Santa Maria Vacations from $315

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Your Santa Maria Vacation

Make planning your travels easy by reserving a vacation package to Santa Maria. Let us take care of all the details, so you can focus on appreciating everything this neighborhood has to offer. Can't wait to head out and see the sights during your trip to Santa Maria? Make sure you stop by nearby attractions like Banco Pichincha Monumental Stadium, Mall del Sol Commercial Center and San Marino Mall. Expedia will help you turn your ideal Santa Maria vacation into reality, no matter your travel plans or budget.

The Latest Santa Maria Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Boutique Santa Lucia

Hotel Boutique Santa Lucia

4 out of 5
Downtown Cuenca
Price was $402, price is now $315 per person
$315
per person
May 22 - May 24
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.2/10 Wonderful! (378 reviews)
This is one of the best hotels in Cuenca. They put a hot water bottle in your bed. It’s amazing, and there really isn’t service like this in most hotels. Also, the garden is really nice. I will definitely be back.

Reviewed on Mar 20, 2026

Mantahost Hotel

Mantahost Hotel

4 out of 5
Barbasquillo
Price was $1,445, price is now $1,078 per person
$1,078
per person
May 12 - May 18
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Guayaquil (GYE)
8.6/10 Excellent! (311 reviews)
Hotel was very clean, A/C worked great, quiet area, staff very accommodating, only problem was food at restaurant took really long time to come out

Reviewed on Mar 6, 2026

Casa Olonche Hotel

Casa Olonche Hotel

3 out of 5
Price was $1,366, price is now $1,070 per person
$1,070
per person
May 24 - May 30
found 3 hours ago
Roundtrip flight included
New York (NYC) to Guayaquil (GYE)
8.4/10 Very Good! (6 reviews)
Clean room. Comfortable bed. Generous breakfast

Reviewed on Jan 23, 2026

Balandra Hotel

Balandra Hotel

4 out of 5
Price was $1,073, price is now $871 per person
$871
per person
May 12 - May 18
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Guayaquil (GYE)
9.2/10 Wonderful! (201 reviews)
There was a driver waiting for me at the airport, and he was very kind and helpful. My room was spacious and overlooking the ocean (across the street not beachfront). Breakfast was great. Overall a great stay except for one night, there was a party that sounded like it was on the floor below me but it could have been in the next block.

Reviewed on Nov 25, 2025

Oro Verde Manta

Oro Verde Manta

4.5 out of 5
Price was $687, price is now $564 per person
$564
per person
Jun 3 - Jun 7
found 10 hours ago
Roundtrip non-stop flight included
New York (NYC) to Guayaquil (GYE)
9/10 Wonderful! (708 reviews)
Very safe, clean and excellent staff.

Reviewed on Mar 28, 2026

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria
Fachada colorida de estilo colonial, barrio de Santa Ana, Guayaquil, Ecuador

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Find hotels in Ecuador

Santa Maria Hotel Deals

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N Guayaquil Guayas
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $112 total per night from Apr 26 to Apr 27
$112 total
Apr 26 - Apr 27
9.2/10 Wonderful! (1,005 reviews)
This place was great, service was top notch, they have won several prestigious hotel awards, and you can tell why the best service at a hotel I have experienced in a very long time.

Reviewed on Apr 11, 2026

Wyndham Guayaquil Puerto Santa Ana
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas
Fully refundable
$92 nightly
The price is $104 total per night from May 3 to May 4
$104 total
May 3 - May 4
9.4/10 Exceptional! (1,011 reviews)
Staff was very nice

Reviewed on Apr 9, 2026

Holiday Inn Guayaquil Airport by IHG
Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno Guayaquil Guayas
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $91 total per night from Apr 17 to Apr 18
$91 total
Apr 17 - Apr 18
9.4/10 Exceptional! (1,002 reviews)
Yes, great

Reviewed on Apr 10, 2026

Oro Verde Guayaquil
See all 432 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Maria

Malecon 2000

Malecon 2000

Malecon 2000 is just one of the places to see in Guayaquil, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

Malecon 2000
The river front of Guayaquil

City Mall

During your visit to Guayaquil, you can do some window-shopping at City Mall. Visit the area's cathedral, or simply enjoy its seafood restaurants.

City Mall
Seaside Malecon 2000 walkway with Santa Ana Hill, Ecuador

Santa Ana Hill

Explore the great outdoors at Santa Ana Hill, a lovely green space in Guayaquil. While you're in the area, find time to visit its shops.

Santa Ana Hill

Things to do

Best of Guayaquil - City Tour

Premium City Tour for Seniors - Guayaquil

$150
per adult
Premium City Tour for Seniors - Guayaquil
City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

$65
per adult
100% of travellers recommend
Wine Tasting Experience with Tasting Menu
On our City tours to the city of Guayaquil we want our clients to live a unique and memorable experience. Our main value is personalized attention, which is complemented by the history and traditions

Half Day Guayaquil Historical Tour and Cocoa Culinary Experience

$85
per adult
100% of travellers recommend
Half Day Guayaquil Historical Tour and Cocoa Culinary Experience
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.