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Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Oct 23 - Oct 25
In two months
Dec 4 - Dec 6
In three months
Jan 1 - Jan 3
In four months
Jan 29 - Jan 31

Our top choices for Santa Cruz vacation rentals

A neatly made bed with a wooden headboard, a bedside table with a bottle and a glass, and a chair in a bright room with a large window.

1. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (297 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
$67 nightly
The price is $67
Oct 11 - Oct 12
Portal del Rodeo ApartaHotel - Arkadia Mall
A modern hotel room with a large bed, a desk, a chair, a potted plant, and a view of the mountains.

2. Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (136 reviews)
"Excellent Stay!"
United States
Esdras
$51 nightly
The price is $51
Oct 26 - Oct 27
Go Living and Suites by Jalo
A woman standing by a balcony with a view of a rural landscape.

3. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.2 out of 10, Very good, (495 reviews)
"Very clean and a good rear view of landscape"
United States
roberto
$105 nightly
The price is $105
Oct 9 - Oct 10
Travelers Rio Verde Living Suites
A modern living room with a large window, a sofa set, a coffee table, and a potted plant.

4. Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.0 out of 10, Wonderful, (90 reviews)
"Clean, good location, nice staff"
United States
Sau Yeng
$66 nightly
The price is $66
Oct 25 - Oct 26
Metropolitan Living by HOUSY
A modern hotel room with a bed, bedside table, lamp, and a TV.

5. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (219 reviews)
"My favorite place to stay by far! Everything is within few blocks! Bars,discos, restaurants! You named!! The staff is like family to me ! I highly recommend this hotel!!"
United States
Luis
$56 nightly
The price is $56
Oct 15 - Oct 16
Origen Local Suites
A modern apartment with a living area, kitchenette, and large windows offering city views.

6. Kyux by Jalo

Kyux by Jalo
4.0 star property
Laureles
9.2 out of 10, Wonderful, (184 reviews)
"No complains everything was great very quiet at night lot of restaurants close by also supermarket and pharmacy that was my 5th stay at this hotel and will be back soon highly recommended"
United States
Antonio
$45 nightly
The price is $45
Oct 20 - Oct 21
Kyux by Jalo
A modern hotel room with a large bed, a flat-screen TV, and a view of the city through large windows.

7. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (145 reviews)
"The staff were terrific and helpful. The room was perfect in an ideal location."
United States
Amy
$90 nightly
The price is $90
Oct 15 - Oct 16
Factory Lofts
A modern interior with marble flooring, a reception area, and a seating area with tables and chairs.

8. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (743 reviews)
"When I travel to Medellin I always stay at Haven. Everything is always great!!!"
United States
Aaron
$98 nightly
The price is $98
Oct 13 - Oct 14
Haven, A Design Hotel
An outdoor café with tables and chairs, surrounded by potted plants and a view of buildings.

9. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (104 reviews)
"Excellent breakfast, good location "
United States
dickie
$44 nightly
The price is $44
Oct 15 - Oct 16
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
A balcony with a hot tub, wooden steps, and a potted plant.

10. Wake Living

Wake Living
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (235 reviews)
"Great place"
United States
Pedro
$158 nightly
The price is $158
Oct 14 - Oct 15
Wake Living
A modern restaurant with high ceilings, large windows, and a city view. Tables are set with dishes and drinks.

11. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (75 reviews)
"Room was as expected, didn’t reward the fine print of cooling condition for the room , had a fan available in the room which helped. Appreciate the host, and the security of the building and room especially being I was a solo traveler"
United States
jocelyne
$30 nightly
The price is $30
Oct 13 - Oct 14
Edificio Helena
A modern hotel room with a large bed, a TV mounted on the wall, and a view of the cityscape through large windows.

12. HOUSY Laureles

HOUSY Laureles
4.0 star property
Laureles
9.2 out of 10, Wonderful, (109 reviews)
"The staff was helpfull"
United States
Elsje
$77 nightly
The price is $77
Oct 29 - Oct 30
HOUSY Laureles
A modern hotel room with a large bed, a small table, a potted plant, and a city view through the window.

13. Estelar Apartamentos Medellin

Estelar Apartamentos Medellin
3.5 star property
El Poblado
8.8 out of 10, Excellent, (499 reviews)
"Great location"
United States
Andrew
$108 nightly
The price is $108
Nov 8 - Nov 9
Estelar Apartamentos Medellin
A modern bedroom with a large bed, a built-in wardrobe, a kitchen area, and a balcony with plants.

