Santo Antonio Vacations from $951
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Your Santo Antonio Vacation
From its shopping to its cafes and culture, there are tons of good reasons to book a vacation package to Santo Antonio. When you need to get away from it all, this commercial neighborhood has a spot just for you. When it's time to sightsee, you'll find plenty of big-name attractions nearby including Castle of São Jorge, Rossio Square and Lisbon Cathedral. Tick off one or all during your trip to Santo Antonio. Expedia is here to put your travel plans into action. Book your ultimate Santo Antonio vacation today.
The Latest Santo Antonio vacation packages
Price found within the past 48 hours. Click for updated prices.
Palacio Ramalhete
Lisbon Old Town
$1,075
per person
Nov 6 - Nov 11
found 22 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Lisbon (LIS)
9.4/10 Exceptional! (230 reviews)
Charming palace full of character and with very tasteful decor in the embassy district of Lisbon.
Lovely rooms, great breakfasts, lots of spaces to relax and recover after exploring Lisbon Sintra and Cascais.
Reviewed on Sep 26, 2026
Pousada de Lisboa - Small Luxury Hotels Of The World
Lisbon City Center
$1,545
per person
Nov 8 - Nov 14
found 1 day ago
Roundtrip flight included
Boston (BOS) to Lisbon (LIS)
9.6/10 Exceptional! (674 reviews)
The staff and facilities were outstanding. Hotel centrally located, easy to get everywhere in historic area. One of best overall hotels we have stayed at.
Reviewed on Sep 18, 2026
Don't see what you're looking for?
See all available trips from Columbus to Santo Antonio
View all tripsStay near popular Santo Antonio attractions
Avenida da Liberdade
9.4/10 (3,467 reviews)
You can browse for souvenirs when you visit Avenida da Liberdade, a popular shopping spot in Santo Antonio. Discover the top-notch restaurants in this romantic area, or seek out the local tours.
Amoreiras Shopping Center
8.0/10 (225 reviews)
You can find the perfect gifts to bring home at Amoreiras Shopping Center during your stay in Campo de Ourique. Amble around this vibrant area's riverfront or experience its fascinating museums.
Botanical Garden
8.4/10 (800 reviews)
The oldest botanical garden in Portugal offers great views of the historic Tower of Belem and a peaceful place to rest away from the bustling city streets.
Miradouro de São Pedro de Alcântara
8.8/10 (13 reviews)
You can learn about the history of Misericórdia when you stop by Miradouro de São Pedro de Alcântara. Amble around this vibrant area's riverfront or experience its fascinating museums.
National Museum of Natural History
8.6/10 (17 reviews)
Discover more about the geology of Portugal and the animals that once roamed here in this hands-on museum.
Coracao de Jesus
9.4/10 (3 reviews)
You can find out about the history of Santo Antonio with a trip to Coracao de Jesus. Make time for the shops and local tours in this romantic area.
Cinemateca Portuguesa Museum
8.0/10 (3 reviews)
You can spend an afternoon exploring the galleries in Cinemateca Portuguesa Museum during your trip to Santo Antonio. Experience the acclaimed art scene and fascinating museums in this family-friendly area.
Medeiros e Almeida Museum
8.8/10 (6 reviews)
You can spend an afternoon studying the exhibits at Medeiros e Almeida Museum during your travels in Santo Antonio. Discover the top-notch restaurants and acclaimed art scene in this romantic area.
What to do in Santo Antonio
Lisbon: Sintra, Pena, Regaleira, Cabo da Roca, and Cascais
$40
per adult
92% of travellers recommend
Lisbon: Sintra, Pena, Regaleira & Cabo Roca & Cascais Coast
$28
per adult
92% of travellers recommend
Tour Lisbon: Belém Tower, the Cathedral & Parque das Nações
$88
per adult
96% of travellers recommend
Santo Antonio Hotel Deals
Locke de Santa Joana
18 Rua Camilo Castelo Branco Lisbon
Fully refundableReserve now, pay when you stay
$121 nightly
$137 total
Oct 25 - Oct 26
Total with taxes and fees
easyHotel Lisbon
R. de Santa Marta 60 Lisbon
Fully refundableReserve now, pay when you stay
$84 nightly
$98 total
Oct 20 - Oct 21
Total with taxes and fees
8.8/10 Excellent! (1,745 reviews)
"Room was clean, the bed was comfortable. The air con was nice and quiet and kept the room at a nice temp, but the windows didn't seem fitted properly as we still heard noise from the street (despite being on 5th floor). Also the bathroom door is (frosted) glass, so it can disturb a sleeping partner ..."
Reviewed on Sep 29, 2026
Pestana Lisboa Vintage City Center Suites
Rua Braamcamp, 7 Lisbon
$166 nightly
$185 total
Oct 27 - Oct 28
Total with taxes and fees
8.8/10 Excellent! (742 reviews)
"Great location and lovely room"
Reviewed on Sep 27, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santo Antonio Vacation Packages
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Frequently asked questions
How to find the best Santo Antonio package deals?
Bagging a cheap Santo Antonio package deal is a cinch with Expedia. Once you've entered your destination and preferred dates under our "Packages" tab, set your budget range, add some filters and browse what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Santo Antonio package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
When to book a vacation package to Santo Antonio?
If you're considering a spontaneous Santo Antonio adventure, browse our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can land incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santo Antonio?
- Choose the right time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to go to Santo Antonio.
- Calculate your budget: Ensure you have enough money to pay for everything from dining out and transportation to activities and airfares. Your accommodations will likely be the biggest expense during your trip to Santo Antonio.
- Use our trip planning tool to explore Santo Antonio: Research every aspect of your trip to Santo Antonio with this handy planner. Invite friends or family to collaborate on a group getaway, search for stays or things to do and make bookings.
- Work out your trip length: Consider how much time you want to spend exploring Santo Antonio. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
- Bundle your bookings: With your travel dates in place, you can combine your hotels, car rental, flights and more into a tailored Santo Antonio vacation package.
- Book any day trips or activities: Here's the fun part — locking in everything you want to see and do. Explore some of the incredible things to do in Santo Antonio and book your tickets in advance to save time (and maybe some dollars too!).
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
