Title: TOP 10 Hotels in Greencastle, MO (from $59) - COMPETITIVE PRICES | Expedia.com [Vacation Rentals in Greencastle](https://expedia.com/Greencastle-Vacation-Rentals.d553248634983462000.Travel-Guide-VacationRentals)[Car Rentals in Greencastle](https://expedia.com/Car-Rentals-In-Greencastle.d553248634983462000.Car-Rental-Guide)[Greencastle Vacation Packages](https://expedia.com/Greencastle.d553248634983462000.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Apr 7 - Apr 8](https://www.expedia.com/Hotel-Search?regionId=553248634983462000&startDate=2026-04-07&endDate=2026-04-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 8 - Apr 9](https://www.expedia.com/Hotel-Search?regionId=553248634983462000&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=553248634983462000&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=553248634983462000&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Greencastle hotels ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/6c9e28fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/0bdc571d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/1817d317.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/44eec777.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Depot Inn and Suites [](https://www.expedia.com/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information) La Plata 9.8/10 Exceptional (647 reviews) "Added scrambled eggs and sausage patties to the menu. Everything was excellent!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Doug 5 days ago $89 nightly $96 total Apr 20 - Apr 21 Total with taxes and fees [](https://www.expedia.com/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/fd2e50c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/d203c711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking | Pillowtop beds, desk, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/adba1fe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/9c660a01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Kirksville-University Area [](https://www.expedia.com/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) Kirksville 9.0/10 Wonderful (180 reviews) "Great breakfast choices. Had good dinner recommendations. Will stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marc 4 days ago $65 nightly $73 total Apr 26 - Apr 27 Total with taxes and fees [](https://www.expedia.com/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/c19d4fbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/388c1302.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/0d60e323.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Refrigerator & Microwave | Hypo-allergenic bedding, down comforters, in-room safe, desk](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/de278a36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Kirksville [](https://www.expedia.com/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) Kirksville 9.2/10 Wonderful (606 reviews) "Room was very clean. Staff was very friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura M 5 days ago $122 nightly $138 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/ee47dad5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/4be7f63c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/f363e21b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Kirksville - University Area by IHG [](https://www.expedia.com/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information) Kirksville 9.2/10 Wonderful (529 reviews) "Good distance from airport. To be expected for the location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joshua 2 days ago $127 nightly $144 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information) ![Superior Studio Suite, 1 King Bed, Non Smoking | Jetted tub](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/b428c708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/fe067a47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/661e3930.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/33e2a913.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Kirksville University Area [](https://www.expedia.com/Macon-Hotels-Baymont-By-Wyndham-Kirksville-University-Area.h125458.Hotel-Information) Kirksville 7.6/10 Good (903 reviews) "Our room was very clean. The bed was comfortable. We will stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy November 9th, 2025 $67 nightly $75 total Apr 14 - Apr 15 Total with taxes and fees [](https://www.expedia.com/Macon-Hotels-Baymont-By-Wyndham-Kirksville-University-Area.h125458.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/80d5a891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/f3c5f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/2180aea2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Kirksville [](https://www.expedia.com/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information) Kirksville 6.6/10 (1,001 reviews) "Breakfast was great enjoyed the pool." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dara November 8th, 2025 $66 nightly $74 total May 1 - May 2 Total with taxes and fees [](https://www.expedia.com/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/8a5baebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/b08ddc86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/w1021h682x0y0-c9b85e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/1e205061.