South Main, TX

Houston

A city skyline with modern buildings and a park with a lake.
A modern urban street with a metro train, buildings, and a clear blue sky.

Things to do

Picture 3 for Activity Houston: Space Center Houston Admission Ticket

Houston: Space Center Houston Admission Ticket

$30
per adult
92% of travellers recommend
Houston: Space Center Houston Admission Ticket
Houston Museum of Natural Science: Cockrell Butterfly Center

Houston Museum of Natural Science: Butterfly Center Ticket

$15
per adult
100% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
Houston: Houston Botanic Garden Entry Ticket

Houston: Houston Botanic Garden Entry Ticket

$12
per adult
74% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
The Official Houston City Tour

NASA's Space Center & Official Houston City Tour with tickets

$99
per adult
92% of travellers recommend
NASA's Space Center & Official Houston City Tour with tickets
Houston: Guided City Tour by an Open-Top Double Decker Bus

Houston: Guided City Tour by an Open-Top Double Decker Bus

$40
per adult
98% of travellers recommend
Houston: Guided City Tour by an Open-Top Double Decker Bus
Artechouse Houston Ticket

Artechouse Houston Ticket

$30
per adult
Artechouse Houston Ticket
See all activities in Houston

South Main Hotel Deals

Wyndham Houston at Reliant Park & Medical Center

Wyndham Houston at Reliant Park & Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
$98 nightly
The price is $115 total per night from Oct 11 to Oct 12
$115 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful staff ...
7.2/10 Good! (1,436 reviews)
"The room was clean and the hotel was within walking distance to the event."

Reviewed on Oct 7, 2026

Wyndham Houston at Reliant Park & Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
$98 nightly
The price is $114 total per night from Oct 11 to Oct 12
$114 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.6/10 Excellent! (4,510 reviews)
"Second time staying. Always a pleasure. Walking distance to the ballpark"

Reviewed on Oct 6, 2026

Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
$132 nightly
The price is $155 total per night from Oct 17 to Oct 18
$155 total
Oct 17 - Oct 18
Total with taxes and fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
$137 nightly
The price is $160 total per night from Oct 20 to Oct 21
$160 total
Oct 20 - Oct 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
The Whitehall Houston
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
$106 nightly
The price is $124 total per night from Oct 14 to Oct 15
$124 total
Oct 14 - Oct 15
Total with taxes and fees
Book a stay at this family-friendly hotel in Houston. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the pool and the helpful ...
Grand Tuscany Hotel
Hyatt Regency Houston West

Hyatt Regency Houston West

3.5 out of 5
13210 Katy Fwy Houston TX
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Nov 7 to Nov 8
$111 total
Nov 7 - Nov 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the restaurant and the helpful ...
Hyatt Regency Houston West
See all 7,433 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.
A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Downtown Houston

Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A city skyline with modern skyscrapers and a river flowing through a park.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

South Main, TX

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