Doe Run Vacations from $348

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Doe Run Vacation

Take the stress out of organizing your next big adventure with a Doe Run vacation package. Whether you're visiting for its history, food or something else, this city offers limitless opportunities for discovery. Looking for some sightseeing inspiration for your trip to Doe Run? St. Joe State Park and Crown Pointe Golf Club are two leading attractions here. Browse Expedia's wide range of travel options and start organizing your dream vacation to Doe Run today.

The Latest Doe Run vacation packages

Price found within the past 48 hours. Click for updated prices.
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
Price was $383, price is now $348 per person
$348
per person
Dec 3 - Dec 6
found 20 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
6.8/10 (143 reviews)
Clean Room

Reviewed on Oct 26, 2026

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
Price was $1,070, price is now $1,017 per person
$1,017
per person
Jan 24 - Jan 30
found 1 day ago
Roundtrip non-stop flight included
Manhattan (MHK) to Cape Girardeau (CGI)
8/10 Very Good! (1,003 reviews)
The hallways reeked of marijuana smoke. Changed hotels the second night.

Reviewed on Nov 2, 2026

Perryville RV Resort

Perryville RV Resort

2 out of 5
Price was $373, price is now $355 per person
$355
per person
Dec 3 - Dec 6
found 20 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
8.8/10 Excellent! (8 reviews)

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
Price was $424, price is now $405 per person
$405
per person
Dec 3 - Dec 6
found 20 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to Cape Girardeau (CGI)
9.2/10 Wonderful! (638 reviews)

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
Price was $1,133, price is now $1,087 per person
$1,087
per person
Jan 24 - Jan 30
found 1 day ago
Roundtrip non-stop flight included
Manhattan (MHK) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,003 reviews)
Was really impressed, I don’t normally write reviews. Free drinks and food in the evening, lovely staff. clean room. Was really a cut above.

Reviewed on Nov 1, 2026

Don't see what you're looking for?
See all available trips from Columbus to Doe Run
View all trips

Doe Run Hotel Deals

16 Acres of beauty and relaxation

16 Acres of beauty and relaxation

Park Hills MO
9.8/10 Exceptional! (30 reviews)
"The place was spotless and directions to the property were good. Everything about the place was as described and quite nice. Wish I could have stayed longer."

Reviewed on Aug 7, 2026

Get rates
16 Acres of beauty and relaxation
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$54 nightly
The price is $62 total per night from Nov 10 to Nov 11
$62 total
Nov 10 - Nov 11
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
$133 nightly
The price is $151 total per night from Dec 3 to Dec 4
$151 total
Dec 3 - Dec 4
Total with taxes and fees
10/10 Exceptional! (119 reviews)
"Limpio,muy fácil el check in cómodo y limpio."

Reviewed on Nov 2, 2026

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
See all 171 properties in Doe Run
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Doe Run Vacation Packages

Doe Run Essential Information

Language
English
Currency
U.S dollars
Population
920
Top Sights
Twin Oaks Vineyard & Winery, Sand Creek Winery and Crown Pointe Golf Club

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Doe Run vacation package cost?
You can snap up a vacation package to this destination from $348 on Expedia. However, how much your vacation to Doe Run costs will depend on factors like your hotel choice, length of stay and season.
What are the cheapest months to go to Doe Run?
If you're looking to book a cheap Doe Run vacation package, consider planning a trip in February, September and December. You'll typically find better prices on airfares and hotels during these months — perfect for travelers wishing to save money.
How many days is enough for Doe Run?
Usually, a handful of days is enough to visit the top attractions during your Doe Run vacation. But if you prefer to have time to unwind or go on day tours, think about extending your itinerary.
How to find the best Doe Run package deals?
Begin your search for a Doe Run package deal by entering your destination and preferred travel dates under our "Packages" tab. Then add a few filters, like "Property type" and "Amenities," to fine-tune the results to your exact needs. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the perfect Doe Run package deal straight away, simply play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Doe Run escape underway.
Is it cheaper to book a Doe Run vacation as a package?
An Expedia vacation package could land you great savings when compared to booking hotels and flights separately. Better still, you can personalize your Doe Run trip to match your exact style. Choose your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Doe Run?
If you've got your Doe Run vacation dates locked in, book early to grab some awesome deals. With Expedia, you can typically reserve some flights up to a year in advance. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Doe Run vacation packages?
Your Doe Run break should be an escape from your daily routine, not a reason for money-related stress. So to give you that extra flexibility, we've teamed up with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and spread the total cost over 3, 6 or 12 months. Plus, there are no hidden costs or late payment fees to worry about.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.