Santa Maria Vacations from $188

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Your Santa Maria Vacation

Make planning your travels easy by reserving a vacation package to Santa Maria. Let us take care of all the details, so you can focus on appreciating everything this neighborhood has to offer. Can't wait to head out and see the sights during your trip to Santa Maria? Make sure you stop by nearby attractions like Banco Pichincha Monumental Stadium, Mall del Sol Commercial Center and San Marino Mall. Expedia will help you turn your ideal Santa Maria vacation into reality, no matter your travel plans or budget.

The Latest Santa Maria Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Santa Lucia House - Forum

Santa Lucia House - Forum

4 out of 5
Downtown Cuenca
Price was $259, price is now $188 per person
$188
per person
Mar 9 - Mar 12
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.2/10 Wonderful! (458 reviews)
Ideally located for the centre of Cuenca, good breakfast, comfy bed and a good shower en suite.

Reviewed on Feb 2, 2026

Mansión Alcázar Boutique Hotel

Mansión Alcázar Boutique Hotel

4 out of 5
Downtown Cuenca
Save 100% on your flight
Price was $388, price is now $250 per person
$250
per person
Mar 9 - Mar 12
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.6/10 Exceptional! (323 reviews)
Great clean facilities with wonderful staff.

Reviewed on Dec 31, 2025

Hotel Boutique Santa Lucia

Hotel Boutique Santa Lucia

4 out of 5
Downtown Cuenca
Save 100% on your flight
Price was $416, price is now $268 per person
$268
per person
Mar 9 - Mar 12
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.2/10 Wonderful! (365 reviews)
Una experiencia fabulosa, me hospedé dos noches en el Hotel. Cristina de recepción nos ayudó en todo, el transfer desde el aeropuerto, checkin, recomendaciones de lugares a visitar, taxis seguros, hasta el checkout. las habitaciones limpias y bien abastecidas.

Reviewed on Feb 3, 2026

Hotel del Parque

Hotel del Parque

4.5 out of 5
Save 100% on your flight
Price was $2,834, price is now $1,928 per person
$1,928
per person
Mar 21 - Mar 28
found 9 hours ago
Roundtrip flight included
New York (JFK) to Guayaquil (GYE)
9.8/10 Exceptional! (104 reviews)
Friendly staff. We arrived very early and they were ablemto accommodate an early check-in. The hotel is beautiful

Reviewed on Dec 16, 2025

Rioné Hotel Boutique

Rioné Hotel Boutique

3.5 out of 5
Huayna-Cápac
Price was $302, price is now $227 per person
$227
per person
Apr 10 - Apr 12
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9/10 Wonderful! (53 reviews)
Mucho frío en las noches … sería genial si facilitan calentadores de habitación ..:

Reviewed on Aug 29, 2025

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria
Fachada colorida de estilo colonial, barrio de Santa Ana, Guayaquil, Ecuador

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Find hotels in Ecuador

Santa Maria Hotel Deals

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas
Fully refundable
$88 nightly
The price is $99 total per night from Feb 17 to Feb 18
$99 total
Feb 17 - Feb 18
9.2/10 Wonderful! (1,009 reviews)
The room was vlean, the service wan

Reviewed on Feb 2, 2026

Holiday Inn Guayaquil Airport by IHG
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N Guayaquil Guayas
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Feb 17 to Feb 18
$102 total
Feb 17 - Feb 18
9.2/10 Wonderful! (1,000 reviews)
Excelente localidad y excelente servicio

Reviewed on Jan 29, 2026

Wyndham Guayaquil Puerto Santa Ana
Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno Guayaquil Guayas
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $91 total per night from Feb 8 to Feb 9
$91 total
Feb 8 - Feb 9
9.4/10 Exceptional! (1,003 reviews)
Yes

Reviewed on Jan 30, 2026

Oro Verde Guayaquil
See all 422 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Maria

By the riverside

Malecon 2000

Malecon 2000 is just one of the places to see in Guayaquil, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

Malecon 2000
The river front of Guayaquil

City Mall

During your visit to Guayaquil, you can do some window-shopping at City Mall. Visit the area's cathedral, or simply enjoy its seafood restaurants.

City Mall
Seaside Malecon 2000 walkway with Santa Ana Hill, Ecuador

Santa Ana Hill

Explore the great outdoors at Santa Ana Hill, a lovely green space in Guayaquil. While you're in the area, find time to visit its shops.

Santa Ana Hill

Things to do

City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

$65
per adult
100% of travellers recommend
Wine Tasting Experience with Tasting Menu
Making hot Chocolate!

Cocoa farm and Chocolate making!

$155
per adult
Cocoa farm and Chocolate making!
Cocoa Farm

Small Group Guayaquil and Cocoa Farm Full-Day Tour

$180
per adult
Small Group Guayaquil and Cocoa Farm Full-Day Tour
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.