Lake Nona Medical City Vacations from $243

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Your Lake Nona Medical City Vacation

Our Lake Nona Medical City vacation packages are a simple and practical way to plan and book your next adventure. Experience the magic of this unique neighborhood without the hassle of organizing everything yourself. Need ideas about what to see during your trip to Lake Nona Medical City? University of Central Florida College of Medicine and Sanford-Burnham Medical Research Institute are two nearby attractions to stick on your to-do list. Don't just dream it — turn it into a reality! Lock in your perfect Lake Nona Medical City vacation with Expedia and experience travel your way.

The Latest Lake Nona Medical City Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Westgate River Ranch Resort & Rodeo
ette hotel
Westgate Palace Hotel / Universal / I-Drive
Westgate Vacation Villas Resort
Seasons Florida Resort

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City

Lake Nona Medical City Hotel Deals

Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport

4 out of 5
9300 Jeff Fuqua Boulevard, Orlando, FL
Fully refundableReserve now, pay when you stay
$186 nightly
The price is $209 total per night from Jul 21 to Jul 22
$209 total
Jul 21 - Jul 22
Total includes taxes and fees
9.4/10 Exceptional! (3,371 reviews)
"It was easy to get to the room"

Reviewed on Jul 16, 2025

Hyatt Regency Orlando International Airport
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

4 out of 5
5780 Major Blvd, Orlando, FL
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $95 total per night from Aug 10 to Aug 11
$95 total
Aug 10 - Aug 11
Total includes taxes and fees
8.2/10 Very Good! (6,420 reviews)
"Amazing and quick services. Very close to Universal and shuttle services were fantastic."

Reviewed on Jul 18, 2025

DoubleTree by Hilton at the Entrance to Universal Orlando
Marriott's Grande Vista

Marriott's Grande Vista

4 out of 5
5925 Avenida Vista, Orlando, FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $107 total per night from Aug 9 to Aug 10
$107 total
Aug 9 - Aug 10
Total includes taxes and fees
8.8/10 Excellent! (2,631 reviews)
"The grounds are nice to walk around and the room was clean and had everything we needed for a great trip. Having a washer/dryer is a huge plus! The staff was friendly and helpful. There is an adult pool that has three lap lanes, but it is adults only until 1pm. I wish they would extend those hours ..."

Reviewed on Jul 15, 2025

Marriott's Grande Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Lake Nona Medical City

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.