Lake Nona Medical City Vacations from $243
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Lake Nona Medical City Vacation
Our Lake Nona Medical City vacation packages are a simple and practical way to plan and book your next adventure. Experience the magic of this unique neighborhood without the hassle of organizing everything yourself. Need ideas about what to see during your trip to Lake Nona Medical City? University of Central Florida College of Medicine and Sanford-Burnham Medical Research Institute are two nearby attractions to stick on your to-do list. Don't just dream it — turn it into a reality! Lock in your perfect Lake Nona Medical City vacation with Expedia and experience travel your way.
The Latest Lake Nona Medical City Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Westgate River Ranch Resort & Rodeo
Save 100% on your flight
per person
Aug 23 - Aug 26
found 1 day ago
Roundtrip flight included
Philadelphia (PHL) to Orlando (MCO)
8/10 Very Good! (357 reviews)
Nice place. Kids had a good time. Not encouraged to go there if you are a minority. You wont feel welcomed. The staff is great, but the type of people that go there arent really folks that likely share the same interests as you do. There are Confederate flags all over; etc. Hotel rooms are no bueno, old. IF you want something nice, you need to spend the money glamping or have your own trailer.
Reviewed on Jun 24, 2025
Westgate Palace Hotel / Universal / I-Drive
International Drive District
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Orlando (MCO)
8.6/10 Excellent! (1,006 reviews)
Property needs some TLC, outside looks beautiful but the carpeting is old and needs replaced in the towers
Reviewed on Jul 16, 2025
Where to stay in Lake Nona Medical City
Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City
International Drive District
1 out of top 10 points of interest in this area
Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.
Lake Nona Medical City Hotel Deals
Hyatt Regency Orlando International Airport
9300 Jeff Fuqua Boulevard, Orlando, FL
Fully refundableReserve now, pay when you stay
$186 nightly
The price is $209 total per night from Jul 21 to Jul 22
$209 total
Jul 21 - Jul 22
Total includes taxes and fees
9.4/10 Exceptional! (3,371 reviews)
"It was easy to get to the room"
Reviewed on Jul 16, 2025
DoubleTree by Hilton at the Entrance to Universal Orlando
5780 Major Blvd, Orlando, FL
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $95 total per night from Aug 10 to Aug 11
$95 total
Aug 10 - Aug 11
Total includes taxes and fees
8.2/10 Very Good! (6,420 reviews)
"Amazing and quick services. Very close to Universal and shuttle services were fantastic."
Reviewed on Jul 18, 2025
Marriott's Grande Vista
5925 Avenida Vista, Orlando, FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $107 total per night from Aug 9 to Aug 10
$107 total
Aug 9 - Aug 10
Total includes taxes and fees
8.8/10 Excellent! (2,631 reviews)
"The grounds are nice to walk around and the room was clean and had everything we needed for a great trip. Having a washer/dryer is a huge plus! The staff was friendly and helpful. There is an adult pool that has three lap lanes, but it is adults only until 1pm. I wish they would extend those hours ..."
Reviewed on Jul 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Lake Nona Medical City
VA Medical Center at Lake Nona
4/5(13 reviews)
Though VA Medical Center at Lake Nona might be what brings you to town, perhaps you'll have a chance to explore more of Orlando while you are here.
Nemours Children's Hospital
4/5(5 reviews)
Though Nemours Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Orlando while you are here.
University of Central Florida College of Medicine
5/5(1 review)
Enjoy the collegiate vibe at University of Central Florida College of Medicine as part of your travels around Orlando. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.
Things to do
90 Minute Open Jump at a Trampoline Park in Kissimmee
$23
per adult
2-Hour Clear Kayak & Clear Paddleboard(SUP) Rental in Orlando
$45
per adult
100% of travellers recommend
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Orlando Hotels
- Hotels near Orlando Intl.
