Title: Visit South Main: 2026 South Main, Houston Travel Guide | Expedia.com [Hotels in South Main](https://expedia.com/South-Main-Houston-Hotels.0-n553248635976386992-0.Travel-Guide-Filter-Hotels)[Flights to Houston](https://expedia.com/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.com/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[Car Rentals in South Main](https://expedia.com/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.com/South-Main.d553248635976386992.Destination-Travel-Guides) # South Main, TX ## Houston ![Aerial view of Hermann park in Houston with Japanese Garden, zoo, Space Adventure playground](https://images.trvl-media.com/place/553248635976386992/633bd53d-8369-45ed-9507-93d6ecf02186.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![South Main](https://images.trvl-media.com/place/1503/2eeb9f80-ebf6-42ad-9574-1d77038420db.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit South Main Things to do Hotels Where to stay [Houston Travel Guide](https://expedia.com/Houston.dx178265) --- ### Popular places to visit ![Texans Vs Bears ](https://images.trvl-media.com/place/1503/e9e0c365-cf4d-4e4b-b714-f9dd65c34baf.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### NRG Stadium 4.5/5(627 reviews) Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area. [](https://expedia.com/NRG-Stadium-Astrodome.d553248635929331916.Vacation-Attraction) ![NFL Experience](https://images.trvl-media.com/place/1503/79f85336-9389-4f19-a086-bdba1925534e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### George R. Brown Convention Center 4/5(961 reviews) During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area. [](https://expedia.com/George-R-Brown-Convention-Center-Downtown-Houston.d501247.Vacation-Attraction) ![Houston_MinuteMaidPark_6034772_1](https://images.trvl-media.com/place/6034772/6d7d1cbe-28b6-4078-86cd-2bb274c4f722.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Daikin Park 4.5/5(909 reviews) Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area. [](https://expedia.com/Daikin-Park-Downtown-Houston.d6034772.Vacation-Attraction) ![At the main entrance.](https://images.trvl-media.com/place/1503/00b4e1ca-e78a-46ba-93de-a793739a6117.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Toyota Center 4/5(968 reviews) Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area. [](https://expedia.com/Toyota-Center-Downtown-Houston.d6082241.Vacation-Attraction) ![Space Center Houston which includes interior views](https://images.trvl-media.com/place/6163111/0a492b74-6d09-47ca-8bcb-439f43fd5709.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Space Center Houston 4.5/5(1,083 reviews) This iconic “mission control” was immortalized for its role in the first moon landing. [](https://expedia.com/Space-Center-Houston-Nassau-Bay.d6163111.Vacation-Attraction) ![www.alamy.com](https://images.trvl-media.com/place/501253/9f806038-e019-4ef0-8e59-8c564c0cb29c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### NASA Johnson Space Center 4.5/5(1,218 reviews) After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event. [](https://expedia.com/NASA-Johnson-Space-Center-Nassau-Bay.d501253.Vacation-Attraction) ### Things to do ![Houston Space Center](https://mediaim.expedia.com/localexpert/1341309/02135dd9-3195-40c1-a500-25efe978e608.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Space Center Houston Admission Ticket $33 per adult **92%** of travellers recommend [](https://expedia.com/things-to-do/space-center-houston-admission-ticket.a1341309.activity-details) ![Astroville Tunnel Tour of Downtown Houston](https://mediaim.expedia.com/localexpert/1358845/93d97319-081a-4fec-9e57-9de4737dfee7.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Astroville Tunnel Tour of Downtown Houston (Air-Conditioned) $25 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/astroville-tunnel-tour-of-downtown-houston-air-conditioned.a1358845.activity-details) ![Houston Museum of Natural Science: Cockrell Butterfly Center](https://mediaim.expedia.com/localexpert/44625315/13581a0d-ea47-46d7-8fcf-d3fc7aa4909c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston Museum of Natural Science: Butterfly Center Ticket $15 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/houston-museum-of-natural-science-butterfly-center-ticket.a44625315.activity-details) ![Houston: Houston Botanic Garden Entry Ticket](https://mediaim.expedia.com/localexpert/46150646/bfc34474-c86f-4151-a485-5cc63efe2aab.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Houston Botanic Garden Entry Ticket $12 per adult **80%** of travellers recommend [](https://expedia.com/things-to-do/houston-houston-botanic-garden-entry-ticket.a46150646.activity-details) ![Houston: Sloomoo Institute Entry Ticket](https://mediaim.expedia.com/localexpert/48181877/0194cadc-0356-4ecd-a787-6fed90663fc8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Sloomoo Institute Entry Ticket $32 per adult [](https://expedia.com/things-to-do/houston-sloomoo-institute-entry-ticket.a48181877.activity-details) ![Houston: Children's Museum Houston Entry Ticket](https://mediaim.expedia.com/localexpert/48163948/762108e4-fa0f-48eb-a447-e33069884acf.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Children's Museum Houston Entry Ticket $20 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/houston-childrens-museum-houston-entry-ticket.a48163948.activity-details) [See all activities in Houston](https://expedia.com/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities) --- ## South Main Hotel Deals ![Wyndham Houston near NRG Park/Medical Center](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/99a71929_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Wyndham Houston near NRG Park/Medical Center 8686 Kirby Drive Houston TX $96 nightly $113 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful staff ... 7/10 Good! (1,256 reviews) Great bar Reviewed on Mar 22, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=21297&PinnedHotelID=21297&HadPinnedHotel=true®ionId=553248635976386992) ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/109ddc6c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 5353 Westheimer Rd Houston TX $105 nightly $122 total Apr 5 - Apr 6 Total with taxes and fees Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ... 