Medical Center District Vacation Packages 2026 from $558

Your Medical Center District Vacation

Experience all the wonderful things this neighborhood has to offer with a tailor-made Medical Center District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, adventure and relaxation. Your trip to Medical Center District wouldn't be complete without a visit to major attractions nearby such as University of Texas Health and Science Center at San Antonio, Huebner Oaks and Wonderland of the Americas Mall. Expedia can help you turn your ideal Medical Center District vacation into reality, whatever your budget or travel plans.

The Latest Medical Center District Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Tx Home Group- San Antonio

Midtown

$558

per person

Oct 26 - Oct 30

just found

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to San Antonio (SAT)

7.8/10 Good! (10 reviews)

Hyatt Regency Hill Country Resort and Villas

Far West Side

Save 100% on your flight

$1,358

per person

Dec 10 - Dec 15

found 1 day ago

Roundtrip flight included

New York (JFK) to San Antonio (SAT)

8.8/10 Excellent! (1,001 reviews)

Very clean room and facilities! The room was very spacious (we had a 1 king bed room) and designed to be very homey. The lazy river and slide were the highlight for my husband and 6 year old, spent all day there with poolside food service. The lagoon was beautiful and clean, and it’s probably best for toddlers or families who want some quiet calm swim time (whereas the lazy river and slide area are more exciting). One tip about the lagoon—id say about 40% of it is roped off as a swim area near the shore, while the rest of it is for rental boating only, so my high energy 6 year was a bit disappointed that he couldn’t swim out far into the lagoon. That being said it’s a beautiful spot to relax and have some peace and quiet.

Reviewed on Sep 20, 2026

Hotel Contessa

Downtown San Antonio

$663

per person

Dec 17 - Dec 20

found 4 hours ago

Roundtrip flight included

Chicago (CHI) to San Antonio (SAT)

9/10 Wonderful! (3,885 reviews)

The St. Anthony, A Luxury Collection Hotel, San Antonio

Downtown San Antonio

$836

per person

Dec 17 - Dec 20

found 1 day ago

Roundtrip flight included

Chicago (CHI) to San Antonio (SAT)

8.8/10 Excellent! (1,005 reviews)

Club Wyndham La Cascada

Downtown San Antonio

$855

per person

Dec 10 - Dec 15

found 1 day ago

Roundtrip flight included

New York (JFK) to San Antonio (SAT)

8.4/10 Very Good! (182 reviews)

Muy buen servicio todo muy limpio

Reviewed on Aug 1, 2026

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District

A boat tour on a canal with a bridge in the background.

Downtown San Antonio

5 out of top 10 points of interest in this area

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

An old church with a bell tower and arches, surrounded by greenery and a stone structure.

Far West Side

1 out of top 10 points of interest in this area

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

A city skyline reflected in a calm body of water, a bridge, and a sunset sky.

Uptown Central

While visiting Uptown, you might make a stop by sights like Marion Koogler McNay Art Museum and Alamo Quarry Market.

A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Convocation Center.

A vast landscape with a winding road, dense forest, and a clear blue sky.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.

Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

4431 Horizon Hill Blvd San Antonio TX

Fully refundableReserve now, pay when you stay

$89 nightly

$105 total

Sep 23 - Sep 24

Total with taxes and fees

8.4/10 Very Good! (3,673 reviews)

"I was overcharged and they would not honor the price I had reserved the room for. Had to switch rooms twice because the first room had a horrible smell inside of it. The second room did not have functioning toilets. The room we ended up staying in only had 1 working A/C. The rooms appeared old and ..."

Reviewed on Sep 21, 2026

Drury Inn & Suites San Antonio Northwest Medical Center

9806 Interstate Hwy 10 W San Antonio TX

Fully refundableReserve now, pay when you stay

$90 nightly

$106 total

Oct 1 - Oct 2

Total with taxes and fees

Courtyard by Marriott Medical Center San Antonio

8585 Marriott Dr San Antonio TX

Fully refundableReserve now, pay when you stay

$89 nightly

$105 total

Oct 2 - Oct 3

Total with taxes and fees

See all 4,860 properties in Medical Center District

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.