- Hotels near VA Medical Center at Lake Nona
- Hotels near University of Central Florida College of Medicine
- Hotels near Lake Nona
- Hotels near Nemours Children's Hospital
- Hilton Hotels in Lake Nona
- Pet-friendly Hotels in Lake Nona
- Golf Hotels in Lake Nona
- Extended Stay America Hotels in Lake Nona
- Luxury Hotels in Lake Nona
- 5 Star Hotels in Lake Nona
- Hotels with Bars in Lake Nona
- 4 Star Hotels in Lake Nona
- Hyatt Hotels in Lake Nona
- Hotels with Free Airport Shuttle in Lake Nona
- Hotels with a Gym in Lake Nona
- Hotels with Free Breakfast in Lake Nona
- Walt Disney World Resort in Lake Nona
- La Quinta Inn & Suites Hotels in Lake Nona
- Family Hotels in Lake Nona
- Wyndham Hotels in Lake Nona
- Hotels with a Pool in Lake Nona
- Hotels with Kitchenettes in Lake Nona
- Hotels with an Outdoor Pool in Lake Nona
- Extended Stay Hotels in Lake Nona
- Best Western Hotels in Lake Nona
- Hotels with Laundry Facilities in Lake Nona
- Business Hotels in Lake Nona
- Marriott Hotels & Resorts in Lake Nona
- Cheap Hotels in Lake Nona
- Romantic Hotels in Lake Nona
- Diamond Resorts in Lake Nona
- Motel 6 Hotels in Lake Nona
- Red Lion Hotels in Lake Nona
- Westgate Resorts in Lake Nona
- Hotels with Air Conditioning in Lake Nona
- Hotels with Connecting Rooms in Lake Nona
- Hotels with Free Parking in Lake Nona
- Delta Hotels in Lake Nona
- Adults Only Resorts & in Lake Nona
- Quiet Resorts & in Lake Nona
- Hotels on the Lake in Lake Nona
- Wyndham Extra Holidays Hotels in Lake Nona
- Hotels & Resorts for Couples in Lake Nona
- Non-Smoking Hotels in Lake Nona
- Hotels near Walt Disney World® Resort
- Flights to Orlando
- Flights to Florida
- Flights from New York (JFK) to Orlando (MCO)
- Flights from Boston (BOS) to Orlando (MCO)
- Flights from Philadelphia (PHL) to Orlando (MCO)
- Flights from Chicago (ORD) to Orlando (MCO)
- Flights from Detroit (DTW) to Orlando (MCO)
- Flights from Dallas (DFW) to Orlando (MCO)
- Flights from Los Angeles (LAX) to Orlando (MCO)
- Flights from Minneapolis (MSP) to Orlando (MCO)
- Flights from Raleigh (RDU) to Orlando (MCO)
- Flights from Miami (MIA) to Orlando (MCO)
- Flights from Charlotte (CLT) to Orlando (MCO)
- Flights from Hartford (BDL) to Orlando (MCO)
- Flights from Cleveland (CLE) to Orlando (MCO)
- Flights from Baltimore (BWI) to Orlando (MCO)
- Flights from Washington (DCA) to Orlando (MCO)
- Flights from Houston (HOU) to Orlando (MCO)
- Flights from Denver (DEN) to Orlando (MCO)
- Flights from Pittsburgh (PIT) to Orlando (MCO)
- Flights from Orlando Intl.
- Flights from Nashville (BNA) to Orlando (MCO)
- Flights from Indianapolis (IND) to Orlando (MCO)
- Flights from Cincinnati (CVG) to Orlando (MCO)
- Flights from Fort Lauderdale (FLL) to Orlando (MCO)
- Flights from Seattle (SEA) to Orlando (MCO)
- Car rental Orlando Airport (MCO)
- Car rentals near Orlando
- Car rentals near Nemours Children's Hospital
- Car rentals near Lake Nona
- Enterprise Rental Cars in Lake Nona
- Hertz Rental Cars in Lake Nona
- Luxury Car Rentals in Lake Nona
- Priceless Car Rental Rental Cars in Lake Nona
- Avis Rental Cars in Lake Nona
- Alamo Rent A Car Rental Cars in Lake Nona
- Nextcar Rental Cars in Lake Nona
- Dollar Rent A Car Rental Cars in Lake Nona
- Budget Rental Cars in Lake Nona
- Sixt Rental Cars in Lake Nona
- Thrifty Car Rental Rental Cars in Lake Nona
- Minivan Car Rentals in Lake Nona
- Economy Rent a Car Rental Cars in Lake Nona
- NÜ Car Rentals Rental Cars in Lake Nona
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.