Santa Fe Vacations from $546

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Your Santa Fe Vacation

Our vacation packages to Santa Fe let you customize your own adventure. Tailor your getaway to suit your interests and needs and make the most of your time in this interesting city. Want to explore your surroundings? Alto de Piedra Waterfall, Town Square and Cerro Tute are some of the most popular places to visit during your trip to Santa Fe. Stop daydreaming and start traveling. Browse the wide range of options on Expedia today and finally put your Santa Fe vacation plans into motion!

The Latest Santa Fe vacation packages

Price found within the past 48 hours. Click for updated prices.
Villa Marina Hotel

Villa Marina Hotel

3.5 out of 5
Price was $747, price is now $546 per person
$546
per person
Apr 23 - Apr 27
found 9 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9/10 Wonderful! (143 reviews)
J’ai tout aimé de l’endroit qui était féerique, tranquille, directement sur le bord de la plage. Le personnel impeccable et la chambre parfaite et confortable 😊

Reviewed on Feb 23, 2026

Mahogany Suites

Mahogany Suites

2 out of 5
Price was $1,086, price is now $584 per person
$584
per person
May 27 - Jun 1
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
10/10 Exceptional! (1 review)
Excellent apartment on a golf resort. 5 Star.

Reviewed on Jan 28, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,653, price is now $1,703 per person
$1,703
per person
Apr 8 - Apr 15
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (1,008 reviews)
The staff was great an the hotel

Reviewed on Mar 2, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,142, price is now $791 per person
$791
per person
May 11 - May 15
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,437 reviews)
View of the city but you can ask prior arrival your prefernce. Shops are nearby

Reviewed on Mar 2, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,781, price is now $1,256 per person
$1,256
per person
Apr 8 - Apr 15
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (5,057 reviews)
The poolside service was extremely nice. Havent had issues at most RIUs so as expected hotel was clean, convenient, good location , we walked to restaurant like a block away which was pretty good

Reviewed on Mar 8, 2026

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Discover the most popular places to visit in Santa Fe

Quebrada Las Trancas Spa

Commune with nature and explore the great outdoors at Quebrada Las Trancas Spa during your travels in Santa Fe. While you're in the area, wander around the natural setting.

Quebrada Las Trancas Spa

Alto de Piedra Waterfall

Commune with nature and explore the great outdoors at Alto de Piedra Waterfall during your travels in Santa Fe. While you're in the area, wander around the natural setting.

Alto de Piedra Waterfall

Orchid House

2/5(1 review)

Explore the great outdoors at Orchid House, a lovely green space in Santa Fe. Stroll along the riverfront or visit the churches while you're in the area.

Orchid House

Santa Fe Hotel Deals

La Qhia Eco Retreat

La Qhia Eco Retreat

2.5 out of 5
Barriada el Cerro A 100 Mts De Santa Fe Veraguas
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La Qhia Eco Retreat
Hotel Anachoreo

Hotel Anachoreo

3 out of 5
Calle Chinita Santa Fe Veraguas Province
Fully refundableReserve now, pay when you stay
9.6/10 Exceptional! (40 reviews)
This is a great place to unwind and enjoy the spectacular view. The room was quiet, clean and comfortable. The breakfast was convenient and large. I highly recommend the massage.

Reviewed on Mar 7, 2026

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Hotel Anachoreo
Cabana Vergara Santa Fe

Cabana Vergara Santa Fe

Provincia de Veraguas, Panama Panama
$160 nightly
The price is $160 total per night from Mar 11 to Mar 12
$160 total
Mar 11 - Mar 12
Total with taxes and fees
Cabana Vergara Santa Fe
See all 13 properties in Santa Fe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Fe Vacation Packages

Santa Fe Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
970
Max Temp Winter
90ºF
Max Temp Summer
85ºF
Top Sights
Alto de Piedra Waterfall, Cascada de Bermejo and Town Square

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Frequently asked questions

How much does a Santa Fe vacation package cost?
You'll find cheap prices from $546 on Expedia for your Santa Fe break. However, factors like the season, length of stay and your choice of hotel will determine how much your vacation to Santa Fe costs.
What are the cheapest months to go to Santa Fe?
If you're looking to score a cheap Santa Fe vacation package, consider traveling in April, July and August. You'll generally find lower prices on airfares and hotels during these quieter months — perfect for a budget-friendly break.
How many days is enough for Santa Fe?
Typically, a handful of days is enough to check out the main attractions during your Santa Fe vacation. But if you'd like to have some time to rest or go on day trips, think about extending your itinerary.
Is it worth booking a vacation package to Santa Fe?
Well known for its nature, hiking and a host of other highlights, you can be certain Santa Fe is a good vacation destination. Some of the top attractions to put on your to-do list? Don't miss Alto de Piedra Waterfall and Town Square during your Santa Fe vacation.
How to find the best Santa Fe package deals?
Start your search for a Santa Fe package deal by entering your preferred travel dates and destination under our "Packages" tab. Then add some filters, like "Property type" and "Amenities," to tailor the results to your exact needs. You can also sort by "Package discount" and browse offers that come with big savings. If you don't find the perfect Santa Fe package deal straight away, just play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Fe getaway off to a flying start.
Is it cheaper to book a Santa Fe vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Santa Fe vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Santa Fe?
Enjoy incredible discounts by reserving your flights early with Expedia. If being spontaneous is more your thing, grab one of our last-minute deals for an impromptu Santa Fe trip.
Does Expedia offer Book Now, Pay Later Santa Fe vacation packages?
Secure your ideal getaway to Santa Fe with Expedia's Book Now, Pay Later vacations. There's no need to scrimp and save or wait for your next paycheck — we've partnered with online lender Affirm to give you more flexibility and choice. Our vacation packages with payment plans let you spread the total cost over 3, 6 or 12 months. With no hidden or late payment fees, it's a breeze to stick to your budget and snap up bargains before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.