Name: Holiday Inn Express & Suites Sikeston Southwest by IHG
Price range: $114 total
Rating: 8.6

Your New Madrid County Vacation

With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.

Top destinations in New Madrid County

Good Day Sunshine Early Morning Sunshine passes through the fog and scatters through the leaves of a tree in Scott County Missouri

Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. .

The Latest New Madrid County Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Quality Inn Cape Girardeau North

$720

per person

Jun 26 - Jun 29

found 6 hours ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

7.2/10 Good! (740 reviews)

Left side of upper hallway of ceiling was falling down, it was not blocked off when we checked in. There were several holes in the ceiling of the right end of hallway as well that wasn’t covered or blocked off. Handle of the sink came off in my hand when I went to turn on the water. Overall facility was in disrepair. Would not recommend staying here.

Reviewed on May 16, 2026

The Riverview

$814

per person

Jun 26 - Jun 29

found 6 hours ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

9.4/10 Exceptional! (572 reviews)

Our room was very clean. Nice staff. The hotel was beautiful. It was extremely quite which is surprising being right next to a casino. Would def stay here again!

Reviewed on May 23, 2026

Drury Plaza Hotel Cape Girardeau Conference Center

$785

per person

Jun 26 - Jun 29

found 6 hours ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

9.6/10 Exceptional! (1,010 reviews)

My stay was near perfect-I just wish the fitness center was 24/7

Reviewed on May 22, 2026

Comfort Suites Jackson-Cape Girardeau

$775

per person

Jun 26 - Jun 29

found 6 hours ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

8.2/10 Very Good! (766 reviews)

Hotel was ok, not terribly dirty, but not very clean. Chose for the jetted tub in the photo. Come to find out there was no jetted tub in the rooms, it was a regular very old tub that wasn’t quite clean looking, so definitely false advertising. I would absolutely not have chosen this hotel otherwise. No hot water because a pipe burst in the city so we couldn’t shower or use the pool. Not hotels fault, but very frustrating after a long travel day.

Reviewed on Mar 14, 2026

Pear Tree Inn Cape Girardeau West

$727

per person

Jun 26 - Jun 29

found 6 hours ago

Roundtrip non-stop flight included

Hartford (HFD) to Cape Girardeau (CGI)

9/10 Wonderful! (1,000 reviews)

After midnight checkin was smooth and pleasant

Reviewed on May 21, 2026

Find the Best New Madrid County Vacation Packages

New Madrid County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Lambert-St. Louis Intl. Airport (STL)
Population	3,000

New Madrid County Hotel Deals

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$100 nightly

$114 total

Jun 7 - Jun 8

Total with taxes and fees

9/10 Wonderful! (563 reviews)

"Everything was good"

Reviewed on May 10, 2026

Fairfield Inn & Suites by Marriott Sikeston

1239 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$110 nightly

$125 total

May 31 - Jun 1

Total with taxes and fees

9.4/10 Exceptional! (80 reviews)

"Your typical continental breakfast- decent."

Reviewed on May 19, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

Fully refundable

$101 nightly

$114 total

Jun 21 - Jun 22

Total with taxes and fees

8.6/10 Excellent! (463 reviews)

"Good room, clean, breakfast was good and the staff were very friendly and helpful. Would stay again."

Reviewed on May 23, 2026

See all 98 properties in New Madrid County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.