Serra Mesa Vacations from $400

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Your Serra Mesa Vacation

Take the stress and hassle out of organizing your next escape with a Serra Mesa vacation package. Immerse yourself in the sights and sounds of this captivating neighborhood and experience everything it has to offer. Your trip to Serra Mesa wouldn't be complete without a visit to big-name attractions nearby such as Snapdragon Stadium, Fashion Valley Mall and Mission Valley Mall. No matter what your dream Serra Mesa vacation may look like, you can make it a reality with Expedia.

The Latest Serra Mesa Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Sand Castle Inn

Sand Castle Inn

2.5 out of 5
Price was $764, price is now $400 per person
$400
per person
Dec 3 - Dec 8
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.2/10 Very Good! (483 reviews)
Conveniently located. Spacious room. Best quality and pricing combination in Imperial Beach.

Reviewed on Sep 9, 2025

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Price was $936, price is now $475 per person
$475
per person
Dec 4 - Dec 10
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.4/10 Very Good! (1,567 reviews)
Clean room, friendly staff

Reviewed on Oct 1, 2025

Temecula Creek Inn

Temecula Creek Inn

4 out of 5
Save 100% on your flight
Price was $941, price is now $534 per person
$534
per person
Nov 19 - Nov 23
found 15 hours ago
Roundtrip flight included
Dallas (DFW) to San Diego (SAN)
8.4/10 Very Good! (1,003 reviews)
Very nice place 👌 👏 👍

Reviewed on Sep 22, 2025

Alila Marea Beach Resort Encinitas, a Hyatt Luxury Resort

Alila Marea Beach Resort Encinitas, a Hyatt Luxury Resort

5 out of 5
Save 100% on your flight
Price was $1,889, price is now $1,087 per person
$1,087
per person
Dec 3 - Dec 8
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.8/10 Excellent! (212 reviews)
Everything was excellent as advertised.

Reviewed on Aug 11, 2025

El Cordova Hotel on Coronado Island

El Cordova Hotel on Coronado Island

3.5 out of 5
Historic Downtown Coronado
Save 100% on your flight
Price was $1,040, price is now $608 per person
$608
per person
Dec 4 - Dec 10
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.8/10 Excellent! (1,004 reviews)
We love this hotel. It gives a feel of having your own apartment on the island. The rooms is are clean and comfortable. The staff is welcoming and accommodating. The location is perfect. Close walking distance to the beach, dining, shopping, as well as the famous Del across the street.

Reviewed on Sep 26, 2025

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Serra Mesa Hotel Deals

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
$177 nightly
The price is $205 total per night from Oct 5 to Oct 6
$205 total
Oct 5 - Oct 6
Total with taxes and fees
8.2/10 Very Good! (5,945 reviews)
"The hotel was nice the only downfall I have is they need to let guests know that it is 50.00 a day to park there."

Reviewed on Oct 1, 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
$266 nightly
The price is $308 total per night from Oct 4 to Oct 5
$308 total
Oct 4 - Oct 5
Total with taxes and fees
9/10 Wonderful! (2,830 reviews)
"The Manchester Grand Hyatt is our go to hotel in San Diego due to its convenient location by the Seaport Village and many restaurants and shops. We have stayed there several times and always enjoy the scenic views from our room and the hospitality of the hotel staff. The breakfast buffet has a large ..."

Reviewed on Sep 30, 2025

Manchester Grand Hyatt San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $138 total per night from Oct 13 to Oct 14
$138 total
Oct 13 - Oct 14
Total with taxes and fees
8.6/10 Excellent! (484 reviews)
"Very convenient location to downtown / petco park"

Reviewed on Sep 29, 2025

The DEXTRO Little Italy, BW Premier Collection
See all 8,927 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Serra Mesa

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

San Diego Whale Watching Tour

San Diego Whale Watching Tour

$57
per adult
86% of travellers recommend
San Diego Whale Watching Tour
Great Scenery

San Diego Sunset Cruise from Mission Bay

$40
per adult
78% of travellers recommend
San Diego Sunset Cruise from Mission Bay
San Diego: Museum of Illusions Entry Ticket

San Diego: Museum of Illusions Entry Ticket

$35
per adult
San Diego: Museum of Illusions Entry Ticket
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.