Title: The Best 5 Star Hotels in Mytilene from $74 | Expedia.com

[Mytilene Travel Guide](https://expedia.com/Mytilene.dx6062865)[Hotels in Mytilene](https://expedia.com/Mytilene-Hotels.d6062865.Travel-Guide-Hotels)[Vacation Rentals in Mytilene](https://expedia.com/Mytilene-Vacation-Rentals.d6062865.Travel-Guide-VacationRentals)[Flights to Mytilene](https://expedia.com/Cheap-Flights-To-Mytilene.d6062865.Travel-Guide-Flights)[Car Rentals in Mytilene](https://expedia.com/Car-Rentals-In-Mytilene.d6062865.Car-Rental-Guide)[Mytilene Vacation Packages](https://expedia.com/Mytilene.d6062865.Destination-Travel-Guides)

![Mitylene Island, or better known as Lesvos, Greece. There seriously are 50 different shades of blue in this country. Enjoy practically empty beaches and amazing food on this sleepy little island just off the west coast of Turkey.

http://www.hecktictravels.com/shades-of-blue

#Greece #Lesvos #Travel](https://images.trvl-media.com/place/181073/7db7a0e4-a4c2-4c5e-8866-ee0ae94b63e5.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Hecktic Travels

![](https://images.trvl-media.com/place/181073/7db7a0e4-a4c2-4c5e-8866-ee0ae94b63e5.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Mytilene 5 Star Hotels

Tonight

[Feb 19 - Feb 20](https://www.expedia.com/Hotel-Search?regionId=6062865&startDate=2026-02-19&endDate=2026-02-20&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 20 - Feb 21](https://www.expedia.com/Hotel-Search?regionId=6062865&startDate=2026-02-20&endDate=2026-02-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=6062865&startDate=2026-02-20&endDate=2026-02-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6062865&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Mytilene 5-star hotels

![Exterior](https://images.trvl-media.com/lodging/90000000/89770000/89767000/89766945/9c033abb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/90000000/89770000/89767000/89766945/f5778c8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite | Terrace/patio](https://images.trvl-media.com/lodging/90000000/89770000/89767000/89766945/d5bff33f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89770000/89767000/89766945/a863e526.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mythical Coast Wellness Retreat

[](https://www.expedia.com/Lesvos-Hotels-Mythical-Coast-Wellness-Retreat.h89766945.Hotel-Information)

Lesvos

8.6/10

Excellent

(47 reviews)

"Brand new hotel, lovely staff. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Timothy

[](https://www.expedia.com/Lesvos-Hotels-Mythical-Coast-Wellness-Retreat.h89766945.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/4000000/3740000/3738300/3738267/02835147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/4000000/3740000/3738300/3738267/c21f63e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/4000000/3740000/3738300/3738267/d2766c2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food and drink](https://images.trvl-media.com/lodging/4000000/3740000/3738300/3738267/16401045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Elysion Hotel

[](https://www.expedia.com/Lesvos-Hotels-Elysion-Hotel.h3738267.Hotel-Information)

Lesvos

9.2/10

Wonderful

(46 reviews)

"very good place and the staffs took very good care for us, even to prepare special diet foods. Lovely place and next to sea."

![Turkey](https://a.travel-assets.com/egds/marks/flags/tr.svg)

ANINDYA

[](https://www.expedia.com/Lesvos-Hotels-Elysion-Hotel.h3738267.Hotel-Information)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mytilene.

