Title: Visit Santa Cruz County: 2026 Travel Guide for Santa Cruz County, Arizona | Expedia.com [Santa Cruz County Hotels](https://expedia.com/Destinations-In-Santa-Cruz-County.d553248635640635588.Hotel-Destinations)[Vacation Rentals in Santa Cruz County](https://expedia.com/Destinations-In-Santa-Cruz-County.d553248635640635588.Vacation-Rental-Destinations)[Santa Cruz County Flights](https://expedia.com/Destinations-In-Santa-Cruz-County.d553248635640635588.Flight-Destinations)[Things to do in Santa Cruz County](https://expedia.com/Things-To-Do-In-Santa-Cruz-County.d553248635640635588.Travel-Guide-Activities)[Car Rentals in Santa Cruz County](https://expedia.com/Destinations-In-Santa-Cruz-County.d553248635640635588.Car-Rental-Destinations)[Santa Cruz County Vacations](https://expedia.com/Santa-Cruz-County.d553248635640635588.Destination-Travel-Guides) # Santa Cruz County, AZ ## Arizona ![A Franciscan mission that was built in the late 18th century and was never rebuilt after being abandoned after repeated Apache raids in the 19th century that killed farmers and ranchers in the area. #LikeALocal](https://images.trvl-media.com/place/167653/c194b613-a1f4-456a-8a8a-6caa5209c979.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![A Franciscan mission that was built in the late 18th century and was never rebuilt after being abandoned after repeated Apache raids in the 19th century that killed farmers and ranchers in the area. #LikeALocal](https://images.trvl-media.com/place/167653/c194b613-a1f4-456a-8a8a-6caa5209c979.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Tubac, a historic destination for the arts! Tubac features over 100 eclectic shops and world class galleries situated along meandering streets. #arts #OnTheRoad](https://images.trvl-media.com/place/182938/c039ae2d-2c69-4e70-a386-d1d077a12a7f.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![The colourful hill slopes of Nogales, Arizona, which borders the city of Nogales, Sonora, Mexico, and is Arizona's largest international border community. The highways meeting in Nogales comprise a major road intersection in the CANAMEX Corridor, connecting Canada, the United States and Mexico.](https://images.trvl-media.com/place/6205/9450b6d6-be34-4a64-a078-3a842c9e7849.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Once an active gold mining camp this is all that remains of Alto, Arizona. It's located about 14 miles south of Patagonia, AZ on a mostly 2wd accessible road. The last couple miles require a hike or a 4wd vehicle. ](https://images.trvl-media.com/place/182938/64aaa883-9a0c-43e0-b807-a89d91fc49fb.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ### Popular cities in Santa Cruz County [Tubac Known for Golf, Shopping and Relaxing ](https://expedia.com/Tubac.dx182938) Trip time! Discover the art, golf, and spas in relaxing Tubac. ## Reasons to visit - Tubac Golf Resort - Tubac Center of the Arts - Tubac Presidio State Historic Park [Explore City](https://expedia.com/Tubac.dx182938)[Find Hotels](https://expedia.com/Tubac-Hotels.d182938.Travel-Guide-Hotels) [Nogales Known for Scenery, Sports and Running ](https://expedia.com/Nogales.dx6054715) Nogales is calling! Discover its sunsets, sports, natural setting, and more. ## Reasons to visit - Patagonia Lake State Park - Historic Santa Cruz County Courthouse [Explore City](https://expedia.com/Nogales.dx6054715)[Find Hotels](https://expedia.com/Nogales-Hotels.d6054715.Travel-Guide-Hotels) [Sonoita Known for Wineries and Natural parks ](https://expedia.com/Sonoita.dx6060117) Escape to Sonoita! Enjoy its wineries and parks. ## Reasons to visit - Arizona Hops and Vines - Roadside Rest [Explore City](https://expedia.com/Sonoita.dx6060117)[Find Hotels](https://expedia.com/Sonoita-Hotels.d6060117.Travel-Guide-Hotels) [Tumacacori Known for Natural parks ](https://expedia.com/Tumacacori.dx167653) Explore Tumacacori: its parks and more! ## Reasons to visit - Tumacacori National Historical Park [Explore City](https://expedia.com/Tumacacori.dx167653)[Find Hotels](https://expedia.com/Tumacacori-Hotels.d167653.Travel-Guide-Hotels) [Patagonia Known for Bird watching, Biking and Forests ](https://expedia.com/Patagonia.dx143941) Patagonia awaits: its forests, festivals, horseback riding, and more! [Explore City](https://expedia.com/Patagonia.dx143941)[Find Hotels](https://expedia.com/Patagonia-Hotels.d143941.Travel-Guide-Hotels) [Rio Rico Known for Golf, Spas and Shopping ](https://expedia.com/Rio-Rico.dx181490) Get away to romantic Rio Rico! Enjoy the natural setting, golf, and spas. [Explore City](https://expedia.com/Rio-Rico.dx181490)[Find Hotels](https://expedia.com/Rio-Rico-Hotels.d181490.Travel-Guide-Hotels) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_553248635640635588) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app