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You will find there's only 1 hotel option within a 6-mile radius of central Talofofo, so it's wise securing a place to stay as far in advance as you can.
If you need to stay as close to downtown as possible, the Leopalace Resort Guam is the place to look into.
If you are looking for additional hotel options, the Tumon Bel-Air Serviced Residence and the Hyatt Regency Guam are 13 miles and 13 miles from the heart of Talofofo. 10 miles away sits the Alupang Beach Tower. The Westin Resort, Guam is also near, 13 miles away.
8 miles from Talofofo is Chalan-Pago-Ordot, where you can visit the Plaza and T Galleria by DFS. If you'd like to visit Chalan-Pago-Ordot, check out the Palmridge Inn and Tamuning Plaza Hotel. Or, you could consider staying in Sinajana, 9 miles to the north of Talofofo, where you can choose from the Wyndham Garden Guam and Days Inn Guam-Tamuning. Regardless of whether you're passing through or spending a few nights in Sinajana, set aside a little time to check out Micronesia Mall and UnderWater World.