North Clayton Vacations from $377

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Your North Clayton Vacation

Discover all the amazing things this neighborhood has to offer with a tailor-made North Clayton vacation package. However you imagine yourself spending your time here, you'll find endless opportunities for relaxation, fun and adventure. Wondering what to see and do during your trip to North Clayton? Nearby attractions like St. Louis Zoo, St. Louis Art Museum and Washington University in St. Louis are good places to begin. Expedia will help turn your ideal North Clayton vacation into reality, whatever your travel plans or budget.

The Latest North Clayton Vacation Packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$377

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,665 reviews)

The Cheshire

Save 100% on your flight

$485

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,005 reviews)

HoteLumiere at the Arch Hotel & Casino - A Caesars Rewards Destination

Downtown St. Louis

Save 100% on your flight

$405

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

6.8/10 (1,004 reviews)

Crowne Plaza St. Louis Airport by IHG

Save 100% on your flight

$440

per person

Nov 2 - Nov 7

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8/10 Very Good! (1,003 reviews)

Ameristar Casino Resort and Spa

Save 100% on your flight

$571

per person

Nov 2 - Nov 7

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,043 reviews)

Where to stay in North Clayton

Find the best North Clayton areas and neighborhoods for the activities you enjoy most. Learn more about North Clayton

A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

3 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

An ornate hall with arched ceilings and intricate patterns.

Downtown West

2 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

North Clayton Hotel Deals

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

216 N Meramec Ave St. Louis MO

Fully refundableReserve now, pay when you stay

$130 nightly

$154 total

Sep 6 - Sep 7

Total with taxes and fees

8.8/10 Excellent! (1,003 reviews)

"Rooms could have been better cleaned prior to check in. Staff was very helpful"

Reviewed on Aug 27, 2026

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

$93 nightly

$109 total

Aug 30 - Aug 31

Total with taxes and fees

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

$134 nightly

$158 total

Sep 4 - Sep 5

Total with taxes and fees

See all 1,942 properties in North Clayton

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.