North Clayton Vacations from $443

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Your North Clayton Vacation

Discover all the amazing things this neighborhood has to offer with a tailor-made North Clayton vacation package. However you imagine yourself spending your time here, you'll find endless opportunities for relaxation, fun and adventure. Wondering what to see and do during your trip to North Clayton? Nearby attractions like St. Louis Zoo, St. Louis Art Museum and Washington University in St. Louis are good places to begin. Expedia will help turn your ideal North Clayton vacation into reality, whatever your travel plans or budget.

The Latest North Clayton Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Price was $585, price is now $443 per person
$443
per person
Jan 14 - Jan 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
8.2/10 Very Good! (779 reviews)
Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!

Reviewed on Oct 26, 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $718, price is now $447 per person
$447
per person
Jan 22 - Jan 25
found 3 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
What stood out? Everything! The staff was friendly, the room was spacious and clean, and the breakfast was very good with plenty of variety.. also the lady working in the breakfast area stayed busy restocking breakfast items the whole time we ate. She was also very friendly. If we ever travel the area again we will definitely come back!

Reviewed on Dec 12, 2025

Hermann Grain Bins BNB

Hermann Grain Bins BNB

2 out of 5
Save 100% on your flight
Price was $1,492, price is now $1,064 per person
$1,064
per person
Jan 15 - Jan 19
found 23 hours ago
Roundtrip flight included
New York (NYC) to St. Louis (STL)
2/10 (1 review)
Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection

4 out of 5
Downtown St. Louis
Price was $1,141, price is now $864 per person
$864
per person
Mar 5 - Mar 8
found 3 hours ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
8.8/10 Excellent! (458 reviews)
Property and room was really nice. I will be staying here in the future

Reviewed on Nov 25, 2025

Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

3.5 out of 5
Price was $625, price is now $478 per person
$478
per person
Jan 14 - Jan 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
8/10 Very Good! (1,002 reviews)
Stay was excellent, room was clean and the lobby area is really nice to sit in since there's a pool and a small waterfall-like arrangement. The staff were also very helpful, by mistake I had left a personal item in my room which the staff were kind enough to mail back to me.

Reviewed on Nov 27, 2025

Where to stay in North Clayton

Find the best North Clayton areas and neighborhoods for the activities you enjoy most. Learn more about North Clayton
Meeting of the Waters Fountain showing a statue or sculpture and a fountain

Downtown St. Louis

3 out of top 10 points of interest in this area
4/5(4,004 area reviews)

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis

North Clayton Hotel Deals

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
216 N Meramec Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $131 total per night from Dec 19 to Dec 20
$131 total
Dec 19 - Dec 20
Total with taxes and fees
8.8/10 Excellent! (910 reviews)
Clean, nice staff, hot breakfast with variety of options

Reviewed on Dec 8, 2025

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $99 total per night from Dec 27 to Dec 28
$99 total
Dec 27 - Dec 28
Total with taxes and fees
8.4/10 Very Good! (3,998 reviews)
Great stay

Reviewed on Dec 10, 2025

Hyatt Regency St. Louis at The Arch
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $104 total per night from Dec 17 to Dec 18
$104 total
Dec 17 - Dec 18
Total with taxes and fees
8.6/10 Excellent! (1,149 reviews)
Staff was fantastic and goes above and beyond

Reviewed on Dec 12, 2025

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
See all 1,793 properties in North Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in North Clayton

St. Louis Union Station

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

St. Louis Union Station
Gateway Arch showing a city, a skyscraper and skyline

Gateway Arch

4.5/5(2,511 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Gateway Arch
St. Louis Zoo

St. Louis Zoo

4.5/5(1,212 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

St. Louis Zoo

Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
Best of St. Louis Small Group Tour w/ Arch & River Cruise

Best of St. Louis Small Group Tour w/ Arch & River Cruise

$169
per adult
84% of travellers recommend
Best of St. Louis Small Group Tour w/ Arch & River Cruise
Step into the shadows and discover the haunting tales of our city's past.

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

$32
per adult
100% of travellers recommend
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.