Name: The DEXTRO Little Italy, BW Premier Collection
Price range: $147 total

Your South Mission Beach Vacation

Book a vacation package to South Mission Beach and get ready to experience its walking, families and watersports. However you want to spend your break in this picturesque neighborhood, there are plenty of opportunities to mix adventure with relaxation. Your trip to South Mission Beach wouldn't be complete without exploring big-name attractions nearby such as Mission Beach, Ocean Beach Park and Mission Bay. Expedia will help you turn your dream South Mission Beach vacation into reality, whatever your travel plans or budget.

The Latest South Mission Beach Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Little Italy Inn - Limited Service Apart Hotel

Downtown San Diego

Save 100% on your flight

$411

per person

Nov 11 - Nov 16

found 1 day ago

Roundtrip flight included

Chicago (CHI) to San Diego (SAN)

7.8/10 Good! (53 reviews)

Not luxury, but didn’t expect it. The room itself was clean and bug free.

Reviewed on Aug 29, 2025

The Sofia Hotel

Downtown San Diego

Save 100% on your flight

$525

per person

Nov 11 - Nov 16

found 1 day ago

Roundtrip flight included

Chicago (CHI) to San Diego (SAN)

8.4/10 Very Good! (1,543 reviews)

I stayed at The Sofia Hotel in downtown San Diego and loved its mix of historic charm and modern comfort. The location is excellent—just steps from the Gaslamp Quarter, the waterfront, and conveniently close to the Santa Fe train station, making travel super easy.

Reviewed on Aug 28, 2025

La Jolla Cove Suites

Village of La Jolla

Save 100% on your flight

$576

per person

Nov 1 - Nov 6

found 20 hours ago

Roundtrip flight included

Denver (DEN) to San Diego (SAN)

7/10 Good! (1,023 reviews)

I enjoyed the quietness of the terrace room and how close the shopping area and park are. Great location, simple check in, would love to visit again

Reviewed on Aug 26, 2025

Coronado Beach Resort

Historic Downtown Coronado

Save 100% on your flight

$682

per person

Nov 2 - Nov 8

found 4 hours ago

Roundtrip flight included

Denver (DEN) to San Diego (SAN)

9/10 Wonderful! (722 reviews)

Excellent customer service!!

Reviewed on Aug 21, 2025

Sand Castle Inn

Save 100% on your flight

$682

per person

Nov 3 - Nov 10

found 1 day ago

Roundtrip non-stop flight included

Chicago (CHI) to San Diego (SAN)

8.2/10 Very Good! (477 reviews)

Wasn't looking for anything fancy; this was just right. And right across the street from the beach!

Reviewed on Jul 21, 2025

Where to stay in South Mission Beach

Find the best South Mission Beach areas and neighborhoods for the activities you enjoy most. Learn more about South Mission Beach

Downtown San Diego

2 out of top 10 points of interest in this area

4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

South Mission Beach Hotel Deals

Wyndham San Diego Bayside

1355 N Harbor Drive, San Diego, CA

Fully refundableReserve now, pay when you stay

$174 nightly

$201 total

Sep 1 - Sep 2

Total with taxes and fees

Bay Club Hotel & Marina

2131 Shelter Island Dr, San Diego, CA

Fully refundableReserve now, pay when you stay

$164 nightly

$189 total

Sep 1 - Sep 2

Total with taxes and fees

The DEXTRO Little Italy, BW Premier Collection

1617 1st Avenue, San Diego, CA

Fully refundableReserve now, pay when you stay

$127 nightly

$147 total

Sep 7 - Sep 8

Total with taxes and fees

See all 8,492 properties in South Mission Beach

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.