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Kirksville [](https://www.expedia.com/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information) Kirksville 7.6/10 Good (400 reviews) "The staff was friendly and provided excellent service!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Don October 26th, 2025 $79 nightly $89 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/107000000/106800000/106792500/106792431/855824fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bed sheets](https://images.trvl-media.com/lodging/107000000/106800000/106792500/106792431/61f079d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106800000/106792500/106792431/992ec3ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![24-inch plasma TV with digital channels](https://images.trvl-media.com/lodging/107000000/106800000/106792500/106792431/82e01c38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Thousand Hills [](https://www.expedia.com/Kirksville-Hotels-Thousand-Hills.h106792431.Hotel-Information) Kirksville 9.2/10 Wonderful (15 reviews) "Good food at restaurant. We sat on covered patio on lake." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa 3 days ago [](https://www.expedia.com/Kirksville-Hotels-Thousand-Hills.h106792431.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/120000000/119160000/119156700/119156645/1a68972a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119160000/119156700/119156645/e9120d0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119160000/119156700/119156645/7c72565d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119160000/119156700/119156645/c3fb2dfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Zeke’s Retreat – Hunter’s Getaway with On-Site Taxidermy Shop [](https://www.expedia.com/Zekes-Retreat-Hunters-Getaway-With-On-Site-Taxidermy-Shop.h119156645.Hotel-Information) Greencastle 10/10 Exceptional (3 reviews) "Great spot and worked well for us. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joshua R. $151 nightly $159 total Apr 8 - Apr 9 Total with taxes and fees [](https://www.expedia.com/Zekes-Retreat-Hunters-Getaway-With-On-Site-Taxidermy-Shop.h119156645.Hotel-Information) ![Desk, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/a7e2219f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/9b5928a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/9afc2091.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, towels](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/7f07ee5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Knights Inn Kirksville [](https://www.expedia.com/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information) Kirksville 7.2/10 Good (252 reviews) "Roomy and clean. Price good for what it was." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vicki $62 nightly $70 total Apr 8 - Apr 9 Total with taxes and fees [](https://www.expedia.com/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information) ![Fridge, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/111000000/110440000/110437900/110437864/1adbe3e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/111000000/110440000/110437900/110437864/69c801dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/111000000/110440000/110437900/110437864/c3706403.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/111000000/110440000/110437900/110437864/0c06f820.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rescued Wood Bunkhouse-Sleeps 8 hunters. Full kitchen and bath. Lots of parking. [](https://www.expedia.com/Rescued-Wood-Bunkhouse-Sleeps-8-Hunters-Full-Kitchen-And-Bath.h110437864.Hotel-Information) Greencastle 8.0/10 Very Good (1 review) "Honestly could not have asked for a better host. He's a really nice guy and was very helpful and responsive when i had questions. All amenities were prepared for the stay. House is older and could be cleaner, but is in the process of being remodeled but was not expecting much more as the house served its purpose for my stay. Will be returning in the future." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Austin M. [](https://www.expedia.com/Rescued-Wood-Bunkhouse-Sleeps-8-Hunters-Full-Kitchen-And-Bath.h110437864.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/2000000/1420000/1410900/1410833/bb8d2309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1420000/1410900/1410833/f30d1f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/2000000/1420000/1410900/1410833/a9cf2503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1420000/1410900/1410833/037d52fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Budget Host Village Inn [](https://www.expedia.com/Macon-Hotels-Budget-Host-Village-Inn.h1410833.Hotel-Information) Kirksville 6.0/10 (126 reviews) "Room was tidy. The bed was very firm." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John $53 nightly $59 total May 1 - May 2 Total with taxes and fees [](https://www.expedia.com/Macon-Hotels-Budget-Host-Village-Inn.h1410833.