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Melpignano Vacation Rentals

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Our top choices for Melpignano vacation rentals

Residence in Santa Cesarea Terme

Villa Raffaella
4.0 star property
9.2 out of 10, Wonderful, (38)
"This is a very comfortable, beautiful place with a great breakfast. It’s located near the sea and thermal baths. I really enjoyed my stay!"
United States
Maurice
$107 nightly
The price is $118
Dec 29 - Dec 30
Total with taxes and fees
Villa Raffaella

Townhouse in Lecce Historic Center

Central Plaza
7.8 out of 10, Good, (71)
"Great location, fantastic price. Hard to find but not impossible."
United States
Bruce
Central Plaza

Townhouse in Copertino

Royal House
9.4 out of 10, Exceptional, (11)
"the apartment was very clean, spacious, modern and comfortable. A kitchenette forms part of the apartment. Massimo the owner, was very friendly and helpful. The apartment is only a few minutes walk from the historical centre. The only downside that we were at the second floor and there is no lift. A big plus Massimo's father runs the shop next door to the apartments and he is there from very early in the morning till late in the evening. "
Ireland
Paul
$63 nightly
The price is $69
Dec 26 - Dec 27
Total with taxes and fees
Royal House

Townhouse in Santa Cesarea Terme

Panacea Residence
10.0 out of 10, Exceptional, (3)
"Super lieve mensen, spreken wel nauwelijks engels. Bio produkten, lekkere maaltijden, prachtige home made taarten"
Belgium
Anonymous traveler
Panacea Residence

Townhouse in Martano

Borgoterra
9.0 out of 10, Wonderful, (39)
"For a few days of relaxing this hotel and spa is a good place. "
United States
Johann
$82 nightly
The price is $91
Jan 17 - Jan 18, 2026
Total with taxes and fees
Borgoterra
10.0 out of 10, Exceptional, (2)
"Sehr gepflegte Anlage. Die Hausdame spricht sehr gut Englisch, ist unglaublich hilfsbereit, herzlich und ganz reizend. Das Deluxe Studio ist fantastisch, die Terasse ist riesig. Da es eine Spülmaschine gibt, wäre etwas mehr Besteck wünschenswert. Wir hatten nur 3 Sets. Hinter der Anlage liegt eine Firma mit LKWs die sehr früh mit den Arbeiten beginnt, was durchaus nervig sein kann. Da wir tagsüber unterwegs waren, war uns das egal, wer den Tag auf der sehr schönen Terrassen verbringen will,...
Germany
Nirwana
$285 nightly
The price is $314
Jan 11 - Jan 12, 2026
Total with taxes and fees
La Collina di Montegrappa - Suites with Heated Private Pool - Suites with Shared Pool

Townhouse in Palmariggi

Masseria Corte degli Aromi
9.8 out of 10, Exceptional, (11)
"Fantastic Masseria with excellent food"
Sweden
Nathalie France
$296 nightly
The price is $325
Jan 1 - Jan 2, 2026
Total with taxes and fees
Masseria Corte degli Aromi

Townhouse in Gallipoli Historic Center

Domus Dejana
10.0 out of 10, Exceptional, (16)
"Best breakfast and place to have it on the rooftop "
Sweden
Lars Goran
Domus Dejana

Townhouse in Centro Storico

Relais Il Mignano
8.4 out of 10, Very Good, (28)
"È stato meraviglioso soggiornare da voi❣️ Tutto bellissimo, pulitissimo ed elegante 😍 la colazione ricca e deliziosa......le torte di Luana insuperabili💞"
Italy
Raffaella
Relais Il Mignano

Aparthotel in Lecce Historic Center

Casa dei Mercanti Town House
9.6 out of 10, Exceptional, (21)
"This place was great! Near to everything and super comfortable. Our host Franzi was amazing!"
United States
Daniela
$76 nightly
The price is $88
Jan 8 - Jan 9, 2026
Total with taxes and fees
Casa dei Mercanti Town House

Villa in Lecce

La Pineta
$64 nightly
The price is $73
Jan 14 - Jan 15, 2026
Total with taxes and fees
La Pineta

Townhouse in Lecce

Fourseasons
7.4 out of 10, Good, (36)
"Very good"
Mexico
Horacio
$53 nightly
The price is $62
Jan 1 - Jan 2, 2026
Total with taxes and fees
Fourseasons

