Santo Antonio Vacations from $1,407

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santo Antonio Vacation

From its shopping to its cafes and culture, there are tons of good reasons to book a vacation package to Santo Antonio. When you need to get away from it all, this commercial neighborhood has a spot just for you. When it's time to sightsee, you'll find plenty of big-name attractions nearby including Castle of São Jorge, Rossio Square and Lisbon Cathedral. Tick off one or all during your trip to Santo Antonio. Expedia is here to put your travel plans into action. Book your ultimate Santo Antonio vacation today.

The Latest Santo Antonio vacation packages

Price found within the past 48 hours. Click for updated prices.
TURIM Lisboa Hotel

TURIM Lisboa Hotel

4 out of 5
Lisbon City Center
Price was $1,778, price is now $1,407 per person
$1,407
per person
Jun 16 - Jun 22
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Lisbon (LIS)
8.4/10 Very Good! (731 reviews)
Great location. Good bed.

Reviewed on Apr 19, 2026

Casa Rosário : Three Bedroom Villa with Private Pool;

Casa Rosário : Three Bedroom Villa with Private Pool;

4 out of 5
Save 100% on your flight
Price was $3,373, price is now $2,252 per person
$2,252
per person
Jun 20 - Jun 26
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Lisbon (LIS)
4/10 (1 review)
Aurea Museum by Eurostars Hotel Company

Aurea Museum by Eurostars Hotel Company

5 out of 5
Lisbon City Center
Price was $2,562, price is now $1,866 per person
$1,866
per person
Jul 5 - Jul 11
found 1 day ago
Roundtrip flight included
Boston (BOS) to Lisbon (LIS)
9.4/10 Exceptional! (1,009 reviews)
Sauna was broken. Pool area very small, had to use by appointment max 45 minutes per day....

Reviewed on Apr 26, 2026

Sintra Marmòris Palace

Sintra Marmòris Palace

5 out of 5
Santa Maria e São Miguel
Price was $2,819, price is now $2,066 per person
$2,066
per person
Jun 10 - Jun 16
found 1 hour ago
Roundtrip flight included
New York (JFK) to Lisbon (LIS)
9.8/10 Exceptional! (430 reviews)
A wonderful property with an amazing jaw dropping view! A real boutique, hotel experience with exceptional staff and old world charm!

Reviewed on Apr 19, 2026

Eurostars Lisboa Baixa

Eurostars Lisboa Baixa

4 out of 5
Lisbon City Center
Price was $2,485, price is now $1,826 per person
$1,826
per person
Jul 5 - Jul 11
found 1 day ago
Roundtrip flight included
Boston (BOS) to Lisbon (LIS)
9.8/10 Exceptional! (274 reviews)
The hotel is very clean and it is centrally located. Everything you want is within your footstep. Due to the closure of the road in front of the hotel, the hotel is not extremely

Reviewed on Apr 8, 2026

Don't see what you're looking for?
See all available trips from Columbus to Santo Antonio
View all trips

Discover the most popular places to visit in Santo Antonio

Avenida da Liberdade

Avenida da Liberdade

You can browse for souvenirs when you visit Avenida da Liberdade, a popular shopping spot in Santo Antonio. Discover the charming cafes in this family-friendly area, or seek out the local tours.

Avenida da Liberdade
Marquis of Pombal Square

Marquis of Pombal Square

Crowned by a statue of a Portuguese reformer, this bustling traffic hub is a gateway to a lush city park and one of Lisbon’s chicest avenues.

Marquis of Pombal Square
Belém Tower

Belém Tower

Lisbon constructed a fortification along a waterway to defend its riches. Now access the structure from the shore for lovely views.

Belém Tower

What to do in Santo Antonio

Lisbon Sunset Cruise with Wine and Snacks

Lisbon Sunset Cruise with Wine and Snacks

$36
per adult
80% of travellers recommend
Lisbon Sunset Cruise with Wine and Snacks
Tastes & Traditions of Lisbon Food Tour

Tastes & Traditions of Lisbon Food Tour

$67
per adult
100% of travellers recommend
Tastes & Traditions of Lisbon Food Tour
Lisbon: Tejo River Sightseeing Cruise

Lisbon: Tejo River Sightseeing Cruise

$24
per adult
100% of travellers recommend
Lisbon: Tejo River Sightseeing Cruise
See all activities in Santo Antonio

Santo Antonio Hotel Deals

Locke de Santa Joana

Locke de Santa Joana

4 out of 5
18 Rua Camilo Castelo Branco Lisbon
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $157 total per night from Apr 28 to Apr 29
$157 total
Apr 28 - Apr 29
Total with taxes and fees
9.4/10 Exceptional! (1,731 reviews)
Staff was very helpful. Amazing location and amenities. Great location as well, had a great experience

Reviewed on Apr 26, 2026

Locke de Santa Joana
EPIC SANA Marques Hotel

EPIC SANA Marques Hotel

5 out of 5
Avenida Fontes de Pereira de Melo, 8 Lisbon
$305 nightly
The price is $332 total per night from May 13 to May 14
$332 total
May 13 - May 14
Total with taxes and fees
9.6/10 Exceptional! (1,363 reviews)
Lovely rooftop pool and lobby bar

Reviewed on Apr 26, 2026

EPIC SANA Marques Hotel
HF Fénix Lisboa

HF Fénix Lisboa

4 out of 5
Praca Marques de Pombal, 8 Lisbon
$133 nightly
The price is $150 total per night from Apr 30 to May 1
$150 total
Apr 30 - May 1
Total with taxes and fees
9.2/10 Wonderful! (1,002 reviews)
This has been the best experience ! I can’t thank enough the staff ! The breakfast was incredible ! Location close to it all !! We are coming back

Reviewed on Apr 10, 2026

HF Fénix Lisboa
See all 648 properties in Santo Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santo Antonio Vacation Packages

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How to find the best Santo Antonio package deals?
Bagging a cheap Santo Antonio package deal is a cinch with Expedia. Once you've entered your destination and preferred dates under our "Packages" tab, set your budget range, add some filters and browse what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Santo Antonio package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
When to book a vacation package to Santo Antonio?
If you're considering a spontaneous Santo Antonio adventure, browse our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can land incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santo Antonio?

  1. Choose the right time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to go to Santo Antonio.
  2. Calculate your budget: Ensure you have enough money to pay for everything from dining out and transportation to activities and airfares. Your accommodations will likely be the biggest expense during your trip to Santo Antonio.
  3. Use our trip planning tool to explore Santo Antonio: Research every aspect of your trip to Santo Antonio with this handy planner. Invite friends or family to collaborate on a group getaway, search for stays or things to do and make bookings.
  4. Work out your trip length: Consider how much time you want to spend exploring Santo Antonio. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
  5. Bundle your bookings: With your travel dates in place, you can combine your hotels, car rental, flights and more into a tailored Santo Antonio vacation package.
  6. Book any day trips or activities: Here's the fun part — locking in everything you want to see and do. Explore some of the incredible things to do in Santo Antonio and book your tickets in advance to save time (and maybe some dollars too!).

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.