Las Guías Vacations from $884

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Las Guías vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,201, price is now $884 per person
$884
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (5,733 reviews)
S

Reviewed on Jul 25, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,675, price is now $956 per person
$956
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,014 reviews)

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $1,951, price is now $1,117 per person
$1,117
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,593 reviews)
N

Reviewed on Jul 25, 2026

Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Save 100% on your flight
Price was $2,062, price is now $1,283 per person
$1,283
per person
Sep 17 - Sep 23
found 1 day ago
Roundtrip flight included
Georgetown (GEO) to Panama City (PTY)
8.6/10 Excellent! (1,709 reviews)
Desayuno super bueno. Excelente ubicación con acceso exclusivo al Mall a través de un puente peatonal. Cerca de Avenida Balboa donde se ve el mar. Lo único fue que éramis 3 huéspedes y siempre dejaban 2 qguas y 2 toallas y había q estar llamando para que subieran 1 más.

Reviewed on Jul 24, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was $1,245, price is now $895 per person
$895
per person
Sep 3 - Sep 7
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,818 reviews)
Loved our stay. Staff wonderful.

Reviewed on Jul 24, 2026

Don't see what you're looking for?
See all available trips from Columbus to Las Guías
View all trips

Las Guías Hotel Deals

Hotel Mykonos Panama

Hotel Mykonos Panama

3.5 out of 5
Panamerican Highway Nuevo Santiago Veraguas
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $110 total per night from Jul 26 to Jul 27
$110 total
Jul 26 - Jul 27
Total with taxes and fees
8.8/10 Excellent! (587 reviews)
"Excelente hotel . Muy amable el personal. Buena situación. Todo limpio. Las camas muy buenas. Todo bien"

Reviewed on Jul 12, 2026

Hotel Mykonos Panama
Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana Santiago Veraguas
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $63 total per night from Aug 14 to Aug 15
$63 total
Aug 14 - Aug 15
Total with taxes and fees
Hotel Gran David
HOTEL VISTA LAGO

HOTEL VISTA LAGO

3 out of 5
Rincón Largo La Pena Santiago de Veraguas
Fully refundableReserve now, pay when you stay
$74 nightly
The price is $82 total per night from Aug 5 to Aug 6
$82 total
Aug 5 - Aug 6
Total with taxes and fees
9.4/10 Exceptional! (119 reviews)
"Tiene una vista agradable. Hay silencio. Buen desayuno."

Reviewed on Jul 24, 2026

HOTEL VISTA LAGO
See all 21 properties in Las Guías
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Las Guías Vacation Packages

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How to find the best Las Guías package deals?
Finding a cheap Las Guías package deal is a breeze with Expedia. After you've entered your destination and trip dates under our "Packages" tab, set your budget, apply a few filters and browse what's available. You can tweak your search by "Amenities," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Las Guías package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are typically lower.
When to book a vacation package to Las Guías?
Score incredible bargains by booking your flights early with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for an impromptu Las Guías adventure.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.