144 nightly
The price is $153
Sep 6 - Sep 7
Total with taxes and fees
Nauvoo Vacation Villas & Condos
A hallway with a wooden wall, a door leading to a bedroom, and a staircase.

9. St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!
St. Charles Historic District
9.8 out of 10, Exceptional, (163 reviews)
"Very nice very clean property. Very much enjoyed our stay"
United States
Joe R.
$257 nightly
The price is $275
Sep 8 - Sep 9
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!
A stone wall with a sign reading "Peter Ray House" in front of a textured wall.

10. Peter Ray House

Peter Ray House
Maeystown
10.0 out of 10, Exceptional, (75 reviews)
"This house was incredible. Loved the history and ambience of the town. Peter was one of the nicest homes I’ve stayed in over the years. I would highly recommend it."
United States
Eric
$211 nightly
The price is $224
Sep 6 - Sep 7
Total with taxes and fees
Peter Ray House
A modern kitchen with a marble countertop, white cabinets, and a built-in dishwasher.

11. NEW Modern & Luxe 5BDR House. Sleep 14. Downtown 5min away

NEW Modern & Luxe 5BDR House. Sleep 14. Downtown 5min away
The Gate
9.6 out of 10, Exceptional, (43 reviews)
"Great stay!"
United States
MaryAnn V.
$903 nightly
The price is $980
Sep 26 - Sep 27
Total with taxes and fees
NEW Modern & Luxe 5BDR House. Sleep 14. Downtown 5min away
A rooftop pool area with checkered flooring, lounge chairs, and umbrellas.

12. Memoir Warehouse District

Memoir Warehouse District
4.0 star property
Arts/Warehouse District
9.4 out of 10, Exceptional, (448 reviews)
"Excellent apartment, clean and spacious."
United States
dayana america
$134 nightly
The price is $159
Sep 7 - Sep 8
Total with taxes and fees
Memoir Warehouse District
A natural outdoor setting with a stone fire pit surrounded by wooden benches and a wooden bridge.

13. Your home away from home in the Country

Your home away from home in the Country
Coatsburg
9.8 out of 10, Exceptional, (44 reviews)
"We will make your place a regular stay when in town to visit my son and wife!"
United States
Kimberly G.
$151 nightly
The price is $160
Sep 10 - Sep 11
Total with taxes and fees
Your home away from home in the Country
A room with a bench, a wall-mounted sign, and a potted plant.

14. Ranch styled home, in a quiet neighborhood, totally remodeled in 2020.

Ranch styled home, in a quiet neighborhood, totally remodeled in 2020.
Bellevue
9.8 out of 10, Exceptional, (126 reviews)
"Super convenient and comfy place to stay in the Bellevue area."
United States
Bruce B.
$182 nightly
The price is $203
Sep 7 - Sep 8
Total with taxes and fees
Ranch styled home, in a quiet neighborhood, totally remodeled in 2020.
A snow-covered deck with a railing, a lamp post, and leafless trees in the background.

15. Mr. Rogers River View

Mr. Rogers River View
Guttenberg
9.6 out of 10, Exceptional, (46 reviews)
"great view and access to the river for fishing"
United States
Anthony K.
$158 nightly
The price is $176
Sep 13 - Sep 14
Total with taxes and fees
Mr. Rogers River View
A wooden cabin with a green door, a number '2' sign, a small porch with a wooden railing, and a wall-mounted lantern.

16. 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (73 reviews)
"Very clean and comfortable stay"
United States
Alison K.
$165 nightly
The price is $182
Sep 9 - Sep 10
Total with taxes and fees
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
A white two-story house with a covered porch, a chimney, and a small garden area with chairs and a table.

17. Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!
Ste. Genevieve
10.0 out of 10, Exceptional, (288 reviews)
"The place was easy to find. Cute, clean, and relaxing. It was the perfect stay for our trip. Highly recommend. "
United States
Shayna P.
$181 nightly
The price is $202
Sep 8 - Sep 9
Total with taxes and fees
Beautiful Modern Loft In Wine Country!
A swimming pool with a house in the background.

18. Only a mile from historic downtown Clarksdale!

Only a mile from historic downtown Clarksdale!
Clarksdale
10.0 out of 10, Exceptional, (29 reviews)
"Absolutely loved this stay!"
United States
Narrea M.
$217 nightly
The price is $232
Sep 7 - Sep 8
Total with taxes and fees
Only a mile from historic downtown Clarksdale!
A rustic cabin with a stone chimney, wooden deck, and a porch.

19. Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.6 out of 10, Exceptional, (50 reviews)
"We enjoyed our stay at the well outfitted cabin near the Shawnee Wine Trail. Cabin is conveniently located near Giant City State Park and the lodge restaurant. "
United States
Janine B.
$193 nightly
The price is $213
Sep 14 - Sep 15
Total with taxes and fees
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
A cozy cabin interior with a stone fireplace, wooden walls, and various framed pictures.

20. Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus

Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus
Carbondale
9.2 out of 10, Wonderful, (153 reviews)
"If your looking for a quite out of the way place this is it."
United States
James B.
$143 nightly
The price is $151
Sep 7 - Sep 8
Total with taxes and fees
Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Great River Road Hotel Reviews

Les Carillons - Arts District Gem Large Groups Welcome! Pool! Elevator!

Les Carillons - Arts District Gem Large Groups Welcome! Pool! Elevator!

10/10 Excellent
"Lee Ann is a wonderful host, and my group and I thoroughly enjoyed our stay. The location is ideal with local bars and restaurants in the immediate vicinity, but it's still walkable to Bourbon St and the Superdome. The house is spacious and amenities like towels and shampoo were plentiful. Pool access was easy and the leftover sunscreen and festive hats were much appreciated. We would absolutely stay here again."
Ed Q. 3-night trip
Posted 3 weeks ago
Les Carillons - Arts District Gem Large Groups Welcome! Pool! Elevator!

Find out more about Great River Road

Everything you need to know about Great River Road vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Great River Road vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Great River Road vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Great River Road vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Great River Road. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Great River Road in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Great River Road rentals

At Expedia, we put the best Great River Road vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Great River Road rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Great River Road vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Great River Road. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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