Santo Antonio Vacations from $1,027
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Your Santo Antonio Vacation
From its shopping to its cafes and culture, there are tons of good reasons to book a vacation package to Santo Antonio. When you need to get away from it all, this commercial neighborhood has a spot just for you. When it's time to sightsee, you'll find plenty of big-name attractions nearby including Castle of São Jorge, Rossio Square and Lisbon Cathedral. Tick off one or all during your trip to Santo Antonio. Expedia is here to put your travel plans into action. Book your ultimate Santo Antonio vacation today.
The Latest Santo Antonio vacation packages
Price found within the past 48 hours. Click for updated prices.
The Homeboat Company Parque das Nações
$1,888
per person
Jan 8 - Jan 14
found 1 day ago
Roundtrip flight included
Boston (BOS) to Lisbon (LIS)
10/10 Exceptional! (25 reviews)
This place was the best. The nicest people at check-in, such cute houseboats with awesome roofs to watch the water or lay in the sun. We loved it and wish we could have stayed longer.
Reviewed on Oct 20, 2026
Don't see what you're looking for?
See all available trips from Columbus to Santo Antonio
View all tripsStay near popular Santo Antonio attractions
Avenida da Liberdade
9.4/10 (3,467 reviews)
You can browse for souvenirs when you visit Avenida da Liberdade, a popular shopping spot in Santo Antonio. Discover the top-notch restaurants in this romantic area, or seek out the local tours.
Botanical Garden
8.4/10 (800 reviews)
The oldest botanical garden in Portugal offers great views of the historic Tower of Belem and a peaceful place to rest away from the bustling city streets.
Amoreiras Shopping Center
8.0/10 (225 reviews)
You can find the perfect gifts to bring home at Amoreiras Shopping Center during your stay in Campo de Ourique. Amble around this vibrant area's riverfront or experience its fascinating museums.
Miradouro de São Pedro de Alcântara
8.8/10 (13 reviews)
You can learn about the history of Misericórdia when you stop by Miradouro de São Pedro de Alcântara. Amble around this vibrant area's riverfront or experience its fascinating museums.
National Museum of Natural History
8.6/10 (17 reviews)
Discover more about the geology of Portugal and the animals that once roamed here in this hands-on museum.
Torel Garden
Explore the great outdoors at Torel Garden, a lovely green space in Santo Antonio. Check out the shops and top-notch restaurants in this romantic area.
Coracao de Jesus
9.4/10 (3 reviews)
You can find out about the history of Santo Antonio with a trip to Coracao de Jesus. Make time for the shops and local tours in this romantic area.
Cinemateca Portuguesa Museum
8.0/10 (3 reviews)
You can spend an afternoon exploring the galleries in Cinemateca Portuguesa Museum during your trip to Santo Antonio. Experience the acclaimed art scene and fascinating museums in this family-friendly area.
What to do in Santo Antonio
Lisbon: Sintra, Pena, Regaleira, Cabo da Roca, and Cascais
$32
per adult
92% of travellers recommend
Tour Lisbon: Belém Tower, the Cathedral & Parque das Nações
$87
per adult
94% of travellers recommend
Lisbon: Sintra, Pena, Regaleira & Cabo Roca & Cascais Coast
$40
per adult
92% of travellers recommend
Santo Antonio Hotel Deals
Locke de Santa Joana
18 Rua Camilo Castelo Branco Lisbon
Fully refundableReserve now, pay when you stay
$92 nightly
$107 total
Nov 23 - Nov 24
Total with taxes and fees
9.4/10 Exceptional! (2,207 reviews)
"👍👍"
Reviewed on Oct 22, 2026
easyHotel Lisbon
R. de Santa Marta 60 Lisbon
Fully refundableReserve now, pay when you stay
$58 nightly
$70 total
Nov 16 - Nov 17
Total with taxes and fees
Pestana Lisboa Vintage City Center Suites
Rua Braamcamp, 7 Lisbon
Fully refundableReserve now, pay when you stay
$94 nightly
$108 total
Nov 22 - Nov 23
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions
How to find the best Santo Antonio package deals?
Bagging a cheap Santo Antonio package deal is a cinch with Expedia. Once you've entered your destination and preferred dates under our "Packages" tab, set your budget range, add some filters and browse what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Santo Antonio package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
When to book a vacation package to Santo Antonio?
If you're considering a spontaneous Santo Antonio adventure, browse our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can land incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santo Antonio?
- Choose the right time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to go to Santo Antonio.
- Calculate your budget: Ensure you have enough money to pay for everything from dining out and transportation to activities and airfares. Your accommodations will likely be the biggest expense during your trip to Santo Antonio.
- Use our trip planning tool to explore Santo Antonio: Research every aspect of your trip to Santo Antonio with this handy planner. Invite friends or family to collaborate on a group getaway, search for stays or things to do and make bookings.
- Work out your trip length: Consider how much time you want to spend exploring Santo Antonio. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
- Bundle your bookings: With your travel dates in place, you can combine your hotels, car rental, flights and more into a tailored Santo Antonio vacation package.
- Book any day trips or activities: Here's the fun part — locking in everything you want to see and do. Explore some of the incredible things to do in Santo Antonio and book your tickets in advance to save time (and maybe some dollars too!).
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.