New Madrid County Vacations & Trips from $524
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Your New Madrid County Vacation
With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.
Top destinations in New Madrid County
Sikeston
New Madrid
The Latest New Madrid County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
EC Reed's Mercantile and Hotel
$792
per person
Nov 18 - Nov 24
found 6 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Cape Girardeau (CGI)
9.4/10 Exceptional! (109 reviews)
Cool setup in the Mercantile. The "Continental breakfast" was virtually non-existent, consisting of a Keurig coffeemaker, a handful of apples and bananas, and if you timed it right, Entemanns muffins. The restaurant was closed my entire time there. The room was odd-sized: low toilet, which was too close to the wall (the toilet roll holder pressed against my upper arm when sitting), and the sink was too tall (hitting me in the ribs).
Reviewed on Aug 28, 2026
Candlewood Suites Cape Girardeau by IHG
$884
per person
Nov 18 - Nov 24
found 6 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Cape Girardeau (CGI)
8/10 Very Good! (997 reviews)
Showed up at 2am and the staff was friendly. Appreciate the fast check in process.
Reviewed on Sep 6, 2026
Find the Best New Madrid County Vacation Packages
New Madrid County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 3,000 |
New Madrid County Hotel Deals
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$102 nightly
$115 total
Sep 20 - Sep 21
Total with taxes and fees
Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Fully refundable
$107 nightly
$121 total
Sep 20 - Sep 21
Total with taxes and fees
Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$101 nightly
$114 total
Sep 17 - Sep 18
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular New Madrid County attractions
Hunter-Dawson State Historic Site
7.6/10 (13 reviews)
You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.
River Ridge Winery
8.4/10 (15 reviews)
You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.
New Madrid Historical Museum
8.2/10 (36 reviews)
You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.
Marston Community Center
Marston Community Center is just one of the places to see in Marston, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its museums.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