14. Living by Armoniko

Living by Armoniko
4.0 star property
Laureles
9.6 out of 10, Exceptional, (85 reviews)
"Amazing gem in Laureles! This place is addictive and I will surely return and reccommend to others for staying in Medellin. Great service, beautiful and clean property and facilities @ great value."
United States
Ryan
$126 nightly
The price is $126
Oct 16 - Oct 17
Living by Armoniko
A rooftop patio with tables and chairs, a bar area, and a view of the cityscape.

15. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (26 reviews)
"Exceptionally friendly staff, the property is top notch. Cafe Soler is incredible."
United States
Frederick
$55 nightly
The price is $55
Nov 8 - Nov 9
B 48 Living by B Rent
A modern living room with a large window, a sofa, a coffee table, and a kitchen area with a marble island.

16. Loft 43

Loft 43
3.0 star property
Laureles
8.8 out of 10, Excellent, (37 reviews)
"We stayed 1 week. The unit was clean, friendly staff and location was the best. Near several restaurants, grocery. Not noisy"
United States
Mario
$49 nightly
The price is $49
Oct 15 - Oct 16
Loft 43
A person relaxing in a hot tub with a scenic view of mountains and clouds.

17. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (44 reviews)
"Good location with amazing views, a bit difficult finding . But overall great place to visit."
United States
Giovanni
$73 nightly
The price is $73
Oct 12 - Oct 13
Skyline Ecoliving
A building with a brick facade, storefronts for jewelry and MUZEM, and a tree in front.

18. Living 10-36 Dieztreintayseis Short & Long Term

Living 10-36 Dieztreintayseis Short & Long Term
3.5 star property
El Poblado
9.0 out of 10, Wonderful, (63 reviews)
"Loved the room I stayed in and the staff was always accommodating. Great Boutique Hotel to stay."
United States
Rob
$61 nightly
The price is $61
Oct 14 - Oct 15
Living 10-36 Dieztreintayseis Short & Long Term
A modern living room with a white sofa, round coffee table, and a dining area with a wooden table and chairs.

19. Apartment Go Living & Suites by HOUSY HOST

Apartment Go Living & Suites by HOUSY HOST
3.5 star property
El Poblado
8.4 out of 10, Very good, (459 reviews)
"Great location, secure place, quiet, private parking"
United States
CAMILO
$77 nightly
The price is $77
Nov 8 - Nov 9
Apartment Go Living & Suites by HOUSY HOST
A rooftop terrace with two hot tubs, a dining area with chairs and a table, and a view of a cityscape with mountains in the background.

20. Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (114 reviews)
"Beautiful hotel great location great breakfast"
United States
gary
$48 nightly
The price is $48
Nov 8 - Nov 9
Quadrato Studios
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Urbit Social Lofts

Urbit Social Lofts

8/10 Good
"They could gotten a 10 but the false advertisement/ publicidad enganosa for executive room is false. It is a standard room. Ejecutivo habatacion es falso, es una habitacion standard. THEY GOT AN 8 BECAUSE OF THAT. I HAD TO PAY EXTRA TO GET A BETTER ROOM , PER EXPEDIA I COULD GET AN UPGRADE PER MY STATUS. THEY SAID IT IS NOT. HOTEL IS WELL SITUATED, RESTAURANTS NEXT DOOR, ACROSS, IN THE CORNER, SUPER MARKET 2 BLOCKS. CLEANING LADY EXCELLENT. BREAKFAST IS NOT OF QUALITY MINI BAR IS EXPENSIVE BUY YOUR OWN WATER AND SODA, COST ME 12 D0LLARS FOR 3 SODAS. VERY SAFE. GOOD HOTEL TO STAY. RECEPTION DESK VERY POLITE."
Rulph and Monica 3-night trip
Posted less than an hour ago
Urbit Social Lofts

Find out more about Santa Cruz

Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $32 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

6 Bedrooms House near Tourist Spots with backyard, Bar, Jacuzzi and heated pool: Visitors like this Santa Cruz vacation home rental. It offers an outdoor pool, a patio, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 6 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You can relax into your vacation with a garden and a hot tub.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.