Isla Santa María Vacations from $587

Book a Hotel + Flight or Car together to unlock savings

Photo by Delen Wong

Your Isla Santa María Vacation

Amazing adventures await when you reserve a vacation package to Isla Santa María. Whether you're a foodie, history buff or just a traveler who loves to experience new places, there's something for everyone in this lively city. Post Office Bay is one of the top attractions to include on your sightseeing agenda during a trip to Isla Santa María. Expedia is here to help you escape the everyday. Tailor your vacation to Isla Santa María to suit your travel style, whatever that may be.

The Latest Isla Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Galapagos Native

Galapagos Native

3 out of 5
Price was $854, price is now $587 per person
$587
per person
Aug 21 - Aug 25
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
7.8/10 Good! (96 reviews)
Confortablenstop over for a family

Reviewed on Dec 28, 2024

Hotel Galapagos Tortuga Bay

Hotel Galapagos Tortuga Bay

2 out of 5
Price was $810, price is now $601 per person
$601
per person
Aug 21 - Aug 25
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
7.6/10 Good! (5 reviews)
The staff were really nice, they care about each person that stays in their hotel. Highly recommend.

Reviewed on Mar 2, 2023

Angermeyer Waterfront Inn

Angermeyer Waterfront Inn

3.5 out of 5
Price was $1,195, price is now $895 per person
$895
per person
Jul 5 - Jul 8
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9.4/10 Exceptional! (136 reviews)
Beautiful hotel, with friendly welcoming staff, awesome choice of meals, definitely recommend it! Easy to get to the town, a beach closeby and spacious rooms facing the waters....plenty of wildlife around

Reviewed on May 14, 2026

Galapagos Coliving Ecuador Casa Tuna

Galapagos Coliving Ecuador Casa Tuna

3 out of 5
Price was $751, price is now $602 per person
$602
per person
Aug 21 - Aug 25
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
No reviews
Ikala Galapagos Hotel

Ikala Galapagos Hotel

4 out of 5
Price was $1,042, price is now $836 per person
$836
per person
Jul 29 - Aug 1
found 15 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9.6/10 Exceptional! (147 reviews)
We stayed here for 4 nights and really liked it. All of the staff were very pleasant, professional, friendly and accommodating. One of the servers at the breakfast buffet even ran down the street to get an avocado for my vegan niece!! The beautiful restaurant is located on the roof top with nice views of the port and nice breezes blowing through, they even have room service!! The room was spacious with a nice covered deck where you could sit and watch the tropical rain. The a/c was nice and the shower had very good water pressure. The pool was closed for renovations on our first day, but opened the next day and it was so nice to be able to cool down after a hot day! It’s a beautiful blue tiled pool with the perfect temperature . We took advantage of the bikes they offer for free to ride around the quaint town. It is in a nice location, less than 5 minute walk to the docks, multiple restaurants , a deli with vegan options and killer vegan sorbet, an ATM and a super market! The hospital is very close. I would definitely stay here again and I highly recommend this hotel to others.

Reviewed on May 12, 2026

Don't see what you're looking for?
See all available trips from Columbus to Isla Santa María
View all trips

Discover the most popular places to visit in Isla Santa María

Punta Suarez

Punta Suarez

Explore the great outdoors at Punta Suarez, a lovely green space in Isla Santa María. Wander the seaside and white-sand beaches while you're in the area.

Punta Suarez
Post Office Bay

Post Office Bay

Commune with nature and explore the great outdoors at Post Office Bay during your travels in Isla Santa María. While you're in the area, wander around the natural setting.

Post Office Bay

What to do in Isla Santa María

Learn about the history of Floreana

Full Day Floreana Tour

$220
per adult
Full Day Floreana Tour
Galapagos Enchanting 3 Islands

Galapagos Enchanting 3 Islands (5 Days)

$1,349
per adult
Galapagos Enchanting 3 Islands (5 Days)
Faune seeing at the snorkeling

Full Day Santa Fe Playa escondida snorkeling tour

$230
per adult
Full Day Santa Fe Playa escondida snorkeling tour
See all activities in Isla Santa María

Isla Santa María Hotel Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $152 total per night from Jun 6 to Jun 7
$152 total
Jun 6 - Jun 7
9/10 Wonderful! (409 reviews)
"La atencion"

Reviewed on May 27, 2026

Hotel Fiesta
Maidith Galapagos Inn

Maidith Galapagos Inn

3 out of 5
Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
$93 nightly
The price is $93 total per night from Jun 15 to Jun 16
$93 total
Jun 15 - Jun 16
10/10 Exceptional! (138 reviews)
"Niko and his staff were VERY helpful and kind. They made breakfast from scratch every morning. If you couldn’t make breakfast due to a tour, you just had to tell him and he’d make a box lunch instead. He also gave us recommendations for places to eat and his phone number if needed. The Maidith was ..."

Reviewed on Jun 1, 2026

Maidith Galapagos Inn
Finch Bay Galapagos Hotel

Finch Bay Galapagos Hotel

4.5 out of 5
Barrio Punta Estrada Puerto Ayora Galapagos
$554 nightly
The price is $611 total per night from Jun 3 to Jun 4
$611 total
Jun 3 - Jun 4
9.4/10 Exceptional! (99 reviews)
"Highly recomended"

Reviewed on May 1, 2026

Finch Bay Galapagos Hotel
See all 221 properties in Isla Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Isla Santa María Vacation Packages

Isla Santa Marían Essential Information

Language
Spanish
Currency
U.S dollars
Local Welcome
¡Hola!
Local Goodbye
Adiós

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does an Isla Santa María vacation package cost?
You can grab a vacation package to this top destination from $587 on Expedia. However, how much your vacation to Isla Santa María costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Isla Santa María?
January, August and December are great times to search for cheap Isla Santa María vacation packages. Traveling in less busy months means you can typically find reduced prices on flights and hotels.
How many days is enough for Isla Santa María?
The ideal length of your Isla Santa María vacation depends on what you'd like to see. Usually, a handful of days to a week will give you time to check out all the top sights and explore some hidden treasures along the way.
How to find the best Isla Santa María package deals?
Start your search for an Isla Santa María package deal by entering your travel dates and destination under our "Packages" tab. Then select a few filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect Isla Santa María package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Isla Santa Marían escape underway.
Is it cheaper to book an Isla Santa María vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Isla Santa María vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Isla Santa María?
If you have your Isla Santa María vacation dates locked in, book as early as you can to snap up some terrific deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are great for jetting off on a whim.
How to plan a trip to Isla Santa María?

  1. Choose your travel dates: What you want to do in Isla Santa Marían and your preferred season will help you decide when to travel.
  2. Set a budget: Factor in costs such as transportation, flights and meals when working out how much to put aside for your trip to Isla Santa María. Then, select a property that matches your budget, whether that's an affordable option or a lavish getaway.
  3. Organize your Isla Santa María getaway with Expedia's trip planning tool: Look for and book stays and things to do all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Isla Santa María together.
  4. Decide your trip length: Think about how long you want to spend exploring Isla Santa María. Plan your days so you can get to all the attractions and experiences you're interested in at a leisurely pace.
  5. Bundle your flights and hotel: Awesome destination, check. Length of stay, check. All that's left now is to pick an Isla Santa María vacation package that brings all your bookings together.
  6. Add on experiences and excursions: Read our dedicated travel guide to find some incredible things to do in Isla Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Isla Santa María vacation packages?
If you're like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Isla Santa María trip across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can snap up cheap vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.