Large rocks and a sandy beach with sparse vegetation.
Photo by Delen Wong
Open Photo by Delen Wong

Isla Santa María Vacations from $491

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The Latest Isla Santa María Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Sep 5 - Sep 8

    Galapagos Native + Flight

    Puerto Ayora
    3 nights
    3.0 star property
    7.8/10 - Good (96 reviews)
    Roundtrip Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPSNonstop GPS - GYENonstop
    $637
    $491
    per traveler
    found 1 day ago
    Galapagos Native
  • Oct 11 - Oct 16

    Mi Playa Galapagos Beachfront + Flight

    Puerto Villamil
    5 nights
    3.0 star property
    9.4/10 - Exceptional (9 reviews)
    "Mi Playa offers unobstructed view and access to the beach. It is also a big space, perfect for families."
    Reviewed April 13, 2026
    Roundtrip Quito (UIO) - Santa Cruz Island (GPS)
    UIO - GPS1 stop GPS - UIONonstop
    Save 100% on your flight
    $1,708
    $1,255
    per traveler
    found 1 day ago
    Mi Playa Galapagos Beachfront
  • Aug 21 - Aug 24

    Hotel Albemarle Galapagos Beachfront + Flight

    Puerto Villamil
    3 nights
    3.5 star property
    9.0/10 - Wonderful (109 reviews)
    "Right on the beach! Exactly what we expected. Beautiful view— great staff."
    Reviewed July 12, 2026
    Roundtrip Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPSNonstop GPS - GYENonstop
    $971
    $715
    per traveler
    found 1 day ago
    Hotel Albemarle Galapagos Beachfront
  • Sep 20 - Sep 22

    Blu Galapagos Sustainable Waterfront Lodge + Flight

    Puerto Ayora
    2 nights
    4.0 star property
    8.8/10 - Excellent (131 reviews)
    Roundtrip Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPSNonstop GPS - GYENonstop
    $1,018
    $758
    per traveler
    found 1 day ago
    Blu Galapagos Sustainable Waterfront Lodge
  • Sep 20 - Sep 22

    BAY VIEW HOUSE + Flight

    Puerto Ayora
    2 nights
    3.5 star property
    10/10 - Exceptional (6 reviews)
    "I had a wonderful stay at this Bay View House  in the Galápagos Islands. The location was excellent, with easy access to local attractions, restaurants, and the waterfront. The hotel was very clean, well-maintained, and comfortable. The staff was friendly and helpful throughout my stay. The rooms were spacious, quiet, and nicely furnished, making it a great place to relax after a day of exploring. I highly recommend this hotel to anyone visiting the Galápagos."
    Reviewed June 9, 2026
    Roundtrip Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPSNonstop GPS - GYENonstop
    $727
    $546
    per traveler
    found 1 day ago
    BAY VIEW HOUSE

What to do in Isla Santa María

Isla Santa María Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

How much does an Isla Santa María vacation package cost?

You can grab a vacation package to this top destination from $491 on Expedia. However, how much your vacation to Isla Santa María costs will depend on factors like the season, length of stay and hotel choice.

What are the cheapest months to go to Isla Santa María?

January, August and December are great times to search for cheap Isla Santa María vacation packages. Traveling in less busy months means you can typically find reduced prices on flights and hotels.

How many days is enough for Isla Santa María?

The ideal length of your Isla Santa María vacation depends on what you'd like to see. Usually, a handful of days to a week will give you time to check out all the top sights and explore some hidden treasures along the way.

How to find the best Isla Santa María package deals?

Start your search for an Isla Santa María package deal by entering your travel dates and destination under our "Packages" tab. Then select a few filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect Isla Santa María package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Isla Santa Marían escape underway.

Is it cheaper to book an Isla Santa María vacation as a package?

Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Isla Santa María vacation by choosing your favorite airline, accommodation type and car class.

When to book a vacation package to Isla Santa María?

If you have your Isla Santa María vacation dates locked in, book as early as you can to snap up some terrific deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are great for jetting off on a whim.

How to plan a trip to Isla Santa María?

  1. Choose your travel dates: What you want to do in Isla Santa Marían and your preferred season will help you decide when to travel.
  2. Set a budget: Factor in costs such as transportation, flights and meals when working out how much to put aside for your trip to Isla Santa María. Then, select a property that matches your budget, whether that's an affordable option or a lavish getaway.
  3. Organize your Isla Santa María getaway with Expedia's trip planning tool: Look for and book stays and things to do all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Isla Santa María together.
  4. Decide your trip length: Think about how long you want to spend exploring Isla Santa María. Plan your days so you can get to all the attractions and experiences you're interested in at a leisurely pace.
  5. Bundle your flights and hotel: Awesome destination, check. Length of stay, check. All that's left now is to pick an Isla Santa María vacation package that brings all your bookings together.
  6. Add on experiences and excursions: Read our dedicated travel guide to find some incredible things to do in Isla Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Isla Santa María vacation packages?

If you're like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Isla Santa María trip across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can snap up cheap vacation packages with payment plans as soon as you spot them.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.