Santo Antonio Vacations from $850

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Your Santo Antonio Vacation

From its shopping to its cafes and culture, there are tons of good reasons to book a vacation package to Santo Antonio. When you need to get away from it all, this commercial neighborhood has a spot just for you. When it's time to sightsee, you'll find plenty of big-name attractions nearby including Castle of São Jorge, Rossio Square and Lisbon Cathedral. Tick off one or all during your trip to Santo Antonio. Expedia is here to put your travel plans into action. Book your ultimate Santo Antonio vacation today.

The Latest Santo Antonio vacation packages

Price found within the past 48 hours. Click for updated prices.
Pousada Alfama

Pousada Alfama

4 out of 5
Lisbon City Center
Price was $1,083, price is now $850 per person
$850
per person
Nov 30 - Dec 5
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Lisbon (LIS)
9.8/10 Exceptional! (224 reviews)
We loved the location! I was sure about it but it was perfect. So many restaurants and some shopping around the area. Easy to get a tuk tuk to other neighborhoods. Room was clean and the staff was great. I never received my bottle of wine but that won’t stop me from giving it 5 stars.

Reviewed on Oct 17, 2025

The Emerald House Lisbon, Curio Collection By Hilton

The Emerald House Lisbon, Curio Collection By Hilton

4 out of 5
Lisbon Old Town
Price was $1,961, price is now $1,334 per person
$1,334
per person
Dec 31 - Jan 6
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Lisbon (LIS)
9.6/10 Exceptional! (410 reviews)
Clean, friendly. Walkable to attractions.

Reviewed on Oct 28, 2025

Stylish Stay in Lisbon-Scenic Views

Stylish Stay in Lisbon-Scenic Views

2.5 out of 5
Save 100% on your flight
Price was $4,482, price is now $3,053 per person
$3,053
per person
Dec 24 - Dec 28
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Lisbon (LIS)
8/10 Very Good! (1 review)
Aurea Museum by Eurostars Hotel Company

Aurea Museum by Eurostars Hotel Company

5 out of 5
Lisbon City Center
Price was $2,552, price is now $1,816 per person
$1,816
per person
Dec 30 - Jan 4
found 1 day ago
Roundtrip flight included
Boston (BOS) to Lisbon (LIS)
9.4/10 Exceptional! (1,013 reviews)
The room was very spacious and comfortable! Hotel staff was very accommodating and friendly, especially the restaurant staff at breakfast! Good location and easy to navigate to anywhere in the city.

Reviewed on Oct 28, 2025

Eurostars Lisboa Baixa

Eurostars Lisboa Baixa

4 out of 5
Lisbon City Center
Price was $2,502, price is now $1,796 per person
$1,796
per person
Dec 30 - Jan 4
found 1 day ago
Roundtrip flight included
Boston (BOS) to Lisbon (LIS)
9.8/10 Exceptional! (209 reviews)
Perfect stay with a very wonderful room and breakfast

Reviewed on Sep 25, 2025

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Discover the most popular places to visit in Santo Antonio

Avenida da Liberdade featuring a city and a statue or sculpture

Avenida da Liberdade

You can browse for souvenirs when you visit Avenida da Liberdade, a popular shopping spot in Santo Antonio. Discover the top-notch restaurants in this romantic area, or seek out the local tours.

Avenida da Liberdade
Belem Tower which includes a sunset, heritage architecture and a bridge

Belém Tower

4.5/5(1,337 reviews)

Lisbon constructed a fortification along a waterway to defend its riches. Now access the structure from the shore for lovely views.

Belém Tower
Lisbon City Center showing a monument and a statue or sculpture

Marquis of Pombal Square

4.5/5(254 reviews)

Crowned by a statue of a Portuguese reformer, this bustling traffic hub is a gateway to a lush city park and one of Lisbon’s chicest avenues.

Marquis of Pombal Square

What to do in Santo Antonio

Lisbon Sunset Cruise with Wine and Snacks

Lisbon Sunset Cruise with Wine and Snacks

$35
per adult
78% of travellers recommend
Lisbon Sunset Cruise with Wine and Snacks
Lisbon: Sailing Tour on the Tagus River

Lisbon: Sailing Tour on the Tagus River

$23
per adult
96% of travellers recommend
Lisbon: Sailing Tour on the Tagus River
Hop-On Hop-Off Yellow Boat Tour

Hop-On Hop-Off Yellow Boat Tour

$28
per adult
72% of travellers recommend
Hop-On Hop-Off Yellow Boat Tour
See all activities in Santo Antonio

Santo Antonio Hotel Deals

Locke de Santa Joana

Locke de Santa Joana

4 out of 5
18 Rua Camilo Castelo Branco, Lisbon
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $120 total per night from Nov 16 to Nov 17
$120 total
Nov 16 - Nov 17
Total with taxes and fees
9.4/10 Exceptional! (1,396 reviews)
Very Friendly Staff and Helpful

Reviewed on Oct 26, 2025

Locke de Santa Joana
HF Fénix Lisboa

HF Fénix Lisboa

4 out of 5
Praca Marques de Pombal, 8, Lisbon
$97 nightly
The price is $112 total per night from Nov 25 to Nov 26
$112 total
Nov 25 - Nov 26
Total with taxes and fees
9/10 Wonderful! (1,003 reviews)
Great location

Reviewed on Oct 19, 2025

HF Fénix Lisboa
EPIC SANA Marques Hotel

EPIC SANA Marques Hotel

5 out of 5
Avenida Fontes de Pereira de Melo, 8, Lisbon
Fully refundableReserve now, pay when you stay
$242 nightly
The price is $266 total per night from Nov 1 to Nov 2
$266 total
Nov 1 - Nov 2
Total with taxes and fees
9.6/10 Exceptional! (1,221 reviews)
Rooms were modern and bed linen delightful! The rooftop pool is an extra bonus. Rooms service twice daily meant always a clean feel in room. Lovely hotel! Would highly recommend

Reviewed on Oct 28, 2025

EPIC SANA Marques Hotel
See all 728 properties in Santo Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santo Antonio Vacation Packages

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Frequently asked questions

How to find the best Santo Antonio package deals?
Bagging a cheap Santo Antonio package deal is a cinch with Expedia. Once you've entered your destination and preferred dates under our "Packages" tab, set your budget range, add some filters and browse what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Santo Antonio package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
When to book a vacation package to Santo Antonio?
If you're considering a spontaneous Santo Antonio adventure, browse our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can land incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santo Antonio?

  1. Choose the right time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to go to Santo Antonio.
  2. Calculate your budget: Ensure you have enough money to pay for everything from dining out and transportation to activities and airfares. Your accommodations will likely be the biggest expense during your trip to Santo Antonio.
  3. Use our trip planning tool to explore Santo Antonio: Research every aspect of your trip to Santo Antonio with this handy planner. Invite friends or family to collaborate on a group getaway, search for stays or things to do and make bookings.
  4. Work out your trip length: Consider how much time you want to spend exploring Santo Antonio. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
  5. Bundle your bookings: With your travel dates in place, you can combine your hotels, car rental, flights and more into a tailored Santo Antonio vacation package.
  6. Book any day trips or activities: Here's the fun part — locking in everything you want to see and do. Explore some of the incredible things to do in Santo Antonio and book your tickets in advance to save time (and maybe some dollars too!).

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.