Santa Maria Vacations from $401

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Your Santa Maria Vacation

Make planning your travels easy by reserving a vacation package to Santa Maria. Let us take care of all the details, so you can focus on appreciating everything this neighborhood has to offer. Can't wait to head out and see the sights during your trip to Santa Maria? Make sure you stop by nearby attractions like Banco Pichincha Monumental Stadium, Mall del Sol Commercial Center and San Marino Mall. Expedia will help you turn your ideal Santa Maria vacation into reality, no matter your travel plans or budget.

The Latest Santa Maria Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Presidente Internacional

Hotel Presidente Internacional

3.5 out of 5
Downtown Guayaquil
Price was $500, price is now $401 per person
$401
per person
Feb 26 - Mar 3
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)
6/10 (27 reviews)
Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE

3.5 out of 5
Puerto Santa Ana
Price was $633, price is now $485 per person
$485
per person
Feb 26 - Mar 3
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)
9.4/10 Exceptional! (99 reviews)
The apartment was in a great location and very clean and well maintained.

Reviewed on Nov 16, 2025

Hotel Marcelius

Hotel Marcelius

3.5 out of 5
Kennedy
Price was $592, price is now $469 per person
$469
per person
Feb 26 - Mar 3
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)
8.2/10 Very Good! (221 reviews)
I am very happy with the services, the Staff, breakfast , parking, location excellent for me Thanks

Reviewed on Nov 5, 2025

Hotel Air Suites

Hotel Air Suites

2.5 out of 5
Simón Bolívar
Price was $518, price is now $416 per person
$416
per person
Feb 26 - Mar 3
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)
6.8/10 (205 reviews)
It was a very convenient place. Near of airport and good customer service

Reviewed on Sep 28, 2025

Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
Downtown Guayaquil
Price was $670, price is now $541 per person
$541
per person
Feb 26 - Mar 3
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)
9.4/10 Exceptional! (1,004 reviews)
Staff, room cleanliness, bkfast and of course, the renovations look wonderful!

Reviewed on Dec 11, 2025

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria
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Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Find hotels in Ecuador

Santa Maria Hotel Deals

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas
Fully refundable
$80 nightly
The price is $91 total per night from Jan 5 to Jan 6
$91 total
Jan 5 - Jan 6, 2026
9.2/10 Wonderful! (1,001 reviews)
I arrived at 12:15am and they had the shuttle I requested ready. I go upgraded to a suite which was very nice.

Reviewed on Dec 11, 2025

Holiday Inn Guayaquil Airport by IHG
Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno Guayaquil Guayas
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $96 total per night from Dec 21 to Dec 22
$96 total
Dec 21 - Dec 22
9.4/10 Exceptional! (1,007 reviews)
Lovely hotel

Reviewed on Dec 8, 2025

Oro Verde Guayaquil
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N Guayaquil Guayas
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $124 total per night from Dec 14 to Dec 15
$124 total
Dec 14 - Dec 15
9.2/10 Wonderful! (1,003 reviews)
Excelente lugar

Reviewed on Dec 9, 2025

Wyndham Guayaquil Puerto Santa Ana
See all 414 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Maria

By the riverside

Malecon 2000

4.5/5(180 reviews)

Malecon 2000 is just one of the places to see in Guayaquil, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

Malecon 2000
Santa Ana Hill

Santa Ana Hill

4.5/5(14 reviews)

Explore the great outdoors at Santa Ana Hill, a lovely green space in Guayaquil. While you're in the area, find time to visit its shops.

Santa Ana Hill

U.S. Consulate General

4/5(22 reviews)

U.S. Consulate General is just one of the places to see in San Eduardo, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

U.S. Consulate General

Things to do

City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

$65
per adult
100% of travellers recommend
Wine Tasting Experience with Tasting Menu
Making hot Chocolate!

Cocoa farm and Chocolate making!

$155
per adult
Cocoa farm and Chocolate making!
Cocoa Farm

Small Group Guayaquil and Cocoa Farm Full-Day Tour

$162
per adult
Small Group Guayaquil and Cocoa Farm Full-Day Tour
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.