Santa Cruz Vacations from $365

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Your Santa Cruz Vacation

An easy way to experience this unique city is with a custom-made Santa Cruz vacation package. Base yourself in the neighborhood of La Candelaria, which is good for dining, history and shopping or go someplace else — our packages are all about you. Every trip to Santa Cruz needs a well-thought-out itinerary. Fill yours with major attractions such as Atanasio Giradot Stadium, Botero Plaza and Lights Park. A couple of quick clicks is all it takes to build your dream Santa Cruz vacation on Expedia.

The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Aparta Suites Torre Poblado

Aparta Suites Torre Poblado

3 out of 5
El Poblado
Save 100% on your flight
Price was $637, price is now $365 per person
$365
per person
Apr 22 - Apr 26
found 1 day ago
Roundtrip non-stop flight included
Fort Lauderdale (FLL) to Medellín (MDE)
8.8/10 Excellent! (863 reviews)
Staff was courteous and super helpful. It's in a good location to access Poblado spots. It's noisy outside, but that's expected for the area. The hotel isn't fancy, but clean place to rest after sightseeing.

Reviewed on Feb 4, 2026

Sonata 44 Hotel Laureles

Sonata 44 Hotel Laureles

3 out of 5
Laureles
Price was $973, price is now $427 per person
$427
per person
Apr 22 - Apr 26
found 18 hours ago
Roundtrip non-stop flight included
Fort Lauderdale (FLL) to Medellín (MDE)
9.2/10 Wonderful! (57 reviews)
Buen servicio. Desayunos con mucho sabor y céntrico para conocer la ciudad.

Reviewed on Feb 2, 2026

Hotel Villa Real

Hotel Villa Real

2.5 out of 5
Laureles - Estadio
Save 100% on your flight
Price was $711, price is now $398 per person
$398
per person
Mar 22 - Mar 26
found 14 hours ago
Roundtrip flight included
San Juan (SJU) to Medellín (MDE)
7.2/10 Good! (52 reviews)
Estuvo genial gracias

Reviewed on Sep 28, 2025

Tau House

Tau House

4 out of 5
Price was $1,922, price is now $1,144 per person
$1,144
per person
Apr 1 - Apr 7
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Medellín (MDE)
9.4/10 Exceptional! (112 reviews)
Todo fue excelente.. Super recomendado. Lindo, limpio, agradable!

Reviewed on Jan 5, 2026

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Discover the most popular places to visit in Santa Cruz

Foto aérea del Parque de El Poblado, en la ciudad de Medellín, aparece la Iglesia de San José, Católica.

Poblado Park

After visiting Poblado Park, make a plan to see the other sights and activities in Medellín. Check out the shops and top-notch restaurants in this walkable area.

Poblado Park
Such an impressive mall. With the heat that we struggled to adapt to in Medellin, we often found ourselves seeking out the comfort of air conditioned malls. Although, malls are not are favorite thing, this was definitely our favorite mall in Medellin. A must see, if you're in the area. #colombia #shopping #travel

Santafé Mall

During your visit to Medellín, you can search for that perfect souvenir at Santafé Mall. Check out the top-notch restaurants or lively bars in this walkable area.

Santafé Mall
Medellín, Antioquia, Colombia. August 3, 2009: Plaza Mayor Convention Center

Plaza Mayor Convention Center

Learn about the events happening at Plaza Mayor Convention Center during your trip to Medellín. Make time to visit the area's shops, or simply enjoy its lively bars.

