A city skyline at dusk with a prominent bridge arching over a body of water.

Southhampton Vacations from $605

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Your Southhampton Vacation

Make planning your travels easy by snapping up a vacation package to Southhampton. Let us take care of all the details, so you can focus on appreciating everything this neighborhood can offer. When it's time to head out and explore, you'll find plenty of big-name attractions nearby including St. Louis Science Center, Tower Grove Park and The Focal Point. Visit one, two (or even all!) during your trip to Southhampton. Expedia will help you turn your dream Southhampton vacation into reality, whatever your budget or travel plans.

The Latest Southhampton Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A cozy lounge area with leather sofas, a fireplace, and a bar counter.
    Dec 18 - Dec 22

    The Cheshire + Flight

    Richmond Heights
    4 nights
    4.0 star property
    8.8/10 - Excellent (1,001 reviews)
    Roundtrip • Denver (DEN) - St. Louis (STL)
    DEN - STL • Nonstop STL - DEN • Nonstop
    $736
    $605
    per traveler
    found 1 day ago
    The Cheshire
  • A hotel with a prominent tower, a fountain, and a landscaped garden.
    Jan 20 - Jan 24

    The Wildwood Hotel + Flight

    Wildwood
    4 nights
    3.5 star property
    9.2/10 - Wonderful (1,681 reviews)
    Roundtrip • Los Angeles (LAX) - St. Louis (STL)
    LAX - STL • Nonstop STL - LAX • Nonstop
    $978
    $673
    per traveler
    found 1 day ago
    The Wildwood Hotel
  • An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
    Dec 18 - Dec 22

    Ameristar Casino Resort and Spa + Flight

    St. Charles
    4 nights
    4.5 star property
    8.8/10 - Excellent (1,088 reviews)
    "We were here for a wedding. Our room was very nice but my son’s bathroom was disgusting and not clean, they had to switch rooms and the only compensation they gave them was a food voucher. Not acceptable with blood and vomit not cleaned from previous guest. We expected more for this caliber of hotel."
    Reviewed November 8, 2026
    Roundtrip • Denver (DEN) - St. Louis (STL)
    DEN - STL • Nonstop STL - DEN • Nonstop
    $782
    $662
    per traveler
    found 1 day ago
    Ameristar Casino Resort and Spa
  • A modern interior with a staircase illuminated by colorful lights, a glass door entrance, and a high ceiling.
    Jan 20 - Jan 24

    Moonrise Hotel + Flight

    Delmar Loop
    4 nights
    4.0 star property
    9.0/10 - Wonderful (2,051 reviews)
    Roundtrip • Los Angeles (LAX) - St. Louis (STL)
    LAX - STL • Nonstop STL - LAX • Nonstop
    $861
    $734
    per traveler
    found 1 day ago
    Moonrise Hotel
  • A multi-level hotel interior with a large glass atrium, a swimming pool, and multiple balconies.
    Jan 20 - Jan 24

    Crowne Plaza St. Louis Airport by IHG + Flight

    Bridgeton
    4 nights
    3.5 star property
    8.0/10 - Very good (1,000 reviews)
    Roundtrip • Los Angeles (LAX) - St. Louis (STL)
    LAX - STL • Nonstop STL - LAX • Nonstop
    $777
    $665
    per traveler
    found 1 day ago
    Crowne Plaza St. Louis Airport by IHG

Where to stay in Southhampton

Find the best Southhampton areas and neighborhoods for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Southhampton Hotel Deals

Lobby

Drury Inn & Suites St. Louis Forest Park

Drury Inn & Suites St. Louis Forest Park
3.0 star property
2.1 mi from Southhampton
9.4 out of 10, Exceptional, (1,029 reviews)
$135 nightly
The price is $158
Nov 17 - Nov 18
Total with taxes and fees
Drury Inn & Suites St. Louis Forest Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Southhampton
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.