New Madrid County Vacations & Trips from $867
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Your New Madrid County Vacation
With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.
Top destinations in New Madrid County
Sikeston
New Madrid
The Latest New Madrid County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Atrium - A Boutique Hotel
$867
per person
Dec 22 - Dec 27
found 5 hours ago
Roundtrip flight included
Fort Myers (RSW) to Cape Girardeau (CGI)
9.2/10 Wonderful! (10 reviews)
The property was beautiful. However it was listed on Expedia as having a sofa bed which we required. It did not have a sofa bed. It didn’t even have a sofa, it had a love seat. Pretty hard for someone to sleep on. Also, the bar/nightclub attached will keep you up till closing. Very loud. Check with who rented the room next to you. We had a group shooting an adult film. Loud sexual noises followed by a shower and then repeated numerous times. Started in the evening and went all night until 7am. They then quit until 930am when they started again. Not family friendly at all. We left a day early. After messaging the owner with this same information, they apologized for Expedia listing a sofa bed. We go to Perryville every year. We will not be staying here again.
Reviewed on Oct 18, 2026
EC Reed's Mercantile and Hotel
$921
per person
Dec 22 - Dec 27
found 5 hours ago
Roundtrip flight included
Fort Myers (RSW) to Cape Girardeau (CGI)
9.4/10 Exceptional! (114 reviews)
Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!
Reviewed on Oct 19, 2026
Find the Best New Madrid County Vacation Packages
New Madrid County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 3,000 |
New Madrid County Hotel Deals
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$95 nightly
$108 total
Nov 22 - Nov 23
Total with taxes and fees
9/10 Wonderful! (648 reviews)
"Great hotel, clean spacious room, good breakfast choice"
Reviewed on Oct 22, 2026
Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$101 nightly
$115 total
Oct 29 - Oct 30
Total with taxes and fees
Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Fully refundable
$91 nightly
$103 total
Nov 22 - Nov 23
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular New Madrid County attractions
Marston Community Center
Marston Community Center is just one of the places to see in Marston, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its museums.
New Madrid Historical Museum
8.2/10 (36 reviews)
You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.
Hunter-Dawson State Historic Site
7.6/10 (13 reviews)
You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.
River Ridge Winery
8.4/10 (15 reviews)
You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
