Lake Nona Medical City Vacations from $240

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Your Lake Nona Medical City Vacation

Our Lake Nona Medical City vacation packages are a simple and practical way to plan and book your next adventure. Experience the magic of this unique neighborhood without the hassle of organizing everything yourself. Need ideas about what to see during your trip to Lake Nona Medical City? University of Central Florida College of Medicine and Sanford-Burnham Medical Research Institute are two nearby attractions to stick on your to-do list. Don't just dream it — turn it into a reality! Lock in your perfect Lake Nona Medical City vacation with Expedia and experience travel your way.

The Latest Lake Nona Medical City Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Palazzo Lakeside Hotel
Westgate Palace Hotel / Universal / I-Drive
Westgate Towers Resort
Westgate Lakes Resort & Spa Universal Studios Area
Westgate River Ranch Resort & Rodeo

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City

Lake Nona Medical City Hotel Deals

Marriott's Grande Vista
Marriott's Grande Vista
4 out of 5
5925 Avenida Vista, Orlando, FL
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $116 total per night from Jul 13 to Jul 14
$116 total
Jul 13 - Jul 14
Total includes taxes and fees
8.8/10 Excellent! (2,529 reviews)
"The room and areas around were clean and safe"

Reviewed on Jun 21, 2025

Marriott's Grande Vista
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
4 out of 5
8800 Vistana Centre Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $131 total per night from Jul 13 to Jul 14
$131 total
Jul 13 - Jul 14
Total includes taxes and fees
9.2/10 Wonderful! (3,073 reviews)
"My friends and I loved staying at this resort and especially in a villa!! The pools were amazing and it was in such a convenient area. We will definitely be returning!"

Reviewed on Jun 20, 2025

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Rosen Inn Lake Buena Vista
Rosen Inn Lake Buena Vista
3.5 out of 5
8442 Palm Parkway, Orlando, FL
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $71 total per night from Jul 20 to Jul 21
$71 total
Jul 20 - Jul 21
Total includes taxes and fees
8.4/10 Very Good! (5,174 reviews)
"Nice staff, good location (though a car helps). Free parking very welcome. Value is often good, though prices sometimes go above appropriate levels for this motel-style value find."

Reviewed on Jun 21, 2025

Rosen Inn Lake Buena Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Lake Nona Medical City

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.