8.4/10 Very Good! (3,580 reviews) Rooms were clean but it felt outdated. Took a long time just to check in. Reviewed on Mar 22, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=20116&PinnedHotelID=20116&HadPinnedHotel=true®ionId=553248635976386992) ![Hotel Zaza Houston Museum District](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/0f950f88_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Zaza Houston Museum District 5701 Main Street Houston TX $272 nightly $318 total Mar 29 - Mar 30 Total with taxes and fees Book a stay at this luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ... 9/10 Wonderful! (1,923 reviews) Very Beautiful and welcoming! Reviewed on Mar 19, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=3306&PinnedHotelID=3306&HadPinnedHotel=true®ionId=553248635976386992) ![The Royal Sonesta Houston Galleria](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/5506d9bf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Royal Sonesta Houston Galleria 2222 West Loop South Houston TX $144 nightly $168 total Apr 4 - Apr 5 Total with taxes and fees Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ... 8.6/10 Excellent! (1,703 reviews) The Staff was Outstanding from the reservation desk check in to the service at the bar, valet and house keeping! Reviewed on Mar 22, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F4%2F2026&endDate=4%2F5%2F2026&selected=878652&PinnedHotelID=878652&HadPinnedHotel=true®ionId=553248635976386992) ![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/d170df91_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Club Quarters Hotel Downtown, Houston 1085 Rusk Street Houston TX $110 nightly $128 total Mar 29 - Mar 30 Total with taxes and fees Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ... 8.6/10 Excellent! (4,064 reviews) Right in the heart of downtown! Reviewed on Mar 20, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=1156923&PinnedHotelID=1156923&HadPinnedHotel=true®ionId=553248635976386992) ![Blossom Hotel Houston, Curio Collection by Hilton](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/w3837h2505x3y0-1cfabad9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Blossom Hotel Houston, Curio Collection by Hilton 7118 Bertner Ave Houston TX $161 nightly $188 total Mar 29 - Mar 30 Total with taxes and fees Book a stay at this spa hotel in Houston. Enjoy a full-service spa, 2 bars/lounges, and a rooftop terrace. Our guests praise the pool and the helpful staff in ... 9/10 Wonderful! (3,756 reviews) The room was nice and clean staff super friendly Reviewed on Mar 22, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=58985846&PinnedHotelID=58985846&HadPinnedHotel=true®ionId=553248635976386992) [See all 6,410 properties in South Main](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F23%2F2026&endDate=3%2F24%2F2026®ionId=553248635976386992) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check South Main hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2026-03-22&endDate=2026-03-23)[Mar 22 - Mar 23](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2026-03-22&endDate=2026-03-23) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2026-03-23&endDate=2026-03-24)[Mar 23 - Mar 24](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2026-03-23&endDate=2026-03-24) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026)[Mar 27 - Mar 29](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026) --- ### Other neighborhoods around South Main ![Whether or not you're a little bit country, Rodeo Houston is a BLAST!! Each spring you're able to grab some great BBQ, catch some live country music acts, and check out the good looking cowboys riding for 8 seconds of fame!! A Texas MUST DO!](https://images.trvl-media.com/place/1503/18186f36-2267-4279-b375-1bb94762cced.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Astrodome 4/5(277 area reviews) If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station. [](https://expedia.com/Houston-Astrodome.dx553248635976007975) ![Aerial view of Hermann park in Houston with Japanese Garden, zoo](https://images.trvl-media.com/place/6143504/f45257e8-ab2c-4d2e-9332-ef0898a9cb17.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Texas Medical Center 4/5(569 area reviews) Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience. [](https://expedia.com/Houston-Texas-Medical-Center.dx6143504) ![TMC](https://images.trvl-media.com/place/1503/58fd4720-60ea-4071-96b7-0d260c453508.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Museum District Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city. [](https://expedia.com/Houston-Museum-District.dx6164045) ![TMC](https://images.trvl-media.com/place/1503/58fd4720-60ea-4071-96b7-0d260c453508.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### South Central Houston 4.5/5(75 area reviews) If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station. [](https://expedia.com/Houston-South-Central-Houston.dx553248635976476176) ![EyeEm Custom Shoots Q4 2018](https://images.trvl-media.com/place/3000663145/5fc14982-6419-4f20-a21b-2dee7a209053.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Montrose 4/5(128 area reviews) Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area. [](https://expedia.com/Houston-Montrose.dx3000663145) ![White Oak and Buffalo Bayou Rivers confluence, Downtown Houston, Texas, United States of America](https://images.trvl-media.com/place/553248635074842911/efd49955-b5d4-4334-9f25-c05c51a02456.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### River Oaks 5/5(1 area review) Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area. [](https://expedia.com/Houston-River-Oaks.dx553248635074842911) [See our Where To Stay guide](https://expedia.com/Houston.dx178265.Where-To-Stay?rfrr=TG.LP.Dest.Neigh.Neighborhoods) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # South Main, TX ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app