Santa Maria Vacations from $723

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Your Santa Maria Vacation

Make planning your travels easy by reserving a vacation package to Santa Maria. Let us take care of all the details, so you can focus on appreciating everything this neighborhood has to offer. Can't wait to head out and see the sights during your trip to Santa Maria? Make sure you stop by nearby attractions like Banco Pichincha Monumental Stadium, Mall del Sol Commercial Center and San Marino Mall. Expedia will help you turn your ideal Santa Maria vacation into reality, no matter your travel plans or budget.

The Latest Santa Maria Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Hotel Ramada

Downtown Guayaquil

$723

per person

Nov 10 - Nov 17

found 11 hours ago

Roundtrip non-stop flight included

New York (JFK) to Guayaquil (GYE)

8/10 Very Good! (410 reviews)

Hotel Boutique Santa Lucia

Downtown Cuenca

$870

per person

Nov 11 - Nov 18

found 8 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)

9.2/10 Wonderful! (405 reviews)

Everything in this boutique hotel is perfect, no doubt and book it

Reviewed on Aug 26, 2026

Santa Lucia House - Forum

Downtown Cuenca

$757

per person

Nov 11 - Nov 18

found 4 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guayaquil (GYE)

9.4/10 Exceptional! (532 reviews)

Nos encantó todo, la ubicación del hotel , tiene todo cerca ,la atención del personal excelente y la habitación hermosa y muy cómoda, el desayuno riquísimo, lo recomendamos 100%

Reviewed on Aug 29, 2026

Hotel Río Guayas by Art Hotels Ecuador

Tarqui

$1,708

per person

Nov 25 - Nov 29

found 1 day ago

Roundtrip non-stop flight included

Chicago (CHI) to Guayaquil (GYE)

10/10 Exceptional! (3 reviews)

Hotel del Parque

$1,274

per person

Nov 25 - Nov 29

found 1 day ago

Roundtrip non-stop flight included

Chicago (CHI) to Guayaquil (GYE)

9.8/10 Exceptional! (133 reviews)

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria

A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A densely packed urban area with numerous buildings and a prominent tower on a hill.

Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Botanical Garden while you're exploring Puerto Santa Ana and the surrounding neighborhoods.

A statue of a soldier on a pedestal with a building in the background.

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Central Market while you're in town.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

1 out of top 10 points of interest in this area

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area.

A green and yellow iguana on a rocky surface.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Policentro.

Santa Maria Hotel Deals

Oro Verde Guayaquil

9 De Octubre Y Garcia Moreno Guayaquil Guayas

Fully refundableReserve now, pay when you stay

$92 nightly

$104 total

Sep 18 - Sep 19

9.6/10 Exceptional! (1,008 reviews)

"Honestly recommend staff was very helpful understanding"

Reviewed on Sep 1, 2026

Holiday Inn Guayaquil Airport by IHG

Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas

Fully refundable

$97 nightly

$109 total

Sep 26 - Sep 27

9.4/10 Exceptional! (1,005 reviews)

"Everything was great !! Really liked my stay there. Really would recommend the visiting."

Reviewed on Aug 31, 2026

Wyndham Guayaquil Puerto Santa Ana

Calle Numa Pompilio Llona S N Guayaquil Guayas

$115 nightly

$129 total

Sep 13 - Sep 14

See all 449 properties in Santa Maria

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.