Title: Madison County Vacation Packages 2026 from $451 | Expedia.com [Madison County Hotels](https://expedia.com/Destinations-In-Madison-County.d553248635976433936.Hotel-Destinations)[Vacation Rentals in Madison County](https://expedia.com/Destinations-In-Madison-County.d553248635976433936.Vacation-Rental-Destinations)[Madison County Flights](https://expedia.com/Destinations-In-Madison-County.d553248635976433936.Flight-Destinations)[Car Rentals in Madison County](https://expedia.com/Destinations-In-Madison-County.d553248635976433936.Car-Rental-Destinations) ![](https://images.trvl-media.com/place/6053585/8c7339a9-8f54-4d4c-a8cb-a60a50c3cafd.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Madison County Vacations & Trips from $451 ## Book a Hotel + Flight or Car together to unlock savings Photo by Morgan O'riley - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Madison County Vacation When adventure calls, answer it with a tailor-made vacation package to Madison County. Wherever you're headed and whatever you have planned, prepare to experience a destination with plenty to offer. Want to know where to go on your trip to Madison County? [Fredericktown](https://www.expedia.com/Fredericktown.d55114.Destination-Travel-Guides) is a leading city you won't want to miss. When it's time to stop dreaming and start traveling, Expedia will help turn your Madison County vacation into reality. ## Top destinations in Madison County ![Castor River Shut-Ins Fredericktown Missouri Ozarks](https://images.trvl-media.com/place/55114/91abb0ab-7f41-436b-8c30-7968c3ac1879.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Fredericktown [](https://expedia.com/Fredericktown.d55114.Destination-Travel-Guides) ## The Latest Madison County Vacation Packages Price found within the past 48 hours. Click for updated prices. ![University Inn of Carbondale](https://images.trvl-media.com/lodging/60000000/59970000/59964600/59964501/e36c2c4c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### University Inn of Carbondale $451 per person Jun 12 - Jun 19 found 7 hours ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 6/10 (349 reviews) The room was alright, it needed cleaned a litter better..... The staff on the kiosk, was nice, however, the woman was not very kind at all Reviewed on Jan 22, 2026 ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Drury Plaza Hotel Cape Girardeau Conference Center $754 per person Jun 12 - Jun 19 found 7 hours ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 9.6/10 Exceptional! (1,001 reviews) Beds were clean and well made however carpet in room was stained. There was a chicken nugget on the floor in the elevator upon arrival and was still there the next morning. Breakfast was good except for preparer wiping her nose with her plastic serving gloves on. Good coffee and easy check in. Reviewed on Mar 20, 2026 ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau $613 per person Jun 12 - Jun 19 found 7 hours ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 9/10 Wonderful! (720 reviews) Hotel staff were friendly and helpful. Store and restaurants were a short drive away. Reviewed on Mar 17, 2026 ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG $735 per person Jun 12 - Jun 19 found 7 hours ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 9.4/10 Exceptional! (1,007 reviews) This hotel was recommended by a friend of ours. The hotel staff were great. It was clean and quiet. Me and my husband enjoyed our stay. Reviewed on Mar 22, 2026 ![Holiday Inn Carbondale-Conference Center by IHG](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/189476cd_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Holiday Inn Carbondale-Conference Center by IHG $689 per person Jun 12 - Jun 19 found 7 hours ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 8.8/10 Excellent! (660 reviews) Clean and well taken care of. Breakfast was amazing. Staff was on top of everything! Reviewed on Mar 9, 2026 ## Find the Best Madison County Vacation Packages ## Madison County Essential Information | Language | English | | --------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | U.S dollars | | Closest Airport | Lambert-St. Louis Intl. Airport (STL) | | Top Sights | [Millstream Gardens Conservation Area](https://www.expedia.com/Millstream-Gardens-Conservation-Area-Fredericktown.d553248621592517773.Vacation-Attraction), [Silver Mine Recreation Area](https://www.expedia.com/Silver-Mine-Recreation-Area-Fredericktown.d553248621592517772.Vacation-Attraction) and [Millstream Gardens Conservation Area](https://www.expedia.com/Millstream-Gardens-Conservation-Area-Fredericktown.d553248621592517773.Vacation-Attraction) | ## Madison County Hotel Deals ![St Francis River: The Blue Yurt and Hot Tub](https://images.trvl-media.com/lodging/104000000/103280000/103277100/103277006/152bb922_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### St Francis River: The Blue Yurt and Hot Tub Fredericktown MO $196 nightly $212 total Mar 23 - Mar 24 Total with taxes and fees 8.8/10 Excellent! (20 reviews) Everything was easy to understand to find the place I wanted. Host is 5 stars Reviewed on Jan 2, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=103277006&PinnedHotelID=103277006&HadPinnedHotel=true®ionId=553248635976433936) ![Madison Inn Lodge](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/db122c9a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Madison Inn Lodge 730 Plaza Drive Fredericktown MO Fully refundableReserve now, pay when you stay $88 nightly $96 total Mar 23 - Mar 24 Total with taxes and fees 7.6/10 Good! (298 reviews) Rooms were clean! Beds were comfortable, and the staff were very accommodating. Reviewed on Mar 18, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=59960&PinnedHotelID=59960&HadPinnedHotel=true®ionId=553248635976433936) ![Micro house cabin located near Silver Mines Recreation Area.](https://images.trvl-media.com/lodging/67000000/66890000/66883200/66883194/a2da870a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Micro house cabin located near Silver Mines Recreation Area. Fredericktown MO 10/10 Exceptional! (79 reviews) This is an awesome cozy little cabin! Reviewed on Mar 17, 2026 [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=66883194&PinnedHotelID=66883194&HadPinnedHotel=true®ionId=553248635976433936) [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=66883194&PinnedHotelID=66883194&HadPinnedHotel=true®ionId=553248635976433936) [See all 200 properties in Madison County](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F23%2F2026&endDate=3%2F24%2F2026®ionId=553248635976433936) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf 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[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) Explore a world of travel with Expedia ## Other vacations you might like - Top cities in Madison County - Vacations and getaways similar to Madison County - Best vacation destinations by month - [Fredericktown Vacations ](https://expedia.com/Fredericktown.d55114.Destination-Travel-Guides) - [Tennessee Vacations ](https://expedia.com/Tennessee.d244.Destination-Travel-Guides) - [Kentucky Vacations ](https://expedia.com/Kentucky.d219.Destination-Travel-Guides) - [Illinois Vacations ](https://expedia.com/Illinois.d215.Destination-Travel-Guides) - [Arkansas Vacations ](https://expedia.com/Arkansas.d205.Destination-Travel-Guides) - [Oklahoma Vacations 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](https://www.expedia.com/lp/b/where-to-go/vacations-august) - [September Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-september) - [October Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-october) - [November Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-november) - [December Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-december) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app