A tree with white blossoms in a grassy area surrounded by trees.
Photo by Abbie Moon
Open Photo by Abbie Moon

Scott County Vacations & Trips from $416

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Scott County Vacation

Leave all the planning to us with a Scott County vacation package. With everything organized before you go, the only thing left to do is sit back, relax and experience this destination's countless delights. Start your trip to Scott County by spending a few nights in Sikeston, one of the top cities here. Quit dreaming and get packing, because your Scott County vacation is only a few clicks away with Expedia.

Top destinations in Scott County

A tree with sunlight filtering through its leaves, creating a warm glow.
FlightsHotels

Sikeston

Sikeston

The Latest Scott County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A bathroom with a bathtub, shower, and toilet. There is a small sink and a toilet paper holder. The bathroom has a shower curtain and a towel rack.
    Jan 15 - Jan 17

    Wingfield Inn + Flight

    Mayfield
    2 nights
    2.0 star property
    7.8/10 - Good (629 reviews)
    Roundtrip • Washington (DCA) - Paducah (PAH)
    DCA - PAH • 1 stop PAH - DCA • 1 stop
    $440
    $416
    per traveler
    found 1 day ago
    Wingfield Inn
  • A pool table with balls, a chandelier, and framed pictures on the wall.
    Jan 15 - Jan 17

    The Respite Bed and Breakfast + Flight

    Paducah
    2 nights
    4.5 star property
    9.8/10 - Exceptional (382 reviews)
    "the place was nice........."
    Reviewed November 13, 2026
    Roundtrip • Washington (DCA) - Paducah (PAH)
    DCA - PAH • 1 stop PAH - DCA • 1 stop
    $580
    $525
    per traveler
    found 1 day ago
    The Respite Bed and Breakfast
  • A small wooden structure labeled "General Store" with a porch and benches.
    Jan 15 - Jan 17

    The Outpost + Flight

    Grand Rivers
    2 nights
    2.0 star property
    9.4/10 - Exceptional (38 reviews)
    "10 out of 10 experience. Nice little area with them all grouped together but still felt private."
    Reviewed November 13, 2026
    Roundtrip • Washington (DCA) - Paducah (PAH)
    DCA - PAH • 1 stop PAH - DCA • 1 stop
    $583
    $528
    per traveler
    found 1 day ago
    The Outpost
  • A Comfort Suites hotel with a modern design, featuring a stone facade and a covered entrance.
    Jan 15 - Jan 17

    Comfort Suites Paducah Mall Area + Flight

    Paducah
    2 nights
    2.5 star property
    8.4/10 - Very good (1,048 reviews)
    "Great place to stay! We stayed 2 nights and was able to explore Paducah."
    Reviewed November 11, 2026
    Roundtrip • Washington (DCA) - Paducah (PAH)
    DCA - PAH • 1 stop PAH - DCA • 1 stop
    $502
    $470
    per traveler
    found 1 day ago
    Comfort Suites Paducah Mall Area
  • An outdoor seating area with blue Adirondack chairs arranged around a central fire pit.
    Jan 15 - Jan 17

    The Lakehouse Inn at Sledd Creek + Flight

    Gilbertsville
    2 nights
    2.0 star property
    10/10 - Exceptional (192 reviews)
    "We were so presently surprised how wonderful this property was! Beautifully decorated, close to Patti's 1800 Settlement, clean beyond clean room, breakfast too - and the espresso iced coffees were made for us! Highly recommend!!"
    Reviewed November 8, 2026
    Roundtrip • Washington (DCA) - Paducah (PAH)
    DCA - PAH • 1 stop PAH - DCA • 1 stop
    $544
    $514
    per traveler
    found 1 day ago
    The Lakehouse Inn at Sledd Creek

Discover the most popular places to visit in Scott County

Sikeston Depot Museum

7.6/10 (57 reviews)
You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Scott County Hotel Deals

A Drury Inn & Suites building with a covered entrance, multiple windows, and a parking lot.

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
11.2 mi from Scott County
9.6 out of 10, Exceptional, (1,002 reviews)
$94 nightly
The price is $108
Nov 22 - Nov 23
Total with taxes and fees
Drury Inn & Suites Sikeston, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Scott County
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.