Lake Nona Medical City Vacations from $183

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Your Lake Nona Medical City Vacation

Our Lake Nona Medical City vacation packages are a simple and practical way to plan and book your next adventure. Experience the magic of this unique neighborhood without the hassle of organizing everything yourself. Need ideas about what to see during your trip to Lake Nona Medical City? University of Central Florida College of Medicine and Sanford-Burnham Medical Research Institute are two nearby attractions to stick on your to-do list. Don't just dream it — turn it into a reality! Lock in your perfect Lake Nona Medical City vacation with Expedia and experience travel your way.

The Latest Lake Nona Medical City Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Palazzo Lakeside Hotel
Westgate Palace Hotel / Universal / I-Drive
ette hotel
Westgate River Ranch Resort & Rodeo
Westgate Lakes Resort & Spa Universal Studios Area

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City

Lake Nona Medical City Hotel Deals

Hyatt Regency Orlando International Airport
Hyatt Regency Orlando International Airport
4 out of 5
9300 Jeff Fuqua Boulevard, Orlando, FL
Fully refundableReserve now, pay when you stay
$203 nightly
The price is $229 total per night from Jul 21 to Jul 22
$229 total
Jul 21 - Jul 22
Total includes taxes and fees
9.4/10 Exceptional! (3,383 reviews)
"Beautiful property, conveniently located I Terminal B. Excellent food."

Reviewed on Jul 15, 2025

Hyatt Regency Orlando International Airport
DoubleTree by Hilton at the Entrance to Universal Orlando
DoubleTree by Hilton at the Entrance to Universal Orlando
4 out of 5
5780 Major Blvd, Orlando, FL
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $95 total per night from Aug 4 to Aug 5
$95 total
Aug 4 - Aug 5
Total includes taxes and fees
8.2/10 Very Good! (6,474 reviews)
"Convenient for visiting Iniversal, large rooms with great beds, lovely large pool area, helpful staff, could have more and better restaurants or addition food options. Very useable transportation to Universal."

Reviewed on Jul 15, 2025

DoubleTree by Hilton at the Entrance to Universal Orlando
Marriott's Grande Vista
Marriott's Grande Vista
4 out of 5
5925 Avenida Vista, Orlando, FL
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $107 total per night from Aug 5 to Aug 6
$107 total
Aug 5 - Aug 6
Total includes taxes and fees
8.8/10 Excellent! (2,625 reviews)
"This hotel was excellent. It is close to all the attractions. Has a resort-like feel with many amenities during the day & night. The staff was also friendly. Hotel was clean. I would recommending staying here if you have a family or just coupling up, this place was great."

Reviewed on Jul 14, 2025

Marriott's Grande Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Lake Nona Medical City

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.