Santa Cruz Vacations from $387

Book a Hotel + Flight or Car together to unlock savings

Your Santa Cruz Vacation

An easy way to experience this unique city is with a custom-made Santa Cruz vacation package. Base yourself in the neighborhood of La Candelaria, which is good for dining, history and shopping or go someplace else — our packages are all about you. Every trip to Santa Cruz needs a well-thought-out itinerary. Fill yours with major attractions such as Atanasio Giradot Stadium, Botero Plaza and Lights Park. A couple of quick clicks is all it takes to build your dream Santa Cruz vacation on Expedia.

The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Casa Linda Guatapé

Casa Linda Guatapé

3 out of 5
Price was $616, price is now $387 per person
$387
per person
Nov 18 - Nov 25
found 1 day ago
Roundtrip non-stop flight included
San Juan (SJU) to Medellín (MDE)
7.6/10 Good! (14 reviews)
Staff súper amable Desayuno muy completo El cuarto y baño muy limpio y amplio Definitivamente para volver.

Reviewed on Sep 8, 2024

EP Casa Uribe Architecture Art & Nature

EP Casa Uribe Architecture Art & Nature

4 out of 5
El Poblado
Save 100% on your flight
Price was $3,129, price is now $1,752 per person
$1,752
per person
Nov 13 - Nov 16
found 2 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Medellín (MDE)
10/10 Exceptional! (3 reviews)
The house is extremely comfortable and spacious. Luxury amenities that made us feel at home. The pool, jacuzzi and sauna. Graciela the house keeper and Charles our private chef made our stay amazing. It was nice that they had a lunch and dinner menu available for those days we wanted to stay in. Probably one of the best stays in Medellin. The location is just minutes away from Provenza and surroundings. Manuela the host was super attentive, helping us with reservations at restaurants.

Reviewed on Mar 24, 2025

Sonata 44 Hotel Laureles

Sonata 44 Hotel Laureles

3 out of 5
Laureles
Price was $1,560, price is now $884 per person
$884
per person
Dec 27 - Jan 3
found 1 day ago
Roundtrip flight included
Fort Lauderdale (FLL) to Medellín (MDE)
9/10 Wonderful! (54 reviews)
Excellent service and very clean.

Reviewed on Sep 18, 2024

Moet Medellin Hotel

Moet Medellin Hotel

3 out of 5
El Poblado
Price was $1,129, price is now $679 per person
$679
per person
Dec 29 - Jan 2
found 1 day ago
Roundtrip flight included
Fort Lauderdale (FLL) to Medellín (MDE)
9/10 Wonderful! (100 reviews)
Excellent customer service in

Reviewed on Sep 7, 2025

Tau House

Tau House

3 out of 5
Price was $1,030, price is now $658 per person
$658
per person
Nov 26 - Nov 30
found 1 day ago
Roundtrip flight included
Fort Lauderdale (FLL) to Medellín (MDE)
9.4/10 Exceptional! (100 reviews)
The location, resort, and staff were great. The only down fall is that the bathroom did not have ventilation and the window in the bathroom felt like you did not have privacy, but besides that It was wonderful stay.

Reviewed on Oct 4, 2025

Don't see what you're looking for?
See all available trips from Columbus to Santa Cruz
View all trips

Discover the most popular places to visit in Santa Cruz

Such an impressive mall. With the heat that we struggled to adapt to in Medellin, we often found ourselves seeking out the comfort of air conditioned malls. Although, malls are not are favorite thing, this was definitely our favorite mall in Medellin. A must see, if you're in the area. #colombia #shopping #travel

Santafé Mall

4.5/5(485 reviews)

During your visit to Medellín, you can search for that perfect souvenir at Santafé Mall. Check out the top-notch restaurants or lively bars in this walkable area.

Santafé Mall
Botero Square Sculpture Park featuring a church or cathedral, a square or plaza and a city

Botero Plaza

4.5/5(476 reviews)

Walk among comically obese statues made by the illustrious artist Fernando Botero in this spacious plaza full of artisans and restaurants.

Botero Plaza
The Colombians are big supporters of soccer and watching a soccer game of Medellin Independente or Nacional in the Estadio in Medellin is a very special experience! 90 mins of singing, jumping, playing the drums and supportung the team. Be careful to go to the South or North area in the stadium, that's where the very extreme fans are. Seats in the Occidental and Oriental area are good places to watch the games.

Atanasio Giradot Stadium

4.5/5(122 reviews)

Catch an event at Atanasio Giradot Stadium during your trip to Medellín. Check out the shops and top-notch restaurants in this walkable area.

