Lake Nona Vacations from $148

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Your Lake Nona Vacation

Experience all the wonderful things this neighborhood has to offer with a tailor-made Lake Nona vacation package. However you imagine spending your days here, you'll find endless opportunities for relaxation, fun and adventure. Start your trip to Lake Nona by visiting nearby attractions such as University of Central Florida College of Medicine, Sanford-Burnham Medical Research Institute and David Leadbetter Golf Academy. Expedia can put your travel plans into action. Book your dream Lake Nona vacation today.

The Latest Lake Nona Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Palazzo Lakeside Hotel
Westgate Palace Hotel / Universal / I-Drive
Westgate Lakes Resort & Spa Universal Studios Area
Westgate Blue Tree Resort in Lake Buena Vista
Westgate Cocoa Beach Resort

Where to stay in Lake Nona

Find the best Lake Nona areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona

Lake Nona Hotel Deals

Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport

4 out of 5
9300 Jeff Fuqua Boulevard, Orlando, FL
Fully refundableReserve now, pay when you stay
$180 nightly
The price is $203 total per night from Oct 20 to Oct 21
$203 total
Oct 20 - Oct 21
Total with taxes and fees
9.4/10 Exceptional! (3,640 reviews)
"Clean room"

Reviewed on Oct 8, 2025

Hyatt Regency Orlando International Airport
Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

3.5 out of 5
6550 Adventure Way, Orlando, FL
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $150 total per night from Nov 5 to Nov 6
$150 total
Nov 5 - Nov 6
Total with taxes and fees
8.8/10 Excellent! (5,365 reviews)
"Rooms need to be cleaned better."

Reviewed on Oct 9, 2025

Universal's Cabana Bay Beach Resort
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $103 total per night from Nov 2 to Nov 3
$103 total
Nov 2 - Nov 3
Total with taxes and fees
9.2/10 Wonderful! (3,633 reviews)
"Nice area, lots to do, very cost effective compared to other resorts in area"

Reviewed on Oct 6, 2025

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Lake Nona

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.