![Heliotrope Hotels](https://images.trvl-media.com/lodging/1000000/900000/890400/890395/a1f3c9aa_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Heliotrope Hotels

Varia Lesvos Lesvos Island

$86 nightly

$98 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://expedia.com/Lesvos-Hotels-Heliotrope-Hotels.h890395.Hotel-Information)

![Theofilos Paradise Boutique Hotel](https://images.trvl-media.com/lodging/13000000/12320000/12319300/12319222/96fa5ce4_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Theofilos Paradise Boutique Hotel

7, Skra str, Hatzidimitriou Park Lesvos 

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F5%2F2026&endDate=3%2F6%2F2026&selected=12319222&PinnedHotelID=12319222&HadPinnedHotel=true&regionId=6062865)

9.6/10 Exceptional! (160 reviews)

[](https://expedia.com/Lesvos-Hotels-Theofilos-Paradise-Boutique-Hotel.h12319222.Hotel-Information)

![The Loriet](https://images.trvl-media.com/lodging/12000000/11100000/11098400/11098314/5445108d_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Loriet

Vareia, Mitilene Lesvos Lesvos Island

$64 nightly

$74 total

Mar 4 - Mar 5

Total with taxes and fees

8.4/10 Very Good! (78 reviews)

[](https://expedia.com/Lesvos-Hotels-Loriet-Hotel.h11098314.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Mytilene.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&regionId=6062865&star=50)

You can also use these popular filters to refine your search.

[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&regionId=6062865&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&regionId=6062865&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&regionId=6062865&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&regionId=6062865&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=2%2F20%2F2026&endDate=2%2F21%2F2026&regionId=6062865&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Mytilene

The harbor city's neoclassical mansions and Byzantine castle offer glimpses into its rich past as a trading center. Explore the Archaeological Museum's ancient artifacts, then enjoy fresh seafood at tavernas along the waterfront promenade.

[See all hotels in Mytilene](https://www.expedia.com/Hotel-Search?startDate=2026-03-05&endDate=2026-03-06&adults=2&regionId=6062865)

![Mitylene Island, or better known as Lesvos, Greece. There seriously are 50 different shades of blue in this country. Enjoy practically empty beaches and amazing food on this sleepy little island just off the west coast of Turkey.

http://www.hecktictravels.com/shades-of-blue

#Greece #Lesvos #Travel](https://images.trvl-media.com/place/181073/7db7a0e4-a4c2-4c5e-8866-ee0ae94b63e5.jpg?impolicy=fcrop&w=711&h=533&p=1&q=high)

Photo by Hecktic Travels

## Top Mytilene Hotel Reviews

![Mythical Coast Wellness Retreat](https://images.trvl-media.com/lodging/90000000/89770000/89767000/89766945/3d640bb2_y.jpg)

### Mythical Coast Wellness Retreat

2/10 Terrible

"I booked a junior suite. The description does not match the room. The room was to have a balcony and it does not. It was a basic room of 30 square metres with two single beds pushed together and a chair and small table. The service was terrible. The person at teh front desk in the morning was rude and basically could not wait to get me out. This was out of character witht he wonderful hospitality elsewhere on the island. I would NEVER recommend this place. "

[](https://expedia.com/Lesvos-Hotels-Mythical-Coast-Wellness-Retreat.h89766945.Hotel-Information)

## Find out more about Mytilene

## Mytilene Five Star Hotel Information

If you’re searching for the celebrity treatment, the 5 star hotels in Mytilene are your dreams come true. From sprawling resorts to fancy hot spots, theseMytilene 5 star hotels immerse each traveler in the most elite experience money can buy. Want to unwind with a VIP-worthy spa treatment? These hotels have the leisure you're looking for.

Interested in sampling world-class cuisine? The on-site restaurants at the 5 stars hotels in Mytilene, Lesvos, let you do just that. You’ll even be able to book a room (or perhaps a penthouse?) at first-rate hotels near the region’s can’t-miss sights and most bustling shopping centers. Plus, many globe-trotters who visit Mytilene five star hotels find incredible rates and deep discounts thanks to Expedia, so you can score a deal without sacrificing an ounce of quality.

Everything you could possibly want (and a few things you didn’t know you needed): That’s what you’ll receive when you stay at Mytilene 5 star hotels.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Mytilene?

> - Search for the lowest price per night from $74

### What makes a hotel 5 stars in Mytilene?

### Are there any 5-star all-inclusive resorts in Mytilene?