Townhouse in Ugento

Torre Vecchia Relais
$139 nightly
The price is $153
Dec 27 - Dec 28
Total with taxes and fees
Torre Vecchia Relais

Townhouse in Leverano

Villa Ghetta Country House
8.0 out of 10, Very Good, (7)
"Très cher pour ce que c est"
France
brigitte
Villa Ghetta Country House

Townhouse in Gallipoli Historic Center

Suite Porta Terra
6.8 out of 10, (8)
"La réception se trouve à 10min a pied de l hôtel Nous avons pas été prévenu à l’avance. Le logement est sombre, donne sur une mini cour intérieure/terrasse partagée avec un autre logement et où sont entreposés un ancien meuble de salle de bain et une échelle. Il y avait même une vielle assiette en plastique. Pour finir, la montée de escalier est très penture et étroite, pas du tout pratique avec des valises Autrement la chambre est correcte"
France
Florian
$68 nightly
The price is $75
Dec 28 - Dec 29
Total with taxes and fees
Suite Porta Terra

Townhouse in Uggiano la Chiesa

PALAZZO VIGILARIUM - Boutique Rooms
10.0 out of 10, Exceptional, (2)
"Una chicca nel cuore di Uggiano! A pochi minuti di distanza da Otranto e la spiaggia di Porto Badisco. La struttura è stata ristrutturata con gusto e con un’attenzione particolare al suo valore storico. Colazione super! Personale attento, gentile e disponibile. Consigliatissimo "
Italy
Veronica
$153 nightly
The price is $169
Jan 1 - Jan 2, 2026
Total with taxes and fees
PALAZZO VIGILARIUM - Boutique Rooms
$137 nightly
The price is $154
Jan 9 - Jan 10, 2026
Total with taxes and fees
Lùmia Lecce - Urban Residence

Townhouse in Collepasso

LE DUE DIMORE
$69 nightly
The price is $76
Jan 1 - Jan 2, 2026
Total with taxes and fees
LE DUE DIMORE

Townhouse in Lecce Historic Center

Lo Studio di viale Lo Re Camere & Caffè
9.2 out of 10, Wonderful, (11)
"We booked this property last minute, since our initial reservation at another hotel was cancelled by the host and left us stranded. What a gem! It was very clean, modern, friendly staff who allowed early check in, and excellent location to walk around Lecce. Would highly recommend. "
Canada
Diana
Lo Studio di viale Lo Re Camere & Caffè

Residence in Sannicola

TS Residence
10.0 out of 10, Exceptional, (1)
"Eccellente appartamento finemente ristrutturato e strategicamente ubicato per godere del mare del Salento e visitare le principali località di questa splendida regione Ideale per famiglie e gruppi di amici"
Italy
Luca
$253 nightly
The price is $278
Dec 26 - Dec 27
Total with taxes and fees
TS Residence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Melpignano Hotel Reviews

Find out more about Melpignano

Everything you need to know about Melpignano vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Melpignano vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Melpignano vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Melpignano vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Melpignano. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Melpignano in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $74 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Melpignano rentals

At Expedia, we put the best Melpignano vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Melpignano rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Melpignano vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Melpignano. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in Melpignano?

Yes, we offer vacation rentals close to the most popular attractions in Melpignano, or you can go with a more secluded option if you'd like a relaxing place to stay.

What are some of the best vacation rentals that Melpignano has to offer?

Agriturismo La Natura: You might want to consider this vacation home rental near Melpignano, which offers a furnished patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities like a full-sized fridge and a stovetop can make your vacation run smoothly.

What’s there to see and do in Melpignano?

Explore the area and family-friendly sights such as Giardini del Sole, or get out into nature at a spot like Alimini Lakes. In the larger area, you’ll find Basilica of Saint Catherine of Alexandria and Alimini Beach.

What’s a vacation rental in Melpignano like?

A vacation rental is a private property where you can stay for short or long periods in Melpignano. Vacation rentals provide amenities like laundry facilities and kitchens so you'll have everything you need. If you're concerned about cleanliness, vacation rentals can offer a sense of privacy away from shared hotel elevators and lobbies bustling with people while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental a popular choice for family trips or small group gatherings.