Atanasio Giradot Stadium

What to do in Santa Cruz

Pablo Escobar Tour Medellin

Pablo Escobar Tour Medellin

$32
per adult
90% of travellers recommend
Pablo Escobar Tour Medellin
Medellín: Comuna 13 District Tour with Cable Car Ride

Medellín: Comuna 13 District Tour with Cable Car Ride

$27
per adult
96% of travellers recommend
Medellín: Comuna 13 District Tour with Cable Car Ride
See all activities in Santa Cruz

Santa Cruz Hotel Deals

Hotel Dorado La 70

Hotel Dorado La 70

4 out of 5
Carrera 70 No 44 B-66, Laureles, Medellín
Fully refundableReserve now, pay when you stay
8.6/10 Excellent! (1,660 reviews)
My stay
"The hotel sits in a busy nightlife area. The noise at night is ongoing until 4am. Also, the bathroom toilet paper is in one of those dispensers that holds a big round roll. However it is difficult to keep the toilet paper from breaking, and then you have to dig underneath to find the start of the ..."

Reviewed on Oct 6, 2025

Get rates
Hotel Dorado La 70
Heiss Hotel By Jalo

Heiss Hotel By Jalo

4 out of 5
1460 Cra. 43F, Medellín, Antioquia
Fully refundable
$64 nightly
The price is $64 total per night from Oct 19 to Oct 20
$64 total
Oct 19 - Oct 20
9/10 Wonderful! (880 reviews)
"Very clean and modern hotel. Felt safe and many dining options in the area."

Reviewed on Oct 12, 2025

Heiss Hotel By Jalo
York Luxury Suites Medellín

York Luxury Suites Medellín

4 out of 5
Carrera 43a 17sur 63, Medellín, Antioquia
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $148 total per night from Nov 5 to Nov 6
$148 total
Nov 5 - Nov 6
9.4/10 Exceptional! (1,351 reviews)
"Everything was clean and very friendly staff"

Reviewed on Oct 9, 2025

York Luxury Suites Medellín
See all 4,397 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santa Cruz Essential Information

Language
Spanish
Currency
Colombian pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Jose Maria Cordova Intl. Airport (MDE)
Top Sights
Pueblito Paisa, Antioquia Museum and Explora Park

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santa Cruz vacation package cost?
You can grab a vacation package to this top destination from $387 on Expedia. However, how much your vacation to Santa Cruz costs will depend on factors like the length of stay, season and hotel choice.
What are the cheapest months to go to Santa Cruz?
You're likely to find lower rates and better availability in September, November and December. Explore our cheap Santa Cruz vacation packages and you could score some great off-season deals.
How many days is enough for Santa Cruz?
With a well-organized itinerary, you can easily hit the top Santa Cruz attractions in a handful of days. But if you want to discover hidden spots or go on day tours, think about booking your Santa Cruz vacation for longer.
How to find the best Santa Cruz package deals?
Start your search for a Santa Cruz package deal by entering your travel dates and destination under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to fine-tune the results to your exact style. You can also sort by "Package discount" and browse offers that come with huge savings. If you don't find the perfect Santa Cruz package deal straight away, simply change your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Cruz escape underway.
Is it cheaper to book a Santa Cruz vacation as a package?
An Expedia vacation package could score you significant savings when compared to booking accommodations and flights separately. Better still, you can personalize your Santa Cruz getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to Santa Cruz?
If you have your Santa Cruz vacation dates finalized, book as soon as you can to bag some incredible deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for traveling on a whim.
How to plan a trip to Santa Cruz?

  1. Choose your travel dates: What you want to do in Santa Cruz and your favorite season will help you decide when to go.
  2. Budget wisely: As well as the cost of your stay, you should consider other expenses too. These include food, flights and transportation. Also, set aside a little extra for unexpected expenses that could arise during your trip to Santa Cruz.
  3. Use our trip planning tool to discover Santa Cruz: Research every aspect of your trip to Santa Cruz with this comprehensive planner. Invite your friends and family to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Decide how long to go for: Now that you're up to speed on Santa Cruz, you can figure out the right length of your vacation. Create a draft itinerary and allocate enough time to cover everything you want to see.
  5. Combine your airfare and accommodations: After you've nailed down your dates and duration, lock in the perfect Santa Cruz vacation package for you.
  6. Add on excursions and experiences: Read our dedicated travel guide to find some awesome things to do in Santa Cruz in Santa Cruz. Book tickets or make reservations as soon as you can to save time and avoid the stress of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
If you're like us, you love exploring new places but don't love the big price tag that can sometimes come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Santa Cruz vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.