Name: Holiday Inn Express & Suites Sikeston Southwest by IHG
Price range: $105 total
Rating: 8.6

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Your New Madrid County Vacation

With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.

Top destinations in New Madrid County

Pre-teen girl walking through corn maze during fall

Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. .

Find the Best New Madrid County Vacation Packages

New Madrid County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Lambert-St. Louis Intl. Airport (STL)
Population	3,000

New Madrid County Hotel Deals

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$93 nightly

$105 total

Mar 29 - Mar 30

Total with taxes and fees

9/10 Wonderful! (498 reviews)

East, friendly check in. Beautiful, large room.

Reviewed on Mar 9, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

Fully refundable

$93 nightly

$105 total

Mar 22 - Mar 23

Total with taxes and fees

8.6/10 Excellent! (449 reviews)

Nice room

Reviewed on Mar 5, 2026

New Orleans Inn Portageville

600 US-61 Portageville MO

Fully refundableReserve now, pay when you stay

$53 nightly

$58 total

Apr 5 - Apr 6

Total with taxes and fees

8/10 Very Good! (747 reviews)

The staff was great very helpful and friendly

Reviewed on Feb 25, 2026

See all 96 properties in New Madrid County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.