South Main, TX
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and entertainment choices in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the great live music and acclaimed theater scene in this vibrant area.
Rice University
Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's acclaimed art scene and great live music.
Things to do
Space Center Houston Admission Ticket
Houston: Space Center Houston Admission Ticket
NASA's Space Center Admission Plus Official Houston City Tour
Houston: Houston Botanic Garden Entry Ticket
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
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Reviewed on May 2, 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Good place stay at
Reviewed on May 6, 2026
Club Quarters Hotel Downtown, Houston
Fresh clean fillable water bottles and the valet staff.
Reviewed on May 7, 2026
The Whitehall Houston
Friendly staff, fast check in, spacious rooms. The included breakfast was really good and until late. Didn't love that there's no self parking, but overall a good stay.
Reviewed on May 6, 2026
Blossom Hotel Houston, Curio Collection by Hilton
Clean room and areas
Reviewed on May 6, 2026
Hilton Houston Plaza/Medical Center
The staff was wonderful.
Reviewed on May 5, 2026
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Continental Club or Children's Museum of Houston and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