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/33000000/32670000/32666300/32666255/270-a798373b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/33000000/32670000/32666300/32666255/f6665c52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/33000000/32670000/32666300/32666255/95671834.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/33000000/32670000/32666300/32666255/f48e6a5d_edited_93cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lost Branch Lodge. Complete exterior remodel, spring 2026! [](https://www.expedia.com/Brashear-Hotels-Lost-Branch-Lodge-Relaxation-In-A-Quiet.h32666255.Hotel-Information) Brashear 9.8/10 Exceptional (180 reviews) "Absolutely awesome! Fun games, clean and filled with everything. We brought tables, crockpots, bags and everything was already here. Great place! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bryan J. [](https://www.expedia.com/Brashear-Hotels-Lost-Branch-Lodge-Relaxation-In-A-Quiet.h32666255.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76550000/76542600/76542506/bfea647e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/77000000/76550000/76542600/76542506/b1315746.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76550000/76542600/76542506/739493c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/77000000/76550000/76542600/76542506/fb0efaa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private country getaway in the middle of nowhere! [](https://www.expedia.com/Private-Country-Getaway-In-The-Middle-Of-Nowhere.h76542506.Hotel-Information) Newtown 10/10 Exceptional (66 reviews) "Great place and hostess was super nice!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charlotte S. [](https://www.expedia.com/Private-Country-Getaway-In-The-Middle-Of-Nowhere.h76542506.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-21&endDate=2026-04-22®ionId=553248634983462000&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FGreencastle-Hotels.d553248634983462000.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FGreencastle-Hotels.d553248634983462000.Travel-Guide-Hotels) ## Top Greencastle Hotel Reviews ![Hampton Inn Kirksville](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/c19d4fbf_y.jpg) ### Hampton Inn Kirksville 8/10 Good "The pool was freezing cold. " [](https://expedia.com/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) ![Super 8 by Wyndham Kirksville-University Area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/fd2e50c6_y.jpg) ### Super 8 by Wyndham Kirksville-University Area 10/10 Excellent "We were very happy with this hotel.Was clean and the staff was really nice and very helpful.Will definitely stay again.Free breakfast was a bonus" [](https://expedia.com/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) ![Holiday Inn Express & Suites Kirksville - University Area by IHG](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649_y.jpg) ### Holiday Inn Express & Suites Kirksville - University Area by IHG 10/10 Excellent "Clean room, helpful staff, solid outdoor parking space, good distance from airport. Limited amenities but to be expected for the location." [](https://expedia.com/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information) ![Days Inn by Wyndham Kirksville](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76_y.jpg) ### Days Inn by Wyndham Kirksville 4/10 Poor "Staff was nice. I was looking forward to the hot tub, but when we went down, the hot tub was cold, green and a millipede was crawling across the floor. No tiling around the pool, only carpet. The room was okay, and the elevator had a ceiling tile with exposed wires and fan. Breakfast was also mediocre. " [](https://expedia.com/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information) ![Knights Inn Kirksville](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/e004f75c_y.jpg) ### Knights Inn Kirksville 10/10 Excellent "Ppl were very kind, rooms were clean, check in to make sure we didn’t need anything. " [](https://expedia.com/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information) ![Thousand Hills](https://images.trvl-media.com/lodging/107000000/106800000/106792500/106792431/855824fb_y.jpg) ### Thousand Hills 10/10 Excellent "Great location, cabin overlooking lake. Good food at restaurant. We sat on covered patio on lake " [](https://expedia.com/Kirksville-Hotels-Thousand-Hills.h106792431.Hotel-Information) ![Country's Edge Retreat](https://images.trvl-media.com/lodging/121000000/120070000/120065000/120064921/59962910_y.jpg) ### Country's Edge Retreat 10/10 Excellent "The home was very clean, spacious, comfortable and had everything we needed. The host was wonderful, very friendly and even checked in to see if we needed anything. I'd definitely stay here again." [](https://expedia.com/Greentop-Hotels-Countrys-Edge-Retreat.h120064921.Hotel-Information) ![Baymont by Wyndham Kirksville University Area](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/b428c708_y.jpg) ### Baymont by Wyndham Kirksville University Area 4/10 Poor "The room I had was decent though I found there to be a cat wandering around inside the halls. It followed me around more than I liked. I'm allergic