Santa Cruz Vacations from $503

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Your Santa Cruz Vacation

An easy way to experience this unique city is with a custom-made Santa Cruz vacation package. Base yourself in the neighborhood of La Candelaria, which is good for dining, history and shopping or go someplace else — our packages are all about you. Every trip to Santa Cruz needs a well-thought-out itinerary. Fill yours with major attractions such as Atanasio Giradot Stadium, Botero Plaza and Lights Park. A couple of quick clicks is all it takes to build your dream Santa Cruz vacation on Expedia.

The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel La Magdalena

Hotel La Magdalena

3.5 out of 5
Save 100% on your flight
Price was $887, price is now $503 per person
$503
per person
May 26 - Jun 1
found 12 hours ago
Roundtrip non-stop flight included
San Juan (SJU) to Medellín (MDE)
8.4/10 Very Good! (27 reviews)
Clean rooms, helpful staff, and nice views.

Reviewed on Nov 29, 2025

Atma Villas - Holistic Wellness Experience

Atma Villas - Holistic Wellness Experience

3 out of 5
Save 100% on your flight
Price was $1,311, price is now $647 per person
$647
per person
Jun 11 - Jun 15
found 9 hours ago
Roundtrip flight included
Fort Lauderdale (FLL) to Medellín (MDE)
8.8/10 Excellent! (43 reviews)
We had an amazing stay at Atma Villas – Holistic Wellness Experience. Everything was perfect! The place is very clean, and the beds and pillows are extremely comfortable. The staff is incredibly friendly and helpful — they explain everything and make you feel very welcome. The atmosphere is peaceful and relaxing. It takes about 20 minutes by tuk-tuk to get to Guatapé, which is very convenient. The breakfasts are delicious, and the dinners are absolutely outstanding — truly unforgettable! The staff is wonderful, and we would definitely love to come back again.

Reviewed on Mar 24, 2026

PENTHOUSE RIO CLARO 1002

PENTHOUSE RIO CLARO 1002

2 out of 5
El Poblado
Save 100% on your flight
Price was $2,368, price is now $1,252 per person
$1,252
per person
Jun 14 - Jun 21
found 1 day ago
Roundtrip non-stop flight included
San Juan (SJU) to Medellín (MDE)
No reviews
Luxury Home In Aguacatala

Luxury Home In Aguacatala

4 out of 5
El Poblado
Save 100% on your flight
Price was $3,805, price is now $2,140 per person
$2,140
per person
Jun 17 - Jun 22
found 1 day ago
Roundtrip flight included
San Juan (SJU) to Medellín (MDE)
2/10 (1 review)
Luxury Home In Las Lomas

Luxury Home In Las Lomas

4 out of 5
El Poblado
Save 100% on your flight
Price was $3,621, price is now $2,046 per person
$2,046
per person
Jun 17 - Jun 22
found 1 day ago
Roundtrip flight included
San Juan (SJU) to Medellín (MDE)
No reviews
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Discover the most popular places to visit in Santa Cruz

Foto aérea del Parque de El Poblado, en la ciudad de Medellín, aparece la Iglesia de San José, Católica.

Poblado Park

4.5/5(219 reviews)

After visiting Poblado Park, make a plan to see the other sights and activities in Medellín. Check out the shops and lively bars in this walkable area.

Poblado Park
Santafé Mall

Santafé Mall

4.5/5(493 reviews)

During your visit to Medellín, you can search for that perfect souvenir at Santafé Mall. Check out the lively bars or top-notch restaurants in this walkable area.

Santafé Mall
Pueblito Paisa

Pueblito Paisa

4.5/5(380 reviews)

Take a trip back in time to a replica of a typical old town from the region with a stunning view of the new city.

Pueblito Paisa

What to do in Santa Cruz

Medellín: Comuna 13 District Tour with Cable Car Ride

Medellín: Comuna 13 District Tour with Cable Car Ride

$27
per adult
98% of travellers recommend
Medellín: Comuna 13 District Tour with Cable Car Ride
Pablo Escobar Tour Medellin

Pablo Escobar Tour : Museum, History and Beer

$40
per adult
90% of travellers recommend
Pablo Escobar Tour : Museum, History and Beer
See all activities in Santa Cruz

Santa Cruz Hotel Deals

Calle Flora Hotel by Jalo

Calle Flora Hotel by Jalo

4 out of 5
# 37-40 Calle 9A Medellín
Fully refundable
$101 nightly
The price is $101 total per night from Apr 5 to Apr 6
$101 total
Apr 5 - Apr 6
9/10 Wonderful! (665 reviews)
Good location, average service at the front desk but I would probably not stay here again.

