Santo Antonio Vacations from $785
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Your Santo Antonio Vacation
From its shopping to its cafes and culture, there are tons of good reasons to book a vacation package to Santo Antonio. When you need to get away from it all, this commercial neighborhood has a spot just for you. When it's time to sightsee, you'll find plenty of big-name attractions nearby including Castle of São Jorge, Rossio Square and Lisbon Cathedral. Tick off one or all during your trip to Santo Antonio. Expedia is here to put your travel plans into action. Book your ultimate Santo Antonio vacation today.
The Latest Santo Antonio vacation packages
Price found within the past 48 hours. Click for updated prices.
Masa Hotel 5 de Outubro
Lisbon City Center
$785
per person
Nov 6 - Nov 12
found 1 day ago
Roundtrip flight included
New York (NYC) to Lisbon (LIS)
8.8/10 Excellent! (190 reviews)
A newish, basic tourist hotel in a good location. Nothing works with it. Nothing special about it. If you can get a good price, book it.
Reviewed on Sep 21, 2026
Once Upon Lisboa
Lisbon City Center
$1,380
per person
Oct 27 - Nov 1
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Lisbon (LIS)
9.8/10 Exceptional! (12 reviews)
Very well located, however be careful when opening the trunk of the taxi to get your luggage (sloped).. the elevator is slow, but very stable.. Breakfast next door is amazing.. wine bar is awesome !!
Reviewed on Sep 6, 2026
Raw Culture Arts & Lofts Bairro Alto
Lisbon City Center
$1,227
per person
Dec 14 - Dec 19
found 15 hours ago
Roundtrip flight included
Boston (BOS) to Lisbon (LIS)
9.8/10 Exceptional! (186 reviews)
Fantastic location. Lovely spacious room, with plenty of storage space and a great bathroom. All the staff were friendly, helpful and attentive all the time. Breakfast was relaxed with a wide range of options. Would 1000% stay here again!
Reviewed on Sep 15, 2026
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See all available trips from Columbus to Santo Antonio
View all tripsStay near popular Santo Antonio attractions
Avenida da Liberdade
9.4/10 (3,467 reviews)
You can browse for souvenirs when you visit Avenida da Liberdade, a popular shopping spot in Santo Antonio. Discover the top-notch restaurants in this romantic area, or seek out the local tours.
Amoreiras Shopping Center
8.0/10 (225 reviews)
You can find the perfect gifts to bring home at Amoreiras Shopping Center during your stay in Campo de Ourique. Amble around this vibrant area's riverfront or experience its fascinating museums.
Miradouro de São Pedro de Alcântara
8.8/10 (13 reviews)
You can learn about the history of Misericórdia when you stop by Miradouro de São Pedro de Alcântara. Amble around this vibrant area's riverfront or experience its fascinating museums.
Botanical Garden
8.4/10 (800 reviews)
The oldest botanical garden in Portugal offers great views of the historic Tower of Belem and a peaceful place to rest away from the bustling city streets.
Coracao de Jesus
9.4/10 (3 reviews)
You can find out about the history of Santo Antonio with a trip to Coracao de Jesus. Make time for the shops and local tours in this romantic area.
National Museum of Natural History
8.6/10 (17 reviews)
Discover more about the geology of Portugal and the animals that once roamed here in this hands-on museum.
Cinemateca Portuguesa Museum
8.0/10 (3 reviews)
You can spend an afternoon exploring the galleries in Cinemateca Portuguesa Museum during your trip to Santo Antonio. Experience the acclaimed art scene and fascinating museums in this family-friendly area.
Arpad Szenes - Vieira da Silva Museum
8.0/10 (3 reviews)
You can spend an afternoon exploring the galleries in Arpad Szenes - Vieira da Silva Museum during your trip to Santo Antonio. Experience the acclaimed art scene and fascinating museums in this vibrant area.
What to do in Santo Antonio
Lisbon: Sintra, Pena, Regaleira, Cabo da Roca, and Cascais
$40
per adult
92% of travellers recommend
Lisbon: Sintra, Pena, Regaleira & Cabo Roca & Cascais Coast
$28
per adult
92% of travellers recommend
Tour Lisbon: Belém Tower, the Cathedral & Parque das Nações
$88
per adult
96% of travellers recommend
Santo Antonio Hotel Deals
Locke de Santa Joana
18 Rua Camilo Castelo Branco Lisbon
Fully refundableReserve now, pay when you stay
$129 nightly
$146 total
Oct 25 - Oct 26
Total with taxes and fees
easyHotel Lisbon
R. de Santa Marta 60 Lisbon
Fully refundableReserve now, pay when you stay
$83 nightly
$98 total
Oct 20 - Oct 21
Total with taxes and fees
Pestana Lisboa Vintage City Center Suites
Rua Braamcamp, 7 Lisbon
Fully refundableReserve now, pay when you stay
$167 nightly
$186 total
Oct 26 - Oct 27
Total with taxes and fees
8.8/10 Excellent! (741 reviews)
"Nice comfortable beds. About a 15 min walk to the city center."
Reviewed on Sep 25, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions
How to find the best Santo Antonio package deals?
Bagging a cheap Santo Antonio package deal is a cinch with Expedia. Once you've entered your destination and preferred dates under our "Packages" tab, set your budget range, add some filters and browse what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most wallet-friendly Santo Antonio package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
When to book a vacation package to Santo Antonio?
If you're considering a spontaneous Santo Antonio adventure, browse our last-minute deals that can be booked up to one week before you go. Prefer not to wait until the last minute? You can land incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santo Antonio?
- Choose the right time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to go to Santo Antonio.
- Calculate your budget: Ensure you have enough money to pay for everything from dining out and transportation to activities and airfares. Your accommodations will likely be the biggest expense during your trip to Santo Antonio.
- Use our trip planning tool to explore Santo Antonio: Research every aspect of your trip to Santo Antonio with this handy planner. Invite friends or family to collaborate on a group getaway, search for stays or things to do and make bookings.
- Work out your trip length: Consider how much time you want to spend exploring Santo Antonio. Plan your days so you can get to all the activities and attractions you're interested in at a leisurely pace.
- Bundle your bookings: With your travel dates in place, you can combine your hotels, car rental, flights and more into a tailored Santo Antonio vacation package.
- Book any day trips or activities: Here's the fun part — locking in everything you want to see and do. Explore some of the incredible things to do in Santo Antonio and book your tickets in advance to save time (and maybe some dollars too!).
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
