Santa Fe Vacations from $756

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Your Santa Fe Vacation

Our vacation packages to Santa Fe let you customize your own adventure. Tailor your getaway to suit your interests and needs and make the most of your time in this interesting city. Want to explore your surroundings? Alto de Piedra Waterfall, Town Square and Cerro Tute are some of the most popular places to visit during your trip to Santa Fe. Stop daydreaming and start traveling. Browse the wide range of options on Expedia today and finally put your Santa Fe vacation plans into motion!

The Latest Santa Fe vacation packages

Price found within the past 48 hours. Click for updated prices.
Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Price was $1,085, price is now $756 per person
$756
per person
Sep 24 - Sep 28
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $1,870, price is now $1,052 per person
$1,052
per person
Sep 14 - Sep 21
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,574 reviews)
The breakfast was extraordinary, tasty flavorful. The service at bazaar by the staff was accommodating and helpful. The view from my room was spectacular. I found the staff to be well mannered and approachable. I will visit again.

Reviewed on Jul 10, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,427, price is now $1,402 per person
$1,402
per person
Aug 14 - Aug 20
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,001 reviews)
All good

Reviewed on Jul 8, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was $1,464, price is now $959 per person
$959
per person
Aug 14 - Aug 20
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,815 reviews)
Todo fue perfecto

Reviewed on Jul 9, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,543, price is now $1,011 per person
$1,011
per person
Sep 14 - Sep 21
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (5,679 reviews)
Hotel was amazing especially for the price, located in a great spot.

Reviewed on Jul 11, 2026

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Stay near popular Santa Fe attractions

Quebrada Las Trancas Spa

8.0/10 (2 reviews)
Commune with nature and explore the great outdoors at Quebrada Las Trancas Spa during your travels in Santa Fe. While you're in the area, wander around the natural setting.
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Santa Fe Hotel Deals

Hotel Anachoreo

Hotel Anachoreo

3 out of 5
Calle Chinita Santa Fe Veraguas Province
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $93 total per night from Jul 12 to Jul 13
$93 total
Jul 12 - Jul 13
Total with taxes and fees
9.6/10 Exceptional! (43 reviews)
"The pictures on Hotels.com do not so this place justice. Picturesque mountain views."

Reviewed on Apr 18, 2026

Hotel Anachoreo
La Qhia Eco Retreat

La Qhia Eco Retreat

2.5 out of 5
Barriada el Cerro A 100 Mts De Santa Fe Veraguas
Get rates
La Qhia Eco Retreat
Cabana Vergara Santa Fe

Cabana Vergara Santa Fe

Provincia de Veraguas, Panama Panama
$160 nightly
The price is $160 total per night from Jul 12 to Jul 13
$160 total
Jul 12 - Jul 13
Total with taxes and fees
Cabana Vergara Santa Fe
See all 13 properties in Santa Fe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Fe Vacation Packages

Santa Fe Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
970
Max Temp Winter
90ºF
Max Temp Summer
85ºF
Top Sights
Alto de Piedra Waterfall, Cascada de Bermejo and Town Square

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Frequently asked questions

How much does a Santa Fe vacation package cost?
You'll find cheap prices from $756 on Expedia for your Santa Fe break. However, factors like the season, length of stay and your choice of hotel will determine how much your vacation to Santa Fe costs.
What are the cheapest months to go to Santa Fe?
If you're looking to score a cheap Santa Fe vacation package, consider traveling in April, July and August. You'll generally find lower prices on airfares and hotels during these quieter months — perfect for a budget-friendly break.
How many days is enough for Santa Fe?
Typically, a handful of days is enough to check out the main attractions during your Santa Fe vacation. But if you'd like to have some time to rest or go on day trips, think about extending your itinerary.
Is it worth booking a vacation package to Santa Fe?
Well known for its nature, hiking and a host of other highlights, you can be certain Santa Fe is a good vacation destination. Some of the top attractions to put on your to-do list? Don't miss Alto de Piedra Waterfall and Town Square during your Santa Fe vacation.
How to find the best Santa Fe package deals?
Start your search for a Santa Fe package deal by entering your preferred travel dates and destination under our "Packages" tab. Then add some filters, like "Property type" and "Amenities," to tailor the results to your exact needs. You can also sort by "Package discount" and browse offers that come with big savings. If you don't find the perfect Santa Fe package deal straight away, just play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Fe getaway off to a flying start.
Is it cheaper to book a Santa Fe vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Santa Fe vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Santa Fe?
Enjoy incredible discounts by reserving your flights early with Expedia. If being spontaneous is more your thing, grab one of our last-minute deals for an impromptu Santa Fe trip.
Does Expedia offer Book Now, Pay Later Santa Fe vacation packages?
Secure your ideal getaway to Santa Fe with Expedia's Book Now, Pay Later vacations. There's no need to scrimp and save or wait for your next paycheck — we've partnered with online lender Affirm to give you more flexibility and choice. Our vacation packages with payment plans let you spread the total cost over 3, 6 or 12 months. With no hidden or late payment fees, it's a breeze to stick to your budget and snap up bargains before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.