Reviewed on Apr 2, 2026

Calle Flora Hotel by Jalo
Heiss Hotel By Jalo

Heiss Hotel By Jalo

4 out of 5
1460 Cra. 43F Medellín Antioquia
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $70 total per night from May 3 to May 4
$70 total
May 3 - May 4
9.2/10 Wonderful! (1,349 reviews)
We stayed in the Junior suite and had an amazing experience. Great layout with 2 balconies and a separate living room area for tv. Staff were extremely kind and always offered help where needed. For example, one day there was heavy rain when we were headed out to dinner and the front desk offered ...

Reviewed on Apr 1, 2026

Heiss Hotel By Jalo
Hashtag 98 Hotel By Jalo

Hashtag 98 Hotel By Jalo

4 out of 5
Carrera 41 # 10 - 37 Medellín Medellín
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $87 total per night from Apr 26 to Apr 27
$87 total
Apr 26 - Apr 27
9.2/10 Wonderful! (1,830 reviews)
Me encanto la experiencia Hashtag 98 los empleados, el servicio al cliente, los cuartos la atención. Super recomendando es la segunda vez que me hospedo en ese hotel.

Reviewed on Apr 2, 2026

Hashtag 98 Hotel By Jalo
See all 4,175 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Cruz Vacation Packages

Santa Cruz Essential Information

Language
Spanish
Currency
Colombian pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Jose Maria Cordova Intl. Airport (MDE)
Top Sights
Pueblito Paisa, Antioquia Museum and Explora Park

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
You can grab a vacation package to this top destination from $503 on Expedia. However, how much your vacation to Santa Cruz costs will depend on factors like the length of stay, season and hotel choice.
What are the cheapest months to go to Santa Cruz?
You're likely to find lower rates and better availability in September, November and December. Explore our cheap Santa Cruz vacation packages and you could score some great off-season deals.
How many days is enough for Santa Cruz?
With a well-organized itinerary, you can easily hit the top Santa Cruz attractions in a handful of days. But if you want to discover hidden spots or go on day tours, think about booking your Santa Cruz vacation for longer.
How to find the best Santa Cruz package deals?
Start your search for a Santa Cruz package deal by entering your travel dates and destination under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to fine-tune the results to your exact style. You can also sort by "Package discount" and browse offers that come with huge savings. If you don't find the perfect Santa Cruz package deal straight away, simply change your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Cruz escape underway.
Is it cheaper to book a Santa Cruz vacation as a package?
An Expedia vacation package could score you significant savings when compared to booking accommodations and flights separately. Better still, you can personalize your Santa Cruz getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to Santa Cruz?
If you have your Santa Cruz vacation dates finalized, book as soon as you can to bag some incredible deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for traveling on a whim.
How to plan a trip to Santa Cruz?

  1. Choose your travel dates: What you want to do in Santa Cruz and your favorite season will help you decide when to go.
  2. Budget wisely: As well as the cost of your stay, you should consider other expenses too. These include food, flights and transportation. Also, set aside a little extra for unexpected expenses that could arise during your trip to Santa Cruz.
  3. Use our trip planning tool to discover Santa Cruz: Research every aspect of your trip to Santa Cruz with this comprehensive planner. Invite your friends and family to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Decide how long to go for: Now that you're up to speed on Santa Cruz, you can figure out the right length of your vacation. Create a draft itinerary and allocate enough time to cover everything you want to see.
  5. Combine your airfare and accommodations: After you've nailed down your dates and duration, lock in the perfect Santa Cruz vacation package for you.
  6. Add on excursions and experiences: Read our dedicated travel guide to find some awesome things to do in Santa Cruz in Santa Cruz. Book tickets or make reservations as soon as you can to save time and avoid the stress of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
If you're like us, you love exploring new places but don't love the big price tag that can sometimes come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Santa Cruz vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.