Mestre City Center Vacations from $1,904

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Your Mestre City Center Vacation

Leap into your next thrilling adventure with one of our Mestre City Center vacation packages. Spend your days discovering this neighborhood's countless delights, including its bars and pubs. Begin your trip to Mestre City Center by visiting nearby attractions such as San Giuliano Park, Ferretto Square and Porte di Mestre Shopping Center. No matter what your ideal Mestre City Center vacation may look like, you can turn it into reality with Expedia.

The Latest Mestre City Center Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Bisanzio

Hotel Bisanzio

Castello
$1,904
per person
Sep 23 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
9/10 Wonderful! (1,001 reviews)
Hotel San Moisè

Hotel San Moisè

Venice City Center
$2,515
per person
Sep 23 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
7.8/10 Good! (743 reviews)
Orient Express Venezia

Orient Express Venezia

Cannaregio
Save 100% on your flight
$3,698
per person
Oct 23 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Venice (VCE)
No reviews
Hotel Ca' Alvise

Hotel Ca' Alvise

Venice City Center
$2,158
per person
Sep 26 - Sep 30
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
8.4/10 Very Good! (659 reviews)
The site is well placed, the staff are welcoming, and the breakfast is solid.

Reviewed on Aug 1, 2026

Hotel Ai Reali di Venezia

Hotel Ai Reali di Venezia

Castello
Save 100% on your flight
$2,781
per person
Oct 23 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Venice (VCE)
9.6/10 Exceptional! (1,002 reviews)

Where to stay in Mestre City Center

Find the best Mestre City Center areas and neighborhoods for the activities you enjoy most. Learn more about Mestre City Center
A historic building with a dome and bell tower by the water.

Venice City Center

5 out of top 10 points of interest in this area

Discover an abundance of architectural monuments and great art by grandmasters in the heart of an Italian city built on water.

Find hotels in Venice City Center
A canal with gondolas, people walking on the steps, and storefronts with signs like "Giorgio Armani".

San Marco

In the heart of Venice, this densely built area boasts iconic attractions like St Mark's Square, Saint Mark's Basilica, and the Doge's Palace. Find numerous hotels, banks, and high-end shops amid the bustling tourist scene.

Find hotels in San Marco
A canal in Venice with colorful buildings and a bridge.

Cannaregio

Explore historic churches like Santa Maria di Nazareth and Santa Maria dei Miracoli, or admire stunning palazzos such as Ca' d'Oro and Ca' Vendramin Calergi. Enjoy morning markets, local shops, and quaint cafés in this residential, peaceful district.

Find hotels in Cannaregio
A canal with boats docked, historic buildings, and a clear sky.

San Polo

Smallest and most central sestiere, San Polo boasts churches in the west, palaces in the east, and iconic attractions like Rialto Bridge and Scuola Grande di San Rocco.

Find hotels in San Polo
A narrow canal flanked by historic buildings with arched windows and balconies.

Santa Croce

1 out of top 10 points of interest in this area

In the northwestern part of Venice, Santa Croce boasts a mix of medieval charm in the east and 20th-century land reclamation in the west. Explore churches like San Giacomo dell'Orio and visit the Museum of the History of Fabric and Costume, while enjoying the convenience of Piazzale Roma's transportation hub.

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Mestre City Center Hotel Deals

Antico Panada

Antico Panada

Calle degli Specchieri 646 Venice VE
Fully refundableReserve now, pay when you stay
$85 nightly
$102 total
Aug 24 - Aug 25
Total with taxes and fees
7/10 Good! (1,152 reviews)
"A minute from famous attractio … AC works … warm n lovely place"

Reviewed on Aug 15, 2026

Antico Panada
B&B HOTEL Venezia Laguna

B&B HOTEL Venezia Laguna

Isola Nova del Tronchetto 16 Venice VE
Fully refundableReserve now, pay when you stay
$117 nightly
$137 total
Aug 23 - Aug 24
Total with taxes and fees
9/10 Wonderful! (537 reviews)
"Hôtel récent"

Reviewed on Aug 20, 2026

B&B HOTEL Venezia Laguna
Hotel Cavalletto e Doge Orseolo

Hotel Cavalletto e Doge Orseolo

Piazza San Marco 1107 Venice VE
Fully refundable
$144 nightly
$169 total
Aug 23 - Aug 24
Total with taxes and fees
Hotel Cavalletto e Doge Orseolo
See all 6,014 properties in Mestre City Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Mestre City Center attractions

Ferretto Square

8.6/10 (290 reviews)
Take photos of the imposing bell tower in this historic square before dropping in at the upscale boutiques along the colonnade.
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M9 Mestre Museum

8.0/10 (1 review)
You can spend time browsing the exhibits at M9 Mestre Museum during your trip to Mestre. Find some time to visit the casinos or monuments in this walkable area.
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Toniolo Theatre

8.4/10 (7 reviews)
Enjoy a performance at Toniolo Theatre, a storied theater in Mestre. Stroll along the marina or visit the churches in the area.
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Municipal Tower of Mestre

8.6/10 (27 reviews)
You can find out about the history of Mestre when you stop by Municipal Tower of Mestre. Discover the area's acclaimed art scene and stunning cathedral.
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Teatro Corso

8.0/10 (1 review)
Get tickets for a show at Teatro Corso, a theater with a story to tell in Mestre. Discover the area's acclaimed art scene and stunning cathedral.
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Duomo di San Lorenzo Martire

Learn about the local history of Mestre when you spend time at Duomo di San Lorenzo Martire. Find some time to visit the casinos or monuments in this walkable area.
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Cinema Teatro Corso

Cinema Teatro Corso is just one of the places to see in Mestre, so why not enjoy the other things to explore during your travels? Find some time to visit the casinos or monuments in this walkable area.
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Things to do

Venice in a Day with St. Mark's Basilica, Doge's Palace, & Gondola Ride

Venice in a Day:Gondola Ride, Doge's Palace, St Mark's Basilica & City Tour

$174
per adult
94% of travellers recommend
Venice in a Day:Gondola Ride, Doge's Palace, St Mark's Basilica & City Tour
Sidewalk flanked by colorful buildings in Burano

Murano & Burano Tour

$57
per adult
90% of travellers recommend
Murano & Burano Tour
Taste of Venice: Local Tapas Tastings & Wine Tour

Venice Small Group Tour: Venetian Tapas, Wine, Spritz & Gondola Ride

$90
per adult
96% of travellers recommend
Venice Small Group Tour: Venetian Tapas, Wine, Spritz & Gondola Ride
See all activities in Venice
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.