Find hotels in Santa Maria from $41

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Maria hotels

Termas el Corazon

Termas el Corazon
3.0 star property
Los Andes
7.2 out of 10, Good, (10)
"Perfect place to relax. Clean, quiet with great food and excellent service"
Canada
Jean-Luc
$236 nightly
The price is $236
Dec 28 - Dec 29
Termas el Corazon

Inca Hoteles

Inca Hoteles
3.5 star property
Los Andes
9.2 out of 10, Wonderful, (135)
"Restaurant and breakfast buffet are delicious! Rooms were perfect size and very clean. Staff is incredibly friendly and helpful. Easy drive to Portillo to ski! "
United States
CAMERON
$110 nightly
The price is $110
Dec 26 - Dec 27
Inca Hoteles

Hotel Genova

Hotel Genova
2.5 star property
Los Andes
7.2 out of 10, Good, (39)
"The staff wasn’t very friendly Good place to stay."
United States
Jose
$41 nightly
The price is $41
Dec 28 - Dec 29
Hotel Genova

Casona El Resguardo

Casona El Resguardo
3.0 star property
San Esteban
9.6 out of 10, Exceptional, (5)
"Lovely stay in this BnB style hotel. The food was the best part! Excellent chef that makes a special meal nightly considering all dietary restrictions. Location close enough to Portillo Ski resort to drive for daily skiing. Highly recommend. "
United States
Anonymous traveler
$139 nightly
The price is $139
Jan 25 - Jan 26, 2026
Casona El Resguardo

Hotel y Cabañas Palomar - Caja los Andes

Hotel y Cabañas Palomar - Caja los Andes
2.0 star property
San Felipe
9.4 out of 10, Exceptional, (3)
"Excelente "
Costa Rica
Anonymous traveler
$73 nightly
The price is $73
Dec 30 - Dec 31
Hotel y Cabañas Palomar - Caja los Andes
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Santa Maria attractions

Top Santa Maria Hotel Reviews

More cheap stays in Santa Maria

Hotels in Santa Maria with star-rating

Frequently asked questions

What are the best hotels in Santa Maria that travelers recommend?
Termas Jahuel Hotel & Spa is a fantastic choice for travelers seeking a blend of relaxation and adventure, boasting an excellent review score of 8.4. Nestled in the scenic Valparaiso region of Chile, this hotel offers an array of rejuvenating amenities, including both indoor and outdoor pools, making it great for unwinding after a day of adventure. The on-site tennis facilities cater to sports enthusiasts, while the inclusive setting makes it a great spot for couples looking to escape the hustle and bustle of everyday life.
What are the best family hotels in Santa Maria?
Termas Jahuel Hotel & Spa in Santa Maria, Chile, is an excellent choice for families seeking a relaxing getaway with plenty of amenities to keep everyone entertained. With an excellent review score of 8.4, this family-friendly hotel features spacious rooms, including rooms equipped with sofa beds, great for accommodating larger families or providing extra comfort for kids. Find more child-friendly accommodations in Santa Maria.
What are the best spa hotels in Santa Maria?
For a revitalizing escape, the Termas Jahuel Hotel & Spa in Santa Maria, Chile, boasts a great rating of 8.4/10 from guests who appreciate its serene atmosphere and attentive service. This spa hotel is a haven for relaxation, featuring a full-service spa that offers a diverse range of treatments, including deep tissue massages, aromatherapy, and invigorating body scrubs. Guests can also indulge in luxurious facial treatments and unwind in the soothing hot tub, creating an environment great for rejuvenation. See all spa hotels in Santa Maria.
What are the best budget hotels in Santa Maria?
Termas Jahuel Hotel & Spa is a delightful option in Santa Maria, Chile, superb for travelers seeking a blend of comfort and relaxation. With an excellent review rating of 8.4, this hotel offers an array of amenities that cater to both families and couples alike. View all budget hotels in Santa Maria.
When is the best time to go to Santa Maria?
The most popular time to visit Santa Maria is April, when the weather is pleasantly warm and inviting. During this period, temperatures typically range from the mid-60s to low 70s Fahrenheit, making it ideal for enjoying the beautiful beaches and outdoor activities that the region is known for.

As you plan your trip, it's important to note that the peak season spans from February to April, attracting many travelers who are eager to experience the vibrant local culture and stunning natural landscapes. This time of year is superb for those who enjoy sightseeing, as the comfortable climate allows for leisurely strolls along the coast or through charming local markets.

For couples and adventure seekers alike, April offers a wonderful opportunity to engage in various outdoor pursuits, from hiking scenic trails to taking part in water sports. The lively atmosphere, combined with numerous events and festivals, adds an extra touch of excitement to your visit. Restaurants and cafes, many with outdoor seating, allow you to savor delicious local cuisine while soaking in the beautiful surroundings.

If you're looking for a more budget-friendly experience, consider visiting in October. This time can be less crowded, allowing you to explore at your own pace while still enjoying the region's unique charm.
Where can I find the best nightlife in Santa Maria?
Santa Maria is a vibrant neighborhood in Valparaíso, Chile, known for its artistic flair and lively atmosphere.

For an exciting nightlife experience, the nearby Cerro Alegre and Cerro Concepción areas are particularly noteworthy. These neighborhoods are famous for their colorful streets filled with charming bars, pubs, and restaurants, offering an array of options for both locals and visitors. You can enjoy a laid-back evening at a cozy wine bar or dance the night away at a lively club featuring local and international music.

Additionally, the waterfront area in Valparaíso boasts several eateries and bars with stunning views of the harbor, superb for a relaxed night out with friends or a romantic evening. Many establishments in this region often showcase local artists and musicians, adding a unique cultural touch to your nightlife experience.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Santa Maria hotel for you.
How can I save on a Santa Maria hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Santa Maria hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santa Maria hotel?
Prices for hotels in Santa Maria often vary, but you can find a great deal from $41 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia