Name: Holiday Inn Express & Suites Sikeston Southwest by IHG
Price range: $121 total
Rating: 8.6

Your New Madrid County Vacation

With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.

Top destinations in New Madrid County

Good Day Sunshine Early Morning Sunshine passes through the fog and scatters through the leaves of a tree in Scott County Missouri

Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. .

The Latest New Madrid County Vacation Packages

Price found within the past 48 hours. Click for updated prices.

EC Reed's Mercantile and Hotel

$803

per person

Jun 26 - Jun 29

found 1 day ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

9.6/10 Exceptional! (90 reviews)

It was cute and clean and affordable! Highly recommend!

Reviewed on May 25, 2026

The Riverview

$886

per person

Jun 26 - Jun 29

found 1 day ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

9.4/10 Exceptional! (572 reviews)

Front desk staff was not welcoming at all, was extremely rude to myself and my children. The room itself was nice, however due to the rude staff we will not stay here again.

Reviewed on May 25, 2026

Drury Plaza Hotel Cape Girardeau Conference Center

$854

per person

Jun 26 - Jun 29

found 1 day ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

9.6/10 Exceptional! (1,007 reviews)

Great place to stay as a family

Reviewed on May 25, 2026

Makanda Inn

$1,006

per person

Jun 26 - Jun 29

found 1 day ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

10/10 Exceptional! (37 reviews)

Jackie was amazing. She was very informative and helpful. Great communication. The room was really comfortable. And breakfast was great.

Reviewed on May 10, 2026

Drury Inn & Suites Cape Girardeau

$846

per person

Jun 26 - Jun 29

found 1 day ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

9.4/10 Exceptional! (1,003 reviews)

Excellent hotel! We enjoy the perks of an evening meal and a good breakfast. Rooms are well maintained and clean.

Reviewed on May 12, 2026

Find the Best New Madrid County Vacation Packages

New Madrid County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Lambert-St. Louis Intl. Airport (STL)
Population	3,000

New Madrid County Hotel Deals

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$102 nightly

$115 total

Jun 7 - Jun 8

Total with taxes and fees

9/10 Wonderful! (566 reviews)

"Ok stay"

Reviewed on May 24, 2026

Fairfield Inn & Suites by Marriott Sikeston

1239 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$110 nightly

$125 total

Jun 4 - Jun 5

Total with taxes and fees

9.4/10 Exceptional! (81 reviews)

"Your typical continental breakfast- decent."

Reviewed on May 19, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

Fully refundable

$107 nightly

$121 total

May 31 - Jun 1

Total with taxes and fees

8.6/10 Excellent! (464 reviews)

"Overall everythong was excellent."

Reviewed on May 25, 2026

See all 98 properties in New Madrid County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.