A pier with a boat rental sign, a colorful building, and a calm sea.

Find 5 Star Hotels in Layton, FL from $222

Check availability on Layton 5 Star Hotels

Tonight
Sep 27 - Sep 28
Tomorrow
Sep 28 - Sep 29
Next weekend
Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Our top choices for Layton 5-star hotels

A bathroom with a large bathtub, a window with curtains, and a view of palm trees and the sea.
A bar area with a thatched roof, wooden chairs, and a view of the ocean.
A spacious lobby with a seating area, a bar, and a large window providing a view of the outdoors.
A hotel room with a large bed, a television, a dining area with chairs, a table, and a view of the ocean.

1. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
United States
RAIBEL
$198 nightly
$222 total
Oct 4 - Oct 5
Total with taxes and fees
Cheeca Lodge & Spa
An aerial view of a resort with a central pool, multiple buildings, and a beach area with sun loungers.
A beach scene with two white chairs, a hammock, and palm trees.
A beach with white chairs and kayaks, palm trees, and a clear view of the ocean.
A bar area with wooden chairs, a bar counter, and a variety of bottles and glasses.

2. Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
Marathon
United States
Andrew
$258 nightly
$290 total
Sep 28 - Sep 29
Total with taxes and fees
Isla Bella Beach Resort & Spa
A balcony with a wooden table, two chairs, and a view of the ocean and palm trees.
A beachside patio with a thatched roof, two lounge chairs, and a view of the ocean.
A pool area with clear blue water, white lounge chairs, and palm trees.
A gated entrance to a resort with palm trees and a clear sky.

3. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
United States
Christian
$466 nightly
$523 total
Oct 1 - Oct 2
Total with taxes and fees
The Islands of Islamorada
A resort pool with a view of the sea, surrounded by palm trees and lounge chairs.
A modern kitchen with white cabinetry, a marble island, and wooden bar stools.
A clean, empty garage with fluorescent lighting, a metal garage door, and visible plumbing on the ceiling.
A wooden deck with a spiral staircase leading to an upper level.

4. Sea Glass Cove

Sea Glass Cove
Marathon
Sea Glass Cove
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Layton.
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd Marathon FL
$255 nightly
$286 total
Oct 4 - Oct 5
Total with taxes and fees
8.2/10 Very Good! (1,004 reviews)
Hawks Cay Resort
Amara Cay Resort

Amara Cay Resort

80001 Overseas Hwy Islamorada FL
$208 nightly
$234 total
Sep 30 - Oct 1
Total with taxes and fees
Amara Cay Resort
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

84001 Overseas Hwy Islamorada FL
$272 nightly
$306 total
Oct 13 - Oct 14
Total with taxes and fees
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Still don't see what you're looking for?
See all properties in Layton.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Layton

Nestled in the Florida Keys, this small coastal gem invites you to explore Anne's Beach and Long Key State Park's pristine shorelines. Snorkel from Bud n' Mary's Dive Center or kayak through Curry Hammock State Park's mangroves for an authentic Keys experience.

See all hotels in Layton
A long bridge over turquoise water with a clear sky.

Top Layton Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"My wife and I truly enjoyed this resort. The staff were very accommodating and made us feel right at home.We were free to be alone on the property or mix with others. Marathon was right in the middle of the Florida Keys and just what we expected and more. We visited Key West on one day and Islamorada and ran a Cat Boat around the local waters and mangroves. The Resort Bar was always there with sight of our Ocean Front Balcony. Thanks!!!!!"
Douglas M 4-night trip
Posted 17 hours ago
Isla Bella Beach Resort & Spa
Cheeca Lodge & Spa

Cheeca Lodge & Spa

8/10 Good
"Overall, it was a wonderful and beautiful place to stay. The main downside was that our elevator was not working the entire 6 days we were here and having to pay $73/day in resort fees makes me think they should have fixed it promptly. We had to climb 4 flights of stairs every time we left our room. Also be warned that they put a $200 hold per night on your credit card which I was not aware of. So $1000 was immediately taken from my bank account which I had intended to use for spending money. The staff were great. Thanks"
Angela 5-night trip
Posted 1 day ago
Cheeca Lodge & Spa

Find out more about Layton

Why not demand complete opulence during your trip to Layton? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Layton so popular in the last year. There's no reason to delay a getaway to Layton any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Layton and get ready to enjoy the getaway of a lifetime. Don't wait any longer!

5-Star Hotels in Layton

You'll have a fantastic time at one of these 5-star hotels. Exceptional service, delicious meals, and one-on-one attention are all waiting for you. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. How do you want to relax? A Swedish massage to help your cares fall away? A concierge to help you make reservations at that outstanding restaurant? High thread-count sheets, piping hot coffees, and even a hot tub in the bathroom...these hotels will astonish you.

Ready for experiences outside your hotel room? You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Layton are waiting for you to rest up after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Your Getaway Starts Today

The results are in, and Layton 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Opt for one of the 5-star hotels in Layton today and relax in the lap of luxury tomorrow.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Layton?
How much you pay for a 5-star hotel in Layton can vary according to when you prefer to travel and how long you plan to stay, among a range of factors. Take advantage of our price per night filter and other search tools to find the best rate on an indulgent stay.
  • Search for the lowest price per night from $234
What makes a hotel 5 stars in Layton?
In Layton, a hotel must offer a specific level of upscale conveniences to earn 5 stars. These can include on-site gyms, spas and saunas, gourmet restaurants, complimentary luxury toiletries, premium bedding and more. What also sets 5-star hotels apart is their exceptional standard of service. You'll enjoy things like concierge services, nightly turn-down services and in-room massage. Some may even offer extra touches such as a welcome gift.
Are there any 5-star all-inclusive resorts in Layton?
Find an indulgent getaway that includes your lodging, food, activities and entertainment in Layton with Expedia's filter tool. Search for hotels rated 5 stars and select the "All inclusive" filter. Be sure to check what's included in the upfront price. This way, you're ready to take advantage of the many perks on offer when you get there.

Explore a world of travel with Expedia