Santa Ana Vacations from $147

Book a Hotel + Flight or Car together to unlock savings

Photo by Alicia Panta

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Ana Vacation

Amazing adventures await when you lock in a vacation package to Santa Ana. Whether you're a history buff, art enthusiast or just a traveler who loves to discover new places, there's something for everyone in this lively city. A trip to Santa Ana is a wonderful opportunity to do a bit of sightseeing. Be sure to look around popular attractions like Plaza de Armas, San Pedro Market and Cusco Cathedral. Your Santa Ana vacation is a few clicks away. Search hotels, airfares and more on Expedia for an adventure that's tailored just for you.

The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Avraham Holtels

Avraham Holtels

3 out of 5
Price was $355, price is now $147 per person
$147
per person
Jan 6 - Jan 8
found 1 day ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
6/10 (1 review)
Very friendly staff - gave tips and helpful suggestions while around the town. Stay is simple - but having an open mindset regarding the location, it was enough for my needs.

Reviewed on Oct 18, 2025

Antigua Casona San Blas

Antigua Casona San Blas

4 out of 5
Cusco Historic Center
Price was $774, price is now $339 per person
$339
per person
Jan 23 - Jan 27
found 1 day ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
20/10 Exceptional! (1,000 reviews)
Incredibly welcoming and attentive staff. The room was spotless and beautiful. The breakfast was fantastic. Highly recommend

Reviewed on Nov 16, 2025

Yabar Hotel Plaza

Yabar Hotel Plaza

3 out of 5
Cusco Historic Center
Save 100% on your flight
Price was $332, price is now $178 per person
$178
per person
Jan 23 - Jan 27
found 1 day ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
8.6/10 Excellent! (304 reviews)
All the staff were very nice and the breakfast was great as well. The location is perfect. I just hope that WiFi can be stronger.

Reviewed on Nov 17, 2025

Casa San Blas Cusco Exquisite By Xima

Casa San Blas Cusco Exquisite By Xima

3 out of 5
Cusco Historic Center
Save 100% on your flight
Price was $441, price is now $238 per person
$238
per person
Jan 23 - Jan 27
found 1 day ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
9.2/10 Wonderful! (491 reviews)
If you plan on visiting Cusco, you have to stay here. It’s located right in the middle of eveything. San Blas is a beautiful neighborhood and you are less than a 10min walk to the Plaza De Armas. The staff was fantastic and super helpful. They were very accommodating. This place is fantastic!

Reviewed on Oct 29, 2025

RHouse Cusco

RHouse Cusco

3 out of 5
Tahuantinsuyo
Save 100% on your flight
Price was $303, price is now $168 per person
$168
per person
Jan 23 - Jan 27
found 1 day ago
Roundtrip flight included
Lima (LIM) to Cusco (CUZ)
8.4/10 Very Good! (181 reviews)
Friendly staff, great for big groups

Reviewed on Nov 14, 2025

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
La Merced Church which includes a city

Cusco Historic Center

7 out of top 10 points of interest in this area
4.5/5(904 area reviews)

Explore museums like Museo de Arte Precolombino and savor fusion and neo-Andean cuisine at local restaurants. Stroll through the artisan-filled San Blas neighborhood for a picturesque shopping experience.

Find hotels in Cusco Historic Center

Santa Ana Hotel Deals

Hilton Garden Inn Cusco

Hilton Garden Inn Cusco

3.5 out of 5
Santa Ana, Avenida Abancay 207, Cusco, Cusco
$119 nightly
The price is $119 total per night from Dec 15 to Dec 16
$119 total
Dec 15 - Dec 16
9.2/10 Wonderful! (1,003 reviews)
Everything was clean, we had a great view or Cusco and the buffet in the morning was great!

Reviewed on Nov 16, 2025

Hilton Garden Inn Cusco
Wyndham Costa del Sol Cusco

Wyndham Costa del Sol Cusco

4 out of 5
Santa Teresa N 344 Cusco Cusco
$132 nightly
The price is $132 total per night from Dec 8 to Dec 9
$132 total
Dec 8 - Dec 9
9.4/10 Exceptional! (1,084 reviews)
El hotel es bello, la cama super comoda. El lugar silencioso, se puede descansar. El personal de primera. Y la arquitectura del lugar es bella. Recomendable 100% El desayuno es muy bueno.

Reviewed on Nov 13, 2025

Wyndham Costa del Sol Cusco
Palacio del Inka, A Luxury Collection Hotel by Marriott

Palacio del Inka, A Luxury Collection Hotel by Marriott

5 out of 5
Plazoleta Santo Domingo No 259 Cusco Cusco
Fully refundableReserve now, pay when you stay
$437 nightly
The price is $437 total per night from Dec 1 to Dec 2
$437 total
Dec 1 - Dec 2
9.4/10 Exceptional! (959 reviews)
Very clean and safe with extremely attentive staff. Great location for restaurants and shops. I would highly recommend this hotel.

Reviewed on Nov 14, 2025

Palacio del Inka, A Luxury Collection Hotel by Marriott
See all 1,767 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Ana

Plaza de Armas featuring a garden and a church or cathedral

Plaza de Armas

4.5/5(853 reviews)

Cusco’s busy main square has been the center of public life for centuries. Enjoy its spacious layout, ancient churches and restaurants.

Plaza de Armas
Cusco San Pedro Market showing markets and food as well as a small group of people

San Pedro Market

4.5/5(451 reviews)

Get caught up in the chaos of this intriguing attraction and enjoy a uniquely Andean experience.

San Pedro Market
Cusco Cathedral

Cusco Cathedral

4.5/5(551 reviews)

An imposing building constructed with stones from an Inca fortress is celebrated for its beautiful architecture and artwork that spans three centuries.

Cusco Cathedral

Things to do

Excursion to Rainbow Mountain Full Day.

Excursion to Rainbow Mountain Full Day Optional Red Valley

$25
per adult
94% of travellers recommend
Excursion to Rainbow Mountain Full Day Optional Red Valley
Cusco City Tour Four Ruins Half-Day Tour

Cusco City Tour Four Ruins in Half-Day

$40
per adult
100% of travellers recommend
Cusco City Tour Four Ruins in Half-Day
Quad Bike Tour To Moray and Salt Mines in Sacred Valley

Quad Bike Tour To Moray and Salt Mines in Sacred Valley

$29
per adult
90% of travellers recommend
Quad Bike Tour To Moray and Salt Mines in Sacred Valley
See all activities in Cusco
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.