A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Mytilene Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Oct 9 - Oct 11
In two months
Nov 20 - Nov 22
In three months
Dec 18 - Dec 20
In four months
Jan 15 - Jan 17

Our top choices for Mytilene vacation rentals

A pathway flanked by lush greenery and palm trees, leading to a distant structure.

1. Loriet Hotel

Loriet Hotel
4.0 star property
Lesvos
8.4 out of 10, Very good, (91 reviews)
"Lovely mansion house and a great breakfast."
United States
Malcolm
$89 nightly
The price is $108
Oct 4 - Oct 5
Total with taxes and fees
Loriet Hotel
A hotel room with two beds, a desk, and a view of the ocean.

2. Akti Vigla Premium

Akti Vigla Premium
Lesvos
10.0 out of 10, Exceptional, (19 reviews)
"Very clean room, excellent easy check in. Easy to find and free parking. Perfect location close to the airport. Ocean view."
United States
Gertrud
$75 nightly
The price is $85
Oct 25 - Oct 26
Total with taxes and fees
Akti Vigla Premium
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

3. Elies Residences

Elies Residences
Lesvos
9.8 out of 10, Exceptional, (36 reviews)
"Beautiful quiet nice little place.Very cosy !!"
Australia
Anonymous traveler
$126 nightly
The price is $141
Oct 5 - Oct 6
Total with taxes and fees
Elies Residences
A hotel room with a bed, a nightstand with a lamp, a view of the city through the window, and a painting on the wall.

4. Your refuge overlooking port

Your refuge overlooking port
Mytilene
$120 nightly
The price is $120
Sep 26 - Sep 27
Total with taxes and fees
Your refuge overlooking port
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

5. Villa PETRA

Villa PETRA
ΜΥΤΙΛΗΝΗ
10.0 out of 10, Exceptional, (1 review)
"Rena and Anna were very helpful and friendly. The property had very high standards. We stayed there for a week. Breakfast can be ordered to room with a fee. We ordered a chicken pancake for €7.2 which came in 4 pieces, it was large enough for 2 people. There is a place called Istoriko at seaside within 10min walk which serves food&coctails we liked it so much. Cab costs €8, local bus €2 if you want to go to the city centre. I highly recommend this villa."
United Kingdom
Yigit
$195 nightly
The price is $195
Oct 1 - Oct 2
Total with taxes and fees
Villa PETRA
A bedroom with a wooden bed, a blue bedspread, a wall-mounted lamp, a painting of a sunset, and a small bedside table with a lamp.

6. Experience Comfort in our Newly Remodeled 5A

Experience Comfort in our Newly Remodeled 5A
Mitilini
2.0 out of 10, (1 review)
$130 nightly
The price is $140
Sep 26 - Sep 27
Total with taxes and fees
Experience Comfort in our Newly Remodeled 5A
A compact living space with a dining area, kitchenette, and a sofa.

7. The Heart of Mytilene

The Heart of Mytilene
Mitilini
$92 nightly
The price is $92
Sep 28 - Sep 29
Total with taxes and fees
The Heart of Mytilene
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

8. Villa SIGRI

Villa SIGRI
MYTILENE
$195 nightly
The price is $195
Oct 1 - Oct 2
Total with taxes and fees
Villa SIGRI
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

9. Villa ERESOS

Villa ERESOS
ΜΥΤΙΛΗΝΗ
$195 nightly
The price is $195
Oct 1 - Oct 2
Total with taxes and fees
Villa ERESOS
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.

10. Villa SYKAMIA

Villa SYKAMIA
ΜΥΤΙΛΗΝΗ
$195 nightly
The price is $195
Oct 1 - Oct 2
Total with taxes and fees
Villa SYKAMIA
A coastal area with a beach, boats, and buildings.

11. Casa Di Nonno-Jacuzzi Mountain View Stay in Lesvos

Casa Di Nonno-Jacuzzi Mountain View Stay in Lesvos
Agiasos
$256 nightly
The price is $265
Sep 26 - Sep 27
Total with taxes and fees
Casa Di Nonno-Jacuzzi Mountain View Stay in Lesvos
A two-story building with a white facade and stone exterior.

12. Gianni's House

Gianni's House
Polichnitos
10.0 out of 10, Exceptional, (1 review)
"A nice, quiet, comfy and simple place. I felt welcomed. The village is the same. I really enjoyed it."
Canada
Jean-Philippe
$74 nightly
The price is $86
Oct 2 - Oct 3
Total with taxes and fees
Gianni's House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mytilene Hotel Reviews

Akti Vigla Premium

Akti Vigla Premium

10/10 Excellent
"Breakfast was fantastic and we loved the engineering of the patio doors. They tilt and open"
Rebecca 1-night trip
Posted 10 days ago
Akti Vigla Premium

Find out more about Mytilene

Everything you need to know about Mytilene vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mytilene vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mytilene vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Mytilene vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Mytilene. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Mytilene in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $85 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Mytilene rentals

At Expedia, we put the best Mytilene vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Mytilene rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mytilene vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mytilene. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in Mytilene?

Yes, we give you a choice of vacation rentals close to the most popular attractions in Mytilene, or you can select a more remote option if you want a relaxing place to stay. Nature enthusiasts will enjoy the seaside in Mytilene. Make sure you have time to check out the museums and monuments during your trip.

What's the top vacation rental that Mytilene has to offer?

Mikos - Mansion in the City Center: This highly rated vacation home rental in Mytilene is located on the beach and has a garden, a barbecue grill, and free WiFi to put you at ease in your new surroundings. Some other homes for rent in Mytilene include V House Cozy & Quiet Escape and Villa Laurette Kratigos, Private Escape with Views.

How many vacation rentals will I find in Mytilene?

Choose from 15 Expedia vacation rentals in Mytilene for a memorable vacation.

What’s there to see and do in Mytilene?

Enjoy the outdoors at Thermes Gera Hot Springs and Thermi Beach, or simply take in cultural attractions like Ecclesiastical Byzantine Museum and Theriade Library and Museum of Modern Art. While here, Port of Mytilene and Mytilini Castle are other places worth a visit.

What’s a vacation rental in Mytilene like?

A vacation rental is a private property you can stay in for a couple of days or more in Mytilene. Vacation rentals provide amenities such as kitchens and laundry facilities so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of seclusion away from shared hotel elevators and busy lobbies while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental an attractive choice for family trips.