Sant'Angelo Vacations from $759

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Your SantAngelo Vacation

If you're craving a riverside retreat, our SantAngelo vacation packages are just what you need. Whether you want to experience its history, dining or culture, this neighborhood has a bit of something for every traveler. Begin your trip to SantAngelo by heading to nearby attractions such as St. Peters Basilica, Roman Forum and Pantheon. Don't just think about it — turn it into a reality! Book your perfect SantAngelo vacation with Expedia and experience travel your way.

The Latest Sant'Angelo Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Price was $1,169, price is now $759 per person
$759
per person
Jan 12 - Jan 17
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (267 reviews)
The room was clean and well equipped. It was cleaned every day. There were fresh towels in the bathroom. Hotel is located next to the beautiful park with birds singing! What a great atmosphere! We also liked the breakfast, so yummy with a variety of food to choose from. We would recommend this hotel to anyone, who likes a quiet neighborhood, away from the tourist noise.

Reviewed on Dec 4, 2025

Relais de la Poste

Relais de la Poste

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,613, price is now $952 per person
$952
per person
Feb 14 - Feb 19
found 19 hours ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Rome (FCO)
9.2/10 Wonderful! (612 reviews)
Location is absolutely perfect - great spot for walking everywhere, no need for Taxis at all. Staff incredibly friendly and helpful. Would stay again.

Reviewed on Nov 24, 2025

Charme Spagna Boutique Hotel

Charme Spagna Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,280, price is now $793 per person
$793
per person
Jan 15 - Jan 20
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Rome (FCO)
9.2/10 Wonderful! (208 reviews)
The staff was so lovely and polite and really helpful, hotel was clean and everything you needed. Hotel was brilliant location, only thing I would say is taxis and Ubers are a lot cheaper than the transfer service to airport that the hotel offered, but would defo recommend

Reviewed on Dec 4, 2025

Baglioni Hotel Regina - The Leading Hotels of the World

Baglioni Hotel Regina - The Leading Hotels of the World

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $2,495, price is now $1,574 per person
$1,574
per person
Feb 19 - Feb 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9/10 Wonderful! (490 reviews)
Love our stay for our family of eight. Great staff. Great service. Kid friendly. The rooms are great. We stayed in a suite with two rooms and two bathrooms which is awesome for a big family.

Reviewed on Nov 21, 2025

Albergo Etico Roma

Albergo Etico Roma

3 out of 5
Flaminio
Save 100% on your flight
Price was $1,274, price is now $805 per person
$805
per person
Feb 13 - Feb 16
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
9.6/10 Exceptional! (335 reviews)
Great place to stay

Reviewed on Dec 1, 2025

Where to stay in Sant'Angelo

Find the best Sant'Angelo areas and neighborhoods for the activities you enjoy most. Learn more about Sant'Angelo
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Sant'Angelo Hotel Deals

Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $185 total per night from Dec 8 to Dec 9
$185 total
Dec 8 - Dec 9
Total with taxes and fees
8.6/10 Excellent! (1,917 reviews)
The staff was nice, the room was ample and clean. It was perfectly located near the train station and walk about from all main attractions.

Reviewed on Dec 4, 2025

Hotel Quirinale
The Hive Hotel

The Hive Hotel

4 out of 5
Via Torino 6 Rome RM
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $145 total per night from Dec 23 to Dec 24
$145 total
Dec 23 - Dec 24
Total with taxes and fees
9/10 Wonderful! (1,698 reviews)
Quiet comfortable and great location

Reviewed on Dec 4, 2025

The Hive Hotel
Trastevere Roma | UNA Esperienze

Trastevere Roma | UNA Esperienze

4 out of 5
Via Emilio Morosini 27 Rome RM
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $212 total per night from Dec 14 to Dec 15
$212 total
Dec 14 - Dec 15
Total with taxes and fees
9.2/10 Wonderful! (1,171 reviews)
It’s very clean and smells good

Reviewed on Nov 28, 2025

Trastevere Roma | UNA Esperienze
See all 16,000 properties in Sant'Angelo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Sant'Angelo

Marcello-Theatre & Apollo-Temple -and medieval and baroque buildings. Many centuries build multiple layers in Rome.

Theatre of Marcellus

Find out about the history of Rome when you spend time at Theatre of Marcellus. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Theatre of Marcellus

Great Synagogue of Rome

4.5/5(2 reviews)

You can learn about the history of Rome with a visit to Great Synagogue of Rome. Visit the stunning cathedral and notable monuments in this vibrant area.

Great Synagogue of Rome

Fontana delle Tartarughe

Fontana delle Tartarughe is just one of the places to see in Rome, so why not enjoy the other things to explore during your travels? Visit the stunning cathedral and notable monuments in this vibrant area.

Fontana delle Tartarughe

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$30
per adult
82% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$53
per adult
82% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$39
per adult
88% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.