Santo Spirito

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A town square with historic buildings, a church, and a bell tower.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and notable monuments in this vibrant area.
See properties

Things to do

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

$29
per adult
76% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

$19
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
People riding scooters in Tuscany

Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine

$137
per adult
100% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

$37
per adult
86% of travellers recommend
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$21
per adult
80% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
The Best of Tuscany in One Day Sightseeing Tour

The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery

$84
per adult
98% of travellers recommend
The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery
See all activities in Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
$132 nightly
The price is $161 total per night from Aug 31 to Sep 1
$161 total
Aug 31 - Sep 1
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (718 reviews)
"Everybody on staff was extremely helpful!"

Reviewed on Aug 29, 2026

Hotel Horto Convento
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
$98 nightly
The price is $124 total per night from Aug 31 to Sep 1
$124 total
Aug 31 - Sep 1
Total with taxes and fees
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Pitti Palace are ...
9.2/10 Wonderful! (302 reviews)
"The room was very specious and clean. AC was amazing and worked great. Perfect location too"

Reviewed on Aug 29, 2026

La Torre Del Cestello
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $149 total per night from Sep 4 to Sep 5
$149 total
Sep 4 - Sep 5
Total with taxes and fees
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
UNA Hotels Vittoria Firenze
Casa Santo Nome di GesĆ¹

Casa Santo Nome di GesĆ¹

Piazza del Carmine, 21 Florence FI
$115 nightly
The price is $140 total per night from Aug 31 to Sep 1
$140 total
Aug 31 - Sep 1
Total with taxes and fees
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (381 reviews)
"Beautiful hotel in great location. Staff really helpful with local knowledge. Communal fridge available at reception, which was great for storing drinks."

Reviewed on Aug 27, 2026

Casa Santo Nome di GesĆ¹
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and premium bedding. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (1,162 reviews)
"Staff is very friendly and the location is close to everything."

Reviewed on Aug 30, 2026

Get rates
Palazzo Mannaioni Suites
Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie

Via dei Serragli 49 Florence FI
$83 nightly
The price is $105 total per night from Aug 31 to Sep 1
$105 total
Aug 31 - Sep 1
Total with taxes and fees
Stay at this guesthouse in Florence. Enjoy free WiFi, 2 meeting rooms, and satellite TV channels. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (235 reviews)
"There was a fridge and AC in the room which was nice. Check-in desk was friendly, we actually checked in like an hour early and when checking out we checked out 15 minutes late, not charged and were able to drop our bags with a bathroom available in the lobby. The area felt safe at night and there ..."

Reviewed on Aug 14, 2026

Foresteria Valdese di Firenze - Casa per Ferie
See all 500 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

Cathedral of Santa Maria del Fiore and Piazza di Santa Maria Novella are a few top attractions in Historic Centre of Florence. Hop around the city on the metro at UnitĆ  Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop and check out the area's fascinating museums, stunning cathedral, and stunning river views.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Piazza del Duomo and Piazza di Santa Maria Novella are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing.

An ornate building with intricate architectural details and a clear blue sky in the background.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito

Choose one or more items to build your trip:

Explore a world of travel with Expedia