North Clayton Vacations from $321

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Your North Clayton Vacation

Discover all the amazing things this neighborhood has to offer with a tailor-made North Clayton vacation package. However you imagine yourself spending your time here, you'll find endless opportunities for relaxation, fun and adventure. Wondering what to see and do during your trip to North Clayton? Nearby attractions like St. Louis Zoo, St. Louis Art Museum and Washington University in St. Louis are good places to begin. Expedia will help turn your ideal North Clayton vacation into reality, whatever your travel plans or budget.

The Latest North Clayton Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3 out of 5
Price was $423, price is now $321 per person
$321
per person
Apr 10 - Apr 13
found 1 day ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8/10 Very Good! (1,018 reviews)
There are many dogs at the property and unfortunately most people do not pick up the excrement of their animal which is disturbing. The property is not kept clean enough. The rooms have very old furniture and carpeting that needs a refresh. I had them come and reclean the room and it was better.

Reviewed on Jan 2, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $560, price is now $344 per person
$344
per person
Apr 10 - Apr 12
found 22 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Clean room and easy parking.

Reviewed on Feb 2, 2026

White House at Grand Central

White House at Grand Central

4 out of 5
Grand Center
Price was $532, price is now $392 per person
$392
per person
Apr 10 - Apr 13
found 1 day ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.6/10 Excellent! (123 reviews)
Very clean and very friendly people

Reviewed on Nov 11, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was $523, price is now $394 per person
$394
per person
Apr 10 - Apr 13
found 1 day ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
It was good and beautiful on the inside. Loved all the art. The bed was comfy and the room was like an apartment .The only thing that stunk is that there wasn't a microwave in the room. But there was one on the floor so it worked out.

Reviewed on Feb 3, 2026

The Cheshire

The Cheshire

4 out of 5
Price was $580, price is now $441 per person
$441
per person
Apr 10 - Apr 13
found 1 day ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.6/10 Excellent! (1,002 reviews)
The Cheshire is in a class by itself. The halls and sitting areas are so full of history and there’s an ambiance that we just love. Our suite, Treasure Island, was amazing! Large, clean, luxurious and cozy with a beautiful fireplace and large jacuzzi. We had a delicious dinner at the Basso, relaxed in the very British, cozy Fox & Hound, enjoyed a coffee at the Tudor styled Starbucks and as always, enjoyed breakfast beside the fireplace. We loved our stay!

Reviewed on Jan 28, 2026

Where to stay in North Clayton

Find the best North Clayton areas and neighborhoods for the activities you enjoy most. Learn more about North Clayton
Meeting of the Waters Fountain showing a statue or sculpture and a fountain

Downtown St. Louis

4 out of top 10 points of interest in this area
4/5(4,004 area reviews)

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Find hotels in Downtown St. Louis

North Clayton Hotel Deals

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
216 N Meramec Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $139 total per night from Feb 26 to Feb 27
$139 total
Feb 26 - Feb 27
Total with taxes and fees
8.8/10 Excellent! (933 reviews)
Pleasant and professional staff. Updated property and was incredibly clean!

Reviewed on Jan 29, 2026

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
$138 nightly
The price is $162 total per night from Feb 12 to Feb 13
$162 total
Feb 12 - Feb 13
Total with taxes and fees
9/10 Wonderful! (1,581 reviews)
Very nice and clean

Reviewed on Jan 29, 2026

21C Museum Hotel St Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $116 total per night from Feb 8 to Feb 9
$116 total
Feb 8 - Feb 9
Total with taxes and fees
8.8/10 Excellent! (3,081 reviews)
Lovely hotel. Great breakfast

Reviewed on Jan 29, 2026

Clayton Plaza Hotel & Extended Stay
See all 1,816 properties in North Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Kid Friendly Vacations

Discover the most popular places to visit in North Clayton

Union Station, St. Louis, MO

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's acclaimed art scene or attend a baseball game.

St. Louis Union Station
St. Louis Cardinals Baseball.

Busch Stadium

4.5/5(1,469 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

Busch Stadium
Gateway Arch showing a city, a skyscraper and skyline

Gateway Arch

4.5/5(2,511 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Gateway Arch

Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$32
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
Best of St. Louis Small Group Tour w/ Arch & River Cruise

Best of St. Louis Small Group Tour w/ Arch & River Cruise

$169
per adult
84% of travellers recommend
Best of St. Louis Small Group Tour w/ Arch & River Cruise
St. Louis Premium Driving Tour with Boat Ride & Arch

St. Louis Premium Driving Tour with Boat Ride & Arch

$174
per adult
100% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.