It's fascinating to look into different belief systems. A visit to Oratory of the Rosary of St. Cita is a good way to deepen your understanding of a part of the local culture.
You'll be spoiled for sightseeing choice when staying in Palermo Historical Center. Oratory of the Rosary of St. Cita is an ideal place to start here, but there are many other worthy sights to consider. Teatro Massimo, Palermo Cathedral, and Palace of the Normans are not far from the house of prayer and will round out your day nicely.