Plaza Mayor Convention Center

What to do in Santa Cruz

Pablo Escobar Tour Medellin

Pablo Escobar Tour : Museum, History and Beer

$32
per adult
94% of travellers recommend
Pablo Escobar Tour : Museum, History and Beer
Medellin: Coffee Tour with Hotel Transfers and Meals

Medellin: Coffee Tour with Hotel Transfers and Meals

$69
per adult
98% of travellers recommend
Medellin: Coffee Tour with Hotel Transfers and Meals
See all activities in Santa Cruz

Santa Cruz Hotel Deals

Calle Flora Hotel by Jalo

Calle Flora Hotel by Jalo

3.5 out of 5
# 37-40 Calle 9A Medellín
Fully refundable
$64 nightly
The price is $64 total per night from Feb 22 to Feb 23
$64 total
Feb 22 - Feb 23
9/10 Wonderful! (460 reviews)
great

Reviewed on Feb 13, 2026

Calle Flora Hotel by Jalo
Heiss Hotel By Jalo

Heiss Hotel By Jalo

4 out of 5
1460 Cra. 43F Medellín Antioquia
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $60 total per night from Mar 9 to Mar 10
$60 total
Mar 9 - Mar 10
9/10 Wonderful! (1,183 reviews)
All of the above then some, will definitely be staying again

Reviewed on Feb 11, 2026

Heiss Hotel By Jalo
Hotel Dorado La 70

Hotel Dorado La 70

4 out of 5
Carrera 70 No 44 B-66 Medellín
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $68 total per night from Feb 17 to Feb 18
$68 total
Feb 17 - Feb 18
8.8/10 Excellent! (1,839 reviews)
Clean, great area

Reviewed on Feb 7, 2026

Hotel Dorado La 70
See all 4,250 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Cruz Vacation Packages

Santa Cruz Essential Information

Language
Spanish
Currency
Colombian pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Jose Maria Cordova Intl. Airport (MDE)
Top Sights
Pueblito Paisa, Antioquia Museum and Explora Park

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
You can grab a vacation package to this top destination from $365 on Expedia. However, how much your vacation to Santa Cruz costs will depend on factors like the length of stay, season and hotel choice.
What are the cheapest months to go to Santa Cruz?
You're likely to find lower rates and better availability in September, November and December. Explore our cheap Santa Cruz vacation packages and you could score some great off-season deals.
How many days is enough for Santa Cruz?
With a well-organized itinerary, you can easily hit the top Santa Cruz attractions in a handful of days. But if you want to discover hidden spots or go on day tours, think about booking your Santa Cruz vacation for longer.
How to find the best Santa Cruz package deals?
Start your search for a Santa Cruz package deal by entering your travel dates and destination under our "Packages" tab. Then add some filters, like "Guest rating" and "Property type," to fine-tune the results to your exact style. You can also sort by "Package discount" and browse offers that come with huge savings. If you don't find the perfect Santa Cruz package deal straight away, simply change your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Cruz escape underway.
Is it cheaper to book a Santa Cruz vacation as a package?
An Expedia vacation package could score you significant savings when compared to booking accommodations and flights separately. Better still, you can personalize your Santa Cruz getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to Santa Cruz?
If you have your Santa Cruz vacation dates finalized, book as soon as you can to bag some incredible deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for traveling on a whim.
How to plan a trip to Santa Cruz?

  1. Choose your travel dates: What you want to do in Santa Cruz and your favorite season will help you decide when to go.
  2. Budget wisely: As well as the cost of your stay, you should consider other expenses too. These include food, flights and transportation. Also, set aside a little extra for unexpected expenses that could arise during your trip to Santa Cruz.
  3. Use our trip planning tool to discover Santa Cruz: Research every aspect of your trip to Santa Cruz with this comprehensive planner. Invite your friends and family to collaborate on a group trip, search for hotels or things to do and make bookings.
  4. Decide how long to go for: Now that you're up to speed on Santa Cruz, you can figure out the right length of your vacation. Create a draft itinerary and allocate enough time to cover everything you want to see.
  5. Combine your airfare and accommodations: After you've nailed down your dates and duration, lock in the perfect Santa Cruz vacation package for you.
  6. Add on excursions and experiences: Read our dedicated travel guide to find some awesome things to do in Santa Cruz in Santa Cruz. Book tickets or make reservations as soon as you can to save time and avoid the stress of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
If you're like us, you love exploring new places but don't love the big price tag that can sometimes come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can break down the overall cost of your Santa Cruz vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.