Photo by Ronald Wilson
Find all hotels by Red Roof Inn in Lake City, FL
Upfront pricing
Our total price for your stay includes taxes and fees
Treat yourself
Save 10% or more on over 100,000 hotels worldwide with Member Prices
Be picky
Search almost a million properties worldwide
Check prices for these dates
Compare rooms and suites by Red Roof Inn in Lake City with rates, reviews, and availability. Most hotels are fully refundable.
Find out more about Lake City
Find out more about Lake City
Red Roof Inn Lake City Hotel Guide
Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Red Roof Inn hotels in Lake City, Florida. Known for well-appointed rooms and friendly, personalized service, each of the top Red Roof Inn Lake City hotels guarantees an unparalleled level of comfort and quality.
You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Lake City Red Roof Inn locations may even offer extra little benefits and discounts for frequent travelers.
Recent reviews of Lake City hotels
Recent reviews of Lake City hotels

Home2 Suites by Hilton Lake City
5/5 Excellent
"Staff was so excellent and friendly. Hotel and room was clean. Felt safe. "
A verified traveler stayed at Home2 Suites by Hilton Lake City
Posted 1 day ago
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Hotels near Columbia County Courthouse
- Hotels near Lake City Columbia County Historical Museum
- Hotels near Lake DeSoto Farmers Market
- Hotels near Lake City Veterans Affairs Medical Center
- Hotels near Florida Department of Transportation
- Watertown Hotels
- Hotels near Southside Recreation Complex
- Hotels near Southside Sports Complex
- Hotels near Epiphany Catholic Church
- Hotels near Lake City Mall
- Hotels near The Country Club At Lake City
- Hotels near North Florida Speedway
- Hotels near Gar Pond
- Lulu Hotels
- Cabin Rentals in Lulu
- 4 Star Hotels in Lulu
- 3 Star Hotels in Lulu
- 5 Star Hotels in Lulu
- RV Parks in Lulu
- Motels in Lulu
- Hotels near Big Shoals State Park
- Wellborn Hotels
- Cabin Rentals in Wellborn
- Motels in Wellborn
- 4 Star Hotels in Wellborn
- 5 Star Hotels in Wellborn
- RV Parks in Wellborn
- Marriott Hotels & Resorts in White Springs
- Hilton Hotels in White Springs
- White Springs Hotels
- Hotels near Florida Nature and Heritage Tourism Center
- Cabin Rentals in White Springs
- Cottages in White Springs
- Cheap Hotels in White Springs
- Historic Hotels in White Springs
- B&B in White Springs
- Hotels with Restaurants in White Springs
- Romantic Hotels in White Springs
- RV Parks in White Springs
- Pet-friendly Hotels in White Springs
- Hotels with a Pool in White Springs
- Motels in White Springs
- Family Hotels in White Springs
- Quiet Resorts & in White Springs
- Vacation Homes in White Springs
- Olustee Hotels
- Cabin Rentals in Olustee
- RV Parks in Olustee
- Hotels near Stephen Foster State Folk Center
- Hotels near Stephen Foster Folk Culture Center
- Hotels near Osceola National Forest
- Hotels near Blue Sink Canoe Launch
- Hotels near Olustee Battlefield Historic State Park
- Hotels near Ichetucknee Springs State Park
- Hotels near Ichetucknee River
- La Quinta Inn & Suites Hotels in Fort White
- Marriott Hotels & Resorts in Fort White
- Fort White Hotels
- Cabin Rentals in Fort White
- Hotels with a View in Fort White
- Lake City Columbia County Historical Museum
- Lake DeSoto Farmers Market
- Florida Department of Transportation
- Southside Recreation Complex
- Southside Sports Complex
- Epiphany Catholic Church
- Pine Grove Baptist Church
- The Country Club At Lake City
- North Florida Speedway
- Lulu Vacations
- Big Shoals State Park
- Visit Wellborn
- Wellborn Vacations
- Florida Nature and Heritage Tourism Center
- Visit White Springs
- White Springs Vacations
- Visit Olustee
- Stephen Foster Folk Culture Center
- Blue Sink Canoe Launch
- Ichetucknee Springs State Park
- Visit Fort White
- Car rentals near Columbia County Courthouse
- Car rentals near Lake City Veterans Affairs Medical Center
- Car rentals near Florida Department of Transportation
- Car rentals near Watertown
- Car rentals near Lulu
- Avis Rental Cars in Lulu
- Enterprise Rental Cars in Lulu
- Dollar Rent A Car Rental Cars in Lulu
- Car rentals near Wellborn
- Car rentals near White Springs
- Car rentals near Ichetucknee Springs State Park
- Car rentals near Fort White