Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Los Cabos One&Only Resorts Hotels

See all 368 Hotels in Los Cabos
One&Only Palmilla Resort

One&Only Palmilla Resort

Km 7.5 Carretera Transpeninsular, San Jose Del Cabo
5.0 out of 5.0
4.9 out of 5 (140 reviews)
My husband and I celebrated our 22nd Anniversary here. Everything was absolutely amazing!! We can't … - 

$785

$785
Map

Recently booked Los Cabos hotels

Riu Santa Fe All Inclusive
3.5 out of 5.0
Last booking: 36 minutes ago
Dreams Los Cabos Suites Golf Resort & Spa All Inclusive
4.0 out of 5.0
Last booking: 58 minutes ago
Solmar Resort
3.5 out of 5.0
Last booking: 1 hour ago
Riu Palace Cabo San Lucas All Inclusive
4.0 out of 5.0
Last booking: 1 hour ago
Seven Crown Express & Suites Cabo San Lucas
2.0 out of 5.0
Last booking: 1 hour ago
Tropicana Inn
3.0 out of 5.0
Last booking: 2 hours ago
Royal Solaris Los Cabos & Spa - All Inclusive
3.5 out of 5.0
Last booking: 3 hours ago
Grand Solmar Lands End Resort and Spa
4.5 out of 5.0
Last booking: 3 hours ago
One&Only Palmilla Resort
5.0 out of 5.0
Last booking: 4 hours ago

One&Only Resorts Los Cabos Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of One&Only Resorts hotels in Los Cabos, Baja California Sur. Known for well-appointed rooms and friendly, personalized service, each of the top One&Only Resorts Los Cabos hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Los Cabos One&Only Resorts locations may even offer extra little benefits and discounts for frequent travelers.