to cats usually but I wasn't near enough I guess. Also the hotel looked to have water damage in the ceiling of one hall. Parking was okay but tight for someone with a trailer. " [](https://expedia.com/Macon-Hotels-Baymont-By-Wyndham-Kirksville-University-Area.h125458.Hotel-Information) ![Base Camp Cottage](https://images.trvl-media.com/lodging/112000000/111840000/111833600/111833563/c8a88b56_y.jpg) ### Base Camp Cottage 10/10 Excellent "Clean and cozy " [](https://expedia.com/Kirksville-Hotels-Base-Camp-Cottage.h111833563.Hotel-Information) ## More cheap stays in Greencastle ![Super 8 by Wyndham Kirksville-University Area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/fd2e50c6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Super 8 by Wyndham Kirksville-University Area 1101 Country Club Dr Kirksville MO $65 nightly $73 total Apr 26 - Apr 27 Total with taxes and fees 9/10 Wonderful! (180 reviews) [](https://expedia.com/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) ![Days Inn by Wyndham Kirksville](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Kirksville 3805 S Baltimore St Kirksville MO $66 nightly $74 total May 1 - May 2 Total with taxes and fees 6.6/10 (1,001 reviews) [](https://expedia.com/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information) ![Quality Inn Kirksville](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/8a5baebb_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Kirksville 2209 N. Baltimore Street Kirksville MO $79 nightly $89 total Apr 12 - Apr 13 Total with taxes and fees [](https://expedia.com/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information) ![Hampton Inn Kirksville](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/c19d4fbf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Kirksville 2604 N. Baltimore Street Kirksville MO $122 nightly $138 total Apr 19 - Apr 20 Total with taxes and fees 9.2/10 Wonderful! (606 reviews) [](https://expedia.com/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) ![Holiday Inn Express & Suites Kirksville - University Area by IHG](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Kirksville - University Area by IHG 2523 South Franklin St. Kirksville MO $127 nightly $144 total Apr 19 - Apr 20 Total with taxes and fees 9.2/10 Wonderful! (529 reviews) [](https://expedia.com/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information) ![Thousand Hills](https://images.trvl-media.com/lodging/107000000/106800000/106792500/106792431/855824fb_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Thousand Hills 20431 Missouri 157 Kirksville MO [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F21%2F2026&endDate=4%2F22%2F2026&selected=106792431&PinnedHotelID=106792431&HadPinnedHotel=true®ionId=553248634983462000) 9.2/10 Wonderful! (15 reviews) [](https://expedia.com/Kirksville-Hotels-Thousand-Hills.h106792431.Hotel-Information) ## Hotels in Greencastle with star-rating ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 8 properties [](https://expedia.com/2Star-Greencastle-Hotels.s20-0-d553248634983462000.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What is the best area to stay in Greencastle? > This central area offers convenience, with local eateries and shops clustered within walking distance. It provides easy access to the few local points of interest, making it a practical base for visitors. > > > For couples seeking a quiet retreat, staying in this central area provides access to the town's limited amenities while allowing for peaceful evenings. ### When is the best time to go to Greencastle? > Spring, particularly from April to May, offers pleasant weather with blooming landscapes. This is an excellent time for nature enthusiasts and those who enjoy outdoor activities like exploring the nearby conservation areas or taking scenic drives. The temperatures are mild, making it comfortable for sightseeing without the summer heat. > > > Fall, from September to October, is another ideal period, characterized by cooler temperatures and the vibrant colors of autumn foliage. This season is great for travelers who appreciate picturesque scenery and a relaxed pace. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Greencastle hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Greencastle hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Novinger Hotels ](https://www.expedia.com/Novinger-Hotels.d3000349483.Travel-Guide-Hotels) - [Pollock Hotels ](https://www.expedia.com/Pollock-Hotels.d553248634983299062.Travel-Guide-Hotels) - [Milan Hotels ](https://www.expedia.com/Milan-Hotels.d3000445240.Travel-Guide-Hotels) - [Hotels near Thousand Hills State Park ](https://www.expedia.com/Thousand-Hills-State-Park-Hotels.0-l553248621532649029-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Milan ](https://www.expedia.com/3Star-Milan-Hotels.s30-0-d3000445240.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Milan ](https://www.expedia.com/5Star-Milan-Hotels.s50-0-d3000445240.Travel-Guide-Filter-Hotels) - [Kirksville Hotels ](https://www.expedia.com/Kirksville-Hotels.d1630.Travel-Guide-Hotels) - [Hotels near A.T. 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