South Main, TX
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the great live music and lively festivals in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and great live music in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art scene and entertainment choices in this vibrant area.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
Things to do
Space Center Houston Admission Ticket
NASA's Space Center Admission Plus Houston City Tour
Houston: Houston Botanic Garden Entry Ticket
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
Houston Museum of Natural Science: Cockrell Butterfly Center
Houston: Children's Museum Houston Entry Ticket
South Main Hotel Deals
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Great
Reviewed on Feb 2, 2026
Blossom Hotel Houston, Curio Collection by Hilton
Staff was pleasant and helpful. Room was clean comfortable and spacious
Reviewed on Jan 31, 2026
Hotel Zaza Houston Museum District
Great location
Reviewed on Feb 1, 2026
The Whitehall Houston
Staff was very welcoming and nice! My experience was lovely and I enjoyed a great view of outside! Everything I needed I had there, very organized.
Reviewed on Feb 1, 2026
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Checking in was fairly easy and checking out was as easy.
Reviewed on Jan 30, 2026
Club Quarters Hotel Downtown, Houston
Great staff! Only issue was the slow elevator
Reviewed on Feb 2, 2026
Other neighborhoods around South Main
Astrodome
If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Arena and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Museum District
Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Greater Third Ward
While you're in Greater Third Ward, take in top sights like Carl Lewis International Track and Field Complex or Fertitta Center, and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.