Santo Antonio Vacations from $695

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Your Santo Antonio Vacation

From its shopping to its cafes and culture, there are tons of good reasons to book a vacation package to Santo Antonio. When you need to get away from it all, this commercial neighborhood has a spot just for you. When it's time to sightsee, you'll find plenty of big-name attractions nearby including Castle of São Jorge, Rossio Square and Lisbon Cathedral. Tick off one or all during your trip to Santo Antonio. Expedia is here to put your travel plans into action. Book your ultimate Santo Antonio vacation today.

The Latest Santo Antonio vacation packages

Price found within the past 48 hours. Click for updated prices.
Blue Tide - Two Bedroom Apartment

Blue Tide - Two Bedroom Apartment

3 out of 5
Price was $1,073, price is now $695 per person
$695
per person
Nov 27 - Nov 30
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Lisbon (LIS)
No reviews
The staff was very accommodating and helpful. But the check in time was a little late in the day and the check out time is a little too early in the day. The manager was lovely.

Reviewed on Aug 30, 2025

TURIM Boulevard Hotel – Adults Only

TURIM Boulevard Hotel – Adults Only

5 out of 5
Lisbon City Center
Save 100% on your flight
Price was $1,709, price is now $1,172 per person
$1,172
per person
Oct 27 - Nov 2
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Lisbon (LIS)
9/10 Wonderful! (374 reviews)
Friendly staff, comfortable rooms, and a great location. Perfect for a city stay.

Reviewed on Aug 4, 2025

The Emerald House Lisbon, Curio Collection By Hilton

The Emerald House Lisbon, Curio Collection By Hilton

4 out of 5
Lisbon Old Town
Save 100% on your flight
Price was $1,341, price is now $823 per person
$823
per person
Nov 15 - Nov 20
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Lisbon (LIS)
9.6/10 Exceptional! (373 reviews)
Beautiful hotel, clean room , staff are very nice and friendly. Good breakfast

Reviewed on Sep 2, 2025

Torel Palace Lisbon

Torel Palace Lisbon

5 out of 5
Lisbon City Center
Save 100% on your flight
Price was $3,235, price is now $2,152 per person
$2,152
per person
Oct 12 - Oct 18
found 10 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Lisbon (LIS)
9.6/10 Exceptional! (472 reviews)
This stunning boutique hotel has gorgeous, surprisingly spacious rooms, exceptional views and delicious food. There is easy access to a tram that takes you right to the city center. It was a hot day when we arrived, after a long day of travel, so lounging at the picturesque pool with a glass of sparkling wine was how we spent our time here.

Reviewed on Aug 23, 2025

Chiado Arty flats

Chiado Arty flats

4 out of 5
Lisbon City Center
Save 100% on your flight
Price was $3,977, price is now $2,736 per person
$2,736
per person
Oct 20 - Oct 25
found 13 hours ago
Roundtrip flight included
Boston (BOS) to Lisbon (LIS)
10/10 Exceptional! (243 reviews)
Its in a great area,ample breakfast,friendly front desk

Reviewed on Jul 13, 2025

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Discover the most popular places to visit in Santo Antonio

Avenida da Liberdade featuring a city and a statue or sculpture

Avenida da Liberdade

You can browse for souvenirs when you visit Avenida da Liberdade, a popular shopping spot in Santo Antonio. Discover the charming cafes in this family-friendly area, or seek out the local tours.

Avenida da Liberdade
Belem Tower which includes a sunset, heritage architecture and a bridge

Belém Tower

4.5/5(1,337 reviews)

Lisbon constructed a fortification along a waterway to defend its riches. Now access the structure from the shore for lovely views.

Belém Tower
Lisbon City Center showing a monument and a statue or sculpture

Marquis of Pombal Square

4.5/5(254 reviews)

Crowned by a statue of a Portuguese reformer, this bustling traffic hub is a gateway to a lush city park and one of Lisbon’s chicest avenues.

Marquis of Pombal Square

What to do in Santo Antonio

Lisbon: Guided Day Tour of Sintra, Pena, Regaleira & Cascais

Lisbon: Sintra, Pena, Regaleira, Cabo da Roca & Cascais

$29
per adult
86% of travellers recommend
Lisbon: Sintra, Pena, Regaleira, Cabo da Roca & Cascais
Tuk tuk tour in Lisbon historical center.

Lisbon: 5-Hour All Inclusive Tour on a Exclusive Tuk Tour

$58
per adult
Lisbon: 5-Hour All Inclusive Tour on a Exclusive Tuk Tour
Lisbon: Fado Night with Dinner in authentic Fado Club

Lisbon: Fado Night with Dinner with Live Performance

$58
per adult
98% of travellers recommend
Lisbon: Fado Night with Dinner with Live Performance
See all activities in Santo Antonio

Santo Antonio Hotel Deals

Locke de Santa Joana

Locke de Santa Joana

4 out of 5
18 Rua Camilo Castelo Branco, Lisbon
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $172 total per night from Sep 21 to Sep 22
$172 total
Sep 21 - Sep 22
Total with taxes and fees
Locke de Santa Joana
EPIC SANA Marques Hotel

EPIC SANA Marques Hotel

5 out of 5
Avenida Fontes de Pereira de Melo, 8, Lisbon
Fully refundableReserve now, pay when you stay
$338 nightly
The price is $368 total per night from Sep 28 to Sep 29
$368 total
Sep 28 - Sep 29
Total with taxes and fees
EPIC SANA Marques Hotel
Mama Shelter Lisboa

Mama Shelter Lisboa

3 out of 5
Rua do Vale de Pereiro 19, Lisbon
Fully refundableReserve now, pay when you stay
$160 nightly
The price is $179 total per night from Sep 28 to Sep 29
$179 total
Sep 28 - Sep 29
Total with taxes and fees
Mama Shelter Lisboa
See all 734 properties in Santo Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How to find the best Santo Antonio package deals?
Bagging a cheap Santo Antonio package deal is a cinch with Expedia. Once you've entered your destination and preferred dates under our "Packages" tab, set your budget range, add some filters and browse what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Santo Antonio package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
When to book a vacation package to Santo Antonio?
If you're considering a spontaneous Santo Antonio adventure, browse our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can land incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santo Antonio?

  1. Choose the right time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to go to Santo Antonio.
  2. Calculate your budget: Ensure you have enough money to pay for everything from dining out and transportation to activities and airfares. Your accommodations will likely be the biggest expense during your trip to Santo Antonio.
  3. Use our trip planning tool to explore Santo Antonio: Research every aspect of your trip to Santo Antonio with this handy planner. Invite friends or family to collaborate on a group getaway, search for stays or things to do and make bookings.
  4. Work out your trip length: Consider how much time you want to spend exploring Santo Antonio. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
  5. Bundle your bookings: With your travel dates in place, you can combine your hotels, car rental, flights and more into a tailored Santo Antonio vacation package.
  6. Book any day trips or activities: Here's the fun part — locking in everything you want to see and do. Explore some of the incredible things to do in Santo Antonio and book your tickets in advance to save time (and maybe some dollars too!).

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.