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Find hotels in Medical Center District, San Antonio from $67
Most hotels are fully refundable. Because flexibility matters.
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Discover 3,955 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.
320 Bonham, San Antonio, TX
Fully refundable
The price is $109 per night from Oct 26 to Oct 27
$109
per night
Oct 26 - Oct 27
8.6/10 Excellent! (1,154 reviews)
"It was such a cool historical hotel. Very pretty inside. Rooms are older but clean and well kept. Super convenient to the Riverwalk and I am so glad I picked the crocket for my 1st stay in San Antonio."
Reviewed on Sep 30, 2023
150 E Houston St, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $199 per night from Oct 8 to Oct 9
$199
per night
Oct 8 - Oct 9
8.8/10 Excellent! (1,790 reviews)
"Had a bottle of wine waiting in room when arrived. Nice sized room, comfortable bed and linens. Quiet hotel, elegant lobby and common area. Didn’t eat at hotel so can’t comment there. Hotel staff very friendly and helpful. Good location in downtown; walkable to downtown sights….Alamo, river, dining. ..."
Reviewed on Oct 2, 2023
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $167 per night from Oct 8 to Oct 9
$167
per night
Oct 8 - Oct 9
8.8/10 Excellent! (2,586 reviews)
"Very nice!"
Reviewed on Oct 2, 2023
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105 N Alamo, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $119 per night from Oct 4 to Oct 5
$119
per night
Oct 4 - Oct 5
9/10 Wonderful! (2,285 reviews)
Nice, but not super
"Nice old hotel, incredibly close to the Alamo On the top floor a constant noise from probably the cooling units on the roof With the bed headbord against the window side of the room the view was verry limited, and the cold air from the AC would fall down on the bed"
Reviewed on Oct 3, 2023
420 W Market St, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $193 per night from Oct 12 to Oct 13
$193
per night
Oct 12 - Oct 13
8.6/10 Excellent! (1,006 reviews)
"This hotel was renovated several years ago and is in good shape. It has traditional furniture with a comfortable lobby, and several sitting nooks that look out over the Riverwalk. The room had all the amenities you would expect in a hotel of this class. The bed was not as firm as I would have liked. ..."
Reviewed on Oct 1, 2023
850 Halm Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $80 per night from Oct 9 to Oct 10
$80
per night
Oct 9 - Oct 10
7.6/10 Good! (2,258 reviews)
"Amazing service"
Reviewed on Sep 30, 2023
1111 NE Loop 410, San Antonio, TX
Fully refundable
The price is $89 per night from Oct 8 to Oct 9
$89
per night
Oct 8 - Oct 9
8.2/10 Very Good! (435 reviews)
"The second time staying here. Always a good experience"
Reviewed on Oct 3, 2023
4800 Woodstone Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $67 per night from Oct 8 to Oct 9
$67
per night
Oct 8 - Oct 9
8.2/10 Very Good! (1,106 reviews)
"Good value for money. Clean, good size, nice dining options within minutes drive distance. Feels safe and friendly staff"
Reviewed on Oct 2, 2023
408 East Houston Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $135 per night from Oct 10 to Oct 11
$135
per night
Oct 10 - Oct 11
8.2/10 Very Good! (1,002 reviews)
"Had a great time staff was nice and very helpful"
Reviewed on Sep 29, 2023
212 W Crockett Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $269 per night from Oct 8 to Oct 9
$269
per night
Oct 8 - Oct 9
9.4/10 Exceptional! (1,002 reviews)
"Gorgeous property Absolutely impeccable service. They were even pretty cool about it when we threw a few ice cubes at people from the balcony. Not pushovers or anything, but understanding and sort of funny about it all."
Reviewed on Oct 1, 2023
603 Navarro St, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $118 per night from Oct 22 to Oct 23
$118
per night
Oct 22 - Oct 23
8/10 Very Good! (1,000 reviews)
"The location is perfect and there is a public parking garage right across the street that is much more reasonable than the valet, especially if you're not taking your car in and out a lot. Clean property and the kitchenette is helpful for snacks and reheats."
Reviewed on Oct 1, 2023
115 Lexington Avenue, San Antonio, TX
Fully refundable
The price is $259 per night from Oct 8 to Oct 9
$259
per night
Oct 8 - Oct 9
8.8/10 Excellent! (399 reviews)
"I had a wonderful time doing me stay."
Reviewed on Sep 30, 2023
9821 Colonnade Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $111 per night from Oct 8 to Oct 9
$111
per night
Oct 8 - Oct 9
8.2/10 Very Good! (1,007 reviews)
"Good place"
Reviewed on Oct 2, 2023
600 S Santa Rosa Ave, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $114 per night from Oct 24 to Oct 25
$114
per night
Oct 24 - Oct 25
8.6/10 Excellent! (1,002 reviews)
"We enjoyed our stay at the hotel. It was very comfortable and quiet."
Reviewed on Sep 29, 2023
1103 E Commerce Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $99 per night from Oct 8 to Oct 9
$99
per night
Oct 8 - Oct 9
9/10 Wonderful! (98 reviews)
Best Anniversary Ever
"Amazing and just what we needed for our anniversary. Room was spacious and comfortable. Staff friendly and helpful. Thanks for making this trip Great!"
Reviewed on Sep 28, 2023
830 N Saint Marys St, San Antonio, TX
Fully refundable
The price is $113 per night from Oct 15 to Oct 16
$113
per night
Oct 15 - Oct 16
7.8/10 Good! (1,001 reviews)
Excellent place
"Was wonderful stay , nice and quiet and staff friendly"
Reviewed on Sep 27, 2023
8902 Jones Maltsberger Rd, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is $93 per night from Oct 10 to Oct 11
$93
per night
Oct 10 - Oct 11
8.2/10 Very Good! (1,003 reviews)
"Extra comfy bed and quiet"
Reviewed on Sep 26, 2023
114 Soledad, San Antonio, TX
The price is $144 per night from Oct 10 to Oct 11
$144
per night
Oct 10 - Oct 11
8.4/10 Very Good! (1,051 reviews)
Awesome
"We had an amazing time at this hotel"
Reviewed on Sep 24, 2023
