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Our top choices for Greencastle hotels

Depot Inn and Suites

Depot Inn and Suites
3.5 star property
La Plata
9.8 out of 10, Exceptional, (647 reviews)
"Added scrambled eggs and sausage patties to the menu. Everything was excellent!"
United States
Doug
10 days ago
$89 nightly
The price is $96
Apr 26 - Apr 27
Total with taxes and fees
Depot Inn and Suites

Super 8 by Wyndham Kirksville-University Area

Super 8 by Wyndham Kirksville-University Area
2.5 star property
Kirksville
9.2 out of 10, Wonderful, (183 reviews)
"The price is the best part."
United States
Jen
15 hours ago
$65 nightly
The price is $73
Apr 26 - Apr 27
Total with taxes and fees
Super 8 by Wyndham Kirksville-University Area

Hampton Inn Kirksville

Hampton Inn Kirksville
2.5 star property
Kirksville
9.2 out of 10, Wonderful, (609 reviews)
"Room was very clean. Staff was very friendly."
United States
Laura M
11 days ago
$122 nightly
The price is $138
Apr 26 - Apr 27
Total with taxes and fees
Hampton Inn Kirksville

Holiday Inn Express & Suites Kirksville - University Area by IHG

Holiday Inn Express & Suites Kirksville - University Area by IHG
2.5 star property
Kirksville
9.2 out of 10, Wonderful, (529 reviews)
"Good distance from airport. To be expected for the location."
United States
Joshua
8 days ago
$127 nightly
The price is $144
Apr 19 - Apr 20
Total with taxes and fees
Holiday Inn Express & Suites Kirksville - University Area by IHG

Baymont by Wyndham Kirksville University Area

Baymont by Wyndham Kirksville University Area
2.5 star property
Kirksville
7.6 out of 10, Good, (903 reviews)
"Our room was very clean. The bed was comfortable. We will stay here again."
United States
Amy
November 9th, 2025
$67 nightly
The price is $75
Apr 20 - Apr 21
Total with taxes and fees
Baymont by Wyndham Kirksville University Area

Days Inn by Wyndham Kirksville

Days Inn by Wyndham Kirksville
2.0 star property
Kirksville
6.6 out of 10, (1,002 reviews)
"Breakfast was great enjoyed the pool."
United States
Dara
November 8th, 2025
$66 nightly
The price is $74
Apr 26 - Apr 27
Total with taxes and fees
Days Inn by Wyndham Kirksville

Quality Inn Kirksville

Quality Inn Kirksville
2.5 star property
Kirksville
7.6 out of 10, Good, (400 reviews)
"The staff was friendly and provided excellent service!"
United States
Don
October 26th, 2025
$79 nightly
The price is $89
Apr 16 - Apr 17
Total with taxes and fees
Quality Inn Kirksville

Thousand Hills

Thousand Hills
2.0 star property
Kirksville
9.2 out of 10, Wonderful, (15 reviews)
"Good food at restaurant. We sat on covered patio on lake."
United States
Lisa
9 days ago
Thousand Hills

Zeke’s Retreat – Hunter’s Getaway with On-Site Taxidermy Shop

Zeke’s Retreat – Hunter’s Getaway with On-Site Taxidermy Shop
Greencastle
10.0 out of 10, Exceptional, (3 reviews)
"Great spot and worked well for us. "
United States
Joshua R.
$151 nightly
The price is $159
Apr 14 - Apr 15
Total with taxes and fees
Zeke’s Retreat – Hunter’s Getaway with On-Site Taxidermy Shop

Knights Inn Kirksville

Knights Inn Kirksville
1.5 star property
Kirksville
7.2 out of 10, Good, (252 reviews)
"Roomy and clean. Price good for what it was."
United States
Vicki
$62 nightly
The price is $70
Apr 14 - Apr 15
Total with taxes and fees
Knights Inn Kirksville

Rescued Wood Bunkhouse-Sleeps 8 hunters. Full kitchen and bath. Lots of parking.

Rescued Wood Bunkhouse-Sleeps 8 hunters. Full kitchen and bath. Lots of parking.
Greencastle
8.0 out of 10, Very Good, (1 review)
"Honestly could not have asked for a better host. He's a really nice guy and was very helpful and responsive when i had questions. All amenities were prepared for the stay. House is older and could be cleaner, but is in the process of being remodeled but was not expecting much more as the house served its purpose for my stay. Will be returning in the future."
United States
Austin M.
Rescued Wood Bunkhouse-Sleeps 8 hunters. Full kitchen and bath. Lots of parking.

Budget Host Village Inn

Budget Host Village Inn
2.0 star property
Kirksville
6.0 out of 10, (128 reviews)
"Looks newly remodeled balcony for the second floor. Affordable price with the great location."
United States
James
1 day ago
$53 nightly
The price is $59
Apr 26 - Apr 27
Total with taxes and fees
Budget Host Village Inn

Lost Branch Lodge. Complete exterior remodel, spring 2026!

Lost Branch Lodge. Complete exterior remodel, spring 2026!
Brashear
9.8 out of 10, Exceptional, (180 reviews)
"Absolutely awesome! Fun games, clean and filled with everything. We brought tables, crockpots, bags and everything was already here. Great place! "
United States
Bryan J.
Lost Branch Lodge. Complete exterior remodel, spring 2026!

Private country getaway in the middle of nowhere!

Private country getaway in the middle of nowhere!
Newtown
10.0 out of 10, Exceptional, (66 reviews)
"Great place and hostess was super nice!"
United States
Charlotte S.
Private country getaway in the middle of nowhere!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is the best area to stay in Greencastle?
The best area to stay in Greencastle is near the town center, particularly around the intersection of Main Street and Highway 147, as this is where most of the town's facilities are located.

This central area offers convenience, with local eateries and shops clustered within walking distance. It provides easy access to the few local points of interest, making it a practical base for visitors.

For couples seeking a quiet retreat, staying in this central area provides access to the town's limited amenities while allowing for peaceful evenings.
When is the best time to go to Greencastle?
The best time to go to Greencastle, Missouri, is during the spring and fall months.

Spring, particularly from April to May, offers pleasant weather with blooming landscapes. This is an excellent time for nature enthusiasts and those who enjoy outdoor activities like exploring the nearby conservation areas or taking scenic drives. The temperatures are mild, making it comfortable for sightseeing without the summer heat.

Fall, from September to October, is another ideal period, characterized by cooler temperatures and the vibrant colors of autumn foliage. This season is great for travelers who appreciate picturesque scenery and a relaxed pace.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Greencastle.
How can I save on a Greencastle hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Greencastle hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Greencastle hotel?
Prices for hotels in Greencastle often vary, but you can find a great deal from $59 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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