Santo Spirito

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A historic church with a dome and bell tower, surrounded by trees and a fountain in a public square.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
See properties

Things to do

Picture 1 for Activity Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine

Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine

$20
per adult
94% of travellers recommend
Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine
City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

$26
per adult
74% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Michaelangelo's David

Accademia timed-entry Ticket with App Guide

$44
per adult
90% of travellers recommend
Accademia timed-entry Ticket with App Guide
Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$20
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
The Best of Tuscany in One Day Sightseeing Tour

The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery

$90
per adult
98% of travellers recommend
The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery
People riding scooters in Tuscany

Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine

$146
per adult
98% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
See all activities in Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
$122 nightly
The price is $150 total per night from Nov 25 to Nov 26
$150 total
Nov 25 - Nov 26
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (749 reviews)
"A very nice hotel with great staff members. The front desk staff was extremely helpful and friendly, assisting us with every matter we had. The room was nice and clean, but the bathroom was a little small, but it didn’t affect our stay. The breakfast was good and staff was excellent. One thing I ..."

Reviewed on Oct 28, 2026

Hotel Horto Convento
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
$72 nightly
The price is $95 total per night from Nov 10 to Nov 11
$95 total
Nov 10 - Nov 11
Total with taxes and fees
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Piazza del Duomo ...
9/10 Wonderful! (364 reviews)
"Room was terrible, the AC didn't work and it had no windows."

Reviewed on Oct 26, 2026

La Torre Del Cestello
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
$75 nightly
The price is $98 total per night from Nov 10 to Nov 11
$98 total
Nov 10 - Nov 11
Total with taxes and fees
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,002 reviews)
"Conveniently located, easy parking, extremely friendly staff, delicious breakfast, quirky rooms."

Reviewed on Oct 27, 2026

UNA Hotels Vittoria Firenze
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
$121 nightly
The price is $149 total per night from Nov 9 to Nov 10
$149 total
Nov 9 - Nov 10
Total with taxes and fees
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and premium bedding. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (1,196 reviews)
"Lovely modern hotel a cross the river, but walking distance to city center. Lots of neighborhood restaurants and bars. Staff was professional and friendly. Note: nearby restaurants and street parties can get very loud some nights when evenings are in"

Reviewed on Oct 28, 2026

Palazzo Mannaioni Suites
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6 Florence FI
$62 nightly
The price is $77 total per night from Nov 16 to Nov 17
$77 total
Nov 16 - Nov 17
Total with taxes and fees
Stay at this hostel in Florence. Enjoy free WiFi, daily housekeeping, and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Piazza del ...
Hostel Santa Monaca
Hotel Firenze 2000

Hotel Firenze 2000

2 out of 5
Viale Raffaello Sanzio, 16 Florence FI
$86 nightly
The price is $105 total per night from Nov 1 to Nov 2
$105 total
Nov 1 - Nov 2
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Popular attractions Ponte Vecchio and Piazza del Duomo are located ...
Hotel Firenze 2000
See all 536 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Florence.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Piazza del Duomo and Piazza di Santa Maria Novella are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

A grand cathedral with intricate architectural details, including statues and ornate decorations.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito

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